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EA201690087A1 - Новые квиназолиноны как ингибиторы бромодомена - Google Patents

Новые квиназолиноны как ингибиторы бромодомена

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Publication number
EA201690087A1
EA201690087A1 EA201690087A EA201690087A EA201690087A1 EA 201690087 A1 EA201690087 A1 EA 201690087A1 EA 201690087 A EA201690087 A EA 201690087A EA 201690087 A EA201690087 A EA 201690087A EA 201690087 A1 EA201690087 A1 EA 201690087A1
Authority
EA
Eurasian Patent Office
Prior art keywords
quinazolinons
bromomodenial
inhibitors
new
therapy
Prior art date
Application number
EA201690087A
Other languages
English (en)
Inventor
Джон Фредерик Квинн
Владимир Хлебников
Original Assignee
Зенит Эпидженетикс Корп.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зенит Эпидженетикс Корп. filed Critical Зенит Эпидженетикс Корп.
Publication of EA201690087A1 publication Critical patent/EA201690087A1/ru

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

Данное изобретение относится к соединениям, которые применяют для ингибирования функции белка BET посредством связывания с бромодоменами, а также их применению в терапии.
EA201690087A 2013-07-31 2014-07-30 Новые квиназолиноны как ингибиторы бромодомена EA201690087A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361860403P 2013-07-31 2013-07-31
PCT/IB2014/002510 WO2015015318A2 (en) 2013-07-31 2014-07-30 Novel quinazolinones as bromodomain inhibitors

Publications (1)

Publication Number Publication Date
EA201690087A1 true EA201690087A1 (ru) 2016-08-31

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US (2) US9855271B2 (ru)
EP (1) EP3027604B1 (ru)
JP (1) JP6542212B2 (ru)
KR (1) KR20160038008A (ru)
CN (1) CN105593224B (ru)
AU (1) AU2014298051B2 (ru)
CA (1) CA2919948C (ru)
EA (1) EA201690087A1 (ru)
HK (1) HK1218547A1 (ru)
IL (1) IL243479B (ru)
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