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EA201591766A1 - Мутеины интерлейкина-2 для экспансии регуляторных т-клеток - Google Patents

Мутеины интерлейкина-2 для экспансии регуляторных т-клеток

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Publication number
EA201591766A1
EA201591766A1 EA201591766A EA201591766A EA201591766A1 EA 201591766 A1 EA201591766 A1 EA 201591766A1 EA 201591766 A EA201591766 A EA 201591766A EA 201591766 A EA201591766 A EA 201591766A EA 201591766 A1 EA201591766 A1 EA 201591766A1
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EA
Eurasian Patent Office
Prior art keywords
cells
expansion
present
proposed
regulatory
Prior art date
Application number
EA201591766A
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English (en)
Other versions
EA034326B1 (ru
Inventor
Марк А. Гэйвин
Гунасекаран Каннан
Ли Ли
Джошуа Т. Пирсон
Маргарет Кароу
Original Assignee
Эмджен Инк.
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Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201591766A1 publication Critical patent/EA201591766A1/ru
Publication of EA034326B1 publication Critical patent/EA034326B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В настоящем изобретении предложены мутеины ИЛ-2 и гибридные молекулы, содержащие мутеин ИЛ-2 и фрагмент Fc, которые предпочтительно стимулируют экспансию и активируют регуляторные Т-клетки и пригодны для крупномасштабного производства. В настоящем изобретении также предложены варианты молекул Fc IgG1 человека со значительно сниженной эффекторной функцией или лишенные ее и имеющие высокую стабильность, несмотря на отсутствие гликозилирования в положении N297. В настоящем изобретении также предложены линкерные пептиды, которые подвергаются гликозилированию при экспрессии в клетках млекопитающих.
EA201591766A 2013-03-14 2014-03-14 Мутеин интерлейкина-2 человека, стимулирующий регуляторные т-клетки, и его применения EA034326B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784669P 2013-03-14 2013-03-14
PCT/US2014/029111 WO2014153111A2 (en) 2013-03-14 2014-03-14 Interleukin-2 muteins for the expansion of t-regulatory cells

Publications (2)

Publication Number Publication Date
EA201591766A1 true EA201591766A1 (ru) 2016-02-29
EA034326B1 EA034326B1 (ru) 2020-01-28

Family

ID=50680166

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201591731A EA032863B1 (ru) 2013-03-14 2014-03-14 АГЛИКОЗИЛИРОВАННЫЕ Fc-СОДЕРЖАЩИЕ ПОЛИПЕПТИДЫ
EA201591766A EA034326B1 (ru) 2013-03-14 2014-03-14 Мутеин интерлейкина-2 человека, стимулирующий регуляторные т-клетки, и его применения

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EA201591731A EA032863B1 (ru) 2013-03-14 2014-03-14 АГЛИКОЗИЛИРОВАННЫЕ Fc-СОДЕРЖАЩИЕ ПОЛИПЕПТИДЫ

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US (8) US9546203B2 (ru)
EP (2) EP2970423B1 (ru)
JP (6) JP6450365B2 (ru)
KR (5) KR102418771B1 (ru)
CN (2) CN105143253B (ru)
AP (1) AP2015008737A0 (ru)
AR (1) AR095541A1 (ru)
AU (2) AU2014236316B2 (ru)
BR (1) BR112015022440B1 (ru)
CA (3) CA3149348C (ru)
CL (2) CL2015002686A1 (ru)
CR (2) CR20200004A (ru)
CY (2) CY1121767T1 (ru)
DK (2) DK2970441T3 (ru)
EA (2) EA032863B1 (ru)
ES (2) ES2737598T3 (ru)
HR (2) HRP20190970T1 (ru)
HU (2) HUE044321T2 (ru)
IL (2) IL241349B (ru)
JO (1) JO3796B1 (ru)
LT (2) LT2970441T (ru)
MA (2) MA38477B1 (ru)
ME (2) ME03482B (ru)
MX (2) MX372880B (ru)
MY (2) MY202248A (ru)
NZ (1) NZ751148A (ru)
PE (1) PE20151763A1 (ru)
PH (1) PH12015502051B1 (ru)
PL (2) PL2970423T3 (ru)
PT (2) PT2970441T (ru)
RS (2) RS58854B1 (ru)
SG (2) SG11201507420UA (ru)
SI (2) SI2970423T1 (ru)
SM (2) SMT201900301T1 (ru)
TN (1) TN2015000416A1 (ru)
TR (2) TR201910802T4 (ru)
TW (3) TWI709572B (ru)
UA (1) UA119140C2 (ru)
UY (2) UY40090A (ru)
WO (2) WO2014153111A2 (ru)

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CN115315437A (zh) * 2020-03-19 2022-11-08 信达生物制药(苏州)有限公司 白介素2突变体及其用途

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