[go: up one dir, main page]

EA201390400A1 - СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО - Google Patents

СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО

Info

Publication number
EA201390400A1
EA201390400A1 EA201390400A EA201390400A EA201390400A1 EA 201390400 A1 EA201390400 A1 EA 201390400A1 EA 201390400 A EA201390400 A EA 201390400A EA 201390400 A EA201390400 A EA 201390400A EA 201390400 A1 EA201390400 A1 EA 201390400A1
Authority
EA
Eurasian Patent Office
Prior art keywords
neutral
immunohlobulins
hystidine
stabilization
help
Prior art date
Application number
EA201390400A
Other languages
English (en)
Other versions
EA027353B1 (ru
Inventor
Харальд Арно Буттервек
Бернхард Кельбль
Лючия Хофбауэр
Вольфганг Тешнер
Ханс-Петер Шварце
Original Assignee
Бакстер Интернэшнл Инк.
Бакстер Хелткэр С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44721088&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390400(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бакстер Интернэшнл Инк., Бакстер Хелткэр С.А. filed Critical Бакстер Интернэшнл Инк.
Publication of EA201390400A1 publication Critical patent/EA201390400A1/ru
Publication of EA027353B1 publication Critical patent/EA027353B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

В настоящем изобретении предложены наряду с другими аспектами стабильные при хранении водные составы иммуноглобулинов с гистидином при рН в диапазоне от слабокислого до нейтрального. В настоящем изобретении также предложены способы стабилизации иммуноглобулиновых композиций путем приготовления их с гистидином при рН в диапазоне от слабокислого до нейтрального. Преимущественно способы и составы, описанные в настоящей заявке, позволяют получить стабильные водные композиции иммуноглобулинов при рН в диапазоне от слабокислого до нейтрального, подходящие для парентерального введения.
EA201390400A 2010-09-17 2011-09-16 СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО EA027353B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38420910P 2010-09-17 2010-09-17
PCT/US2011/052053 WO2012037534A1 (en) 2010-09-17 2011-09-16 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral ph

Publications (2)

Publication Number Publication Date
EA201390400A1 true EA201390400A1 (ru) 2013-08-30
EA027353B1 EA027353B1 (ru) 2017-07-31

Family

ID=44721088

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201390400A EA027353B1 (ru) 2010-09-17 2011-09-16 СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО
EA201692397A EA032336B1 (ru) 2010-09-17 2011-09-16 Стабильная водная иммуноглобулиновая композиция и способ стабилизации иммуноглобулиновой композиции

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201692397A EA032336B1 (ru) 2010-09-17 2011-09-16 Стабильная водная иммуноглобулиновая композиция и способ стабилизации иммуноглобулиновой композиции

Country Status (23)

Country Link
US (4) US20120076779A1 (ru)
EP (3) EP4289445A3 (ru)
JP (4) JP6055412B2 (ru)
KR (1) KR101879885B1 (ru)
CN (2) CN104524566B (ru)
AR (3) AR083034A1 (ru)
AU (2) AU2011301803A1 (ru)
BR (1) BR112013006308B1 (ru)
CA (2) CA2810731A1 (ru)
CL (1) CL2013000724A1 (ru)
CO (1) CO6660498A2 (ru)
DK (1) DK2616090T3 (ru)
EA (2) EA027353B1 (ru)
ES (1) ES2959479T3 (ru)
FI (1) FI2616090T3 (ru)
IL (1) IL225093B (ru)
MX (1) MX351706B (ru)
MY (1) MY188828A (ru)
PL (1) PL2616090T3 (ru)
PT (1) PT2616090T (ru)
SG (1) SG188487A1 (ru)
TW (2) TWI621625B (ru)
WO (2) WO2012037534A1 (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI532498B (zh) 2008-03-17 2016-05-11 巴克斯特保健公司 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法
MX2012003282A (es) * 2009-09-17 2012-04-30 Baxter Healthcare Sa Co-formulacion estable de hialuronidasa e inmunoglobulina, y metodos de su uso.
MX351706B (es) * 2010-09-17 2017-10-25 Baxalta Inc Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro.
KR102362829B1 (ko) 2012-09-07 2022-02-15 코히러스 바이오사이언시즈, 인코포레이티드 아달리무맙의 안정한 수성 제형
WO2014182631A1 (en) * 2013-05-06 2014-11-13 Baxter International Inc. Treatment of alzheimer's disease subpopulations with pooled immunoglobulin g
EP3177317B1 (en) 2014-08-04 2020-03-18 CSL Limited Factor viii formulation
TWI705822B (zh) * 2014-12-19 2020-10-01 美商波麥堤克生物治療股份有限公司 包含纖維蛋白溶酶原之醫藥組合物及其用途
CN104826117B (zh) * 2015-05-05 2017-11-14 广东卫伦生物制药有限公司 用于人体血清免疫球蛋白溶液制剂的储存稳定剂
US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
WO2017121867A1 (en) * 2016-01-13 2017-07-20 Genmab A/S Formulation for antibody and drug conjugate thereof
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
TW201827052A (zh) * 2016-10-26 2018-08-01 日商安斯泰來製藥股份有限公司 安定的醫藥組成物
WO2018181876A1 (ja) * 2017-03-31 2018-10-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 水性製剤及び注射器入り水性製剤、並びに、抗体タンパク脱凝集剤及び抗体タンパク脱凝集方法
BR112020020854A2 (pt) * 2018-04-12 2021-01-19 Amgen Inc. Métodos para produzir composições de proteínas estáveis
KR20220029733A (ko) 2019-07-04 2022-03-08 체에스엘 베링 렝나우 아게 응고 인자 viii의 시험관내 안정성을 증가시키기 위한 절단된 폰 빌레브란트 인자 (vwf)
US20240052020A1 (en) * 2020-09-27 2024-02-15 Emergent Biosolutions Canada Inc. Hyperimmune globulin formulations
EP4240757A2 (en) 2020-11-09 2023-09-13 Takeda Pharmaceutical Company Limited Purification of fviii from plasma using silicon oxide adsorption

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK166763C (da) 1983-03-16 1993-07-12 Immuno Ag Immunoglobulin-g-holdig fraktion
DE3310150A1 (de) 1983-03-21 1984-09-27 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer nebenwirkungsfreien igg-immunglobulinloesung fuer die intravenoese applikation
DE3422000A1 (de) 1984-06-14 1985-12-19 Albert Schrem Werkzeugfabrik GmbH, 7928 Giengen Druckmittelbetaetigte spannvorrichtung zum spannen von werkzeugen oder werkstuecken
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
US4770999A (en) 1985-04-22 1988-09-13 Genetics Institute, Inc. High yield production of active Factor IX
US4786726A (en) 1986-01-06 1988-11-22 Blood Systems, Inc. Factor IX therapeutic blood product, means and methods of preparing same
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5763394A (en) 1988-04-15 1998-06-09 Genentech, Inc. Human growth hormone aqueous formulation
FR2638643B1 (fr) 1988-11-09 1991-04-12 Transgene Sa Sequence d'adn codant pour le facteur ix humain ou une proteine analogue, vecteur d'expression, cellules transformees, procede de preparation du facteur ix et produits obtenus correspondants
JP2871709B2 (ja) 1988-11-21 1999-03-17 住友製薬株式会社 免疫グロブリンｇ結合活性を有する新規な蛋白質プロテインｈ、該蛋白質をコードする遺伝子及び該蛋白質の製造法
AU4803890A (en) 1988-12-15 1990-07-10 Invitron Corporation Use of basic amino acids to solubilize immunoglobulins
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
ATE185601T1 (de) 1990-07-10 1999-10-15 Cambridge Antibody Tech Verfahren zur herstellung von spezifischen bindungspaargliedern
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
WO1994025585A1 (en) 1993-04-26 1994-11-10 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AT402261B (de) 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
WO1993006213A1 (en) 1991-09-23 1993-04-01 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
JP3507073B2 (ja) 1992-03-24 2004-03-15 ケンブリッジ アンティボディー テクノロジー リミティド 特異的結合対の成員の製造方法
ATE381614T1 (de) 1992-07-24 2008-01-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
ATE175979T1 (de) * 1993-12-27 1999-02-15 Rotkreuzstiftung Zentrallab Verfahren zur herstellung eines konzentrates von anti-d-immunoglobulin g und pharmazeutische zusammensetzung, die dieses enthält
GB9418092D0 (en) 1994-09-08 1994-10-26 Red Cross Found Cent Lab Blood Organic compounds
US7253262B2 (en) 1995-01-19 2007-08-07 Quandrant Drug Delivery Limited Dried blood factor composition comprising trehalose
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5925738A (en) * 1995-12-01 1999-07-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
DE69837493T2 (de) * 1997-10-15 2007-12-13 Asahi Kasei Pharma Corp. Verfahren zur qualitätssicherstellung von wässrigen parenteralen lösungen mit thrombomodulin in der lagerung und verteilung
DE19803453A1 (de) * 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
WO1999038522A1 (en) 1998-01-30 1999-08-05 Rhinopharma As Herbal anti-viral agent
CA2349468C (en) 1998-11-10 2013-07-09 Baxter Aktiengesellschaft Factor viii polypeptide having factor viii:c activity
ATE365052T1 (de) * 1999-02-22 2007-07-15 Univ Connecticut Neue albuminfreie faktor viii formulierungen
KR20140094647A (ko) 1999-03-25 2014-07-30 아비에 도이치란트 게엠베하 운트 콤파니 카게 사람 ｉｌ-12에 결합하는 사람 항체 및 이의 제조방법
WO2002013860A1 (fr) * 2000-08-11 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps
US6555391B1 (en) 2000-08-15 2003-04-29 Baxter International, Inc. Methods of conditioning an affinity resin after storage
JP2004532642A (ja) * 2001-06-13 2004-10-28 ジェネンテック・インコーポレーテッド 動物細胞の培養方法と動物細胞でのポリペプチド産生
US20060024346A1 (en) * 2004-07-29 2006-02-02 Brody Richard S Stabilization of biologically active proteins with mixtures of polysaccharides and amino acid based compounds
ATE556591T1 (de) * 2001-11-08 2012-05-15 Abbott Biotherapeutics Corp Stabile pharmazeutische flüssigformulierung von igg-antikörpern
JP4364645B2 (ja) 2002-02-14 2009-11-18 中外製薬株式会社 抗体含有溶液製剤
CN1671741A (zh) * 2002-06-21 2005-09-21 拜奥根Idec公司 浓缩抗体的缓冲剂制剂及其使用方法
AU2003251906B2 (en) 2002-07-12 2008-12-04 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
US7857828B2 (en) 2003-01-30 2010-12-28 Integrated Vascular Systems, Inc. Clip applier and methods of use
AU2004210679A1 (en) * 2003-02-10 2004-08-26 Elan Pharmaceuticals, Inc. Immunoglobulin formulation and method of preparation thereof
JP4869064B2 (ja) 2003-04-04 2012-02-01 ジェネンテック， インコーポレイテッド 高濃度抗体及びタンパク質製剤
CA2737127C (en) * 2003-05-14 2016-07-26 Immunogen, Inc. Maytansinoid-antibody conjugate compositions
WO2004112828A1 (en) * 2003-06-25 2004-12-29 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
DK1698640T4 (da) 2003-10-01 2019-09-02 Kyowa Hakko Kirin Co Ltd Fremgangsmåde til stabilisering af antistof og antistofpræparat som stabiliseret opløsning.
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
EP1713502A1 (de) 2004-02-12 2006-10-25 MERCK PATENT GmbH Hochkonzentrierte, flüssige formulierungen von anti-egfr-antikörpern
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
DE602006015907D1 (de) 2005-01-14 2010-09-16 Bayer Healthcare Llc Verfahren zur reinigung von factor vii
GT200600031A (es) * 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
EP1917030A4 (en) * 2005-08-03 2011-03-09 Immunogen Inc IMMUNKONJUGATFORMULIERUNGEN
KR100667860B1 (ko) 2005-10-18 2007-01-11 주식회사 녹십자 고순도 사람 혈액응고 제9인자의 정제 방법
AU2006330858A1 (en) * 2005-12-21 2007-07-05 Wyeth Protein formulations with reduced viscosity and uses thereof
US9084777B2 (en) * 2005-12-28 2015-07-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
ES2629304T3 (es) 2006-01-04 2017-08-08 Baxalta Incorporated Medio de cultivo celular sin oligopéptidos
AU2007212147A1 (en) 2006-02-03 2007-08-16 Medimmune, Llc Protein formulations
CA2666492C (en) 2006-10-20 2012-07-17 Douglas Rehder Stable polypeptide formulations
CN101199845B (zh) * 2006-12-14 2012-05-23 上海国健生物技术研究院 一种稳定的抗IgE人源化单抗制剂
CA2673260A1 (en) * 2006-12-20 2008-07-03 Bayer Healthcare Llc Factor vii and viia compositions
DK2125866T3 (da) 2007-02-28 2013-07-29 Baxter Int Fremgangsmåde til rensning af rekombinant blodkoagulationsfaktor IX, som er beriget med sulfaterede og/eller phosphorylerede molekyler
EP2136839A4 (en) * 2007-03-22 2010-04-07 Imclone Llc STABLE ANTIBODY FORMULATIONS
US7598560B2 (en) 2007-03-30 2009-10-06 Kavalieros Jack T Hetero-bimos injection process for non-volatile flash memory
EP2068923A4 (en) * 2007-03-30 2010-11-24 Medimmune Llc ANTIBODIES HAVING REDUCED DEAMIDATION PROFILES
US20090208492A1 (en) * 2007-06-14 2009-08-20 Elan Pharmaceuticals, Inc. Lyophilized Immunoglobulin Formulations and Methods of Preparation
WO2009009406A1 (en) * 2007-07-06 2009-01-15 Smithkline Beecham Corporation Antibody formulations
HUE026210T2 (en) 2008-11-12 2016-05-30 Baxalta Inc Procedure for serum-free, insulin-free VII. factor
NZ592644A (en) 2008-11-28 2013-09-27 Abbott Lab Stable antibody compositions and methods for stabilizing same
EP2196476A1 (en) 2008-12-10 2010-06-16 Novartis Ag Antibody formulation
AR076640A1 (es) 2009-03-06 2011-06-29 Genentech Inc Formulacion con anticuerpo. metodo para estabilizar anticuerpo. articulo de manufactura
US8546548B2 (en) 2009-05-27 2013-10-01 Baxter International Inc. Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use
GB0915480D0 (en) * 2009-09-04 2009-10-07 Arecor Ltd Stable formulation of factor viii
WO2011028961A2 (en) * 2009-09-04 2011-03-10 Xoma Technology Ltd. Anti-botulism antibody coformulations
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
SG183983A1 (en) 2010-03-17 2012-10-30 Abbott Res Bv Anti-nerve growth factor (ngf) antibody compositions
MX351706B (es) 2010-09-17 2017-10-25 Baxalta Inc Estabilizacion de inmunoglobulinas a traves de una formulacion acuosa con histidina a ph acido debil a neutro.

Also Published As

Publication number Publication date
JP2013544763A (ja) 2013-12-19
EP2616090A1 (en) 2013-07-24
KR101879885B1 (ko) 2018-07-18
EA201692397A1 (ru) 2017-08-31
WO2012037530A1 (en) 2012-03-22
IL225093B (en) 2018-05-31
EP2616090B8 (en) 2023-10-04
EP2616090B1 (en) 2023-08-23
CO6660498A2 (es) 2013-04-30
JP2018203784A (ja) 2018-12-27
EA032336B1 (ru) 2019-05-31
CN104524566B (zh) 2018-08-07
CN104524566A (zh) 2015-04-22
US8795658B2 (en) 2014-08-05
TW201213342A (en) 2012-04-01
AR083035A1 (es) 2013-01-30
KR20130099956A (ko) 2013-09-06
SG188487A1 (en) 2013-05-31
EP4289445A3 (en) 2024-02-21
CA2810731A1 (en) 2012-03-22
TW201217395A (en) 2012-05-01
US20180250401A1 (en) 2018-09-06
AU2011301807A1 (en) 2013-03-28
JP2017071631A (ja) 2017-04-13
BR112013006308B1 (pt) 2022-03-22
CN103282042B (zh) 2014-12-10
MY188828A (en) 2022-01-06
JP6055412B2 (ja) 2016-12-27
CL2013000724A1 (es) 2014-03-21
DK2616090T3 (da) 2023-09-18
PT2616090T (pt) 2023-10-16
TWI621625B (zh) 2018-04-21
MX2013003018A (es) 2013-06-28
AR122552A2 (es) 2022-09-21
EA027353B1 (ru) 2017-07-31
AU2011301803A1 (en) 2013-03-21
ES2959479T3 (es) 2024-02-26
WO2012037534A1 (en) 2012-03-22
MX351706B (es) 2017-10-25
AU2011301807C1 (en) 2016-02-11
PL2616090T3 (pl) 2023-12-18
US20140370000A1 (en) 2014-12-18
FI2616090T3 (fi) 2023-09-21
BR112013006308A2 (pt) 2016-06-07
US9855331B2 (en) 2018-01-02
CN103282042A (zh) 2013-09-04
AR083034A1 (es) 2013-01-30
EP2616091A1 (en) 2013-07-24
US20120076772A1 (en) 2012-03-29
JP2013544762A (ja) 2013-12-19
US20120076779A1 (en) 2012-03-29
AU2011301807B2 (en) 2015-07-30
CA2810734A1 (en) 2012-03-22
EP4289445A2 (en) 2023-12-13

Similar Documents

Publication Publication Date Title
EA201692397A1 (ru) СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО
EA201590518A1 (ru) Стабильные водные составы адалимумаба
MY185867A (en) Stabilized antibody-containing liquid formulations
EA201490815A1 (ru) Составы этанерцепта, стабилизированные с помощью аминокислот
CY1118601T1 (el) Αλκυλαμινο-υποκατεστημενες δικυανοπυριδινες και προφαρμακα τυπου εστερα αμινοξεος αυτων
EA201400483A1 (ru) Составы собирателей и способы их применения
EA201890333A1 (ru) Противовирусные соединения
EA201591003A1 (ru) Производные бороновой кислоты и их терапевтическое применение
EA201600317A1 (ru) Гербицидные соединения
EA201391495A1 (ru) Производные пиримидина для лечения вирусных инфекций
EA201492002A1 (ru) Противовирусные соединения
EA201492056A1 (ru) Пиримидиниловые ингибиторы тирозинкиназы
EA201590887A1 (ru) Композиция
EA201270216A1 (ru) Фармацевтический состав
EA201600344A1 (ru) Гербицидные соединения
EA201270741A1 (ru) Пероральные композиции и липофильные соли метилналтрексона
BR112015000229A2 (pt) formulações aquosas estáveis de etanercept
EA201591512A9 (ru) Борсодержащие молекулы, способы и составы
EA201691141A1 (ru) Соединения против ccr6
EA201590041A1 (ru) Твердая форма холиновой соли вемурафениба
EA201590379A1 (ru) Пирролопиразолы, используемые в качестве блокаторов кальциевых каналов n-типа
MX387269B (es) Formulaciones de factor ix liofilizadas.
EA201992509A1 (ru) Гетероарилфениламинохинолины и аналоги
GT200800230A (es) Novedosos derivados de imidazol
PH12015502717B1 (en) Anti-fibrogenic compounds, methods and uses thereof

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM