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EA201290209A1 - Новые модуляторы бензопиран киназы - Google Patents

Новые модуляторы бензопиран киназы

Info

Publication number
EA201290209A1
EA201290209A1 EA201290209A EA201290209A EA201290209A1 EA 201290209 A1 EA201290209 A1 EA 201290209A1 EA 201290209 A EA201290209 A EA 201290209A EA 201290209 A EA201290209 A EA 201290209A EA 201290209 A1 EA201290209 A1 EA 201290209A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kenazes
benzipirane
new modulators
methods
modulators
Prior art date
Application number
EA201290209A
Other languages
English (en)
Other versions
EA027123B1 (ru
Inventor
Мейяппан Мутуппаланиаппан
Срикант Висванадха
Говиндараджулу Бабу
Сваруп Кумар В.С. Ваккаланка
Original Assignee
Ризен Фармасьютикалз С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ризен Фармасьютикалз С.А. filed Critical Ризен Фармасьютикалз С.А.
Publication of EA201290209A1 publication Critical patent/EA201290209A1/ru
Publication of EA027123B1 publication Critical patent/EA027123B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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Abstract

В настоящем изобретении представлены модуляторы протеинкиназы PI3K, способы их получения, фармацевтические композиции, содержащие их, а также способы лечения, предупреждения и/или улучшения киназа-опосредованных заболеваний или нарушений, связанных с ней.
EA201290209A 2009-11-05 2010-11-03 Ингибиторы киназы pi3k EA027123B1 (ru)

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IN1429CH2010 2010-05-24
US36466110P 2010-07-15 2010-07-15
PCT/IB2010/002804 WO2011055215A2 (en) 2009-11-05 2010-11-03 Novel kinase modulators

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