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EA201200086A1 - Замещенные 2-карбоксамиды циклоаминомочевин - Google Patents

Замещенные 2-карбоксамиды циклоаминомочевин

Info

Publication number
EA201200086A1
EA201200086A1 EA201200086A EA201200086A EA201200086A1 EA 201200086 A1 EA201200086 A1 EA 201200086A1 EA 201200086 A EA201200086 A EA 201200086A EA 201200086 A EA201200086 A EA 201200086A EA 201200086 A1 EA201200086 A1 EA 201200086A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cycloaminom
ceams
carboxamides
substituted
compounds
Prior art date
Application number
EA201200086A
Other languages
English (en)
Inventor
Робин Алек Фэрхёрст
Паскаль Фюре
Марк Гершпахер
Роберт Мах
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201200086A1 publication Critical patent/EA201200086A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В заявке описаны соединения формулы Iи их соли, где заместители имеют значения, как определено в настоящем описании, а также композиции указанных соединений и их применение при лечении заболеваний, интенсивность симптомов которых снижается при ингибировании фосфатидилинозит-3-киназы.
EA201200086A 2009-07-02 2010-07-01 Замещенные 2-карбоксамиды циклоаминомочевин EA201200086A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27002909P 2009-07-02 2009-07-02
PCT/EP2010/059352 WO2011000905A1 (en) 2009-07-02 2010-07-01 Substituted 2-carboxamide cycloamino ureas

Publications (1)

Publication Number Publication Date
EA201200086A1 true EA201200086A1 (ru) 2012-07-30

Family

ID=42727680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201200086A EA201200086A1 (ru) 2009-07-02 2010-07-01 Замещенные 2-карбоксамиды циклоаминомочевин

Country Status (14)

Country Link
US (1) US8293753B2 (ru)
EP (1) EP2448935B1 (ru)
JP (1) JP2012531456A (ru)
KR (1) KR20120092552A (ru)
CN (1) CN102471332A (ru)
AR (1) AR077367A1 (ru)
AU (1) AU2010268019A1 (ru)
BR (1) BRPI1015909A2 (ru)
CA (1) CA2766855A1 (ru)
EA (1) EA201200086A1 (ru)
MX (1) MX2012000177A (ru)
TW (1) TW201105666A (ru)
UY (1) UY32747A (ru)
WO (1) WO2011000905A1 (ru)

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BRPI0820722A2 (pt) * 2007-12-20 2015-06-16 Novartis Ag Derivados de tiazol usados como inibidores de pi 3 cinases
WO2013174794A1 (en) 2012-05-23 2013-11-28 F. Hoffmann-La Roche Ag Compositions and methods of obtaining and using endoderm and hepatocyte cells
HUE040520T2 (hu) * 2012-09-20 2019-03-28 Novartis Ag Foszfatidil-inozitol 3-kináz inhibitort és egy aromatáz inhibitort tartalmazó gyógyászati kombináció
US9156831B2 (en) 2013-01-23 2015-10-13 Astrazeneca Ab Chemical compounds
TWI687220B (zh) 2013-03-01 2020-03-11 美商英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
TW201726140A (zh) 2015-09-17 2017-08-01 瑞典商阿斯特捷利康公司 治療癌症之新型生物標記及方法
TW202432552A (zh) * 2022-10-28 2024-08-16 法國國家健康及醫學研究中心 磷脂醯肌醇3-激酶的新穎抑制劑
CN116239591A (zh) * 2023-02-14 2023-06-09 嘉兴学院 一种(4r)-磺酰氨基-l-脯氨酰胺类化合物、制备方法、应用及其药物组合
CN116987072A (zh) * 2023-07-27 2023-11-03 武汉呈瑞生物医药科技有限公司 化合物及其应用

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UY32747A (es) 2011-01-31
JP2012531456A (ja) 2012-12-10
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US20110003818A1 (en) 2011-01-06
WO2011000905A1 (en) 2011-01-06
KR20120092552A (ko) 2012-08-21
CN102471332A (zh) 2012-05-23
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