EA201170596A1 - ФЕНАНТРОИНДОЛИЗИДИНОВОЕ СОЕДИНЕНИЕ И ИНГИБИТОР NFkB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ ДЕЙСТВУЮЩЕГО ИНГРЕДИЕНТА - Google Patents
ФЕНАНТРОИНДОЛИЗИДИНОВОЕ СОЕДИНЕНИЕ И ИНГИБИТОР NFkB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ ДЕЙСТВУЮЩЕГО ИНГРЕДИЕНТАInfo
- Publication number
- EA201170596A1 EA201170596A1 EA201170596A EA201170596A EA201170596A1 EA 201170596 A1 EA201170596 A1 EA 201170596A1 EA 201170596 A EA201170596 A EA 201170596A EA 201170596 A EA201170596 A EA 201170596A EA 201170596 A1 EA201170596 A1 EA 201170596A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- hydrogen atom
- formed together
- compound
- lower alkyloxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000004615 ingredient Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- -1 methylenedioxy group Chemical group 0.000 abstract 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
Abstract
Представлено новое соединение, обладающее отличным ингибирующим эффектом в отношении NFkB, и конкретно раскрыто соединение, представленное общей формулой (1), или его соль:в котором Rпредставляет собой атом водорода, низшую алкильную группу, низшую алкилоксигруппу или атом галогена; Rпредставляет собой гидроксильную группу или низшую алкилоксигруппу; Rпредставляет собой атом водорода, низшую алкильную группу или атом галогена; Rпредставляет собой атом водорода или низшую алкилоксигруппу; Rпредставляет собой атом водорода, низшую алкилоксигруппу, атом галогена, гидроксильную группу или метилендиоксигруппу, образованную вместе с R, или изопропилидендиоксигруппу, образованную вместе с R; Rпредставляет собой атом водорода, низшую алкилоксигруппу или метилендиоксигруппу, образованную вместе с R, или изопропилидендиоксигруппу, образованную вместе с R; Rпредставляет собой атом водорода или низшую алкильную группу и Rпредставляет собой атом водорода, гидроксильную группу, аминогруппу или низшую алкилкарбонилоксигруппу (за исключением случая, когда R, R, Rи Rпредставляют собой атомы водорода, Rи Rпредставляют собой гидроксильныа группы и Rи Rпредставляют собой метоксигруппы).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008273610 | 2008-10-23 | ||
| PCT/JP2009/005594 WO2010047127A1 (ja) | 2008-10-23 | 2009-10-23 | フェナンスロインドリジジン化合物及びこれを有効成分とするＮＦκＢ阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201170596A1 true EA201170596A1 (ru) | 2011-12-30 |
| EA019927B1 EA019927B1 (ru) | 2014-07-30 |
Family
ID=42119179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201170596A EA019927B1 (ru) | 2008-10-23 | 2009-10-23 | ФЕНАНТРОИНДОЛИЗИДИНОВОЕ СОЕДИНЕНИЕ И ИНГИБИТОР NFκB, СОДЕРЖАЩИЙ ЕГО В КАЧЕСТВЕ ДЕЙСТВУЮЩЕГО ИНГРЕДИЕНТА |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9174979B2 (ru) |
| EP (1) | EP2351754B1 (ru) |
| JP (1) | JP5583590B2 (ru) |
| KR (1) | KR101708511B1 (ru) |
| CN (2) | CN102186849A (ru) |
| AU (1) | AU2009307581B2 (ru) |
| CA (1) | CA2740810C (ru) |
| EA (1) | EA019927B1 (ru) |
| ES (1) | ES2541589T3 (ru) |
| NZ (1) | NZ592392A (ru) |
| WO (1) | WO2010047127A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI504394B (zh) | 2011-04-29 | 2015-10-21 | Ind Tech Res Inst | 安托芬之製備方法 |
| CN103509012B (zh) * | 2012-06-25 | 2015-12-16 | 南开大学 | 菲并吲哚里西啶生物碱c14位胺化衍生物及其制备和抗植物病毒活性 |
| CN104744263A (zh) * | 2013-12-30 | 2015-07-01 | 南开大学 | 一种高效合成6-羟基-2,3-二甲氧基-9-菲甲酸甲酯新方法 |
| WO2017182609A1 (en) | 2016-04-22 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of inflammatory skin diseases associated with desmoglein-1 deficiency |
| KR101921524B1 (ko) * | 2017-05-02 | 2018-11-26 | 순천향대학교 산학협력단 | 신규한 화합물 및 이를 포함하는 결핵의 치료용 약학 조성물 |
| CN110294752B (zh) * | 2018-03-21 | 2022-01-11 | 中国医学科学院药物研究所 | 光学纯(s)-3-新戊酰氧基-6,7-二甲氧基菲并吲哚里西啶的制备 |
| CN110283170B (zh) * | 2019-07-17 | 2020-11-06 | 清华大学 | 一种化合物制备及其在抑制多种肿瘤细胞生长中的应用 |
| KR102249543B1 (ko) | 2020-08-26 | 2021-05-11 | 한국화학연구원 | 페난트로인돌리지딘 및 페난트로퀴놀리지딘 알칼로이드 유도체, 이의 광학이성질체, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 코로나바이러스감염증-19 치료용 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3497593A (en) * | 1966-10-12 | 1970-02-24 | Pfizer & Co C | Alkaloids of tylophora indica and tylophora dalzellii |
| JP4769959B2 (ja) * | 1999-09-27 | 2011-09-07 | 独立行政法人国立がん研究センター | 抗腫瘍剤 |
| WO2003070166A2 (en) | 2002-02-15 | 2003-08-28 | Yale University | Novel tyloindicines and related processes, pharmaceutical compositions and methods |
| US7332502B2 (en) * | 2004-06-11 | 2008-02-19 | National Health Research Institutes | Phenanthroindolizidine alkaloids |
| WO2006003676A1 (en) | 2004-07-07 | 2006-01-12 | Secretary, Department Of Atomic Energy | A novel method to inhibit inflammation and tumor growth by tylophora alkaloids |
| CN101189968B (zh) * | 2006-11-23 | 2011-06-01 | 南开大学 | 菲并吲哚里西啶和菲并喹喏里西啶衍生物及其盐在农药上的应用 |
| CN101348483B (zh) | 2007-07-17 | 2011-04-20 | 南开大学 | 菲并吲哚里西啶衍生物的制备 |
-
2009
- 2009-10-23 JP JP2010534720A patent/JP5583590B2/ja not_active Expired - Fee Related
- 2009-10-23 ES ES09821827.4T patent/ES2541589T3/es active Active
- 2009-10-23 US US13/125,698 patent/US9174979B2/en not_active Expired - Fee Related
- 2009-10-23 NZ NZ592392A patent/NZ592392A/xx not_active IP Right Cessation
- 2009-10-23 KR KR1020117008932A patent/KR101708511B1/ko active Active
- 2009-10-23 CN CN200980141088.6A patent/CN102186849A/zh active Pending
- 2009-10-23 AU AU2009307581A patent/AU2009307581B2/en not_active Ceased
- 2009-10-23 CA CA2740810A patent/CA2740810C/en not_active Expired - Fee Related
- 2009-10-23 EP EP09821827.4A patent/EP2351754B1/en not_active Not-in-force
- 2009-10-23 CN CN201510390058.6A patent/CN105037357A/zh active Pending
- 2009-10-23 WO PCT/JP2009/005594 patent/WO2010047127A1/ja active Application Filing
- 2009-10-23 EA EA201170596A patent/EA019927B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2541589T3 (es) | 2015-07-22 |
| US20110201638A1 (en) | 2011-08-18 |
| JP5583590B2 (ja) | 2014-09-03 |
| CN102186849A (zh) | 2011-09-14 |
| CA2740810C (en) | 2017-08-22 |
| CA2740810A1 (en) | 2010-04-29 |
| EA019927B1 (ru) | 2014-07-30 |
| EP2351754A4 (en) | 2012-06-13 |
| KR20110081199A (ko) | 2011-07-13 |
| NZ592392A (en) | 2012-12-21 |
| WO2010047127A1 (ja) | 2010-04-29 |
| AU2009307581A1 (en) | 2010-04-29 |
| JPWO2010047127A1 (ja) | 2012-03-22 |
| AU2009307581B2 (en) | 2015-05-28 |
| EP2351754B1 (en) | 2015-06-24 |
| KR101708511B1 (ko) | 2017-02-20 |
| CN105037357A (zh) | 2015-11-11 |
| EP2351754A1 (en) | 2011-08-03 |
| US9174979B2 (en) | 2015-11-03 |
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