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EA200970332A1 - Новые антигены и антитела, ассоциированные с аденокарциномой панкреатического протока - Google Patents

Новые антигены и антитела, ассоциированные с аденокарциномой панкреатического протока

Info

Publication number
EA200970332A1
EA200970332A1 EA200970332A EA200970332A EA200970332A1 EA 200970332 A1 EA200970332 A1 EA 200970332A1 EA 200970332 A EA200970332 A EA 200970332A EA 200970332 A EA200970332 A EA 200970332A EA 200970332 A1 EA200970332 A1 EA 200970332A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pancreatic
antibodies
pda
adhenocarcinoma
identified
Prior art date
Application number
EA200970332A
Other languages
English (en)
Other versions
EA016731B1 (ru
Inventor
Франческо Новелли
Барбара Томаино
Паола Каппелло
Original Assignee
Рибовакс Байотекнолоджиз Са
Биолине Дианьостичи Срл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рибовакс Байотекнолоджиз Са, Биолине Дианьостичи Срл filed Critical Рибовакс Байотекнолоджиз Са
Publication of EA200970332A1 publication Critical patent/EA200970332A1/ru
Publication of EA016731B1 publication Critical patent/EA016731B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение относится к новым белковым антигенам человека и соответствующим антителам, которые были идентифицированы как специфически экспрессируемые в ассоциации с аденокарциномой панкреатического протока человека (PDA). В частности, идентифицированы новые фосфорилированные изоформы альфа-енолазы в трансформированных клеточных линиях панкреатического происхождения и антитела, связывающие такие изоформы, которые присутствуют специфически в сыворотках пациентов с PDA. Указанные белки и антитела могут использоваться для диагностики и лечения PDA и других видов рака, которые характеризуются соответствующими, близкими к рассматриваемым молекулярными особенностями.
EA200970332A 2006-09-29 2007-09-28 Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения EA016731B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06121552 2006-09-29
EP06126726 2006-12-20
PCT/EP2007/060305 WO2008037792A1 (en) 2006-09-29 2007-09-28 Novel antigens and antibodies associated to pancreatic ductal adenocarcinoma

Publications (2)

Publication Number Publication Date
EA200970332A1 true EA200970332A1 (ru) 2009-10-30
EA016731B1 EA016731B1 (ru) 2012-07-30

Family

ID=38895810

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970332A EA016731B1 (ru) 2006-09-29 2007-09-28 Изоформа человеческой альфа-енолазы, антитело к указанной изоформе и способы их применения

Country Status (18)

Country Link
US (1) US8071721B2 (ru)
EP (1) EP2069395B1 (ru)
JP (1) JP2010505104A (ru)
KR (1) KR20090094227A (ru)
CN (1) CN101578295B (ru)
AT (1) ATE542831T1 (ru)
AU (1) AU2007301966B2 (ru)
BR (1) BRPI0717282A2 (ru)
CA (1) CA2664841A1 (ru)
DK (1) DK2069395T3 (ru)
EA (1) EA016731B1 (ru)
ES (1) ES2381304T3 (ru)
IL (2) IL197868A (ru)
NO (1) NO20091662L (ru)
NZ (1) NZ576409A (ru)
PL (1) PL2069395T3 (ru)
PT (1) PT2069395E (ru)
WO (1) WO2008037792A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2277049A4 (en) * 2008-05-09 2012-05-30 Univ Duke AUTOANTIKÖRPER FOR THE PROOF AND THE TREATMENT OF CANCER
IT1398782B1 (it) 2009-09-11 2013-03-18 Novelli Peptide monofosforilato isolato derivato dall'alfa-enolasi umana utile per la diagnosi e il trattamento dell'adenocarcinoma pancreatico, anticorpi diretti contro il suddetto peptide monofosforilato e loro usi.
ITTO20120523A1 (it) * 2012-06-15 2013-12-16 Natimab Therapeutics S R L Procedimento e kit per la diagnosi in vitro dell'adenocarcinoma duttale pancreatico o per determinare la predisposizione all'adenocarcinoma duttale pancreatico
CN106488932B (zh) * 2013-12-20 2020-07-14 财团法人生物技术开发中心 α-烯醇化酶特异性抗体及其在癌症治疗中的使用方法
SG11201605698XA (en) 2014-01-13 2016-08-30 Berg Llc Enolase 1 (eno1) compositions and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753446A (en) * 1993-04-15 1998-05-19 National Jewish Center For Immunology & Respiratory Medicine Mitogen ERK kinase kinase (MEKK) assay

Also Published As

Publication number Publication date
IL197868A0 (en) 2011-08-01
PT2069395E (pt) 2012-04-27
IL218442A0 (en) 2012-04-30
WO2008037792A1 (en) 2008-04-03
CN101578295B (zh) 2013-02-27
EA016731B1 (ru) 2012-07-30
EP2069395B1 (en) 2012-01-25
NO20091662L (no) 2009-06-29
AU2007301966A1 (en) 2008-04-03
CN101578295A (zh) 2009-11-11
KR20090094227A (ko) 2009-09-04
AU2007301966B2 (en) 2013-02-21
US20100028907A1 (en) 2010-02-04
JP2010505104A (ja) 2010-02-18
ATE542831T1 (de) 2012-02-15
IL197868A (en) 2013-03-24
CA2664841A1 (en) 2008-04-03
US8071721B2 (en) 2011-12-06
PL2069395T3 (pl) 2012-06-29
NZ576409A (en) 2012-02-24
EP2069395A1 (en) 2009-06-17
BRPI0717282A2 (pt) 2013-10-15
DK2069395T3 (da) 2012-05-14
ES2381304T3 (es) 2012-05-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU