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EA200300792A1 - Хиназолины в качестве ингибиторов ммр-13 - Google Patents

Хиназолины в качестве ингибиторов ммр-13

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Publication number
EA200300792A1
EA200300792A1 EA200300792A EA200300792A EA200300792A1 EA 200300792 A1 EA200300792 A1 EA 200300792A1 EA 200300792 A EA200300792 A EA 200300792A EA 200300792 A EA200300792 A EA 200300792A EA 200300792 A1 EA200300792 A1 EA 200300792A1
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EA
Eurasian Patent Office
Prior art keywords
description
sulfur
alkyl
oxygen
possibly
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Application number
EA200300792A
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English (en)
Inventor
Шарль Андрианьяра
Николь Шантэль-Бэрвиан
Бернар Годийер
Анри Якобелли
Дэниел Фред Ортвайн
Уильям Честер Патт
Лай Фам
Кэтрин Роуз Костлэн
Майкл Уильям Уилсон
Original Assignee
УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
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Publication of EA200300792A1 publication Critical patent/EA200300792A1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

Соединение, выбранное из соединений формулы (I), в котором Rпредставляет собой группу, выбранную из водорода, амино, алкила, алкенила, аминоалкила, арила, арилалкила, гетероцикла и циклоалкилалкила, возможно замещенных, W представляет собой кислород, серу или =N-R', где R' является таким, как определено в описании, X, Xи Xпредставляют собой азот или -C-R, где Rявляется таким, как определено в описании, Y представляет собой кислород, серу, -NH или -N(C-C)алкил, Z представляет собой кислород, серу, -NR, где Rявляется таким, как определено в описании, и, возможно, атом углерода, n является целым числом от 1 до 8 включительно, Zпредставляет собой -CRR, где Rи Rявляются такими, как определено в описании, A представляет собой ароматическую или неароматическую гетероциклическую или негетероциклическую кольцевую систему, m является целым числом от 0 до 7 включительно, группа(ы) Rявляется(ются) такой(ими), как определено в описании, Rпредставляет собой водород, алкил, алкенил, алкинил или группу формулы, в которой Z, B, R, P и q являются такими, как определено в описании, возможно, его рацемические формы, его изомеры, его N-оксиды и его фармацевтически приемлемые соли и лекарственные продукты, содержащие их, полезны в качестве специфических ингибиторов матриксной металлопротеазы типа 13.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300792A 2001-02-14 2002-02-11 Хиназолины в качестве ингибиторов ммр-13 EA200300792A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26866101P 2001-02-14 2001-02-14
PCT/EP2002/001979 WO2002064572A1 (en) 2001-02-14 2002-02-11 Quinazolines as mmp-13 inhibitors

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EA200300792A1 true EA200300792A1 (ru) 2004-02-26

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US (1) US20020193377A1 (ru)
EP (1) EP1368324A1 (ru)
JP (1) JP2004523546A (ru)
KR (1) KR20030074827A (ru)
CN (1) CN1537105A (ru)
AP (1) AP2003002841A0 (ru)
AR (1) AR032676A1 (ru)
BG (1) BG108091A (ru)
BR (1) BR0207268A (ru)
CA (1) CA2437122A1 (ru)
CZ (1) CZ20032142A3 (ru)
EA (1) EA200300792A1 (ru)
EC (1) ECSP034730A (ru)
EE (1) EE200300384A (ru)
HU (1) HUP0303164A2 (ru)
IL (1) IL157109A0 (ru)
IS (1) IS6886A (ru)
MA (1) MA26994A1 (ru)
MX (1) MXPA03007248A (ru)
NO (1) NO20033593D0 (ru)
OA (1) OA12550A (ru)
PA (1) PA8539401A1 (ru)
PE (1) PE20021005A1 (ru)
PL (1) PL367396A1 (ru)
SK (1) SK10012003A3 (ru)
SV (1) SV2003000876A (ru)
TN (1) TNSN03045A1 (ru)
UY (1) UY27173A1 (ru)
WO (1) WO2002064572A1 (ru)
ZA (1) ZA200306008B (ru)

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US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
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BR0312736A (pt) * 2002-07-17 2005-04-26 Warner Lambert Co Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com celecoxib ou valdecoxib
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JP2006503812A (ja) * 2002-07-17 2006-02-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー アロステリックカルボキシルマトリックスメタロプロテイナーゼ−１３阻害薬とセレコキシブまたはバルデコキシブではない選択的シクロオキシゲナーゼ−２阻害薬との組み合わせ
CA2492379A1 (en) * 2002-07-17 2004-01-22 Warner-Lambert Company Llc Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib
MXPA05001603A (es) 2002-08-13 2005-04-25 Warner Lambert Co Derivados monociclicos como inhibidores de metaloproteinasa de matriz.
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