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EA200201019A1 - Антагонисты рецептора il-8 - Google Patents

Антагонисты рецептора il-8

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Publication number
EA200201019A1
EA200201019A1 EA200201019A EA200201019A EA200201019A1 EA 200201019 A1 EA200201019 A1 EA 200201019A1 EA 200201019 A EA200201019 A EA 200201019A EA 200201019 A EA200201019 A EA 200201019A EA 200201019 A1 EA200201019 A1 EA 200201019A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor antagonists
interleukin
published
compositions
formula
Prior art date
Application number
EA200201019A
Other languages
English (en)
Inventor
Майкл Роберт Палович
Кэтрин Л. Уиддоусон
Хонг Ние
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA200201019A1 publication Critical patent/EA200201019A1/ru

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
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    • C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
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Abstract

Данное изобретение относится к новым соединениям формулы (I) и их композициям, которые могут использоваться при лечении болезненных состояний, опосредованных хемокином интерлейкином-8 (IL-8).Отчет о международном поиске был опубликован 2002.02.21.
EA200201019A 2000-03-24 2001-03-23 Антагонисты рецептора il-8 EA200201019A1 (ru)

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US19213200P 2000-03-24 2000-03-24
PCT/US2001/009216 WO2001072960A2 (en) 2000-03-24 2001-03-23 Il-8 receptor antagonists

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CO5170528A1 (es) * 1999-05-28 2002-06-27 Smithkline Beecham Corp Antagonistas de los receptores de la il-8 nistas del recpetor de la il-8
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
JP2007537272A (ja) 2004-05-12 2007-12-20 シェーリング　コーポレイション Ｃｘｃｒ１およびｃｘｃｒ２ケモカインアンタゴニスト
EP1812008A4 (en) * 2004-10-20 2008-10-29 Smithkline Beecham Corp ANTAGONISTS OF THE IL-8 RECEPTOR
US7893089B2 (en) * 2006-04-21 2011-02-22 GlaxoSmithKline, LLC IL-8 receptor antagonists
CN101495113A (zh) * 2006-04-21 2009-07-29 史密丝克莱恩比彻姆公司 Il-8受体拮抗剂
PE20080943A1 (es) * 2006-06-23 2008-09-27 Smithkline Beecham Corp Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
US20090131329A1 (en) * 2007-09-14 2009-05-21 Edmund John Miller Treatment for allograft rejection
RU2593759C2 (ru) * 2010-09-03 2016-08-10 ФОРМА ТиЭм, ЭлЭлСИ Гуанидиновые соединения и композиции для ингибирования nampt
US8648070B2 (en) 2010-12-17 2014-02-11 Boehringer Ingelheim International Gmbh Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
BR112014027700A2 (pt) * 2012-05-08 2017-06-27 Ishihara Sangyo Kaisha método para produção de um composto de ácido benzoico substituído
US12227501B2 (en) 2019-02-07 2025-02-18 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as CSNK1 inhibitors

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EP0809492A4 (en) * 1995-02-17 2007-01-24 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
AR008290A1 (es) 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
EP1115701B1 (en) * 1998-09-23 2003-05-21 Tularik Inc. Arylsulfonanilide ureas
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

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MXPA02009355A (es) 2003-02-12
PL205103B1 (pl) 2010-03-31
KR20040014901A (ko) 2004-02-18
OA12235A (en) 2003-11-06
HK1053789A1 (zh) 2003-11-07
BR0108867A (pt) 2005-02-09
NO20024554D0 (no) 2002-09-23
US20030216375A1 (en) 2003-11-20
CA2403787A1 (en) 2001-10-04
CZ20023192A3 (cs) 2003-02-12
AR031101A1 (es) 2003-09-10
MY128154A (en) 2007-01-31
SK13682002A3 (sk) 2003-06-03
JP2004508287A (ja) 2004-03-18
HUP0302614A3 (en) 2005-05-30
DE60141896D1 (de) 2010-06-02
AP2002002599A0 (en) 2002-09-30
ES2344587T3 (es) 2010-09-01
CN1452483A (zh) 2003-10-29
IL151210A0 (en) 2003-04-10
AU2001249354A1 (en) 2001-10-08
DZ3333A1 (fr) 2001-10-04
EP1272175B1 (en) 2010-04-21
US6680317B2 (en) 2004-01-20
WO2001072960A3 (en) 2002-02-21
PL366315A1 (en) 2005-01-24
ZA200207576B (en) 2004-04-08
WO2001072960A2 (en) 2001-10-04
EP1272175A4 (en) 2005-08-31
HUP0302614A2 (hu) 2003-11-28
EP1272175A2 (en) 2003-01-08
ATE464893T1 (de) 2010-05-15
UY26627A1 (es) 2001-09-28
AP1548A (en) 2006-01-16
PE20020839A1 (es) 2002-12-04
MA25739A1 (fr) 2003-04-01
BG107035A (bg) 2003-04-30

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