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EA200400971A1 - Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения - Google Patents

Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения

Info

Publication number
EA200400971A1
EA200400971A1 EA200400971A EA200400971A EA200400971A1 EA 200400971 A1 EA200400971 A1 EA 200400971A1 EA 200400971 A EA200400971 A EA 200400971A EA 200400971 A EA200400971 A EA 200400971A EA 200400971 A1 EA200400971 A1 EA 200400971A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
cycloalkanoylindoles
fluorine
compounds
treatment
Prior art date
Application number
EA200400971A
Other languages
English (en)
Other versions
EA006134B1 (ru
Inventor
Карл Бертелетт
Николя Ляшанс
Лианхай Ли
Клаудио Стурино
Заойин Ванг
Original Assignee
Мерк Фросст Кэнада Энд Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Фросст Кэнада Энд Ко. filed Critical Мерк Фросст Кэнада Энд Ко.
Publication of EA200400971A1 publication Critical patent/EA200400971A1/ru
Publication of EA006134B1 publication Critical patent/EA006134B1/ru

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)

Abstract

Фторзамещенные производные циклоалканоиндолов являются антагонистами простагландинов и могут быть использованы для лечения заболеваний, опосредуемых простагландинами.Отчет о международном поиске был опубликован 2003.12.04.
EA200400971A 2002-01-24 2003-01-22 Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения EA006134B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35138402P 2002-01-24 2002-01-24
PCT/CA2003/000084 WO2003062200A2 (en) 2002-01-24 2003-01-22 Fluoro substituted cycloalkanoindoles and their use as prostaglandin d2 receptor antagonists

Publications (2)

Publication Number Publication Date
EA200400971A1 true EA200400971A1 (ru) 2004-12-30
EA006134B1 EA006134B1 (ru) 2005-10-27

Family

ID=27613492

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200400971A EA006134B1 (ru) 2002-01-24 2003-01-22 Фторзамещенные циклоалканоиндолы, композиции, содержащие такие соединения, и способы лечения

Country Status (39)

Country Link
US (6) US20030158246A1 (ru)
EP (3) EP2045241B1 (ru)
JP (2) JP4008885B2 (ru)
KR (2) KR20070056166A (ru)
CN (3) CN101851191A (ru)
AR (1) AR038136A1 (ru)
AT (1) ATE414690T1 (ru)
AU (1) AU2003202343B2 (ru)
BR (1) BR0307050A (ru)
CA (1) CA2471952C (ru)
CY (3) CY1108841T1 (ru)
DE (2) DE60324767D1 (ru)
DK (2) DK1470107T3 (ru)
DO (1) DOP2003000566A (ru)
EA (1) EA006134B1 (ru)
EC (1) ECSP045203A (ru)
EG (1) EG24978A (ru)
ES (2) ES2316717T3 (ru)
FR (1) FR09C0010I2 (ru)
GE (1) GEP20074078B (ru)
HR (1) HRP20040665B1 (ru)
IL (3) IL162825A0 (ru)
IS (2) IS2633B (ru)
JO (1) JO2481B1 (ru)
LU (1) LU91534I2 (ru)
MX (1) MXPA04007167A (ru)
MY (1) MY137040A (ru)
NL (1) NL300377I2 (ru)
NO (3) NO327322B1 (ru)
NZ (1) NZ533786A (ru)
PE (1) PE20030982A1 (ru)
PL (1) PL208527B1 (ru)
PT (2) PT2045241E (ru)
RS (2) RS20100338A (ru)
SI (2) SI2045241T1 (ru)
TW (1) TWI259080B (ru)
UA (1) UA75520C2 (ru)
WO (1) WO2003062200A2 (ru)
ZA (1) ZA200404999B (ru)

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