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EA200100972A1 - Новые соединения и композиции как ингибиторы протеаз - Google Patents

Новые соединения и композиции как ингибиторы протеаз

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Publication number
EA200100972A1
EA200100972A1 EA200100972A EA200100972A EA200100972A1 EA 200100972 A1 EA200100972 A1 EA 200100972A1 EA 200100972 A EA200100972 A EA 200100972A EA 200100972 A EA200100972 A EA 200100972A EA 200100972 A1 EA200100972 A1 EA 200100972A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
new compounds
inhibitors
proteas
proteas inhibitors
Prior art date
Application number
EA200100972A
Other languages
English (en)
Inventor
Клиффорд М. Брайант
Джеймс Т. Пэлмер
Роберт М. Ридзевски
Эдуардо Л. Сетти
Зонг-Квианг Тиан
Шанкар Венкатраман
Дан-Ксионг Ванг
Original Assignee
Аксис Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аксис Фармасьютикалз, Инк. filed Critical Аксис Фармасьютикалз, Инк.
Publication of EA200100972A1 publication Critical patent/EA200100972A1/ru

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Настоящее изобретение касается новых N-цианометиламидов, являющихся ингибиторами цистеиновых протеаз, их фармацевтически приемлемых солей и N-оксидов, их применения в качестве лекарственных средств и способов их получения.Отчет о международном поиске был опубликован 2001.02.22.
EA200100972A 1999-03-15 2000-03-15 Новые соединения и композиции как ингибиторы протеаз EA200100972A1 (ru)

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PCT/US2000/006837 WO2000055126A2 (en) 1999-03-15 2000-03-15 N-cyanomethylamides as protease inhibitors

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