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EA200100696A1 - Способ получения 5-цианофталида - Google Patents

Способ получения 5-цианофталида

Info

Publication number
EA200100696A1
EA200100696A1 EA200100696A EA200100696A EA200100696A1 EA 200100696 A1 EA200100696 A1 EA 200100696A1 EA 200100696 A EA200100696 A EA 200100696A EA 200100696 A EA200100696 A EA 200100696A EA 200100696 A1 EA200100696 A1 EA 200100696A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cyanophthalide
amide
formula
carboxyphthalide
obtaining
Prior art date
Application number
EA200100696A
Other languages
English (en)
Other versions
EA003057B1 (ru
Inventor
Ханс Петерсен
Поуль Дальберг Нильсен
Original Assignee
Х.Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Лундбекк А/С filed Critical Х.Лундбекк А/С
Publication of EA200100696A1 publication Critical patent/EA200100696A1/ru
Publication of EA003057B1 publication Critical patent/EA003057B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Способ получения 5-цианофталида, в котором 5-карбоксифталид преобразуют в соответствующий амид формулы (IV), где R представляет собой водород или Cалкил, после чего указанный амид подвергают реакции с дегидратирующим агентом с получением 5-цианофталида. Преобразование 5-карбоксифталида в соответствующий амид формулы (IV) может быть осуществлено через соответствующий Cалкиловый или фениловый эфир или хлорангидрид, который преобразуют в амид формулы (IV) путем амидирования аммиаком или Cалкиламином. В соответствии с этим, 5-цианофталид, который является важным промежуточным соединением для получения антидепрессантного лекарственного средства циталопрама, получают с высоким выходом эффективным и экономически выгодным способом.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100696A 1998-12-23 1999-12-22 Способ получения 5-цианофталида EA003057B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199801718 1998-12-23
PCT/DK1999/000728 WO2000039112A1 (en) 1998-12-23 1999-12-22 Method for the preparation of 5-cyanophthalide

Publications (2)

Publication Number Publication Date
EA200100696A1 true EA200100696A1 (ru) 2001-12-24
EA003057B1 EA003057B1 (ru) 2002-12-26

Family

ID=8107494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100696A EA003057B1 (ru) 1998-12-23 1999-12-22 Способ получения 5-цианофталида

Country Status (31)

Country Link
US (1) US6392060B2 (ru)
EP (1) EP1140886B1 (ru)
JP (1) JP2002533450A (ru)
KR (1) KR100454008B1 (ru)
CN (1) CN1149208C (ru)
AR (1) AR019791A1 (ru)
AT (1) ATE236145T1 (ru)
AU (1) AU764161B2 (ru)
BG (1) BG64986B1 (ru)
BR (1) BR9916955A (ru)
CA (1) CA2356188C (ru)
CZ (1) CZ300408B6 (ru)
DE (1) DE69906580T2 (ru)
DK (1) DK1140886T3 (ru)
EA (1) EA003057B1 (ru)
ES (1) ES2195644T3 (ru)
HK (1) HK1043130B (ru)
HU (1) HUP0104856A3 (ru)
IL (1) IL143422A0 (ru)
IS (1) IS2261B (ru)
IT (1) IT1315269B1 (ru)
NO (1) NO326516B1 (ru)
NZ (1) NZ512073A (ru)
PL (1) PL203275B1 (ru)
PT (1) PT1140886E (ru)
SI (1) SI1140886T1 (ru)
SK (1) SK285530B6 (ru)
TR (1) TR200101796T2 (ru)
UA (1) UA70979C2 (ru)
WO (1) WO2000039112A1 (ru)
ZA (1) ZA200104262B (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69904853T2 (de) 1998-10-20 2003-09-04 Lundbeck As Valby H Verfahren zur herstellung von citalopram
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) * 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
ATE355268T1 (de) 1999-10-25 2006-03-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CA2395404A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
IL150367A0 (en) 1999-12-30 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
IL150561A0 (en) 2000-01-14 2003-02-12 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
NZ521204A (en) 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
HRP20020744A2 (en) 2000-03-13 2004-12-31 Lundbeck & Co As H Method for the preparation of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
CN1418206A (zh) * 2000-03-16 2003-05-14 H·隆德贝克有限公司 5－氰基－1－(4－氟苯基)－1,3－二氢异苯并呋喃的制备方法
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622L (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
AU2001100405B4 (en) 2000-12-22 2002-03-21 H Lundbeck As Process for the preparation of pure citalopram
TR200200018T1 (tr) 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
US7687645B2 (en) 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (ru) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
EA001728B1 (ru) * 1997-07-08 2001-08-27 Х.Лундбекк А/С Способ получения циталопрама
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
BR9714925A (pt) 1997-11-11 2003-07-22 Lundbeck & Co As H Método para preparação de citalopran, composto e composição farmacêutica antidepressiva
DE69904853T2 (de) 1998-10-20 2003-09-04 Lundbeck As Valby H Verfahren zur herstellung von citalopram
IL143422A0 (en) 1998-12-23 2002-04-21 Lundbeck & Co As H Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
EA004033B1 (ru) 1999-04-14 2003-12-25 Х.Лундбекк А/С Способ получения циталопрама
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
WO2000012044A2 (en) 1999-10-25 2000-03-09 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate

Also Published As

Publication number Publication date
PL203275B1 (pl) 2009-09-30
ES2195644T3 (es) 2003-12-01
TR200101796T2 (tr) 2001-11-21
US20020019546A1 (en) 2002-02-14
DE69906580T2 (de) 2004-02-12
EP1140886B1 (en) 2003-04-02
CA2356188A1 (en) 2000-07-06
HUP0104856A2 (hu) 2002-04-29
CZ20012335A3 (cs) 2001-12-12
ZA200104262B (en) 2001-12-11
AU1774200A (en) 2000-07-31
CA2356188C (en) 2006-05-23
AR019791A1 (es) 2002-03-13
JP2002533450A (ja) 2002-10-08
KR20010082370A (ko) 2001-08-29
HUP0104856A3 (en) 2003-01-28
IL143422A0 (en) 2002-04-21
BG105655A (en) 2002-01-31
BR9916955A (pt) 2001-09-11
PL348608A1 (en) 2002-06-03
SK285530B6 (sk) 2007-03-01
ITMI992696A0 (it) 1999-12-23
SI1140886T1 (en) 2003-08-31
IS2261B (is) 2007-06-15
KR100454008B1 (ko) 2004-10-20
NO20013150D0 (no) 2001-06-22
SK8962001A3 (en) 2003-03-04
ATE236145T1 (de) 2003-04-15
NO326516B1 (no) 2008-12-22
HK1043130B (zh) 2005-03-04
IT1315269B1 (it) 2003-02-03
EP1140886A1 (en) 2001-10-10
DE69906580D1 (de) 2003-05-08
US6392060B2 (en) 2002-05-21
BG64986B1 (bg) 2006-11-30
NO20013150L (no) 2001-08-20
HK1043130A1 (en) 2002-09-06
CN1331686A (zh) 2002-01-16
UA70979C2 (ru) 2004-11-15
DK1140886T3 (da) 2003-07-28
PT1140886E (pt) 2003-08-29
WO2000039112A1 (en) 2000-07-06
CZ300408B6 (cs) 2009-05-13
CN1149208C (zh) 2004-05-12
ITMI992696A1 (it) 2001-06-23
EA003057B1 (ru) 2002-12-26
AU764161B2 (en) 2003-08-14
IS5952A (is) 2001-05-22
NZ512073A (en) 2003-10-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY RU