EA200000011A1 - MEANS AND METHODS OF DELIVERY OF MEDICINAL PREPARATIONS FOR THERAPY OF VIRAL AND BACTERIAL INFECTIONS AND SYNDROME OF DESTRUCTION - Google Patents
MEANS AND METHODS OF DELIVERY OF MEDICINAL PREPARATIONS FOR THERAPY OF VIRAL AND BACTERIAL INFECTIONS AND SYNDROME OF DESTRUCTIONInfo
- Publication number
- EA200000011A1 EA200000011A1 EA200000011A EA200000011A EA200000011A1 EA 200000011 A1 EA200000011 A1 EA 200000011A1 EA 200000011 A EA200000011 A EA 200000011A EA 200000011 A EA200000011 A EA 200000011A EA 200000011 A1 EA200000011 A1 EA 200000011A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- viral
- methods
- bacterial infections
- delivery
- syndrome
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000035143 Bacterial infection Diseases 0.000 title abstract 2
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 2
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 230000003612 virological effect Effects 0.000 title abstract 2
- 230000006378 damage Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Заявляются новые средства доставки лекарственных веществ, способы и терапевтические композиции для лечения вирусных и бактериальных инфекций и синдромов истощения у больных животных, включая человека. Согласно изобретению, больному, нуждающемуся в лечении, вводится полярное соединение, например диметилформамид или диметилсульфоксид, предпочтительно через кожу. Дополнительно изобретение предоставляет вакцину, полученную на основе антител больного, который подвергался анти-ВИЧ-терапии по способу изобретения.Международная заявка была опубликована вместе с отчетом о международном поиске.New means of drug delivery, methods and therapeutic compositions for the treatment of viral and bacterial infections and depletion syndromes in sick animals, including humans, are claimed. According to the invention, a polar compound, for example dimethylformamide or dimethyl sulfoxide, is preferably administered to a patient in need of treatment, preferably through the skin. Additionally, the invention provides a vaccine derived from the antibodies of a patient who has undergone anti-HIV therapy according to the method of the invention. The international application was published along with an international search report.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/874,425 US5935597A (en) | 1995-12-15 | 1997-06-13 | Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes |
| PCT/US1998/011956 WO1998056325A1 (en) | 1997-06-13 | 1998-06-09 | Drug delivery devices and methods for treatment of viral and microbial infections and wasting syndromes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200000011A1 true EA200000011A1 (en) | 2000-08-28 |
Family
ID=25363728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000011A EA200000011A1 (en) | 1997-06-13 | 1998-06-09 | MEANS AND METHODS OF DELIVERY OF MEDICINAL PREPARATIONS FOR THERAPY OF VIRAL AND BACTERIAL INFECTIONS AND SYNDROME OF DESTRUCTION |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1011567A4 (en) |
| JP (1) | JP4531141B2 (en) |
| KR (1) | KR20010013709A (en) |
| CN (1) | CN1260703A (en) |
| AP (1) | AP1629A (en) |
| AR (1) | AR012970A1 (en) |
| AU (1) | AU7831598A (en) |
| BG (1) | BG103997A (en) |
| BR (1) | BR9810095A (en) |
| CA (1) | CA2295176A1 (en) |
| CZ (1) | CZ298510B6 (en) |
| EA (1) | EA200000011A1 (en) |
| EE (1) | EE9900562A (en) |
| ES (1) | ES2161187B1 (en) |
| FI (1) | FI19992648A (en) |
| GB (1) | GB2341319B (en) |
| HU (1) | HUP0003034A2 (en) |
| ID (1) | ID23516A (en) |
| IL (2) | IL133396A0 (en) |
| IS (1) | IS5289A (en) |
| LT (1) | LT4714B (en) |
| LV (1) | LV12490B (en) |
| NO (1) | NO996117L (en) |
| NZ (1) | NZ501669A (en) |
| OA (1) | OA11307A (en) |
| PL (1) | PL196256B1 (en) |
| RO (1) | RO121252B1 (en) |
| SI (1) | SI20191A (en) |
| SK (1) | SK172299A3 (en) |
| TN (1) | TNSN98086A1 (en) |
| TR (1) | TR200000540T2 (en) |
| WO (1) | WO1998056325A1 (en) |
| YU (1) | YU66099A (en) |
| ZA (1) | ZA984649B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1699430A1 (en) * | 2003-12-05 | 2006-09-13 | Namibia Medical Investments (PTY) Limited | Patch |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE60941B1 (en) * | 1986-07-10 | 1994-09-07 | Elan Transdermal Ltd | Transdermal drug delivery device |
| US4855294A (en) * | 1988-09-06 | 1989-08-08 | Theratech, Inc. | Method for reducing skin irritation associated with drug/penetration enhancer compositions |
| US5534260A (en) * | 1989-02-23 | 1996-07-09 | University Of Utah | Percutaneous drug delivery system |
| US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
| US5624912A (en) * | 1991-08-21 | 1997-04-29 | Burcoglu; Arsinur | Method of treating HIV infection and related secondary infections with defibrotide |
| ES2115756T3 (en) * | 1992-02-20 | 1998-07-01 | Merrell Pharma Inc | SULPHONIC ACID DERIVATIVES USED IN THE TREATMENT OF VIRAL DISEASES. |
| CZ182098A3 (en) * | 1995-12-15 | 1998-11-11 | Cryopreservation Technologies Cc | Preparation used during cryogenic preservation of organs and for treating viral and bacterial infections |
-
1998
- 1998-05-29 ZA ZA9804649A patent/ZA984649B/en unknown
- 1998-06-09 ES ES009950072A patent/ES2161187B1/en not_active Expired - Lifetime
- 1998-06-09 EE EEP199900562A patent/EE9900562A/en unknown
- 1998-06-09 RO RO99-01313A patent/RO121252B1/en unknown
- 1998-06-09 JP JP50311899A patent/JP4531141B2/en not_active Expired - Fee Related
- 1998-06-09 BR BR9810095-5A patent/BR9810095A/en not_active Application Discontinuation
- 1998-06-09 KR KR1019997011724A patent/KR20010013709A/en not_active Application Discontinuation
- 1998-06-09 YU YU66099A patent/YU66099A/en unknown
- 1998-06-09 HU HU0003034A patent/HUP0003034A2/en unknown
- 1998-06-09 CA CA002295176A patent/CA2295176A1/en not_active Abandoned
- 1998-06-09 IL IL13339698A patent/IL133396A0/en active IP Right Grant
- 1998-06-09 SI SI9820040A patent/SI20191A/en unknown
- 1998-06-09 GB GB9929189A patent/GB2341319B/en not_active Expired - Fee Related
- 1998-06-09 WO PCT/US1998/011956 patent/WO1998056325A1/en active IP Right Grant
- 1998-06-09 AU AU78315/98A patent/AU7831598A/en not_active Abandoned
- 1998-06-09 ID IDW20000042A patent/ID23516A/en unknown
- 1998-06-09 SK SK1722-99A patent/SK172299A3/en unknown
- 1998-06-09 EP EP98926488A patent/EP1011567A4/en not_active Withdrawn
- 1998-06-09 PL PL338439A patent/PL196256B1/en unknown
- 1998-06-09 EA EA200000011A patent/EA200000011A1/en unknown
- 1998-06-09 CZ CZ0447399A patent/CZ298510B6/en not_active IP Right Cessation
- 1998-06-09 TR TR2000/00540T patent/TR200000540T2/en unknown
- 1998-06-09 NZ NZ501669A patent/NZ501669A/en unknown
- 1998-06-09 AP APAP/P/1999/001708A patent/AP1629A/en active
- 1998-06-09 CN CN98806085A patent/CN1260703A/en active Pending
- 1998-06-11 AR ARP980102783A patent/AR012970A1/en not_active Application Discontinuation
- 1998-06-12 TN TNTNSN98086A patent/TNSN98086A1/en unknown
-
1999
- 1999-12-08 IS IS5289A patent/IS5289A/en unknown
- 1999-12-09 IL IL133396A patent/IL133396A/en not_active IP Right Cessation
- 1999-12-09 FI FI992648A patent/FI19992648A/en unknown
- 1999-12-10 OA OA9900279A patent/OA11307A/en unknown
- 1999-12-10 NO NO996117A patent/NO996117L/en not_active Application Discontinuation
- 1999-12-13 BG BG103997A patent/BG103997A/en unknown
- 1999-12-20 LT LT99-148A patent/LT4714B/en not_active IP Right Cessation
-
2000
- 2000-02-02 LV LVP-99-182A patent/LV12490B/en unknown
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