[go: up one dir, main page]

EA199700424A1 - Способ гидрирования иминов - Google Patents

Способ гидрирования иминов

Info

Publication number
EA199700424A1
EA199700424A1 EA199700424A EA199700424A EA199700424A1 EA 199700424 A1 EA199700424 A1 EA 199700424A1 EA 199700424 A EA199700424 A EA 199700424A EA 199700424 A EA199700424 A EA 199700424A EA 199700424 A1 EA199700424 A1 EA 199700424A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imine
hydration
imins
hydrogenating
reaction mixture
Prior art date
Application number
EA199700424A
Other languages
English (en)
Other versions
EA000498B1 (ru
Inventor
Ганс-Питер Ялетт
Феликс Шпиндель
Рейнхард Георг Ханрайх
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA199700424A1 publication Critical patent/EA199700424A1/ru
Publication of EA000498B1 publication Critical patent/EA000498B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Способ гидрирования иминов водородом при повышенном давлении в присутствии иридиевых катализаторов и с инертным растворителем или без него, в котором реакционная смесь содержит йодистый водород.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700424A 1995-06-08 1996-06-04 Способ гидрирования иминов EA000498B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH168595 1995-06-08
PCT/EP1996/002419 WO1996041793A1 (en) 1995-06-08 1996-06-04 Process for the hydrogenation of imines

Publications (2)

Publication Number Publication Date
EA199700424A1 true EA199700424A1 (ru) 1999-02-25
EA000498B1 EA000498B1 (ru) 1999-08-26

Family

ID=4216210

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700424A EA000498B1 (ru) 1995-06-08 1996-06-04 Способ гидрирования иминов

Country Status (26)

Country Link
US (1) US5886225A (ru)
EP (1) EP0830337B1 (ru)
JP (1) JP4128623B2 (ru)
KR (1) KR100470884B1 (ru)
CN (1) CN1176900C (ru)
AR (1) AR002359A1 (ru)
AT (1) ATE187957T1 (ru)
AU (1) AU710870B2 (ru)
BR (1) BR9609159A (ru)
CA (1) CA2220999C (ru)
CZ (1) CZ287315B6 (ru)
DE (1) DE69605794T2 (ru)
DK (1) DK0830337T3 (ru)
EA (1) EA000498B1 (ru)
ES (1) ES2141512T3 (ru)
GR (1) GR3032521T3 (ru)
HR (1) HRP960253B1 (ru)
HU (1) HU229337B1 (ru)
IL (1) IL122184A (ru)
PL (1) PL183317B1 (ru)
PT (1) PT830337E (ru)
SK (1) SK281568B6 (ru)
TW (1) TW346482B (ru)
UA (1) UA51652C2 (ru)
WO (1) WO1996041793A1 (ru)
ZA (1) ZA964832B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9505836A (pt) * 1994-02-02 1996-02-27 Ciba Geigy Ag Processo para a hidrogenaçao de iminas
US6228971B1 (en) * 1999-06-21 2001-05-08 Ppg Industries Ohio, Inc. Polymeric imine functional compositions and their use in film-forming compositions
US20070213540A1 (en) * 2006-03-09 2007-09-13 Degussa Ag Process for the hydrogenation of imines
JP5308458B2 (ja) 2008-02-22 2013-10-09 ラジウス ヘルス，インコーポレイテッド 選択的アンドロゲン受容体調節物質
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
MX338831B (es) 2010-02-04 2016-05-03 Radius Health Inc Moduladores selectivos de receptores de androgenos.
EP2568806B1 (en) 2010-05-12 2016-05-11 Radius Health, Inc. Therapeutic regimens
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
ES2550319T3 (es) 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
CN102153589B (zh) 2011-02-28 2013-01-02 大连多相触媒有限公司 一种亚胺的不对称加氢催化剂及其合成方法和应用
EP2892877B1 (en) 2012-09-06 2017-06-21 Council of Scientific and Industrial Research Process for the preparation of (s)-2-ethyl-n-(1-methoxypropan -2-yl)-6-methyl aniline
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
EP3122426B1 (en) 2014-03-28 2023-01-18 Duke University Treating breast cancer using selective estrogen receptor modulators
DK3474841T3 (da) 2016-06-22 2022-05-09 Ellipses Pharma Ltd Fremgangsmåder til behandling af ar+-brystkræft
ES2981967T3 (es) 2017-01-05 2024-10-14 Radius Pharmaceuticals Inc Formas polimórficas de RAD1901-2HCl
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形形態
CN110305025B (zh) * 2019-07-23 2022-05-06 衢州学院 一种由亚胺催化氢化合成苄胺类化合物的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0256982B1 (de) * 1986-08-04 1991-08-28 Ciba-Geigy Ag Verfahren zur Herstellung von optisch aktiven sekundären Arylaminen
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
DE59009835D1 (de) * 1989-09-18 1995-12-07 Ciba Geigy Ag Iridiumkomplexe, Verfahren zu deren Herstellung und deren Verwendung.
SG42936A1 (en) * 1992-04-02 1997-10-17 Ciba Geigy Ag Ferrocenyl diphosphines as ligands for homogeneous catalysts
DE69512765T2 (de) * 1994-02-02 2000-06-29 Novartis Ag, Basel Hydrierungskatalysator, verfahren zu seiner herstellung und hydrierungsverfahren

Also Published As

Publication number Publication date
EA000498B1 (ru) 1999-08-26
WO1996041793A1 (en) 1996-12-27
CN1187183A (zh) 1998-07-08
PL323946A1 (en) 1998-04-27
TW346482B (en) 1998-12-01
DE69605794T2 (de) 2000-07-20
AR002359A1 (es) 1998-03-11
SK168197A3 (en) 1998-05-06
ZA964832B (en) 1996-12-09
PT830337E (pt) 2000-05-31
ES2141512T3 (es) 2000-03-16
HU229337B1 (en) 2013-11-28
BR9609159A (pt) 1999-05-04
CZ287315B6 (en) 2000-10-11
CN1176900C (zh) 2004-11-24
JPH11507917A (ja) 1999-07-13
JP4128623B2 (ja) 2008-07-30
CA2220999A1 (en) 1996-12-27
KR19990021908A (ko) 1999-03-25
CZ391997A3 (cs) 1998-03-18
HRP960253A2 (en) 1997-10-31
IL122184A0 (en) 1998-04-05
CA2220999C (en) 2008-01-29
IL122184A (en) 2000-02-29
KR100470884B1 (ko) 2005-06-22
US5886225A (en) 1999-03-23
HRP960253B1 (en) 2000-10-31
UA51652C2 (ru) 2002-12-16
EP0830337A1 (en) 1998-03-25
ATE187957T1 (de) 2000-01-15
DE69605794D1 (de) 2000-01-27
EP0830337B1 (en) 1999-12-22
GR3032521T3 (en) 2000-05-31
SK281568B6 (sk) 2001-05-10
DK0830337T3 (da) 2000-06-13
AU6221896A (en) 1997-01-09
AU710870B2 (en) 1999-09-30
HUP9802307A3 (en) 1999-03-29
HUP9802307A2 (hu) 1999-02-01
PL183317B1 (pl) 2002-06-28

Similar Documents

Publication Publication Date Title
EA199700424A1 (ru) Способ гидрирования иминов
DK0691949T3 (da) Fremgangsmåde til hydrogenering af iminer
DK0832097T3 (da) System og fremgangsmåde til modifikation og rensning af peptider
TR199902426T2 (xx) Bitki b�ceklerinin kontrol�.
TR199802028T2 (xx) Aminlerin ve aminonitrillerin elde edilmesine y�nelik usul.
ATE343425T1 (de) Fasermatrix zum zusammenbringen von chemischen stoffen, sowie verfahren zur herstellung und anwendung davon
ATE234092T1 (de) 2-alkylpyrrolidine
ID16522A (id) Katalis hidrogenasi untuk produksi hidrogen peroksida, dan metoda pembuatannya
RU94019973A (ru) Полипропилен с улучшенными свойствами и способ его получения
EA199800867A1 (ru) Соединения тетрагидробетакарболина
AR005342A1 (es) Metodo para la manufactura de felodipina
ES2170946T3 (es) Procedimiento de preparacion de compuestos fluorados a partir de las aminas correspondientes.
AU4555797A (en) Process for the preparation of substituted aromatic amino compounds
ES2135143T3 (es) Procedimiento para la fabricacion de pentenales.
DE69816871D1 (de) Verwendung von oxidationsfördernden chemikalien für die oxidation von einem polymer, das die alkoholkonfiguration eines oxidierbaren galaktosetyps enthält.
ATE457317T1 (de) Chemokine rezeptor
MY119626A (en) Method for hydrogenating compounds from the group of imines or enamines.
PE20399A1 (es) Muteina ob
ATE225363T1 (de) Synthese von morphin-6-glucuronid
DE59611293D1 (de) Protein mit dnase-aktivität
MX9707345A (es) Proceso para aminas.
UA32578C2 (ru) Способ селективной гидрогенизации динитрильного соединения
DE59402792D1 (de) Hydrogenolytische Reduktion peroxidischer Ozonolyseprodukte
DK1123396T3 (da) Minimale promotorer og anvendelser deraf
BR9806804A (pt) Sólido não auto-inflámavel, processo para preparar e uso do mesmo.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): TM

MK4A Patent expired

Designated state(s): RU