DK77090D0 - Immunmodulerende azaspiraner - Google Patents

Immunmodulerende azaspiraner

Info

Publication number: DK77090D0
Authority: DK; Denmark
Prior art keywords: immunomodulatory; azaspirans; azaspiranes; formulae; chem
Prior art date: 1987-09-28

Application number

DK077090A

Other languages

English (en)

Other versions

DK77090A (da

DK170042B1 (da

Inventor

Alison Mary Badger

David Aaron Schwartz

Elaine Nicholas Cheeseman

Michael John Dimartino

James Woodrow Dorman

Christopher Kevin Mirabelli

Donald Harold Picker

Original Assignee

Smithkline Beckman Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-28

Filing date

1990-03-23

Publication date

1990-03-23

1990-03-23 Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp

1990-03-23 Publication of DK77090D0 publication Critical patent/DK77090D0/da

1990-03-23 Publication of DK77090A publication Critical patent/DK77090A/da

1995-05-08 Application granted granted Critical

1995-05-08 Publication of DK170042B1 publication Critical patent/DK170042B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
- C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Ceramic Engineering (AREA)
Structural Engineering (AREA)
Manufacturing & Machinery (AREA)
Materials Engineering (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK077090A 1987-09-28 1990-03-23 Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel DK170042B1 (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US10170487A	1987-09-28	1987-09-28
US10170487		1987-09-28
US24422988		1988-09-13
US07/244,229 US4963557A (en)	1987-09-28	1988-09-13	Immunomodulatory azaspiranes
US8803323		1988-09-27
PCT/US1988/003323 WO1989002889A1 (en)	1987-09-28	1988-09-27	Immunomodulatory azaspiranes

Publications (3)

Publication Number	Publication Date
DK77090D0 true DK77090D0 (da)	1990-03-23
DK77090A DK77090A (da)	1990-03-23
DK170042B1 DK170042B1 (da)	1995-05-08

Family

ID=26798539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK077090A DK170042B1 (da)	1987-09-28	1990-03-23	Immunmodulerende azaspiraner, farmaceutiske midler, der indeholder dem, samt anvendelse af azaspiranerne til fremstilling af et immunmodulerende middel

Country Status (24)

Country	Link
US (1)	US4963557A (da)
EP (1)	EP0310321B1 (da)
JP (1)	JP2582888B2 (da)
KR (1)	KR0166336B1 (da)
CN (1)	CN1031618C (da)
AT (1)	ATE114463T1 (da)
AU (1)	AU619780B2 (da)
CA (1)	CA1313189C (da)
CY (1)	CY1955A (da)
DE (1)	DE3852266T2 (da)
DK (1)	DK170042B1 (da)
ES (1)	ES2064356T3 (da)
FI (1)	FI93006C (da)
GR (1)	GR3014931T3 (da)
HK (1)	HK1006274A1 (da)
HU (1)	HU208809B (da)
IE (1)	IE67891B1 (da)
IL (1)	IL87908A (da)
MX (1)	MX9203765A (da)
NO (1)	NO173824C (da)
NZ (1)	NZ226354A (da)
PT (1)	PT88603B (da)
WO (1)	WO1989002889A1 (da)
ZW (1)	ZW12388A1 (da)

Families Citing this family (55)

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US6051596A (en) *	1990-08-10	2000-04-18	Anormed, Inc.	Immunosuppressive compositions
DK0542860T3 (da) *	1990-08-10	1999-02-15	Anormed Inc	Immunosuppressive sammensætninger
EP0550595A4 (en) *	1990-09-24	1993-09-08	Smithkline Beecham Corporation	Methods
ZA921120B (en) *	1991-02-19	1993-01-27	Smithkline Beecham Corp	Cytokine inhibitors
US5591748A (en) *	1991-06-07	1997-01-07	Smithkline Beecham Corporation	Immunomodulatory azaspiranes
PT100566B (pt) *	1991-06-07	1999-06-30	Smithkline Beecham Corp	Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
GB9122721D0 (en) *	1991-10-25	1991-12-11	Smithkline Beecham Corp	Methods
US5455247A (en) *	1991-10-25	1995-10-03	Smithkline Beecham Corporation	Methods for the treatment of hyperlipidemia using azaspiranes
GB9122735D0 (en) *	1991-10-25	1991-12-11	Smithkline Beecham Corp	Methods
ATE150296T1 (de) *	1991-12-18	1997-04-15	Minnesota Mining & Mfg	Aerosolzusammensetzungen für arzneimittelsuspensionen
US7101534B1 (en)	1991-12-18	2006-09-05	3M Innovative Properties Company	Suspension aerosol formulations
US7105152B1 (en)	1991-12-18	2006-09-12	3M Innovative Properties Company	Suspension aerosol formulations
GB9201804D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Corp	Methods
US5482959A (en) *	1992-01-28	1996-01-09	Smithkline Beecham Corporation	Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201803D0 (en) *	1992-01-28	1992-03-11	Smithkline Beecham Corp	Methods
DE4222459C2 (de) *	1992-07-08	1995-09-14	Sigma Tau Ind Farmaceuti	3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217116D0 (en) *	1992-08-13	1992-09-23	Smithkline Beecham Corp	Methods
GB9217121D0 (en) *	1992-08-13	1992-09-23	Smithkline Beecham Corp	Methods
US5484788A (en) *	1993-03-26	1996-01-16	Beth Israel Hospital Association	Buspirone as a systemic immunosuppressant
ES2201074T3 (es) *	1993-03-26	2004-03-16	Beth Israel Hospital Association	Utilizacion topica o sistemica de buspirona o de derivados de esta para el tratamiento de trastornos patologicos asociados con reacciones inmunitarias.
US5631017A (en) *	1993-03-26	1997-05-20	Beth Israel Deaconess Medical Center, Inc.	Topical application of buspirone for treatment of pathological conditions associated with immune responses
GB9308780D0 (en) *	1993-04-28	1993-06-09	Smithkline Beecham Corp	Methods
US5708019A (en) *	1993-04-28	1998-01-13	Smithkline Beecham Corporation	Methods of treating hyperlipidemia using azaspirane derivatives
US5505948A (en) *	1993-06-01	1996-04-09	Dermatology Home Products, Inc.	Home skin peel composition for producing healthy and attractive skin
GB9315351D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315298D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315340D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315271D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315341D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
GB9315306D0 (en) *	1993-07-23	1993-09-08	Smithkline Beecham Corp	Methods
US5461054A (en) *	1993-12-09	1995-10-24	Bayer Aktiengesellschaft	Anthracene-spiro-pyrrolindines
GB9325854D0 (en) *	1993-12-17	1994-02-23	Smithkline Beecham Corp	Porcess
GB9414902D0 (en) *	1994-07-23	1994-09-14	Smithkline Beecham Corp	Methods
GB9414901D0 (en) *	1994-07-23	1994-09-14	Smithkline Beecham Corp	Methods
US5786376A (en) *	1994-07-23	1998-07-28	Smithkline Beecham Corporation	Methods of treating opportunistic infections with azaspiranes
US5734061A (en) *	1994-12-07	1998-03-31	Smithkline Beecham Corporation	Process for preparing spirocyclic lactams
US5637314A (en) *	1995-06-07	1997-06-10	Beth Israel Deaconess Medical Center, Inc.	Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BG62359B1 (bg) *	1995-07-13	1999-09-30	Anormed	N,n-диетил-8,8-дипропил-2-азаспиро[4,5]декан-2-пропанаминдималеат
JP2001519754A (ja) *	1995-07-13	2001-10-23	アノーメッド・インコーポレイテッド	２−［２−（ジメチルアミノ）エチル］−８，８−ジプロピル−２−アザスピロ［４．５］デカンジマレイン酸塩
BR9601909A (pt) *	1995-07-13	1999-10-13	Smithkline Beecham Corp	N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
JP3195364B2 (ja) *	1995-07-13	2001-08-06	アノーメッドインコーポレイティド	Ｎ，ｎ−ジメチル−８，８−ジプロピル−２−アザスピロ〔４．５〕デカン−２−プロパンアミン・ジマレエート
CN1219129A (zh) *	1996-05-17	1999-06-09	安诺梅德公司	取代的氮杂螺烷在治疗哮喘中的用途
US5843936A (en) *	1996-06-28	1998-12-01	Bernstein; Lawrence R.	Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en)	2002-04-17	2002-05-29	Bradford Particle Design Ltd	Particulate materials
US7582284B2 (en)	2002-04-17	2009-09-01	Nektar Therapeutics	Particulate materials
JP4458514B2 (ja)	2002-07-18	2010-04-28	第一三共株式会社	高純度のエナミン類の製造方法
JP2006519842A (ja) *	2003-03-10	2006-08-31	カリスト・ファーマシューティカルズ・インコーポレイテッド	アザスピラン化合物による癌治療法
US20110104186A1 (en)	2004-06-24	2011-05-05	Nicholas Valiante	Small molecule immunopotentiators and assays for their detection
WO2006010379A1 (en)	2004-07-29	2006-02-02	Actelion Pharmaceuticals Ltd.	Novel thiophene derivatives as immunosuppressive agents
EP1802601A1 (en) *	2004-09-20	2007-07-04	Targacept, Inc.	Azaspiroalkene and azapiroalkane compounds with nicotinic cholinergic receptor activity
PT1863787E (pt)	2005-03-23	2011-07-29	Actelion Pharmaceuticals Ltd	Derivados de benzo(c)tiofenos hidrogenados como imunomoduladores
AR057894A1 (es)	2005-11-23	2007-12-26	Actelion Pharmaceuticals Ltd	Derivados de tiofeno
PL1979345T3 (pl)	2006-01-24	2010-04-30	Actelion Pharmaceuticals Ltd	Nowe pochodne pirydyny
US7973011B2 (en) *	2006-02-13	2011-07-05	The Board Of Trustees Of The Leland Stanford Junior University	Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
DK2120875T3 (da)	2007-02-11	2018-10-22	Map Pharmaceuticals Inc	Fremgangsmåde til terapeutisk administration af dhe med henblik på at muliggøre hurtig lindring af migræne samtidig med minimering af bivirkningsprofilen

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US3256277A (en) *		1966-06-14		Azaspiro alkanes
GB823338A (en) *	1956-11-07	1959-11-11	Thomae Gmbh Dr K	Diquaternary salts of aminoalkyl piperidines
US3106552A (en) *	1960-07-19	1963-10-08	Geschickter Fund Med Res	Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
US3418324A (en) *	1961-03-13	1968-12-24	Geschickter Fund Med Res	Heterocyclic secondary amines
US3282947A (en) *	1962-05-17	1966-11-01	Geschickter Fund Med Res	Unsymmetrically substituted 3, 9-diazaspiro(5, 5)undecane compounds
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US3424755A (en) *	1964-03-09	1969-01-28	Rolf Denss	4-piperidine-p-fluorobutyrophenones and related compounds
US3432499A (en) *	1965-04-02	1969-03-11	Geschickter Fund Med Res	Trifluoromethylazaspiranes and azaspirane diones
DE1770697C3 (de) *	1967-07-06	1981-04-23	Dupher International Research B.V., Weesp	2,2-(N-Methyl-2-azatetramethylen)- -adamantan, dessen Salze, Verfahren zu deren Herstellung und Arzneimittel
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
BE788490A (fr) *	1971-09-08	1973-01-02	Geschickter Fund Med Res	Azaspiranes substitues par du silicium ou du germanium, leur preparation et compositions pharmaceutiques les contenant
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WO1985005031A1 (en) *	1984-05-09	1985-11-21	The Australian National University	A method for the modulation of the immune response
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US4654333A (en) *	1986-02-18	1987-03-31	Unimed, Inc.	Treatment of multiple sclerosis

1988
- 1988-09-13 US US07/244,229 patent/US4963557A/en not_active Expired - Lifetime
- 1988-09-21 ZW ZW123/88A patent/ZW12388A1/xx unknown
- 1988-09-25 IL IL87908A patent/IL87908A/xx not_active IP Right Cessation
- 1988-09-26 EP EP88308914A patent/EP0310321B1/en not_active Expired - Lifetime
- 1988-09-26 DE DE3852266T patent/DE3852266T2/de not_active Expired - Lifetime
- 1988-09-26 AT AT88308914T patent/ATE114463T1/de not_active IP Right Cessation
- 1988-09-26 ES ES88308914T patent/ES2064356T3/es not_active Expired - Lifetime
- 1988-09-27 CA CA000578528A patent/CA1313189C/en not_active Expired - Lifetime
- 1988-09-27 HU HU885889A patent/HU208809B/hu not_active IP Right Cessation
- 1988-09-27 AU AU25333/88A patent/AU619780B2/en not_active Expired
- 1988-09-27 NZ NZ226354A patent/NZ226354A/xx unknown
- 1988-09-27 PT PT88603A patent/PT88603B/pt not_active IP Right Cessation
- 1988-09-27 KR KR1019890700907A patent/KR0166336B1/ko not_active IP Right Cessation
- 1988-09-27 WO PCT/US1988/003323 patent/WO1989002889A1/en active IP Right Grant
- 1988-09-27 JP JP63508105A patent/JP2582888B2/ja not_active Expired - Lifetime
- 1988-09-28 CN CN88109032A patent/CN1031618C/zh not_active Expired - Lifetime
- 1988-09-28 IE IE292988A patent/IE67891B1/en not_active IP Right Cessation
1990
- 1990-03-23 DK DK077090A patent/DK170042B1/da not_active IP Right Cessation
- 1990-03-27 NO NO901392A patent/NO173824C/no not_active IP Right Cessation
- 1990-03-27 FI FI901530A patent/FI93006C/fi not_active IP Right Cessation
1992
- 1992-06-29 MX MX9203765A patent/MX9203765A/es unknown
1995
- 1995-02-01 GR GR950400195T patent/GR3014931T3/el unknown
1997
- 1997-05-16 CY CY195597A patent/CY1955A/xx unknown
1998
- 1998-06-16 HK HK98105430A patent/HK1006274A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU619780B2 (en)	1992-02-06
KR890701562A (ko)	1989-12-20
NO173824C (no)	1994-02-09
FI901530A0 (fi)	1990-03-27
MX9203765A (es)	1992-07-01
DE3852266T2 (de)	1995-05-18
KR0166336B1 (ko)	1999-01-15
HU208809B (en)	1995-06-28
NZ226354A (en)	1991-02-26
EP0310321A3 (en)	1991-02-06
HU885889D0 (en)	1991-11-28
HUT57722A (en)	1991-12-30
NO173824B (no)	1993-11-01
ES2064356T3 (es)	1995-02-01
IL87908A (en)	1993-02-21
IL87908A0 (en)	1989-03-31
HK1006274A1 (en)	1999-02-19
IE67891B1 (en)	1996-05-01
DK77090A (da)	1990-03-23
CY1955A (en)	1997-05-16
JP2582888B2 (ja)	1997-02-19
EP0310321A2 (en)	1989-04-05
NO901392D0 (no)	1990-03-27
DK170042B1 (da)	1995-05-08
CN1031618C (zh)	1996-04-24
US4963557A (en)	1990-10-16
IE882929L (en)	1989-03-28
FI93006B (fi)	1994-10-31
PT88603A (pt)	1988-10-01
JPH03500290A (ja)	1991-01-24
CA1313189C (en)	1993-01-26
PT88603B (pt)	1992-12-31
AU2533388A (en)	1989-04-18
DE3852266D1 (de)	1995-01-12
NO901392L (no)	1990-03-27
FI93006C (fi)	1995-02-10
ZW12388A1 (en)	1989-01-04
EP0310321B1 (en)	1994-11-30
GR3014931T3 (en)	1995-05-31
CN1032437A (zh)	1989-04-19
ATE114463T1 (de)	1994-12-15
WO1989002889A1 (en)	1989-04-06

Publication	Publication Date	Title
DK77090D0 (da)	1990-03-23	Immunmodulerende azaspiraner
DK353385A (da)	1986-02-04	Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper
NZ236589A (en)	1993-02-25	A-nor-steroid-3-carboxylic acid derivatives and pharmaceutical compositions
PT87552A (pt)	1989-05-31	Process for the preparation of novel tetrazole intermediates toantihypertensive compounds
IL84917A0 (en)	1988-06-30	Quinolinone derivative,its preparation and pharmaceutical compositions containing it
ZA883444B (da)	1988-11-16
MY105538A (en)	1994-10-31	Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
DK183789A (da)	1989-10-19	2-alkyl-3-benzoylbenzofuraner og laegemidler indeholdende disse
DK74189A (da)	1989-08-20	Laegemiddel til behandling af mavesaar
ATE69220T1 (de)	1991-11-15	Sechsgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen.
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
NO914192L (no)	1992-04-27	8-azabicyklo(3.2.1)oktylalkylthiazolidinoner, fremgangsmaate for fremstilling og anvendelse som medikamenter
DE3781986D1 (de)	1992-11-05	Substituierte chinoxaline.
DE3660959D1 (de)	1988-11-24	Benz-trisubstituted 2-aminotetralins
GR3007498T3 (da)	1993-07-30
DE3778088D1 (de)	1992-05-14	Substituierte pyrimidochinoxaline.
GR850484B (da)	1985-06-26

Legal Events

Date	Code	Title	Description
1995-05-08	B1	Patent granted (law 1993)
2008-10-13	PUP	Patent expired