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ATE114463T1 - Azaspirane mit immunmodulierender wirkung. - Google Patents

Azaspirane mit immunmodulierender wirkung.

Info

Publication number
ATE114463T1
ATE114463T1 AT88308914T AT88308914T ATE114463T1 AT E114463 T1 ATE114463 T1 AT E114463T1 AT 88308914 T AT88308914 T AT 88308914T AT 88308914 T AT88308914 T AT 88308914T AT E114463 T1 ATE114463 T1 AT E114463T1
Authority
AT
Austria
Prior art keywords
azaspiranes
immunomodulating action
immunomodulating
action
formulae
Prior art date
Application number
AT88308914T
Other languages
English (en)
Inventor
Alison Mary Badger
Michael John Dimartino
Christopher Kevin Mirabelli
Elaine Nicholas Cheeseman
James Woodrow Dorman
Donald Harold Picker
David Aaron Schwartz
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE114463T1 publication Critical patent/ATE114463T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/45—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides
    • C04B35/4504—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on copper oxide or solid solutions thereof with other oxides containing rare earth oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/96—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ceramic Engineering (AREA)
  • Structural Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT88308914T 1987-09-28 1988-09-26 Azaspirane mit immunmodulierender wirkung. ATE114463T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10170487A 1987-09-28 1987-09-28
US07/244,229 US4963557A (en) 1987-09-28 1988-09-13 Immunomodulatory azaspiranes

Publications (1)

Publication Number Publication Date
ATE114463T1 true ATE114463T1 (de) 1994-12-15

Family

ID=26798539

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88308914T ATE114463T1 (de) 1987-09-28 1988-09-26 Azaspirane mit immunmodulierender wirkung.

Country Status (23)

Country Link
US (1) US4963557A (de)
EP (1) EP0310321B1 (de)
JP (1) JP2582888B2 (de)
KR (1) KR0166336B1 (de)
CN (1) CN1031618C (de)
AT (1) ATE114463T1 (de)
AU (1) AU619780B2 (de)
CA (1) CA1313189C (de)
CY (1) CY1955A (de)
DE (1) DE3852266T2 (de)
DK (1) DK170042B1 (de)
ES (1) ES2064356T3 (de)
FI (1) FI93006C (de)
GR (1) GR3014931T3 (de)
HU (1) HU208809B (de)
IE (1) IE67891B1 (de)
IL (1) IL87908A (de)
MX (1) MX9203765A (de)
NO (1) NO173824C (de)
NZ (1) NZ226354A (de)
PT (1) PT88603B (de)
WO (1) WO1989002889A1 (de)
ZW (1) ZW12388A1 (de)

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US6051596A (en) * 1990-08-10 2000-04-18 Anormed, Inc. Immunosuppressive compositions
DE69129459T2 (de) * 1990-08-10 1998-10-15 Anormed Inc Immunosuppressive zusammensetzungen
EP0550595A4 (en) * 1990-09-24 1993-09-08 Smithkline Beecham Corporation Methods
ZA921120B (en) * 1991-02-19 1993-01-27 Smithkline Beecham Corp Cytokine inhibitors
PT100566B (pt) * 1991-06-07 1999-06-30 Smithkline Beecham Corp Azaspiranos imunomoduladores, composicoes farmaceuticas que os contem, sua preparacao e seu uso
US5591748A (en) * 1991-06-07 1997-01-07 Smithkline Beecham Corporation Immunomodulatory azaspiranes
GB9122735D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
GB9122721D0 (en) * 1991-10-25 1991-12-11 Smithkline Beecham Corp Methods
US5455247A (en) * 1991-10-25 1995-10-03 Smithkline Beecham Corporation Methods for the treatment of hyperlipidemia using azaspiranes
EP0617610B1 (de) * 1991-12-18 1997-03-19 Minnesota Mining And Manufacturing Company Aerosolzusammensetzungen für arzneimittelsuspensionen
US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
GB9201804D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
US5482959A (en) * 1992-01-28 1996-01-09 Smithkline Beecham Corporation Method for delaying aids in an HIV infected individual by administration of substituted azaspirane compounds
GB9201803D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Corp Methods
DE4222459C2 (de) * 1992-07-08 1995-09-14 Sigma Tau Ind Farmaceuti 3,9-disubstituierte-Spiro[5.5]undecane, ein Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
GB9217121D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
GB9217116D0 (en) * 1992-08-13 1992-09-23 Smithkline Beecham Corp Methods
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
DE69432749T2 (de) * 1993-03-26 2004-04-08 The Beth Israel Hospital Association, Boston Topische und systemische anwendung von buspiron und seinen derivaten zur behandlung von pathologischen zuständen, die mit immunantworten verbunden sind
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5708019A (en) * 1993-04-28 1998-01-13 Smithkline Beecham Corporation Methods of treating hyperlipidemia using azaspirane derivatives
GB9308780D0 (en) * 1993-04-28 1993-06-09 Smithkline Beecham Corp Methods
US5505948A (en) * 1993-06-01 1996-04-09 Dermatology Home Products, Inc. Home skin peel composition for producing healthy and attractive skin
GB9315351D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315271D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315340D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315298D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315306D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
GB9315341D0 (en) * 1993-07-23 1993-09-08 Smithkline Beecham Corp Methods
US5461054A (en) * 1993-12-09 1995-10-24 Bayer Aktiengesellschaft Anthracene-spiro-pyrrolindines
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
GB9414902D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5786376A (en) * 1994-07-23 1998-07-28 Smithkline Beecham Corporation Methods of treating opportunistic infections with azaspiranes
GB9414901D0 (en) * 1994-07-23 1994-09-14 Smithkline Beecham Corp Methods
US5734061A (en) * 1994-12-07 1998-03-31 Smithkline Beecham Corporation Process for preparing spirocyclic lactams
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
BR9601909A (pt) * 1995-07-13 1999-10-13 Smithkline Beecham Corp N,n-dietil-8,8-dipropil-2-azaspiro(4,5)decano-2-propan amina dimaleato
AU6636996A (en) * 1995-07-13 1997-02-10 Anormed Inc. 2-{2-(dimethylamino)ethyl}-8,8-dipropyl-2-azaspiro{4.5}decan edimaleate
SK281254B6 (sk) * 1995-07-13 2001-01-18 Smithkline Beecham Corporation Použitie@kán-2-propánamínu, farmaceutický prostriedok s jeho obsahom a jeho použitie
WO1997002820A1 (en) * 1995-07-13 1997-01-30 Anormed Inc. N,n-dimethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
AU710542B2 (en) * 1996-05-17 1999-09-23 Anormed Inc. Use of substituted azaspirane in the treatment of asthma
US5843936A (en) * 1996-06-28 1998-12-01 Bernstein; Lawrence R. Topical administration of azaspiranes to prevent or treat skin conditions associated with hyperproliferation of keratinocytes
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
JP4458514B2 (ja) 2002-07-18 2010-04-28 第一三共株式会社 高純度のエナミン類の製造方法
WO2004080408A2 (en) * 2003-03-10 2004-09-23 Callisto Pharmaceuticals, Inc. Method of treating cancer with azaspirane compositions
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
JP2008513482A (ja) * 2004-09-20 2008-05-01 ターガセプト，インコーポレイテッド ニコチン性コリン作動性受容体活性を有するアザスピロアルケンおよびアザピロアルカン
ATE510831T1 (de) 2005-03-23 2011-06-15 Actelion Pharmaceuticals Ltd Hydrierte benzoäcüthiophenderivate als immunmodulatoren
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
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CA2646140C (en) * 2006-02-13 2015-04-28 The Board Of Trustees Of The Leland Stanford Junior University Blockade of gamma-secretase activity to promote myelination by oligodendrocytes
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US3106552A (en) * 1960-07-19 1963-10-08 Geschickter Fund Med Res Nu-substituted azaspiranes and azaspirane-diones and processes for their preparation
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Also Published As

Publication number Publication date
KR0166336B1 (ko) 1999-01-15
NO901392D0 (no) 1990-03-27
CY1955A (en) 1997-05-16
DK170042B1 (da) 1995-05-08
ES2064356T3 (es) 1995-02-01
HK1006274A1 (en) 1999-02-19
EP0310321A2 (de) 1989-04-05
FI93006B (fi) 1994-10-31
CN1032437A (zh) 1989-04-19
JP2582888B2 (ja) 1997-02-19
WO1989002889A1 (en) 1989-04-06
AU619780B2 (en) 1992-02-06
HUT57722A (en) 1991-12-30
PT88603B (pt) 1992-12-31
FI93006C (fi) 1995-02-10
GR3014931T3 (en) 1995-05-31
NO173824C (no) 1994-02-09
DE3852266T2 (de) 1995-05-18
IE67891B1 (en) 1996-05-01
JPH03500290A (ja) 1991-01-24
FI901530A0 (fi) 1990-03-27
MX9203765A (es) 1992-07-01
CA1313189C (en) 1993-01-26
IL87908A (en) 1993-02-21
NZ226354A (en) 1991-02-26
IE882929L (en) 1989-03-28
DK77090A (da) 1990-03-23
CN1031618C (zh) 1996-04-24
PT88603A (pt) 1988-10-01
KR890701562A (ko) 1989-12-20
DE3852266D1 (de) 1995-01-12
DK77090D0 (da) 1990-03-23
AU2533388A (en) 1989-04-18
IL87908A0 (en) 1989-03-31
NO173824B (no) 1993-11-01
HU885889D0 (en) 1991-11-28
NO901392L (no) 1990-03-27
HU208809B (en) 1995-06-28
EP0310321A3 (de) 1991-02-06
EP0310321B1 (de) 1994-11-30
ZW12388A1 (en) 1989-01-04
US4963557A (en) 1990-10-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time