DK431887D0 - Dna-forbindelse samt tpa-lignende protein - Google Patents

Dna-forbindelse samt tpa-lignende protein

Info

Publication number: DK431887D0
Authority: DK; Denmark
Prior art keywords: tpa; analogs; protein; expression; dna connection
Prior art date: 1985-12-20

Application number

DK431887A

Other languages

Danish (da)

English (en)

Other versions

DK431887A (da

Inventor

Keith R Marotti

Edward F Rehberg

Nicole Y Theriault

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-20

Filing date

1987-08-19

Publication date

1987-08-19

1987-08-19 Application filed by Upjohn Co filed Critical Upjohn Co

1987-08-19 Publication of DK431887D0 publication Critical patent/DK431887D0/da

1987-08-19 Publication of DK431887A publication Critical patent/DK431887A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK431887A 1985-12-20 1987-08-19 Dna-forbindelse samt tpa-lignende protein DK431887A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US81160785A	1985-12-20	1985-12-20
US90948286A	1986-09-19	1986-09-19
PCT/US1986/002684 WO1987003906A1 (en)	1985-12-20	1986-12-12	Tissue plasminogen activator (tpa) analogs

Publications (2)

Publication Number	Publication Date
DK431887D0 true DK431887D0 (da)	1987-08-19
DK431887A DK431887A (da)	1987-08-19

Family

ID=27123502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK431887A DK431887A (da)	1985-12-20	1987-08-19	Dna-forbindelse samt tpa-lignende protein

Country Status (12)

Country	Link
EP (2)	EP0231624B1 (de)
JP (1)	JPH0659223B2 (de)
KR (2)	KR880700856A (de)
AT (1)	ATE85081T1 (de)
AU (1)	AU600463B2 (de)
DE (1)	DE3687651T2 (de)
DK (1)	DK431887A (de)
ES (1)	ES2053449T3 (de)
FI (1)	FI97809C (de)
GR (1)	GR3007280T3 (de)
NO (1)	NO176921C (de)
WO (1)	WO1987003906A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0227462B1 (de) *	1985-12-23	1992-04-01	Chiron Corporation	Peptidplasminogenaktivatoren
EP0234051B1 (de) *	1986-02-17	1991-12-11	Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis	Gewebeplasminogen-Aktivator-Mutant, dafür kodierende rekombinante genetische Information und Verfahren zur Herstellung dieser Mutanten, deren Verwendung und pharmazeutische Zusammensetzungen
AU7282687A (en) *	1986-03-28	1987-10-20	Gabriel Alvarado-Urbina	Protein analogues of tissue plasminogen activator
US5047241A (en) *	1986-07-11	1991-09-10	American Home Products Corporation	Tris-Kringle plasminogen activator with novel K2 insert
US5580559A (en) *	1986-12-05	1996-12-03	Ciba-Geigy Corporation	Hybrid plasminogen activator
US5242819A (en) *	1986-12-05	1993-09-07	Ciba-Geigy Corporation	DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
JP2983997B2 (ja) *	1987-01-30	1999-11-29	アメリカン・ホーム・プロダクツ・コーポレイション	脱―表皮細胞成長因子プラスミノーゲンアクチベーター
US5149533A (en) *	1987-06-04	1992-09-22	Zymogenetics, Inc.	Modified t-PA with kringle-/replaced by another kringle
SE8702562L (sv) *	1987-06-18	1988-12-19	Kabigen Ab	Nya fibrinolytiska enzymer
US5100666A (en) *	1987-10-09	1992-03-31	Monsanto Company	Modified tissue plasminogen activator K2K2SP
US5037752A (en) *	1987-10-09	1991-08-06	Monsanto Company	Modified tissue plasminogen activator substituted at cysteine-73 and lysine-277
DE3888619D1 (de) *	1987-10-09	1994-04-28	Monsanto Co	Modifizierter Gewebeplasminogenaktivator.
US5244676A (en) *	1987-10-09	1993-09-14	Monsanto Company	Modified tissue plasminogen activator with modified glycosylation site
US4963357A (en) *	1987-10-09	1990-10-16	Monsanto Company	Tissue plasminogen activator modified by the substitution of Arg for Cys at position 73, methods and pharmaceutical compositions therefor
WO1989003874A1 (en) *	1987-10-29	1989-05-05	Yamanouchi Pharmaceutical Co., Ltd.	Novel polypeptide compounds
US5648254A (en) *	1988-01-15	1997-07-15	Zymogenetics, Inc.	Co-expression in eukaryotic cells
AU619803B2 (en) *	1988-02-05	1992-02-06	Genzyme Corporation	Rearranged tissue plasminogen activators and method for producing same
JPH03505276A (ja) *	1988-02-05	1991-11-21	ジェンザイム・コーポレーション	再配列された組織プラスミノーゲン活性化因子及びその産生方法
AU3064989A (en) *	1988-02-05	1989-08-25	Genzyme Corporation	Modified gene sequences encoding modified tpa and products therefrom
US5270198A (en) *	1988-05-20	1993-12-14	Genentech, Inc.	DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) *	1988-05-20	1994-09-13	Genentech, Inc.	DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
DE3823805A1 (de) *	1988-07-14	1990-01-18	Basf Ag	Neue polypeptide, ihre herstellung und verwendung
DE3825253A1 (de) *	1988-07-25	1990-02-01	Boehringer Mannheim Gmbh	T-pa-derivat und seine herstellung
US5262170A (en) *	1988-09-02	1993-11-16	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) *	1988-09-02	1998-02-03	Genentech, Inc.	Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3836200A1 (de) *	1988-10-24	1990-04-26	Boehringer Mannheim Gmbh	Domaenenduplikations-muteine des gewebsplasminogen-aktivators (t-pa)
EP0440709B1 (de) *	1988-10-27	1995-05-24	Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno	Trombolytischer wirkstoff mit modifikation der domäne der kringle
CA2007364A1 (en) *	1989-01-17	1990-07-17	David J. Livingston	Gene sequences encoding modified residues situated in the protease domain of tpa
DE3927865A1 (de) *	1989-08-23	1991-02-28	Boehringer Mannheim Gmbh	T-pa-mutante gk1l
DE69333127T2 (de) *	1992-06-03	2004-05-06	Genentech, Inc., South San Francisco	Varianten des Gewebeplasminogenaktivators mit verbesserter therapeutischer Wirkung
IL104355A (en)	1993-01-10	2006-08-20	Yeda Res & Dev	Tnf receptor promoter
US5795975A (en) *	1993-01-10	1998-08-18	Yeda Research And Development Co. Ltd.	TNF receptor promoter
US6706504B1 (en)	1996-11-12	2004-03-16	The Scripps Research Institute	Tissue type plasminogen activator (t-PA) variants: compositions and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR241654A1 (es)	1982-05-05	1992-10-30	Genentech Inc	Procedimiento para producir activador de plasminogeno de tejido humano.
ZA837173B (en)	1982-11-08	1984-05-30	Univ Case Western Reserve	Genomic bovine growth hormone
US4511503A (en)	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
US4511502A (en)	1982-12-22	1985-04-16	Genentech, Inc.	Purification and activity assurance of precipitated heterologous proteins
ES8801374A1 (es)	1985-04-04	1988-01-01	Beecham Group Plc	Un procedimiento para preparar un activante de plasminogeno.
US4916071A (en) *	1985-08-14	1990-04-10	American Home Products Corporation	Poly-kringle plasminogen activator
NZ217331A (en) *	1985-08-26	1989-05-29	Lilly Co Eli	Tissue plasminogen activator derivatives and genetically engineered product

1986
- 1986-12-12 EP EP86309704A patent/EP0231624B1/de not_active Expired - Lifetime
- 1986-12-12 AU AU67701/87A patent/AU600463B2/en not_active Ceased
- 1986-12-12 DE DE8686309704T patent/DE3687651T2/de not_active Expired - Fee Related
- 1986-12-12 WO PCT/US1986/002684 patent/WO1987003906A1/en active IP Right Grant
- 1986-12-12 ES ES86309704T patent/ES2053449T3/es not_active Expired - Lifetime
- 1986-12-12 AT AT86309704T patent/ATE85081T1/de active
- 1986-12-12 KR KR870700754A patent/KR880700856A/ko active Granted
- 1986-12-12 EP EP87900529A patent/EP0289508A1/de active Pending
- 1986-12-12 KR KR1019870700754A patent/KR950000303B1/ko not_active Expired - Fee Related
1987
- 1987-08-19 DK DK431887A patent/DK431887A/da not_active Application Discontinuation
- 1987-08-20 NO NO873517A patent/NO176921C/no not_active IP Right Cessation
1988
- 1988-06-17 FI FI882922A patent/FI97809C/fi not_active IP Right Cessation
1993
- 1993-02-15 JP JP5025188A patent/JPH0659223B2/ja not_active Expired - Lifetime
- 1993-03-09 GR GR930400502T patent/GR3007280T3/el unknown

Also Published As

Publication number	Publication date
NO873517D0 (no)	1987-08-20
AU600463B2 (en)	1990-08-16
FI882922A0 (fi)	1988-06-17
JPH0659223B2 (ja)	1994-08-10
ES2053449T3 (es)	1994-08-01
NO176921B (no)	1995-03-13
NO873517L (no)	1987-08-20
EP0289508A1 (de)	1988-11-09
WO1987003906A1 (en)	1987-07-02
JPH05344892A (ja)	1993-12-27
AU6770187A (en)	1987-07-15
ATE85081T1 (de)	1993-02-15
FI882922L (fi)	1988-06-17
FI97809C (fi)	1997-02-25
EP0231624A1 (de)	1987-08-12
DE3687651D1 (de)	1993-03-11
DK431887A (da)	1987-08-19
EP0231624B1 (de)	1993-01-27
DE3687651T2 (de)	1993-06-24
GR3007280T3 (de)	1993-07-30
KR950000303B1 (ko)	1995-01-13
KR880700856A (ko)	1988-04-12
FI97809B (fi)	1996-11-15
NO176921C (no)	1995-06-21

Publication	Publication Date	Title
DK431887D0 (da)	1987-08-19	Dna-forbindelse samt tpa-lignende protein
DK288183D0 (da)	1983-06-22	Fremgangsmade til fremstilling af et oligonucleotidt terapeutisk middel
EP0442961A4 (en)	1992-04-08	Hybrid procoagulant proteins
ES8500322A1 (es)	1984-10-01	Un metodo de modificar un virus para conferirle una nueva funcion biologica.
DK75694A (da)	1994-06-24	Tumornecrosefaktor og derivater og mutantformer deraf, fremgangsmåde til fremstilling deraf, DNA som koder derfor, replicerbar udtrykkelsesvektor indeholdende DNA'en og celle transformeret dermed samt præparater omfattende tumornecrosefaktoren
ATE239789T1 (de)	2003-05-15	Chimäre prokoagulierende proteine
AU573523B2 (en)	1988-06-16	Functional human urokinase proteins
FI862756A0 (fi)	1986-06-27	Fibroektiner.
DK453782A (da)	1983-04-15	Dna-sekvenser, rekombinant plasmid samt anvendelser deraf
DK215287D0 (da)	1987-04-28	Dna-sekvenser, der koder for et protein med angiogen virkning, vektorer, vaertsceller og fremgangsmaader til udtrykkelse af proteinet, samt laegemidler indeholdende dette
DE59207351D1 (de)	1996-11-21	Verbesserte Aktivierung von rekombinanten Proteinen
AU3406493A (en)	1993-09-09	Microsomal triglyceride transfer protein
GR1000172B (el)	1991-11-15	Βελτιωσεις εις η εν σχεσει προς τις σωματοστατινες.
ATE273388T1 (de)	2004-08-15	Veränderte menschliche c3-proteine
IL80562A0 (en)	1987-02-27	Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
ATE113075T1 (de)	1994-11-15	Plasmide und wirtszellen zur expression von ina protein (ice nucleating protein).
CA2002403A1 (en)	1990-05-07	Injury-stimulated dna-sequence from solanum tuberosum and its use
FI885025A0 (fi)	1988-11-01	Koagulationshaemmande protein pp4-x, dess framstaellning och anvaendning.
TR200002611T2 (tr)	2000-12-21	Beta-lipotropin ve kullanımları
NO883611L (no)	1989-02-15	Ekspresjonsplasmider som inneholder deo-promotere, og bakterielle verter som inneholder disse plasmidene.
NO902405D0 (no)	1990-05-30	Vevplasminogenaktivatorderivat, dna-sekvens og ekspresjonsplasmid, samt fremgangsmaate for fremstilling av plasmidet.
ATE84315T1 (de)	1993-01-15	Rekombinante dna zur reprimierbaren und induzierbaren expression von fremdgenen.
NO895154L (no)	1989-12-20	Fremgangsmaate ved fremstilling av et protein eller polypeptid, en dna-sekvens som koder for polypeptidet, en mikroorganisme som inneholder dna-sekvensen samt polypeptidet ogdets anvendelse som et farmasoeytisk preparat.

Legal Events

Date	Code	Title	Description
2001-07-30	AHB	Application shelved due to non-payment