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DK387889D0 - Makrolider, og farmaceutiske praeparater med indhold af saadanne forbindelser - Google Patents

Makrolider, og farmaceutiske praeparater med indhold af saadanne forbindelser

Info

Publication number
DK387889D0
DK387889D0 DK387889A DK387889A DK387889D0 DK 387889 D0 DK387889 D0 DK 387889D0 DK 387889 A DK387889 A DK 387889A DK 387889 A DK387889 A DK 387889A DK 387889 D0 DK387889 D0 DK 387889D0
Authority
DK
Denmark
Prior art keywords
represent
compounds
alkyl
macrolides
groups including
Prior art date
Application number
DK387889A
Other languages
English (en)
Other versions
DK387889A (da
Inventor
Martin Edward Cooper
David Keith Donald
David Norman Hardern
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878728820A external-priority patent/GB8728820D0/en
Priority claimed from GB878728821A external-priority patent/GB8728821D0/en
Priority claimed from GB888803373A external-priority patent/GB8803373D0/en
Priority claimed from GB888803377A external-priority patent/GB8803377D0/en
Priority claimed from GB888803375A external-priority patent/GB8803375D0/en
Priority claimed from GB888803372A external-priority patent/GB8803372D0/en
Priority claimed from GB888803370A external-priority patent/GB8803370D0/en
Priority claimed from GB888803371A external-priority patent/GB8803371D0/en
Priority claimed from GB888803374A external-priority patent/GB8803374D0/en
Priority claimed from GB888809174A external-priority patent/GB8809174D0/en
Priority claimed from GB888817624A external-priority patent/GB8817624D0/en
Priority claimed from GB888818426A external-priority patent/GB8818426D0/en
Publication of DK387889A publication Critical patent/DK387889A/da
Publication of DK387889D0 publication Critical patent/DK387889D0/da
Application filed by Fisons Plc filed Critical Fisons Plc

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK387889A 1987-12-09 1989-08-08 Makrolider, og farmaceutiske praeparater med indhold af saadanne forbindelser DK387889A (da)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GB878728820A GB8728820D0 (en) 1987-12-09 1987-12-09 Compounds
GB878728821A GB8728821D0 (en) 1987-12-09 1987-12-09 Compounds
GB888803377A GB8803377D0 (en) 1988-02-13 1988-02-13 Compound
GB888803373A GB8803373D0 (en) 1988-02-13 1988-02-13 Compound
GB888803375A GB8803375D0 (en) 1988-02-13 1988-02-13 Compound
GB888803372A GB8803372D0 (en) 1988-02-13 1988-02-13 Compound
GB888803370A GB8803370D0 (en) 1988-02-13 1988-02-13 Compound
GB888803371A GB8803371D0 (en) 1988-02-13 1988-02-13 Compound
GB888803374A GB8803374D0 (en) 1988-02-13 1988-02-13 Compound
GB888809174A GB8809174D0 (en) 1988-04-19 1988-04-19 Compounds
GB888817624A GB8817624D0 (en) 1988-07-23 1988-07-23 Compounds
GB888818426A GB8818426D0 (en) 1988-08-03 1988-08-03 Compounds
PCT/GB1988/001093 WO1989005304A1 (en) 1987-12-09 1988-12-02 Macrocyclic compounds

Publications (2)

Publication Number Publication Date
DK387889D0 true DK387889D0 (da) 1989-08-08
DK387889A DK387889A (da) 1989-08-08

Family

ID=27583057

Family Applications (1)

Application Number Title Priority Date Filing Date
DK387889A DK387889A (da) 1987-12-09 1989-08-08 Makrolider, og farmaceutiske praeparater med indhold af saadanne forbindelser

Country Status (16)

Country Link
EP (2) EP0346427B1 (da)
JP (1) JP2799208B2 (da)
KR (1) KR900700494A (da)
CN (1) CN1033458A (da)
AT (1) ATE120466T1 (da)
AU (1) AU630866B2 (da)
CA (1) CA1339128C (da)
DE (1) DE3853477T2 (da)
DK (1) DK387889A (da)
ES (1) ES2071681T3 (da)
FI (1) FI90550C (da)
IE (1) IE66163B1 (da)
IL (1) IL88629A (da)
NO (1) NO893166L (da)
NZ (1) NZ227251A (da)
WO (1) WO1989005304A1 (da)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3275305D1 (en) * 1981-05-19 1987-03-05 Firmadoor Australia Pty Ltd Operator for a door
EP0349061B1 (en) * 1988-06-29 1995-03-29 Merck & Co. Inc. Immunosuppressant agent
US5290772A (en) * 1988-06-29 1994-03-01 Merck & Co., Inc. Immunosuppressant agent
EP0353678B1 (en) * 1988-08-01 1995-12-13 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0356399A3 (en) * 1988-08-26 1991-03-20 Sandoz Ag Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them
EP0358508A3 (en) * 1988-09-08 1991-03-20 Merck & Co. Inc. Novel immunosuppressant compound
BE1003436A3 (fr) * 1988-11-29 1992-03-24 Sandoz Sa Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments.
US5268370A (en) * 1989-01-13 1993-12-07 Merck & Co., Inc. Microbial transformation product of L-679,934
US4975372A (en) * 1989-01-13 1990-12-04 Merck & Co., Inc. Microbial transformation product of L-683,590
EP0378317A3 (en) * 1989-01-13 1990-11-28 Merck & Co. Inc. Microbial transformation product of l-679,934
EP0378320A3 (en) * 1989-01-13 1990-11-28 Merck & Co. Inc. Microbial transformation product
EP0388153B1 (en) * 1989-03-15 1994-12-28 Merck & Co. Inc. Immunosuppressant agent
EP0399579A1 (en) * 1989-04-21 1990-11-28 Merck & Co. Inc. Macrolides having immunosuppressive activity
US5068323A (en) * 1989-04-21 1991-11-26 Merck & Co., Inc. Thermally re-arranged FK-506 derivatives having immunosuppressant activity
CA2018710A1 (en) * 1989-06-13 1990-12-13 Shieh-Shung T. Chen L-683,590 microbial transformation product
US5138052A (en) * 1989-06-13 1992-08-11 Merck & Co., Inc. L-683,590 microbial transformation product
EP0402931A1 (en) * 1989-06-14 1990-12-19 Sandoz Ltd. Heteroatoms-containing tricyclic compounds
US5200411A (en) * 1989-06-14 1993-04-06 Sandoz, Ltd. Heteroatoms-containing tricyclic compounds
EP0413532A3 (en) * 1989-08-18 1991-05-15 Fisons Plc Macrocyclic compounds
AU6286690A (en) * 1989-08-18 1991-04-03 Fisons Plc Macrocyclic compounds
GR1001225B (el) * 1989-09-14 1993-06-30 Fisons Plc Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους.
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
US5215995A (en) * 1989-10-16 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Hair revitalizing agent
US5352671A (en) * 1989-11-09 1994-10-04 Sandoz Ltd. Heteroatoms-containing tricyclic compounds
DE69021833T2 (de) * 1989-11-09 1996-03-21 Sandoz Ag Heteroatome enthaltende tricyclische Verbindungen.
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
GB8925797D0 (en) * 1989-11-15 1990-01-04 Fisons Plc Compositions
EP0444829A3 (en) * 1990-02-27 1992-06-03 Fisons Plc Immunosuppressive compounds
US5260301A (en) * 1990-03-01 1993-11-09 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical solution containing FK-506
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
IE910847A1 (en) * 1990-03-13 1991-09-25 Fisons Plc Immunosuppressive macrocyclic compounds
US5296489A (en) * 1990-03-13 1994-03-22 Fisons Immunosuppressive macrocyclic compounds
CA2040551A1 (en) * 1990-04-30 1991-10-31 Mark T. Goulet Deoxymacrolide derivatives having immunosuppressive activity
JPH05507915A (ja) * 1990-06-11 1993-11-11 藤沢薬品工業株式会社 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのｆｋ５０６等のマクロライド化合物の用途
US5643901A (en) * 1990-06-11 1997-07-01 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating idiopathic thrombocytopenic purpura
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
US5210030A (en) * 1990-06-25 1993-05-11 Merck & Co., Inc. Process for selectively acylating immunomycin
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
US5342935A (en) * 1990-06-25 1994-08-30 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB9014681D0 (en) * 1990-07-02 1990-08-22 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
EP0466365A3 (en) 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism
GB9014881D0 (en) * 1990-07-05 1990-08-22 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
GB2245561A (en) * 1990-07-05 1992-01-08 Fujisawa Pharmaceutical Co Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5384316A (en) * 1990-08-18 1995-01-24 Fisons Plc 4,16-diazatetracyclo[23.3.1.1.Hu 14,17=b . 0 Hu 4,9 triaconta-16,19-diene-2,3,10-trione derivatives
GB2247620A (en) * 1990-09-07 1992-03-11 Fujisawa Pharmaceutical Co The use of macrolide compounds for cytomegalovirus infection
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
EP0480623A1 (en) * 1990-10-11 1992-04-15 Merck & Co. Inc. New halomacrolides and derivatives having immunosuppressive activity
GB2249027A (en) * 1990-10-23 1992-04-29 Fujisawa Pharmaceutical Co Use of macrolide compounds for hepatic failure
US5348966A (en) * 1990-10-24 1994-09-20 Fujisawa Pharmaceutical Co., Ltd. Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds
CA2054128A1 (en) * 1990-10-29 1992-04-30 Kevin M. Byrne Process for the production of analogues of immunomycin
PH31204A (en) * 1990-11-02 1998-05-05 Fujisawa Pharmaceutical Co Pharmaceutical composition.
CA2054983A1 (en) * 1990-11-08 1992-05-09 Sotoo Asakura Suspendible composition and process for preparing the same
GB2249787A (en) * 1990-11-19 1992-05-20 Fujisawa Pharmaceutical Co Lactone compounds
GB9027471D0 (en) * 1990-12-19 1991-02-06 Fujisawa Pharmaceutical Co Novel compound
GB2252041A (en) * 1991-01-23 1992-07-29 Fujisawa Pharmaceutical Co Use of macrolide compounds in treatment of autoimmune myocarditis
WO1992013862A1 (en) * 1991-02-05 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Lactone compounds
US5494820A (en) * 1991-04-11 1996-02-27 Pfizer Inc. Streptomyces braegensis strain and its cultivation in a process for producing C9 -desoxo-FK-520
JP3158437B2 (ja) * 1991-04-26 2001-04-23 藤沢薬品工業株式会社 眼疾患に対するマクロライド化合物の使用
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5225403A (en) * 1991-06-25 1993-07-06 Merck & Co., Inc. C-21 hydroxylated FK-506 antagonist
CA2071332A1 (en) * 1991-06-25 1992-12-26 Laszlo R. Treiber C-21 hydroxylated fk-506 antagonist
US5198358A (en) * 1991-08-28 1993-03-30 Merck & Co., Inc. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5149701A (en) * 1991-08-01 1992-09-22 Merck & Co., Inc. C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents
US5273979A (en) * 1991-08-01 1993-12-28 Merck & Co., Inc. C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
ATE218570T1 (de) * 1991-09-05 2002-06-15 Abbott Lab Makrocyclische immunmodulatoren
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
ZA926812B (en) 1991-09-09 1993-04-28 Merck & Co Inc O-heteroaryl,o-alkylheteroaryl,o-alkenylheteroaryl and o-alkynylheteroaryl macrolides having immunosupressive activity
US5817333A (en) * 1991-10-31 1998-10-06 Fujisawa Pharmaceutical Co., Ltd. Liposome preparation containing a tricyclic compound
US5164399A (en) * 1991-11-18 1992-11-17 American Home Products Corporation Rapamycin pyrazoles
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
GB9203265D0 (en) * 1992-02-15 1992-04-01 Fisons Plc Pharmaceutically active compound
US5747465A (en) * 1992-03-02 1998-05-05 Pfizer Inc. Sugar derivatives of macrolides
CA2091194A1 (en) * 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5264355A (en) * 1992-07-02 1993-11-23 Merck & Co., Inc. Methlating enzyme from streptomyces MA6858
GB9218027D0 (en) * 1992-08-25 1992-10-14 Fisons Plc Novel method of treatment
GB9218597D0 (en) * 1992-08-25 1992-10-14 Fisons Plc Novel method of treatment
GB9218797D0 (en) * 1992-09-04 1992-10-21 Fisons Plc Pharmacologically active compounds
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5258389A (en) * 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
ES2134860T3 (es) * 1992-11-18 1999-10-16 Fujisawa Pharmaceutical Co Preparacion farmaceutica de accion prolongada.
GB9227055D0 (en) * 1992-12-29 1993-02-24 Fujisawa Pharmaceutical Co New use
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
GB2279006A (en) * 1993-06-03 1994-12-21 Fujisawa Pharmaceutical Co Treatment of amyotrophic lateral sclerosis
US5359060A (en) * 1993-07-06 1994-10-25 Pfizer, Inc. Phosponated derivatives of macrolides
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
DK0786986T3 (da) 1994-10-26 2002-04-29 Novartis Ag Anvendelse af en umættet fedtalkohol
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
EP2198858B1 (en) 1998-03-26 2011-06-29 Astellas Pharma Inc. Sustained release preparation of a macrolide compound like tacrolimus
MXPA01003376A (es) 1998-10-02 2002-11-07 Kosan Biosciences Inc Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
AR035411A1 (es) * 2000-12-29 2004-05-26 Fujisawa Pharmaceutical Co Uso de un derivado de tacrolimus para fabricar un agente neurotrofico, composiciones y articulos de fabricacion o kits que lo comprenden, metodo para fabricar un agente que lo comprende y tejidos e injertos con una celula nerviosa tratada con este compuesto
KR100512021B1 (ko) * 2002-07-25 2005-09-02 신득용 Ｆｋ506을 이용한 세포의 노화를 억제하는 방법 및 배양배지
AU2003901023A0 (en) * 2003-03-04 2003-03-20 Fujisawa Pharmaceutical Co., Ltd. New use
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
JP2007518692A (ja) * 2004-01-20 2007-07-12 アステラス製薬株式会社 勃起不全治療方法
EP1860438B1 (en) 2005-08-12 2009-11-18 Astellas Pharma Inc. Method for identifying target protein of agent and method for screening therapeutic agent for diabetes using target protein
JP2009203162A (ja) * 2006-06-05 2009-09-10 Astellas Pharma Inc マクロライド化合物の新規製造法
WO2008026781A1 (fr) 2006-08-31 2008-03-06 Astellas Pharma Inc. Vésicule de lipide à ciblage inverse
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
WO2012089349A2 (en) 2010-12-31 2012-07-05 Acies Bio D.O.O. Novel polyketide compounds and methods of making same
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US10143682B2 (en) 2014-10-28 2018-12-04 Koushi Yamaguchi Medicine for improving state of pregnancy, and use thereof
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
KR20190075120A (ko) 2016-11-10 2019-06-28 노파르티스 아게 Bmp 강화제
EP3834826A4 (en) 2018-08-10 2022-07-27 Koushi Yamaguchi THERAPEUTIC AGENT FOR HUMORAL IMMUNITY-RELATED DISEASES IN THE MATERNO-FETAL RELATIONSHIP
US20220062245A1 (en) 2018-12-18 2022-03-03 Koushi Yamaguchi Agent for improving infertility, recurrent miscarriage, and state of pregnancy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
EP0349061B1 (en) * 1988-06-29 1995-03-29 Merck & Co. Inc. Immunosuppressant agent
EP0353678B1 (en) * 1988-08-01 1995-12-13 Fujisawa Pharmaceutical Co., Ltd. FR-901154 and FR-901155 substances, a process for their production
EP0356399A3 (en) * 1988-08-26 1991-03-20 Sandoz Ag Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them

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IE66163B1 (en) 1995-12-13
DE3853477D1 (de) 1995-05-04
DE3853477T2 (de) 1995-11-09
WO1989005304A1 (en) 1989-06-15
NO893166D0 (no) 1989-08-04
EP0346427B1 (en) 1995-03-29
CN1033458A (zh) 1989-06-21
FI893750A0 (fi) 1989-08-09
DK387889A (da) 1989-08-08
AU630866B2 (en) 1992-11-12
CA1339128C (en) 1997-07-29
AU2822889A (en) 1989-07-05
EP0346427A1 (en) 1989-12-20
FI90550C (fi) 1994-02-25
NZ227251A (en) 1990-02-26
KR900700494A (ko) 1990-08-13
ATE120466T1 (de) 1995-04-15
ES2071681T3 (es) 1995-07-01
NO893166L (no) 1989-08-04
FI90550B (fi) 1993-11-15
JPH02502463A (ja) 1990-08-09
IE883662L (en) 1989-06-09
IL88629A (en) 1994-04-12
EP0323042A1 (en) 1989-07-05
JP2799208B2 (ja) 1998-09-17

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