DK373479A - Fremgangsmaade til fremstilling af et enzymderivat - Google Patents

Fremgangsmaade til fremstilling af et enzymderivat

Info

Publication number: DK373479A
Authority: DK; Denmark
Prior art keywords: procedure; preparation; enzyme derivative; enzyme; derivative
Prior art date: 1978-09-07

Application number

DK373479A

Other languages

English (en)

Other versions

DK160996C (da

DK160996B (da

Inventor

R A G Smith

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-09-07

Filing date

1979-09-06

Publication date

1980-04-11

1979-09-06 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1980-04-11 Publication of DK373479A publication Critical patent/DK373479A/da

1991-05-13 Publication of DK160996B publication Critical patent/DK160996B/da

1991-10-28 Application granted granted Critical

1991-10-28 Publication of DK160996C publication Critical patent/DK160996C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK373479A 1978-09-07 1979-09-06 Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym DK160996C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7835960		1978-09-07
GB7835960		1978-09-07

Publications (3)

Publication Number	Publication Date
DK373479A true DK373479A (da)	1980-04-11
DK160996B DK160996B (da)	1991-05-13
DK160996C DK160996C (da)	1991-10-28

Family

ID=10499512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK373479A DK160996C (da)	1978-09-07	1979-09-06	Analogifremgangsmaade til fremstilling af et derivat af et in-vivo-fibrinolytisk enzym

Country Status (17)

Country	Link
US (2)	US4285932A (da)
EP (1)	EP0009879B1 (da)
JP (3)	JPS5537198A (da)
AR (1)	AR220575A1 (da)
AU (1)	AU524295B2 (da)
CA (1)	CA1134295A (da)
DE (1)	DE2966301D1 (da)
DK (1)	DK160996C (da)
ES (1)	ES8101385A1 (da)
HK (1)	HK65986A (da)
HU (1)	HU182458B (da)
IE (1)	IE48478B1 (da)
IL (1)	IL58079A0 (da)
LU (1)	LU88326I2 (da)
MY (1)	MY8500995A (da)
NZ (1)	NZ191320A (da)
ZA (1)	ZA794294B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ191320A (en) *	1978-09-07	1982-09-14	Beecham Group Ltd	In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
JPS55167275A (en) *	1979-06-15	1980-12-26	Kowa Co	Preparation of amidinophenyl ester derivative
DE3065190D1 (en) *	1979-11-05	1983-11-10	Beecham Group Plc	Enzyme derivatives, and their preparation
DE3207033C2 (de) *	1981-02-27	1984-09-13	Torii & Co., Ltd., Tokyo	Amidinverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
IT1170913B (it) *	1981-04-23	1987-06-03	Manetti & Roberts Italo Brit	Procedimento per la produzione di un principio attivo fibrinolitico vasale prodotto enzimatico specifico angiochinasi cosi' ottenuto e sue applicazioni farmaceutiche
EP0091240B1 (en) *	1982-04-07	1985-12-27	Beecham Group Plc	Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
EP0125269A1 (en) *	1982-11-11	1984-11-21	Beecham Group Plc	Pharmaceutically active compounds
EP0109653A3 (en) *	1982-11-17	1986-01-29	Otsuka Pharmaceutical Co., Ltd.	Process for preparing urokinase complex
GB8319538D0 (en) *	1983-07-20	1983-08-24	Beecham Group Plc	Compounds
JPS60136520A (ja) *	1983-12-23	1985-07-20	Otsuka Pharmaceut Co Ltd	フイブリン吸着性ウロキナ−ゼ複合体
US4880776A (en) *	1983-12-24	1989-11-14	Beecham Group P.L.C.	Plasmin A-chain urokinase B-chain hybrid protein
GB8334498D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Compounds
GB8334499D0 (en) *	1983-12-24	1984-02-01	Beecham Group Plc	Derivatives
GB8609948D0 (en) *	1986-04-23	1986-05-29	Beecham Group Plc	Compounds
GB8400653D0 (en) *	1984-01-11	1984-02-15	Beecham Group Plc	Conjugates
US5174994A (en) *	1985-11-11	1992-12-29	Leuven Research & Development Vzw	Pharmaceutical composition having thrombolytic activity
EP0266032A1 (en) *	1986-08-29	1988-05-04	Beecham Group Plc	Modified fibrinolytic enzyme
GB8707369D0 (en) *	1987-03-27	1987-04-29	Beecham Group Plc	Enzyme derivatives
US5009888A (en) *	1987-04-13	1991-04-23	Genzyme Corporation	Therapeutic enzyme-antibody complexes
GB8715302D0 (en) *	1987-06-30	1987-08-05	Ordidge R J	Nmr spectroscopy
AU615919B2 (en) *	1987-07-01	1991-10-17	Beecham Group Plc	Hybrid plasminogen activators
US5302390A (en) *	1987-07-01	1994-04-12	Beecham Group Plc	Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
US5256642A (en) *	1988-04-01	1993-10-26	The Johns Hopkins University	Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
US6458360B1 (en)	1990-04-25	2002-10-01	The Johns Hopkins University	Soluble complement regulatory molecules
GB9011861D0 (en) *	1990-05-26	1990-07-18	Beecham Group Plc	Novel compounds
GB9013345D0 (en) *	1990-06-14	1990-08-08	Beecham Group Plc	Novel compounds
US20040072757A1 (en) *	1990-09-04	2004-04-15	Cor Therapeutics, Inc.	Agents affecting thrombosis and hemostasis
US5597799A (en) *	1990-09-04	1997-01-28	Cor Therapeutics, Inc.	Recombinant agents affecting thrombosis
US5583107A (en) *	1990-09-04	1996-12-10	Cor Therapeutics, Inc.	Agents affecting thrombosis and hemostasis
WO1992018139A1 (en) *	1991-04-09	1992-10-29	Brigham And Women's Hospital	Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
GB9301289D0 (en) *	1993-01-22	1993-03-17	Smithkline Beecham Plc	Novel composition
US5589571A (en) *	1994-10-28	1996-12-31	Cor Therapeutics, Inc.	Process for production of inhibited forms of activated blood factors
US7544500B2 (en)	1999-11-13	2009-06-09	Talecris Biotherapeutics, Inc.	Process for the production of a reversibly inactive acidified plasmin composition
KR20160110544A (ko)	2008-06-04	2016-09-21	그리폴스 테라퓨틱스 인코포레이티드	플라스민의 제조를 위한 조성물, 방법 및 키트
HUE025670T2 (en)	2009-03-03	2016-04-28	Grifols Therapeutics Inc	A method for producing plasminogen
AU2010270146B9 (en)	2009-07-10	2015-04-02	Thrombogenics Nv	Variants of plasminogen and plasmin
WO2011023805A1 (en)	2009-08-28	2011-03-03	Thrombogenics N.V.	Use of plasmin for the treatment of filtration failure after trabeculectomy
KR20140015289A (ko)	2011-01-05	2014-02-06	쓰롬보제닉스 엔.브이.	플라스미노겐 및 플라스민 변이체
EP2741767A1 (en)	2011-08-12	2014-06-18	ThromboGenics N.V.	Plasminogen and plasmin variants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ191320A (en) *	1978-09-07	1982-09-14	Beecham Group Ltd	In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

1979
- 1979-08-15 NZ NZ191320A patent/NZ191320A/xx unknown
- 1979-08-16 CA CA333,909A patent/CA1134295A/en not_active Expired
- 1979-08-16 ZA ZA00794294A patent/ZA794294B/xx unknown
- 1979-08-17 AU AU50046/79A patent/AU524295B2/en not_active Expired
- 1979-08-20 US US06/068,205 patent/US4285932A/en not_active Expired - Lifetime
- 1979-08-20 IL IL58079A patent/IL58079A0/xx unknown
- 1979-08-22 AR AR277800A patent/AR220575A1/es active
- 1979-08-30 EP EP79301773A patent/EP0009879B1/en not_active Expired
- 1979-08-30 DE DE7979301773T patent/DE2966301D1/de not_active Expired
- 1979-09-04 ES ES483888A patent/ES8101385A1/es not_active Expired
- 1979-09-06 HU HU79BE1364A patent/HU182458B/hu not_active IP Right Cessation
- 1979-09-06 IE IE1696/79A patent/IE48478B1/en not_active IP Right Cessation
- 1979-09-06 DK DK373479A patent/DK160996C/da not_active IP Right Cessation
- 1979-09-07 JP JP11430579A patent/JPS5537198A/ja active Granted
1980
- 1980-12-16 US US06/216,799 patent/US4337244A/en not_active Expired - Lifetime
1985
- 1985-12-30 MY MY995/85A patent/MY8500995A/xx unknown
1986
- 1986-09-04 HK HK659/86A patent/HK65986A/xx not_active IP Right Cessation
1989
- 1989-11-24 JP JP1306342A patent/JPH02154687A/ja active Pending
1992
- 1992-07-13 JP JP4207007A patent/JPH05304957A/ja active Pending
1993
- 1993-06-24 LU LU88326C patent/LU88326I2/fr unknown

Also Published As

Publication number	Publication date
DK160996C (da)	1991-10-28
AU524295B2 (en)	1982-09-09
IE791696L (en)	1980-03-07
ZA794294B (en)	1980-08-27
AR220575A1 (es)	1980-11-14
JPH05304957A (ja)	1993-11-19
HK65986A (en)	1986-09-12
LU88326I2 (fr)	1994-05-04
US4337244A (en)	1982-06-29
IL58079A0 (en)	1979-12-30
IE48478B1 (en)	1985-02-06
DE2966301D1 (en)	1983-11-17
ES483888A0 (es)	1980-12-16
CA1134295A (en)	1982-10-26
JPS5537198A (en)	1980-03-15
EP0009879B1 (en)	1983-10-12
EP0009879A1 (en)	1980-04-16
JPH02154687A (ja)	1990-06-14
DK160996B (da)	1991-05-13
US4285932A (en)	1981-08-25
JPH0231952B2 (da)	1990-07-17
MY8500995A (en)	1985-12-31
AU5004679A (en)	1980-03-13
ES8101385A1 (es)	1980-12-16
HU182458B (en)	1984-01-30
NZ191320A (en)	1982-09-14

Publication	Publication Date	Title
DK373479A (da)	1980-04-11	Fremgangsmaade til fremstilling af et enzymderivat
DK46079A (da)	1979-08-07	Fremgangsmaade til fremstilling af alkylendiaminderivater
DK148752C (da)	1986-02-10	Fremgangsmaade til fremstilling af cyclosporinderivater
DK325079A (da)	1980-02-05	Fremgangsmaade til fremstilling af tiazolidinderivater
DK365079A (da)	1979-08-31	Fremgangsmaade til fremstilling af 1-alfa-hydroxylerede calciferoler
DK156779A (da)	1979-10-19	Fremgangsmaade til fremstilling af cycloalkyltriazoler
DK129879A (da)	1979-10-04	Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer
DK146481C (da)	1984-03-26	Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DK266479A (da)	1980-02-04	Fremgangsmaade til fremstilling af 3-aminopropoxyarylderivater
DK146942C (da)	1984-07-30	Fremgangsmaade til fremstilling af et immobiliseret enzymprodukt
DK303079A (da)	1980-01-27	Fremgangsmaade til fremstilling af imidazolderivater
DK268579A (da)	1980-01-04	Fremgangsmaade til fremstilling af phenetamolaminer
DK186179A (da)	1979-12-10	Fremgangsmaade til fremstilling af carbapenemderivater
DK307279A (da)	1980-01-22	Fremgangsmaade til fremstilling af phenolethere
DK265779A (da)	1979-12-27	Fremgangsmaade til fremstilling af o-methallyloxyphenol
DK415379A (da)	1980-04-05	Fremgangsmaade til fremstilling af chromanolderivater
DK433779A (da)	1980-04-14	Fremgangsmaade til fremstilling af phenylquinolizidiner
DK150471C (da)	1987-11-30	Fremgangsmaade til fremstilling af trifluormethylphenoler
DK160281C (da)	1991-07-29	Fremgangsmaade til fremstilling af steroid-s-thioesterderivater
DK348179A (da)	1980-02-22	Fremgangsmaade til fremstilling af carbazolyderivater
DK177079A (da)	1979-11-26	Fremgangsmaade til fremstilling af et antibioticum neplanocin
DK145179A (da)	1979-10-08	Fremgangsmaade til fremstilling af 4-methyl-5-hydroxymethyl-imidazol
DK428079A (da)	1980-04-12	Fremgangsmaade til fremstilling af cyclohexadienderivater
DK239279A (da)	1979-12-11	Fremgangsmaade til fremstilling af 2-oximinophenylacetonitril
DK185179A (da)	1979-11-06	Fremgangsmaade til fremstilling af 3-halogen-2-hydroxyalkyltrialkylammoniumunchlorider

Legal Events

Date	Code	Title	Description
1999-09-20	PUP	Patent expired