DK156779A - Fremgangsmaade til fremstilling af cycloalkyltriazoler - Google Patents

Fremgangsmaade til fremstilling af cycloalkyltriazoler

Info

Publication number: DK156779A
Authority: DK; Denmark
Prior art keywords: cycloalkyltriazoles; procedure; preparation
Prior art date: 1978-04-18

Application number

DK156779A

Other languages

English (en)

Other versions

DK148480C (da

DK148480B (da

Inventor

B Silvestrini

L Baiocchi

Original Assignee

Acraf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-18

Filing date

1979-04-17

Publication date

1979-10-19

1979-04-17 Application filed by Acraf filed Critical Acraf

1979-10-19 Publication of DK156779A publication Critical patent/DK156779A/da

1985-07-15 Publication of DK148480B publication Critical patent/DK148480B/da

1985-12-16 Application granted granted Critical

1985-12-16 Publication of DK148480C publication Critical patent/DK148480C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK156779A 1978-04-18 1979-04-17 Analogifremgangsmaade til fremstilling af cycloalkyltriazoler DK148480C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT22421/78A IT1094076B (it)	1978-04-18	1978-04-18	Cicloalchiltriazoli
IT2242178		1978-04-18

Publications (3)

Publication Number	Publication Date
DK156779A true DK156779A (da)	1979-10-19
DK148480B DK148480B (da)	1985-07-15
DK148480C DK148480C (da)	1985-12-16

Family

ID=11196066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK156779A DK148480C (da)	1978-04-18	1979-04-17	Analogifremgangsmaade til fremstilling af cycloalkyltriazoler

Country Status (22)

Country	Link
US (2)	US4252721A (da)
JP (1)	JPS5817757B2 (da)
AT (1)	AT374477B (da)
AU (1)	AU520788B2 (da)
BG (2)	BG40654A3 (da)
CA (1)	CA1104567A (da)
CH (1)	CH639847A5 (da)
DE (1)	DE2915318A1 (da)
DK (1)	DK148480C (da)
FI (1)	FI66378C (da)
FR (1)	FR2423221A1 (da)
GB (1)	GB2020269B (da)
HU (1)	HU179917B (da)
IE (1)	IE47965B1 (da)
IL (1)	IL56926A (da)
IT (1)	IT1094076B (da)
NL (1)	NL186635C (da)
PL (1)	PL116103B1 (da)
PT (1)	PT69502A (da)
SE (1)	SE437663B (da)
SU (1)	SU852174A3 (da)
YU (1)	YU41338B (da)

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CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids
FR2580648B1 (fr) *	1985-04-17	1987-05-15	Adir	Nouveaux derives du triazole, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4879294A (en) *	1988-01-28	1989-11-07	Angelini Pharmaceuticals Ltd.	Opthalmic composition
IT1224250B (it) *	1988-06-10	1990-09-26	Acraf	Associzione del depiprazolo con la morfina
IT1250701B (it) *	1991-07-24	1995-04-21	Angelini Francesco Ist Ricerca	Composizione farmaceutica solida per uso orale a base di dapiprazolo
US5288759A (en) *	1992-08-27	1994-02-22	Alcon Laboratories, Inc.	Use of certain sulfamoyl-substituted phenethylamine derivatives to reverse drug-induced mydriasis
US6187774B1 (en)	1996-03-04	2001-02-13	Yoshitomi Pharmaceutical Industries, Ltd.	Fused heterocyclic compounds and pharmaceutical applications thereof
NZ510685A (en)	1998-09-30	2003-10-31	Takeda Chemical Industries Ltd	Drugs for improving vesical excretory strength
IL141235A (en) *	2000-02-09	2012-04-30	Novartis Int Pharm Ltd	Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6730691B1 (en)	2000-02-10	2004-05-04	Miles A. Galin	Uses of alpha adrenergic blocking agents
US20020065286A1 (en) *	2000-08-21	2002-05-30	Davies Michael John	Treatment of wounds
US20020091129A1 (en) *	2000-11-20	2002-07-11	Mitradev Boolell	Treatment of premature ejaculation
US20040192699A1 (en) *	2001-07-02	2004-09-30	Santen Pharmaceutical Co., Ltd.	Optic nerve protecting agents containing alpha1 receptor blocker as active ingredient
GB0130219D0 (en) *	2001-12-18	2002-02-06	Pfizer Ltd	Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) *	2002-01-31	2003-12-11	Pfizer Inc.	Treatment of male sexual dysfunction
OA12905A (en)	2002-08-19	2006-10-13	Pfizer Prod Inc	Combination therapy for hyperproliferative diseases.
GB0219961D0 (en)	2002-08-28	2002-10-02	Pfizer Ltd	Oxytocin inhibitors
US7323462B2 (en) *	2002-12-10	2008-01-29	Pfizer Inc.	Morpholine dopamine agonists
CA2451267A1 (en) *	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) *	2003-03-14	2005-05-24	Pfizer	Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) *	2003-04-30	2004-11-04	Pfizer Inc.	PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
EA009646B1 (ru) *	2003-05-30	2008-02-28	Рэнбакси Лабораториз Лтд.	Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa
US20050065158A1 (en) *	2003-07-16	2005-03-24	Pfizer Inc.	Treatment of sexual dysfunction
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
US7291640B2 (en) *	2003-09-22	2007-11-06	Pfizer Inc.	Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) *	2004-05-26	2005-12-01	Pfizer Inc	New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) *	2004-05-27	2005-12-29	Pfizer Inc	New aminopyridine derivatives and their use as pharmaceuticals
JP2008533193A (ja) *	2005-03-21	2008-08-21	ファイザー・リミテッド	オキシトシン拮抗薬としての置換トリアゾール誘導体
ATE412648T1 (de) *	2005-03-21	2008-11-15	Pfizer Ltd	Substituierte triazolderivate als oxytocinantagonisten
US20100222365A1 (en) *	2005-08-10	2010-09-02	Pfizer Inc	Substituted triazole deriviatives as oxytocin antagonists
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
EP1948599A1 (en) *	2005-11-08	2008-07-30	Ranbaxy Laboratories Limited	Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
TW200744583A (en) *	2006-03-14	2007-12-16	Ranbaxy Lab Ltd	Statin stabilizing dosage formulations
CN101494980A (zh) *	2006-07-14	2009-07-29	兰贝克赛实验室有限公司	HMG-CoA还原酶抑制剂的多晶型形式及其应用
WO2008070496A2 (en)	2006-12-01	2008-06-12	Bristol-Myers Squibb Company	N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
RU2618628C1 (ru)	2013-04-17	2017-05-05	Пфайзер Инк.	Производные N-пиперидин-3-илбензамида для лечения сердечно-сосудистых заболеваний
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
AU2019360953A1 (en)	2018-10-15	2021-05-13	Ocuphire Pharma, Inc.	Methods and compositions for treatment of glaucoma and related conditions
WO2020087021A1 (en)	2018-10-26	2020-04-30	Ocuphire Pharma, Inc.	Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders
CA3125765A1 (en)	2019-01-18	2020-07-23	Astrazeneca Ab	Pcsk9 inhibitors and methods of use thereof
CN115368310A (zh)	2021-05-18	2022-11-22	奥库菲尔医药公司	合成甲磺酸酚妥拉明的方法

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Publication number	Priority date	Publication date	Assignee	Title
US2913454A (en) *	1956-11-23	1959-11-17	Schenley Ind Inc	Certain cycloalkanotriazoles, process and intermediates
IT1066857B (it) *	1965-12-15	1985-03-12	Acraf	Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US3472853A (en) *	1967-05-29	1969-10-14	Sterling Drug Inc	1-((pyrido(2,1-c)-s-triazolyl)-lower-alkyl)-4-substituted- piperazines
JPS5070389A (da) *	1973-10-30	1975-06-11

1978
- 1978-04-18 IT IT22421/78A patent/IT1094076B/it active Protection Beyond IP Right Term
1979
- 1979-03-22 CH CH268579A patent/CH639847A5/it not_active IP Right Cessation
- 1979-03-22 IL IL56926A patent/IL56926A/xx unknown
- 1979-03-29 US US06/025,273 patent/US4252721A/en not_active Expired - Lifetime
- 1979-03-30 NL NLAANVRAGE7902489,A patent/NL186635C/xx not_active IP Right Cessation
- 1979-04-09 AU AU45832/79A patent/AU520788B2/en not_active Ceased
- 1979-04-11 YU YU862/79A patent/YU41338B/xx unknown
- 1979-04-11 FR FR7909229A patent/FR2423221A1/fr active Granted
- 1979-04-11 GB GB7912875A patent/GB2020269B/en not_active Expired
- 1979-04-12 FI FI791217A patent/FI66378C/fi not_active IP Right Cessation
- 1979-04-14 DE DE19792915318 patent/DE2915318A1/de active Granted
- 1979-04-17 SE SE7903327A patent/SE437663B/sv not_active IP Right Cessation
- 1979-04-17 CA CA325,782A patent/CA1104567A/en not_active Expired
- 1979-04-17 SU SU792753553A patent/SU852174A3/ru active
- 1979-04-17 PT PT69502A patent/PT69502A/pt unknown
- 1979-04-17 HU HU79AI284A patent/HU179917B/hu unknown
- 1979-04-17 DK DK156779A patent/DK148480C/da not_active IP Right Cessation
- 1979-04-18 BG BG043291A patent/BG40654A3/xx unknown
- 1979-04-18 JP JP54048519A patent/JPS5817757B2/ja not_active Expired
- 1979-04-18 PL PL1979214969A patent/PL116103B1/pl unknown
- 1979-04-18 AT AT0292479A patent/AT374477B/de not_active IP Right Cessation
- 1979-08-08 IE IE646/79A patent/IE47965B1/en not_active IP Right Cessation
1980
- 1980-08-29 US US06/182,426 patent/US4307095A/en not_active Expired - Lifetime
1994
- 1994-02-25 BG BG098586A patent/BG61367B2/bg unknown

Also Published As

Publication number	Publication date
NL186635C (nl)	1991-01-16
SU852174A3 (ru)	1981-07-30
AU4583279A (en)	1979-10-25
BG61367B2 (bg)	1997-06-30
NL7902489A (nl)	1979-10-22
FR2423221A1 (fr)	1979-11-16
ATA292479A (de)	1983-09-15
FR2423221B1 (da)	1983-03-18
YU41338B (en)	1987-02-28
IL56926A (en)	1983-09-30
US4307095A (en)	1981-12-22
GB2020269A (en)	1979-11-14
IL56926A0 (en)	1979-05-31
JPS5817757B2 (ja)	1983-04-09
DK148480C (da)	1985-12-16
FI791217A (fi)	1979-10-19
AT374477B (de)	1984-04-25
PT69502A (en)	1979-05-01
GB2020269B (en)	1982-06-03
FI66378B (fi)	1984-06-29
IE47965B1 (en)	1984-08-08
IT7822421A0 (it)	1978-04-18
PL214969A1 (da)	1980-03-10
IE790646L (en)	1979-10-18
AU520788B2 (en)	1982-02-25
DE2915318A1 (de)	1979-10-31
YU86279A (en)	1983-12-31
CH639847A5 (it)	1983-12-15
BG40654A3 (en)	1987-01-15
IT1094076B (it)	1985-07-26
PL116103B1 (en)	1981-05-30
DE2915318C2 (da)	1990-12-13
SE437663B (sv)	1985-03-11
HU179917B (en)	1983-01-28
NL186635B (nl)	1990-08-16
CA1104567A (en)	1981-07-07
DK148480B (da)	1985-07-15
JPS54157576A (en)	1979-12-12
US4252721A (en)	1981-02-24
SE7903327L (sv)	1979-10-19
FI66378C (fi)	1984-10-10

Publication	Publication Date	Title
DK325079A (da)	1980-02-05	Fremgangsmaade til fremstilling af tiazolidinderivater
DK365079A (da)	1979-08-31	Fremgangsmaade til fremstilling af 1-alfa-hydroxylerede calciferoler
DK156779A (da)	1979-10-19	Fremgangsmaade til fremstilling af cycloalkyltriazoler
DK129879A (da)	1979-10-04	Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer
DK68179A (da)	1979-09-17	Fremgangsmaade til fremstilling af 9-aminodibenzoepyraner
DK266479A (da)	1980-02-04	Fremgangsmaade til fremstilling af 3-aminopropoxyarylderivater
DK303079A (da)	1980-01-27	Fremgangsmaade til fremstilling af imidazolderivater
DK77479A (da)	1979-08-26	Fremgangsmaade til fremstilling af penicilliner
DK268579A (da)	1980-01-04	Fremgangsmaade til fremstilling af phenetamolaminer
DK318079A (da)	1980-01-29	Fremgangsmaade til fremstilling af piperidinforbindelser
DK307279A (da)	1980-01-22	Fremgangsmaade til fremstilling af phenolethere
DK186179A (da)	1979-12-10	Fremgangsmaade til fremstilling af carbapenemderivater
DK265779A (da)	1979-12-27	Fremgangsmaade til fremstilling af o-methallyloxyphenol
DK69479A (da)	1979-08-18	Fremgangsmaade til fremstilling af 2-phenylimino-imidazolidiner
DK415379A (da)	1980-04-05	Fremgangsmaade til fremstilling af chromanolderivater
DK433779A (da)	1980-04-14	Fremgangsmaade til fremstilling af phenylquinolizidiner
DK150471C (da)	1987-11-30	Fremgangsmaade til fremstilling af trifluormethylphenoler
DK543079A (da)	1980-06-23	Fremgangsmaade til fremstilling af benzaldehyder
DK58579A (da)	1979-08-14	Fremgangsmaade til fremstilling af hydroxyphenylethere
DK145179A (da)	1979-10-08	Fremgangsmaade til fremstilling af 4-methyl-5-hydroxymethyl-imidazol
DK282379A (da)	1980-01-06	Fremgangsmaade til fremstilling af phenylpiperidinderivater isaer substituerede eventuelt enkeltmaettede 1-benzylphenylpiperidiner
DK160281C (da)	1991-07-29	Fremgangsmaade til fremstilling af steroid-s-thioesterderivater
DK348179A (da)	1980-02-22	Fremgangsmaade til fremstilling af carbazolyderivater
DK486079A (da)	1980-05-18	Fremgangsmaade til fremstilling af dihydroxysteroider
DK239279A (da)	1979-12-11	Fremgangsmaade til fremstilling af 2-oximinophenylacetonitril

Legal Events

Date	Code	Title	Description
1989-12-11	PBP	Patent lapsed
1994-02-28	PBP	Patent lapsed