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DK129879A - Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer - Google Patents

Fremgangsmaade til fremstilling af n-heterocyclyl-4-piperidinaminer

Info

Publication number
DK129879A
DK129879A DK129879A DK129879A DK129879A DK 129879 A DK129879 A DK 129879A DK 129879 A DK129879 A DK 129879A DK 129879 A DK129879 A DK 129879A DK 129879 A DK129879 A DK 129879A
Authority
DK
Denmark
Prior art keywords
piperidinamines
heterocyclyl
procedure
preparation
Prior art date
Application number
DK129879A
Other languages
English (en)
Other versions
DK169325B1 (da
Inventor
F Janssens
R Stokbroekx
J Torremans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK129879(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/002,276 external-priority patent/US4219559A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK129879A publication Critical patent/DK129879A/da
Priority to DK083183A priority Critical patent/DK171841B1/da
Application granted granted Critical
Publication of DK169325B1 publication Critical patent/DK169325B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK129879A 1978-04-03 1979-03-29 Analogifremgangsmåde til fremstilling af N-heterocyclyl-4-piperidinaminer DK169325B1 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK083183A DK171841B1 (da) 1978-04-03 1983-02-24 N-hetero-cyclyl-4-piperidinaminer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89253478A 1978-04-03 1978-04-03
US89253478 1978-04-03
US06/002,276 US4219559A (en) 1979-01-10 1979-01-10 N-Heterocyclyl-4-piperidinamines
US227679 1979-01-10

Publications (2)

Publication Number Publication Date
DK129879A true DK129879A (da) 1979-10-04
DK169325B1 DK169325B1 (da) 1994-10-10

Family

ID=26670178

Family Applications (1)

Application Number Title Priority Date Filing Date
DK129879A DK169325B1 (da) 1978-04-03 1979-03-29 Analogifremgangsmåde til fremstilling af N-heterocyclyl-4-piperidinaminer

Country Status (29)

Country Link
EP (1) EP0005318B1 (da)
JP (2) JPS54151982A (da)
AT (1) AT373887B (da)
AU (1) AU523352B2 (da)
BG (1) BG38164A3 (da)
CA (1) CA1140119A (da)
CS (1) CS256358B2 (da)
CY (1) CY1250A (da)
DE (1) DE2961740D1 (da)
DK (1) DK169325B1 (da)
EG (1) EG13913A (da)
ES (1) ES479206A1 (da)
FI (1) FI64801C (da)
GR (1) GR64907B (da)
HK (1) HK3184A (da)
HU (1) HU182965B (da)
IE (1) IE47818B1 (da)
IL (1) IL56992A (da)
MY (1) MY8500046A (da)
NO (2) NO154058C (da)
NZ (1) NZ189978A (da)
PH (1) PH15877A (da)
PL (1) PL123380B1 (da)
PT (1) PT69429A (da)
RO (1) RO79320A (da)
SG (1) SG29883G (da)
SU (1) SU1056902A3 (da)
YU (2) YU42484B (da)
ZA (1) ZA791557B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
IN156065B (da) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−ヘテロシクリル−４−ピペリジンアミン
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
EP0232937B1 (en) * 1986-02-03 1992-08-19 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
CA2322164A1 (en) * 1998-03-06 1999-09-10 Ludo Edmond Josephine Kennis Glycine transport inhibitors
SK18952001A3 (sk) * 1999-06-28 2002-11-06 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncyciálneho vírusu
MXPA02000112A (es) * 1999-06-28 2002-07-02 Janssen Pharmaceutica Nv Inhibidores de la replicacion del virus sincitial respiratorio.
PT1196409E (pt) 1999-06-28 2004-06-30 Janssen Pharmaceutica Nv Inibidores da replicacao do virus sincicial respiratorio
AU780006B2 (en) 2000-03-06 2005-02-24 Acadia Pharmaceuticals, Inc. Azacyclic compounds for use in the treatment of serotonin related diseases
CN1781918A (zh) 2001-02-02 2006-06-07 特瓦制药工业有限公司 制备硫酯化合物的方法
DE60236206D1 (de) 2001-12-28 2010-06-10 Acadia Pharm Inc Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
EP1562937A2 (en) 2002-06-24 2005-08-17 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
BRPI0406591B8 (pt) 2003-01-16 2021-05-25 Acadia Pharm Inc composto e composição farmacêutica
NZ547796A (en) 2003-12-18 2009-04-30 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
TWI382981B (zh) 2003-12-18 2013-01-21 Tibotec Pharm Ltd 作為呼吸道融合病毒複製抑制劑之５-或６-經取代的苯并咪唑衍生物
BRPI0417668A (pt) * 2003-12-18 2007-04-03 Tibotec Pharm Ltd derivados de piperidina-amino-benzimidazol como inibidores de replicação do vìrus sincicial respiratório
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
EP1794126B1 (en) 2004-09-27 2013-03-20 Acadia Pharmaceuticals Inc. Crystalline form of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide hemi-tartrate
US20090053329A1 (en) 2007-03-19 2009-02-26 Acadia Pharmaceuticals, Inc. Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
WO2017015272A1 (en) 2015-07-20 2017-01-26 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
US11135211B2 (en) 2017-04-28 2021-10-05 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin

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US2857391A (en) * 1955-04-15 1958-10-21 Merck & Co Inc Aminomethylbenzimidazoles
US2971005A (en) * 1958-10-17 1961-02-07 Merck & Co Inc Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation

Also Published As

Publication number Publication date
BG38164A3 (en) 1985-10-15
PL214648A1 (da) 1980-03-24
HU182965B (en) 1984-03-28
MY8500046A (en) 1985-12-31
PH15877A (en) 1983-04-13
IE790676L (en) 1979-10-03
JPH01117880A (ja) 1989-05-10
NO154090C (no) 1986-07-16
GR64907B (en) 1980-06-07
EG13913A (en) 1982-09-30
YU42484B (en) 1988-10-31
CY1250A (en) 1984-08-31
YU78479A (en) 1983-10-31
FI64801C (fi) 1984-01-10
YU50283A (en) 1983-12-31
NO154090B (no) 1986-04-07
FI791084A (fi) 1979-10-04
NZ189978A (en) 1984-05-31
SG29883G (en) 1984-04-19
IL56992A (en) 1983-03-31
RO79320A (ro) 1982-08-17
IE47818B1 (en) 1984-06-27
HK3184A (en) 1984-01-20
JPH0240666B2 (da) 1990-09-12
CS256358B2 (en) 1988-04-15
IL56992A0 (en) 1979-07-25
DK169325B1 (da) 1994-10-10
ES479206A1 (es) 1979-12-16
CS222779A2 (en) 1987-03-12
PL123380B1 (en) 1982-10-30
JPS54151982A (en) 1979-11-29
NO791097L (no) 1979-10-04
AU523352B2 (en) 1982-07-22
SU1056902A3 (ru) 1983-11-23
NO154058C (no) 1986-07-09
PT69429A (pt) 1979-05-01
JPS641477B2 (da) 1989-01-11
CA1140119A (en) 1983-01-25
EP0005318B1 (en) 1982-01-06
DE2961740D1 (en) 1982-02-25
EP0005318A1 (en) 1979-11-14
NO842563L (no) 1979-10-04
ATA242579A (de) 1983-07-15
AT373887B (de) 1984-02-27
AU4529679A (en) 1979-10-18
FI64801B (fi) 1983-09-30
YU43158B (en) 1989-04-30
ZA791557B (en) 1980-11-26
NO154058B (no) 1986-04-01

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired