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DK3649257T3 - Berigelse af målrettede genomiske regioner til multiplekset parallel analyse - Google Patents

Berigelse af målrettede genomiske regioner til multiplekset parallel analyse Download PDF

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Publication number
DK3649257T3
DK3649257T3 DK18745508.4T DK18745508T DK3649257T3 DK 3649257 T3 DK3649257 T3 DK 3649257T3 DK 18745508 T DK18745508 T DK 18745508T DK 3649257 T3 DK3649257 T3 DK 3649257T3
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Denmark
Prior art keywords
enrichment
genomic regions
parallel analysis
targeted genomic
multiplex parallel
Prior art date
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DK18745508.4T
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English (en)
Inventor
George Koumbaris
Marios Ioannides
Elena KYPRI
Acilleas Achilleos
Petros MINA
Kyriakos Tsangaras
Philippos Patsalis
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Nipd Genetics Public Company Ltd
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10Complex mathematical operations
    • G06F17/18Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/185Modifications characterised by incorporating bases where the precise position of the bases in the nucleic acid string is important
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    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/204Modifications characterised by specific length of the oligonucleotides
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    • C12Q2535/00Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122Massive parallel sequencing
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    • C12Q2537/00Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/159Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Data Mining & Analysis (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
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  • Computational Mathematics (AREA)
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  • Probability & Statistics with Applications (AREA)
DK18745508.4T 2017-07-07 2018-07-06 Berigelse af målrettede genomiske regioner til multiplekset parallel analyse DK3649257T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762529667P 2017-07-07 2017-07-07
PCT/EP2018/068402 WO2019008148A1 (en) 2017-07-07 2018-07-06 ENRICHMENT OF TARGETED GENOMIC REGIONS FOR MULTIPLEXED PARALLEL ANALYSIS

Publications (1)

Publication Number Publication Date
DK3649257T3 true DK3649257T3 (da) 2022-07-04

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DK18745508.4T DK3649257T3 (da) 2017-07-07 2018-07-06 Berigelse af målrettede genomiske regioner til multiplekset parallel analyse

Country Status (11)

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US (1) US12270069B2 (da)
EP (1) EP3649257B1 (da)
AU (1) AU2018296568B2 (da)
CA (1) CA3068198A1 (da)
CY (1) CY1125226T1 (da)
DK (1) DK3649257T3 (da)
ES (1) ES2920280T3 (da)
PL (1) PL3649257T3 (da)
PT (1) PT3649257T (da)
WO (1) WO2019008148A1 (da)
ZA (1) ZA201908614B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019008167A1 (en) 2017-07-07 2019-01-10 Nipd Genetics Public Company Limited MULTIPLEXED PARALLEL ANALYSIS ENRICHED IN TARGET FOR RISK ASSESSMENT FOR GENETIC DISORDERS
PL3649258T3 (pl) 2017-07-07 2022-10-03 Nipd Genetics Public Company Limited Multipleksowa analiza równoległa ze wzbogaceniem sekwencji docelowych do oznaczania próbek dna płodowego
AU2018296568B2 (en) 2017-07-07 2024-11-14 Medicover Public Co Ltd Enrichment of targeted genomic regions for multiplexed parallel analysis
CA3068122A1 (en) 2017-07-07 2019-01-10 Nipd Genetics Public Company Limited Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers
CN113621692B (zh) * 2021-10-12 2022-02-22 北京求臻医疗器械有限公司 人类fgfr1基因拷贝数变异核酸标准物质及其制备方法、及试剂盒

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2385143T3 (pl) 2006-02-02 2017-02-28 The Board Of Trustees Of The Leland Stanford Junior University Nieinwazyjne genetyczne badania przesiewowe płodu metodą analizy cyfrowej
US20080194414A1 (en) * 2006-04-24 2008-08-14 Albert Thomas J Enrichment and sequence analysis of genomic regions
WO2008027548A2 (en) * 2006-09-01 2008-03-06 Dana-Farber Cancer Institute, Inc. Microarray-based global chromatin structure mapping
SI2334812T1 (sl) 2008-09-20 2017-05-31 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 Neinvazivna diagnoza fetalne anevploidije s sekvenciranjem
US20110039304A1 (en) 2009-08-12 2011-02-17 President And Fellows Of Harvard College Methods to Generate Oligonucleotide Pools and Enrich Target Nucleic Acid Sequences
AU2010339464B2 (en) * 2009-12-31 2014-10-09 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
ES2704701T3 (es) 2010-01-19 2019-03-19 Verinata Health Inc Nuevo protocolo de preparación de bibliotecas de secuenciación
US20120270739A1 (en) 2010-01-19 2012-10-25 Verinata Health, Inc. Method for sample analysis of aneuploidies in maternal samples
US20130123120A1 (en) * 2010-05-18 2013-05-16 Natera, Inc. Highly Multiplex PCR Methods and Compositions
EP3187597B1 (en) * 2011-02-09 2020-06-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20150203907A1 (en) * 2014-01-17 2015-07-23 Florida State University Research Foundation Genome capture and sequencing to determine genome-wide copy number variation
GB201414451D0 (en) * 2014-08-14 2014-10-01 Oxford Gene Technology Operations Ltd Hybridisation column for nucleic acid enrichment
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
PT3666902T (pt) 2015-05-22 2024-09-19 Medicover Public Co Ltd Análise paralela multiplexada de regiões genómicas alvo para testes pré-natais não invasivos
AU2018296568B2 (en) 2017-07-07 2024-11-14 Medicover Public Co Ltd Enrichment of targeted genomic regions for multiplexed parallel analysis
PL3649258T3 (pl) 2017-07-07 2022-10-03 Nipd Genetics Public Company Limited Multipleksowa analiza równoległa ze wzbogaceniem sekwencji docelowych do oznaczania próbek dna płodowego

Also Published As

Publication number Publication date
US12270069B2 (en) 2025-04-08
AU2018296568A1 (en) 2020-01-16
ES2920280T3 (es) 2022-08-02
EP3649257A1 (en) 2020-05-13
EP3649257B1 (en) 2022-03-30
WO2019008148A1 (en) 2019-01-10
WO2019008148A9 (en) 2019-05-16
AU2018296568B2 (en) 2024-11-14
ZA201908614B (en) 2022-07-27
PT3649257T (pt) 2022-05-19
PL3649257T3 (pl) 2022-07-18
US20200157602A1 (en) 2020-05-21
CY1125226T1 (el) 2024-09-20
CA3068198A1 (en) 2019-01-10

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