[go: up one dir, main page]

DK3325664T3 - Analyse af fragmenteringsmønstre for cellefrit DNA - Google Patents

Analyse af fragmenteringsmønstre for cellefrit DNA Download PDF

Info

Publication number
DK3325664T3
DK3325664T3 DK16827283.9T DK16827283T DK3325664T3 DK 3325664 T3 DK3325664 T3 DK 3325664T3 DK 16827283 T DK16827283 T DK 16827283T DK 3325664 T3 DK3325664 T3 DK 3325664T3
Authority
DK
Denmark
Prior art keywords
analysis
cell
free dna
fragmentation patterns
fragmentation
Prior art date
Application number
DK16827283.9T
Other languages
English (en)
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/073753 external-priority patent/WO2016127944A1/en
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Application granted granted Critical
Publication of DK3325664T3 publication Critical patent/DK3325664T3/da

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK16827283.9T 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre for cellefrit DNA DK3325664T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562196250P 2015-07-23 2015-07-23
US201662294948P 2016-02-12 2016-02-12
PCT/CN2016/073753 WO2016127944A1 (en) 2015-02-10 2016-02-14 Detecting mutations for cancer screening and fetal analysis
PCT/CN2016/091531 WO2017012592A1 (en) 2015-07-23 2016-07-25 Analysis of fragmentation patterns of cell-free dna

Publications (1)

Publication Number Publication Date
DK3325664T3 true DK3325664T3 (da) 2022-03-07

Family

ID=57833803

Family Applications (2)

Application Number Title Priority Date Filing Date
DK21196292.3T DK3967775T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre af cellefrit DNA
DK16827283.9T DK3325664T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre for cellefrit DNA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK21196292.3T DK3967775T3 (da) 2015-07-23 2016-07-25 Analyse af fragmenteringsmønstre af cellefrit DNA

Country Status (17)

Country Link
US (5) US10453556B2 (da)
EP (3) EP3325664B1 (da)
JP (3) JP6931236B2 (da)
KR (1) KR20180031742A (da)
CN (2) CN108026572B (da)
AU (2) AU2016295616B2 (da)
CA (1) CA2993362A1 (da)
DK (2) DK3967775T3 (da)
ES (2) ES2907697T3 (da)
FI (1) FI3967775T3 (da)
HK (2) HK1247645A1 (da)
HU (2) HUE057821T2 (da)
IL (3) IL288622B2 (da)
PT (2) PT3325664T (da)
SG (1) SG10202106935UA (da)
TW (3) TWI730973B (da)
WO (1) WO2017012592A1 (da)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3561072A1 (en) 2012-12-10 2019-10-30 Resolution Bioscience, Inc. Methods for targeted genomic analysis
CN106795562B (zh) 2014-07-18 2022-03-25 香港中文大学 Dna混合物中的组织甲基化模式分析
KR102441391B1 (ko) 2014-07-25 2022-09-07 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
IL288622B2 (en) 2015-07-23 2024-03-01 Univ Hong Kong Chinese Analysis of fragmentation patterns of cell-free dna
DK3374525T3 (da) 2015-11-11 2021-04-06 Resolution Bioscience Inc Højeffektiv konstruktion af dna-biblioteker
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
IL312894A (en) 2016-08-25 2024-07-01 Resolution Bioscience Inc Methods for identifying changes in a genomic copy in DNA samples
US9850523B1 (en) 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
SG11201811159SA (en) 2016-09-30 2019-01-30 Guardant Health Inc Methods for multi-resolution analysis of cell-free nucleic acids
MY195527A (en) 2016-10-24 2023-01-30 Grail Inc Methods And Systems For Tumor Detection
AU2017369018B2 (en) 2016-11-30 2021-02-25 The Chinese University Of Hong Kong Analysis of cell-free DNA in urine and other samples
EP4421489A3 (en) * 2017-01-25 2024-11-13 The Chinese University of Hong Kong Diagnostic applications using nucleic acid fragments
EP3635133A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. DETERMINATION OF THE TYPE OF CANCER IN A SUBJECT BY PROBABILISTIC MODELING OF END POINTS OF CIRCULATING NUCLEIC ACID FRAGMENT
EP3635134A4 (en) * 2017-06-09 2021-03-03 Bellwether Bio, Inc. DIAGNOSTIC CANCER OR OTHER PHYSIOLOGICAL CONDITIONS USING CIRCULATING NUCLEIC ACID FRAGMENT SENTINEL END POINTS
JP2020527958A (ja) * 2017-07-26 2020-09-17 ザ チャイニーズ ユニバーシティー オブ ホンコンＴｈｅ Ｃｈｉｎｅｓｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈｏｎｇｋｏｎｇ 無細胞ウイルス核酸を用いる癌スクリーニングの強化
WO2019055819A1 (en) 2017-09-14 2019-03-21 Grail, Inc. METHODS FOR PREPARING A SEQUENCING LIBRARY FROM SINGLE STRANDED DNA
US11851650B2 (en) 2017-09-28 2023-12-26 Grail, Llc Enrichment of short nucleic acid fragments in sequencing library preparation
CA3094717A1 (en) 2018-04-02 2019-10-10 Grail, Inc. Methylation markers and targeted methylation probe panels
WO2019209954A1 (en) * 2018-04-24 2019-10-31 Grail, Inc. Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
KR20210014111A (ko) 2018-05-03 2021-02-08 더 차이니즈 유니버시티 오브 홍콩 세포-무함유 혼합물의 특성을 측정하기 위한 크기-태깅된 바람직한 말단 및 배향-인지 분석
WO2019222657A1 (en) 2018-05-18 2019-11-21 The Johns Hopkins University Cell-free dna for assessing and/or treating cancer
JP2021531016A (ja) * 2018-07-23 2021-11-18 ザ チャイニーズ ユニバーシティ オブ ホンコン 無細胞ｄｎａ損傷分析およびその臨床応用
WO2020023887A1 (en) * 2018-07-27 2020-01-30 Seekin, Inc. Hepatocellular carcinoma screening
CA3111887A1 (en) 2018-09-27 2020-04-02 Grail, Inc. Methylation markers and targeted methylation probe panel
CA3123474A1 (en) * 2018-12-19 2020-06-25 The Chinese University Of Hong Kong Cell-free dna end characteristics
CN109584959B (zh) * 2018-12-27 2020-10-27 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
CN109767813B (zh) * 2018-12-27 2021-06-22 北京优迅医学检验实验室有限公司 测序深度的矫正方法及装置
SG11202012518WA (en) * 2019-01-24 2021-01-28 Illumina Inc Methods and systems for monitoring organ health and disease
US11643693B2 (en) 2019-01-31 2023-05-09 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
EP3696278A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Method of determining the origin of nucleic acids in a mixed sample
EP3696279A1 (en) * 2019-02-13 2020-08-19 Nipd Genetics Public Company Limited Methods for noninvasive prenatal testing of fetal abnormalities
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
WO2021034034A1 (ko) * 2019-08-19 2021-02-25 주식회사 녹십자지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
KR102452413B1 (ko) * 2019-08-19 2022-10-11 주식회사 지씨지놈 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
EP4077721B1 (en) * 2019-12-18 2025-03-05 The Chinese University Of Hong Kong Cell-free dna fragmentation and nucleases
EP4081655A1 (en) 2019-12-24 2022-11-02 Vib Vzw Disease detection in liquid biopsies
WO2021139716A1 (en) * 2020-01-08 2021-07-15 The Chinese University Of Hong Kong Biterminal dna fragment types in cell-free samples and uses thereof
WO2021141220A1 (ko) * 2020-01-09 2021-07-15 서울대학교 산학협력단 ATAC-seq 데이터 정규화 및 이의 활용 방법
US12139750B2 (en) * 2020-02-05 2024-11-12 The Chinese University Of Hong Kong Molecular analyses using long cell-free fragments in pregnancy
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
CN111383757B (zh) * 2020-03-04 2023-08-25 南京亿科人群健康研究院有限公司 一种计算机辅助开发包虫病诊断试剂盒的方法
CN111575347A (zh) * 2020-05-19 2020-08-25 清华大学 构建用于同时获得血浆中游离dna甲基化和片段化模式信息的文库的方法
WO2021262770A1 (en) * 2020-06-22 2021-12-30 Children's Hospital Medical Center De novo characterization of cell-free dna fragmentation hotspots in healthy and early-stage cancers
CN115997035A (zh) 2020-06-30 2023-04-21 通用诊断股份公司 用于检测多种癌症类型的系统和方法
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
EP4359562A1 (en) 2021-06-21 2024-05-01 Guardant Health, Inc. Methods and compositions for copy-number informed tissue-of-origin analysis
WO2023056065A1 (en) 2021-09-30 2023-04-06 Guardant Health, Inc. Compositions and methods for synthesis and use of probes targeting nucleic acid rearrangements
IL316858A (en) * 2022-05-12 2025-01-01 Delfi Diagnostics Inc Use of cell-free DNA fragments in the diagnostic evaluation of patients with signs and symptoms suggestive of cancer
US20240011105A1 (en) * 2022-07-08 2024-01-11 The Chinese University Of Hong Kong Analysis of microbial fragments in plasma
CN118028462A (zh) * 2022-11-02 2024-05-14 深圳湾实验室 一种泛癌种血液诊断标志物及其应用
TW202430650A (zh) * 2022-11-29 2024-08-01 香港商創新診斷科技中心 尿液及血漿中之片段組學
CN117106857B (zh) * 2023-10-24 2024-02-09 北京大学 一种血浆游离染色质的检测方法、试剂盒及其应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002543769A (ja) 1999-04-02 2002-12-24 コリクサ コーポレイション 肺癌の治療および診断のための化合物および方法
US20030219765A1 (en) 2000-03-23 2003-11-27 Jose Costa Methods for evaluating cancer risk
JP2005514956A (ja) 2002-01-18 2005-05-26 ジェンザイム・コーポレーション 胎児ｄｎａの検出および対立遺伝子の定量化のための方法
PL201608B1 (pl) 2003-06-13 2009-04-30 Cezary Cybulski Sposób i zestaw do wykrywania wysokiej genetycznie uwarunkowanej predyspozycji do raka prostaty oraz zastosowanie zmiany germinalnej w obrębie genu NBS1
EP1751306A1 (en) 2004-04-30 2007-02-14 Yale University Methods and compositions for cancer diagnosis
WO2008024009A1 (fr) 2006-08-15 2008-02-28 Institut Molekulyarnoi Genetiki Rossiiskoi Akademii Nauk (Img Ran) Niveau de transcription du gène timp3 utilisé en tant que marqueur servant à diagnostiquer le cancer du poumon non à petites cellules
MX2009012722A (es) 2007-05-25 2009-12-11 Decode Genetics Ehf Variantes geneticas sobre chr 5p12 y 10q26 como marcadores para el uso en la evaluacion del riesgo, diagnostico, pronostico y tratamiento del cancer de mama.
MX2010000846A (es) 2007-07-23 2010-04-21 Univ Hong Kong Chinese Diagnostico de aneuploide cromosomico fetal mediante el uso de secuenciacion genomica.
WO2011051283A1 (en) 2009-10-26 2011-05-05 Lifecodexx Ag Means and methods for non-invasive diagnosis of chromosomal aneuploidy
EA033752B1 (ru) 2009-11-05 2019-11-21 Univ Hong Kong Chinese Способ определения по меньшей мере части генома плода на основе анализа материнского биологического образца
CA2780016C (en) 2009-11-06 2017-09-19 The Chinese University Of Hong Kong Size-based genomic analysis
SG190344A1 (en) 2010-11-30 2013-06-28 Univ Hong Kong Chinese Detection of genetic or molecular aberrations associated with cancer
CA2850781C (en) 2011-10-06 2020-09-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2771483A1 (en) 2011-10-25 2014-09-03 ONCOTYROL - Center for Personalized Cancer Medicine GmbH Method for diagnosing a disease based on plasma-dna distribution
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
WO2013177581A2 (en) 2012-05-24 2013-11-28 University Of Washington Through Its Center For Commercialization Whole genome sequencing of a human fetus
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
EP3842551B1 (en) * 2012-09-04 2023-11-01 Guardant Health, Inc. Methods of analysing cell free polynucleotides
KR102390711B1 (ko) 2012-09-20 2022-04-26 더 차이니즈 유니버시티 오브 홍콩 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정
US9732390B2 (en) * 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
CN105339507A (zh) 2013-02-21 2016-02-17 托马生物科学公司 用于核酸分析的方法、组合物和试剂盒
EP3409791B1 (en) 2013-03-15 2021-06-30 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
CN103215350B (zh) * 2013-03-26 2016-11-02 苏州贝康医疗器械有限公司 一种基于单核苷酸多态性位点的孕妇血浆中胎儿dna含量的测定方法
US10174375B2 (en) 2013-09-20 2019-01-08 The Chinese University Of Hong Kong Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
CN105874082B (zh) 2013-10-07 2020-06-02 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
US20160002717A1 (en) 2014-07-02 2016-01-07 Boreal Genomics, Inc. Determining mutation burden in circulating cell-free nucleic acid and associated risk of disease
CN106795562B (zh) 2014-07-18 2022-03-25 香港中文大学 Dna混合物中的组织甲基化模式分析
KR102441391B1 (ko) 2014-07-25 2022-09-07 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
EP3224380A1 (en) 2014-11-25 2017-10-04 The Broad Institute Inc. Clonal haematopoiesis
JP6905934B2 (ja) 2014-12-05 2021-07-21 ファウンデーション・メディシン・インコーポレイテッド 腫瘍試料の多重遺伝子分析
CA2972433A1 (en) 2014-12-31 2016-07-07 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
CN107771221B (zh) 2015-02-10 2021-11-02 香港中文大学 用于癌症筛查和胎儿分析的突变检测
JP2018513508A (ja) 2015-03-16 2018-05-24 パーソナル ジノーム ダイアグノスティクス， インコーポレイテッド 核酸を分析するためのシステムおよび方法
IL288622B2 (en) 2015-07-23 2024-03-01 Univ Hong Kong Chinese Analysis of fragmentation patterns of cell-free dna
CA3024543A1 (en) 2015-10-22 2017-04-27 The Broad Institute, Inc. Type vi-b crispr enzymes and systems
AU2017292854B2 (en) 2016-07-06 2023-08-17 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
EP3555311B1 (en) 2016-12-13 2024-06-26 Bellwether Bio, Inc. Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample
EP3997242A4 (en) 2019-07-09 2023-08-02 The Translational Genomics Research Institute METHODS OF DETECTING DISEASE AND TREATMENT RESPONSE IN CFDNA

Also Published As

Publication number Publication date
IL257055B (en) 2022-01-01
EP3967775A1 (en) 2022-03-16
US20200005897A1 (en) 2020-01-02
PT3325664T (pt) 2022-03-03
US20230197201A1 (en) 2023-06-22
US20170024513A1 (en) 2017-01-26
SG10202106935UA (en) 2021-08-30
JP2021184732A (ja) 2021-12-09
PT3967775T (pt) 2023-10-10
AU2022224861A1 (en) 2022-10-20
TW202142697A (zh) 2021-11-16
US20200005896A1 (en) 2020-01-02
EP3325664B1 (en) 2021-12-29
EP3325664A1 (en) 2018-05-30
JP7284522B2 (ja) 2023-05-31
AU2016295616B2 (en) 2022-06-02
HUE057821T2 (hu) 2022-06-28
CN108026572B (zh) 2022-07-01
IL288622B2 (en) 2024-03-01
TWI802886B (zh) 2023-05-21
CA2993362A1 (en) 2017-01-26
US11581063B2 (en) 2023-02-14
TW202332776A (zh) 2023-08-16
KR20180031742A (ko) 2018-03-28
DK3967775T3 (da) 2023-10-02
IL288622A (en) 2022-02-01
EP3967775B1 (en) 2023-08-23
HUE064231T2 (hu) 2024-02-28
CN114999567A (zh) 2022-09-02
HK1251264A1 (zh) 2019-01-25
ES2907697T3 (es) 2022-04-26
US11615865B2 (en) 2023-03-28
IL305462A (en) 2023-10-01
JP2023109862A (ja) 2023-08-08
CN108026572A (zh) 2018-05-11
ES2960201T3 (es) 2024-03-01
TW201718872A (zh) 2017-06-01
AU2016295616A1 (en) 2018-02-15
JP6931236B2 (ja) 2021-09-01
US20200005895A1 (en) 2020-01-02
US11605445B2 (en) 2023-03-14
TWI730973B (zh) 2021-06-21
JP2018524991A (ja) 2018-09-06
FI3967775T3 (fi) 2023-09-25
US10453556B2 (en) 2019-10-22
IL257055A (en) 2018-03-29
EP4279612A3 (en) 2024-02-28
WO2017012592A1 (en) 2017-01-26
EP4279612A2 (en) 2023-11-22
EP3325664A4 (en) 2019-01-02
IL288622B1 (en) 2023-11-01
HK1247645A1 (zh) 2018-09-28

Similar Documents

Publication Publication Date Title
DK3325664T3 (da) Analyse af fragmenteringsmønstre for cellefrit DNA
EP3323070A4 (en) Neo-antigen-ANALYSIS
MA42847A (fr) Analyse de micro-moment
DK3433368T3 (da) Transreplikerende rna
DK3497117T3 (da) Nye alkalisk stabile immunglobulin-bindende proteiner
DK3371171T3 (da) Inhibitorer af RET
DK3538864T3 (da) Mikrotom
DK3194612T3 (da) Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna
MA44474A (fr) Nouveaux inhibiteurs de la ferroportine
EP3248980C0 (en) JAK HEMMER
MA45277A (fr) Promédicaments de pth
DK3201361T3 (da) Fremgangsmåder til kvantificering af cellefrit DNA
DK3384287T3 (da) Forbedrede cytometriske analyser
EP3394068A4 (en) TDO2 INHIBITORS
MA43957A (fr) Biomarqueurs de copanlisib
HK1255681A1 (zh) 用於病毒定量的高通量方法
DK3307436T3 (da) Mikrofluidanordning
MA46280A (fr) Inhibiteurs de la dopamine-b-hydroxylase
EP3338088A4 (en) BIOMARKER FOR CORONARY DISEASE
DK3325502T3 (da) Ny art af tobamovirus
EP3381018A4 (en) TRIGGER THE REGIONS
DK3073409T3 (da) Maskering af forskellige indholdstyper
DK3430004T3 (da) Faststofformer af nilotinibsalte
BR112018000296A2 (pt) ensaios de potência de influenza
ES1214960Y (es) Cilindro de gas