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DK3629011T3 - Integreret optisk indretning - Google Patents

Integreret optisk indretning Download PDF

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Publication number
DK3629011T3
DK3629011T3 DK19209994.3T DK19209994T DK3629011T3 DK 3629011 T3 DK3629011 T3 DK 3629011T3 DK 19209994 T DK19209994 T DK 19209994T DK 3629011 T3 DK3629011 T3 DK 3629011T3
Authority
DK
Denmark
Prior art keywords
optical device
integrated optical
integrated
optical
Prior art date
Application number
DK19209994.3T
Other languages
English (en)
Inventor
Cheng Frank Zhong
Paul Lundquist
Mathieu Foquet
Jonas Korlach
Hovig Bayandorian
Original Assignee
Pacific Biosciences California Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California Inc filed Critical Pacific Biosciences California Inc
Application granted granted Critical
Publication of DK3629011T3 publication Critical patent/DK3629011T3/da

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/063—Illuminating optical parts
    • G01N2201/0638—Refractive parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Plasma & Fusion (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Integrated Circuits (AREA)
DK19209994.3T 2008-09-16 2009-09-15 Integreret optisk indretning DK3629011T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19232608P 2008-09-16 2008-09-16
EP09814888.5A EP2331934B1 (en) 2008-09-16 2009-09-15 Analytic device including a zero mode waveguide substrate

Publications (1)

Publication Number Publication Date
DK3629011T3 true DK3629011T3 (da) 2024-01-29

Family

ID=42006374

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19209994.3T DK3629011T3 (da) 2008-09-16 2009-09-15 Integreret optisk indretning

Country Status (7)

Country Link
US (10) US8471230B2 (da)
EP (3) EP4325209A3 (da)
AU (2) AU2009292629B2 (da)
CA (3) CA3063032A1 (da)
DK (1) DK3629011T3 (da)
FI (1) FI3629011T3 (da)
WO (1) WO2010033193A2 (da)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0718706D0 (en) 2007-09-25 2007-11-07 Creative Physics Ltd Method and apparatus for reducing laser speckle
WO2010004115A1 (fr) * 2008-06-27 2010-01-14 Stmicroelectronics (Research & Development) Limited Dispositif d'analyse biologique de type pixel, biocapteur cmos et procedes de fabrication correspondants
CN102227659B (zh) * 2008-09-30 2014-12-24 加利福尼亚太平洋生物科学股份有限公司 超高多路分析系统和方法
WO2010068476A2 (en) * 2008-11-25 2010-06-17 The Regents Of The University Of California Ultra-low loss hollow core waveguide using high-contrast gratings
BRPI0922411A2 (pt) 2008-12-11 2018-06-05 Pacific Biosciences California Inc classificação de templates de ácido nucléico
US8384682B2 (en) * 2009-01-08 2013-02-26 Industrial Technology Research Institute Optical interactive panel and display system with optical interactive panel
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
US8571362B1 (en) * 2009-03-30 2013-10-29 Mellanox Technologies Ltd. Forming optical device using multiple mask formation techniques
US9335604B2 (en) 2013-12-11 2016-05-10 Milan Momcilo Popovich Holographic waveguide display
US11726332B2 (en) 2009-04-27 2023-08-15 Digilens Inc. Diffractive projection apparatus
US8267583B2 (en) * 2009-10-19 2012-09-18 Oracle America, Inc. Three-dimensional macro-chip including optical interconnects
GB0921994D0 (en) * 2009-12-17 2010-02-03 Univ Gent Methods and systems for optical characterisation
EP2537053B1 (en) 2010-02-19 2016-11-02 Pacific Biosciences of California, Inc. An analytical device comprising an optode array chip
US8994946B2 (en) * 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US9580792B2 (en) 2010-06-04 2017-02-28 Advantech Global, Ltd Shadow mask alignment using variable pitch coded apertures
KR101839818B1 (ko) * 2010-06-04 2018-03-19 어드밴텍 글로벌, 리미티드 코딩된 어퍼처를 이용한 섀도우 마스크 정렬
US9122172B2 (en) 2010-06-04 2015-09-01 Advantech Global, Ltd Reflection shadow mask alignment using coded apertures
US8865077B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) * 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
EP2400291A1 (en) 2010-06-17 2011-12-28 Optisense B.V. Integrated optical waveguide evanescent field sensor and longitudinal section of a substrate for use in such a sensor
KR101963462B1 (ko) 2010-10-04 2019-03-28 제납시스 인크. 재사용 가능한 자동화 평행 생물 반응 시스템 및 방법
US8750652B2 (en) 2010-10-12 2014-06-10 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic waveguide detector
US9274349B2 (en) 2011-04-07 2016-03-01 Digilens Inc. Laser despeckler based on angular diversity
US8466437B2 (en) * 2011-04-28 2013-06-18 Aptina Imaging Corporation High resolution fluorescence detection system
US9395240B2 (en) * 2011-05-04 2016-07-19 Siemens Healthcare Diagnostics Inc. Methods, systems, and apparatus for biological sample illumination at multiple wavelengths
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
WO2016020630A2 (en) 2014-08-08 2016-02-11 Milan Momcilo Popovich Waveguide laser illuminator incorporating a despeckler
EP2748670B1 (en) 2011-08-24 2015-11-18 Rockwell Collins, Inc. Wearable data display
IN2014CN01634A (da) * 2011-09-06 2015-05-08 Koninkl Philips Nv
US9759842B2 (en) 2011-11-01 2017-09-12 The Trustees Of Columbia University In The City Of New York Functionalized surfaces and methods related thereto
US9267917B2 (en) * 2011-11-04 2016-02-23 Pacific Biosciences Of California, Inc. Nanopores in zero mode waveguides
US10093975B2 (en) 2011-12-01 2018-10-09 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
US20150010265A1 (en) 2012-01-06 2015-01-08 Milan, Momcilo POPOVICH Contact image sensor using switchable bragg gratings
EP3590948A1 (en) 2012-02-15 2020-01-08 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
US9034222B2 (en) 2012-02-23 2015-05-19 Karlsruhe Institut Fuer Technologie Method for producing photonic wire bonds
US8903205B2 (en) * 2012-02-23 2014-12-02 Karlsruhe Institute of Technology (KIT) Three-dimensional freeform waveguides for chip-chip connections
AU2013240166A1 (en) 2012-03-30 2014-10-30 Pacific Biosciences Of California, Inc. Methods and composition for sequencing modified nucleic acids
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US9257478B2 (en) * 2012-05-22 2016-02-09 The Regents Of The University Of California Spatially resolved spectral-imaging device
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
WO2013192106A1 (en) 2012-06-17 2013-12-27 Pacific Biosciences Of California, Inc. Filter architecture for analytical devices
US9754794B2 (en) 2012-09-03 2017-09-05 Empire Technology Development Llc Plasmonic nano-lithography based on attenuated total reflection
EP2904380A4 (en) * 2012-10-25 2016-06-08 Univ Colorado State Res Found IMPROVED OPTICAL MULTI-ANALYTIC SENSOR
US9933684B2 (en) * 2012-11-16 2018-04-03 Rockwell Collins, Inc. Transparent waveguide display providing upper and lower fields of view having a specific light output aperture configuration
EP3524964B1 (en) * 2012-12-18 2020-07-15 Pacific Biosciences Of California, Inc. An optical analytical device
US9476981B2 (en) 2013-01-08 2016-10-25 Massachusetts Institute Of Technology Optical phased arrays
EP2929382B1 (en) 2013-01-08 2018-05-30 Massachusetts Institute of Technology Optical phased arrays
EP2959283B1 (en) 2013-02-22 2022-08-17 Pacific Biosciences of California, Inc. Integrated illumination of optical analytical devices
US10190960B2 (en) * 2013-03-14 2019-01-29 Cytonome/St, Llc Micro-lens systems for particle processing systems
EP2971141B1 (en) 2013-03-15 2018-11-28 Genapsys, Inc. Systems for biological analysis
WO2014194028A1 (en) 2013-05-31 2014-12-04 Pacific Biosciences Of California, Inc Analytical devices having compact lens train arrays
WO2015009970A1 (en) 2013-07-18 2015-01-22 Erythron Llc Spectroscopic measurements with parallel array detector
WO2015015138A1 (en) 2013-07-31 2015-02-05 Milan Momcilo Popovich Method and apparatus for contact image sensing
GB2543655B (en) * 2013-08-02 2017-11-01 Verifood Ltd Compact spectrometer comprising a diffuser, filter matrix, lens array and multiple sensor detector
MX378010B (es) * 2013-11-17 2025-03-10 Quantum Si Incorporated Sistema óptico y chip de ensayo para sondear, detectar y analizar moléculas.
US9410893B2 (en) * 2013-11-22 2016-08-09 Taiwan Semiconductor Manufacturing Company, Ltd. Bio-chip package with waveguide integrated spectrometer
CN105793692B (zh) * 2013-12-03 2019-09-13 皇家飞利浦有限公司 包含波导的生物传感器
RU2675775C1 (ru) 2013-12-10 2018-12-24 Иллумина, Инк. Биодатчики для биологического или химического анализа и способы их изготовления
JP2017505901A (ja) 2014-01-03 2017-02-23 ベリフード， リミテッドＶｅｒｉｆｏｏｄ， Ｌｔｄ． 分光システム、方法、および用途
US9816935B2 (en) * 2014-01-23 2017-11-14 Imec Vzw Integrated waveguide structure for fluorescence analysis
EP3111216A4 (en) 2014-02-28 2017-11-22 Nueon, Inc. Method and apparatus for determining markers of health by analysis of blood
EP2916125A1 (en) * 2014-03-07 2015-09-09 One Drop Diagnostics Sàrl Fluorescence-detected assays on microfluidic chips
EP3132060B1 (en) 2014-04-18 2019-03-13 Genapsys Inc. Methods and systems for nucleic acid amplification
JP6042482B2 (ja) 2014-04-25 2016-12-14 體學生物科技股▲ふん▼有限公司 光センサおよびその製造方法
US20150338627A1 (en) * 2014-05-22 2015-11-26 Multiprobe, Inc. Apparatus and method for atomic force, near-field scanning optical microscopy
EP3194933B1 (en) 2014-08-08 2024-05-01 Quantum-Si Incorporated Instrument for time resolved reading of fluorescence based assay chip
CA2957546A1 (en) * 2014-08-08 2016-02-11 Quantum-Si Incorporated Integrated device with external light source for probing, detecting, and analyzing molecules
KR102384909B1 (ko) 2014-08-08 2022-04-11 퀀텀-에스아이 인코포레이티드 수신된 광자들의 시간 비닝을 위한 집적 디바이스
US10174363B2 (en) 2015-05-20 2019-01-08 Quantum-Si Incorporated Methods for nucleic acid sequencing
EP2993462B1 (en) 2014-08-12 2019-05-22 Personal Genomics Inc. Optical sensor comprising a waveguide
CN114280023A (zh) * 2014-08-27 2022-04-05 加利福尼亚太平洋生物科学股份有限公司 集成分析器件阵列
WO2016035108A1 (ja) * 2014-09-03 2016-03-10 オリンパス株式会社 撮像装置
US10241330B2 (en) 2014-09-19 2019-03-26 Digilens, Inc. Method and apparatus for generating input images for holographic waveguide displays
CN111323867A (zh) 2015-01-12 2020-06-23 迪吉伦斯公司 环境隔离的波导显示器
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
US9632226B2 (en) 2015-02-12 2017-04-25 Digilens Inc. Waveguide grating device
CN113064236B (zh) 2015-03-16 2022-11-01 加利福尼亚太平洋生物科学股份有限公司 用于自由空间光耦合的集成装置及系统
WO2016154345A1 (en) 2015-03-24 2016-09-29 Pacific Biosciences Of California, Inc. Methods and compositions for single molecule composition loading
US10119915B2 (en) * 2015-04-09 2018-11-06 Visera Technologies Company Limited Detection device for specimens
EP3282937A4 (en) 2015-04-14 2018-11-21 Nueon Inc. Method and apparatus for determining markers of health by analysis of blood
CN114691585B (zh) * 2015-05-07 2023-10-13 加利福尼亚太平洋生物科学股份有限公司 多处理器流水线架构
WO2016183180A1 (en) * 2015-05-11 2016-11-17 Northeastern University Pinhole zero-mode waveguides
US10246742B2 (en) 2015-05-20 2019-04-02 Quantum-Si Incorporated Pulsed laser and bioanalytic system
US10605730B2 (en) 2015-05-20 2020-03-31 Quantum-Si Incorporated Optical sources for fluorescent lifetime analysis
KR102696246B1 (ko) * 2015-05-20 2024-08-20 퀀텀-에스아이 인코포레이티드 펄스 레이저 및 바이오분석 시스템
US11466316B2 (en) 2015-05-20 2022-10-11 Quantum-Si Incorporated Pulsed laser and bioanalytic system
CN107924027B (zh) 2015-06-12 2024-01-23 加利福尼亚太平洋生物科学股份有限公司 用于光耦合的集成靶点波导器件和系统
CN107850537B (zh) * 2015-06-30 2020-05-19 Imec 非营利协会 辐射载体及其在光学传感器中的使用
WO2017024017A1 (en) 2015-08-06 2017-02-09 Pacific Biosciences Of California, Inc. Systems and methods for selectively addressing sparsely arranged electronic measurement devices
JP6598269B2 (ja) 2015-10-05 2019-10-30 ディジレンズ インコーポレイテッド 導波管ディスプレイ
US10300485B2 (en) * 2015-10-23 2019-05-28 The Royal Institution For The Advancement Of Learning/Mcgill University Nanoarray-in-microarray multiplexed analysis methods and systems
TWI794145B (zh) 2015-10-28 2023-03-01 美商加州太平洋生物科學公司 包含整合性帶通濾波器之光學裝置陣列
WO2017087696A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
WO2017096504A1 (en) * 2015-12-07 2017-06-15 Shenzhen Genorivision Technology Co. Ltd. A biosensor
US9778191B2 (en) * 2016-02-05 2017-10-03 Personal Genomics, Inc. Optical sensing module
CN108780044A (zh) 2016-02-17 2018-11-09 泰斯艾科特健康公司 用于寿命成像和检测应用的传感器和设备
WO2017165403A1 (en) * 2016-03-21 2017-09-28 Nueon Inc. Porous mesh spectrometry methods and apparatus
US10859768B2 (en) 2016-03-24 2020-12-08 Digilens Inc. Method and apparatus for providing a polarization selective holographic waveguide device
CN108463287B (zh) * 2016-03-28 2021-01-15 亿明达股份有限公司 多平面微阵列
JP6646830B2 (ja) * 2016-03-30 2020-02-14 パナソニックＩｐマネジメント株式会社 光検出装置および光検出システム
EP3433658B1 (en) 2016-04-11 2023-08-09 DigiLens, Inc. Holographic waveguide apparatus for structured light projection
EP4113104A3 (en) 2016-06-01 2023-02-22 Quantum-si Incorporated Integrated device for detecting and analyzing molecules
US10544457B2 (en) 2016-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Methods and compositions for enriching compositions for polymerase enzyme complexes
CN109790575A (zh) 2016-07-20 2019-05-21 吉纳普赛斯股份有限公司 用于核酸测序的系统和方法
US10711300B2 (en) 2016-07-22 2020-07-14 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US10084979B2 (en) * 2016-07-29 2018-09-25 International Business Machines Corporation Camera apparatus and system, method and recording medium for indicating camera field of view
WO2018057002A1 (en) 2016-09-23 2018-03-29 Intel Corporation Waveguide coupling systems and methods
US10566672B2 (en) 2016-09-27 2020-02-18 Intel Corporation Waveguide connector with tapered slot launcher
US10256521B2 (en) 2016-09-29 2019-04-09 Intel Corporation Waveguide connector with slot launcher
WO2018063367A1 (en) * 2016-09-30 2018-04-05 Intel Corporation Millimeter wave waveguide connector with integrated waveguide structuring
WO2018085699A1 (en) 2016-11-04 2018-05-11 Nueon Inc. Combination blood lancet and analyzer
US11513350B2 (en) 2016-12-02 2022-11-29 Digilens Inc. Waveguide device with uniform output illumination
KR102697140B1 (ko) 2016-12-16 2024-08-22 퀀텀-에스아이 인코포레이티드 콤팩트한 모드 동기 레이저 모듈
WO2018112170A1 (en) 2016-12-16 2018-06-21 Quantum-Si Incorporated Compact beam shaping and steering assembly
BR112019012070A2 (pt) * 2016-12-16 2020-01-07 Quantum-Si Incorporated Acoplador óptico e sistema de guia de ondas
WO2018119347A1 (en) 2016-12-22 2018-06-28 Quantum-Si Incorporated Integrated photodetector with direct binning pixel
WO2018129398A1 (en) 2017-01-05 2018-07-12 Digilens, Inc. Wearable heads up displays
EP3370058A1 (en) 2017-03-01 2018-09-05 Danmarks Tekniske Universitet Planar waveguide device with nano-sized filter
CA3069974A1 (en) * 2017-07-24 2019-01-31 Quantum-Si Incorporated Optical rejection photonic structures
US11547972B2 (en) 2017-07-24 2023-01-10 Northeastern University Porous membranes comprising nanosheets and fabrication thereof
TW201915473A (zh) 2017-07-24 2019-04-16 美商寬騰矽公司 手持，大量平行之生物光電裝置
US20190064735A1 (en) * 2017-08-30 2019-02-28 Digilens, Inc. Methods and Apparatus for Compensating Image Distortion and Illumination Nonuniformity in a Waveguide
EP3684951A4 (en) 2017-09-21 2021-06-16 Genapsys, Inc. NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS
CN107764791B (zh) * 2017-10-11 2021-03-23 河南仕佳光子科技股份有限公司 一种基于倏逝波的离子浓度测试芯片
US11162138B2 (en) 2017-10-30 2021-11-02 Pacific Biosciences Of California, Inc. Multi-amplitude modular labeled compounds
WO2019090192A1 (en) 2017-11-03 2019-05-09 Pacific Biosciences Of California, Inc. Systems, devices, and methods for improved optical waveguide transmission and alignment
NL2020625B1 (en) * 2017-12-22 2019-07-02 Illumina Inc Two-filter light detection devices and methods of manufacturing same
US10655168B2 (en) 2017-12-22 2020-05-19 Pacific Biosciences Of California, Inc. Modified biotin-binding proteins for immobilization
CN111095558B (zh) 2017-12-26 2021-06-18 伊鲁米纳公司 传感器系统
TWI698638B (zh) 2017-12-28 2020-07-11 美商伊路米納有限公司 具有降低的螢光範圍雜訊的檢測器以及用於降低螢光範圍雜訊的方法
MX2020007284A (es) 2018-01-08 2020-09-10 Quantum Si Inc Sistema y metodos para la carga electrocinetica de camaras de reaccion a escala submicrometrica.
US20190212588A1 (en) 2018-01-08 2019-07-11 Digilens, Inc. Systems and Methods for Manufacturing Waveguide Cells
US10732569B2 (en) 2018-01-08 2020-08-04 Digilens Inc. Systems and methods for high-throughput recording of holographic gratings in waveguide cells
JP2021511829A (ja) 2018-01-26 2021-05-13 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ シークエンシングデバイスに関する機械学習可能なパルス決定および塩基決定
WO2019195334A1 (en) * 2018-04-03 2019-10-10 Corning Incorporated Hermetically sealed optically transparent wafer-level packages and methods for making the same
JP2019191300A (ja) * 2018-04-20 2019-10-31 学校法人慶應義塾 波長選択光スイッチ
KR20210005215A (ko) 2018-05-03 2021-01-13 퀀텀-에스아이 인코포레이티드 광학 요소 특성규정
CA3098447A1 (en) 2018-05-14 2019-11-21 Quantum-Si Incorporated Systems and methods for unifying statistical models for different data modalities
US11971963B2 (en) 2018-05-30 2024-04-30 Quantum-Si Incorporated Methods and apparatus for multi-modal prediction using a trained statistical model
US11967436B2 (en) 2018-05-30 2024-04-23 Quantum-Si Incorporated Methods and apparatus for making biological predictions using a trained multi-modal statistical model
CN112424587A (zh) 2018-06-15 2021-02-26 宽腾矽公司 用于具有脉冲光源的先进分析仪器的数据采集控制
KR20210022688A (ko) 2018-06-22 2021-03-03 퀀텀-에스아이 인코포레이티드 가변 검출 시간의 전하 저장 빈을 갖는 집적 광검출기
US11332787B2 (en) 2018-06-29 2022-05-17 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US10365425B1 (en) 2018-07-11 2019-07-30 International Business Machines Corporation Optical waveguide crossing structure
US11402801B2 (en) 2018-07-25 2022-08-02 Digilens Inc. Systems and methods for fabricating a multilayer optical structure
US11953728B2 (en) * 2018-08-06 2024-04-09 Rockley Photonics Limited Method for III-v/silicon hybrid integration
US11378762B2 (en) * 2018-08-06 2022-07-05 Rockley Photonics Limited Method for III-V/silicon hybrid integration
JP2021536563A (ja) * 2018-08-16 2021-12-27 エッセンリックス コーポレーション 粒子の凝集または脱凝集を伴う均一アッセイ方法
MX2021002413A (es) 2018-08-29 2021-04-28 Quantum Si Inc Tecnicas de fabricacion de pocillos de muestra y estructuras para dispositivos de sensores integrados.
DE102018130299B4 (de) * 2018-11-29 2020-08-06 Presens Precision Sensing Gmbh Sensoranordnung und Messverfahren
US12179204B2 (en) 2018-12-03 2024-12-31 Quantum-Si Incorporated Sample well fabrication techniques and structures for integrated sensor
TW202041847A (zh) 2019-01-03 2020-11-16 美商寬騰矽公司 用於傳遞光至光子元件之陣列的光學波導及耦合器
US12153217B2 (en) 2019-01-14 2024-11-26 Vuzix Corporation Digital writing of large diffraction grating patterns
WO2020149956A1 (en) 2019-01-14 2020-07-23 Digilens Inc. Holographic waveguide display with light control layer
EP3924759A4 (en) 2019-02-15 2022-12-28 Digilens Inc. METHODS AND APPARATUS FOR PROVIDING A HOLOGRAPHIC WAVEGUIDE DISPLAY USING INTEGRATED NETWORKS
US20220283377A1 (en) 2019-02-15 2022-09-08 Digilens Inc. Wide Angle Waveguide Display
US11979194B2 (en) * 2019-02-21 2024-05-07 King Abdullah University Of Science And Technology Large-area waveguided photodetection for optical wireless communication
US10641956B1 (en) * 2019-03-04 2020-05-05 Globalfoundries Inc. Polarizers and polarization splitters phase-matched with a back-end-of-line layer
WO2020186113A1 (en) 2019-03-12 2020-09-17 Digilens Inc. Holographic waveguide backlight and related methods of manufacturing
JP7207087B2 (ja) * 2019-03-28 2023-01-18 住友大阪セメント株式会社 光導波路素子
JP2022535460A (ja) 2019-06-07 2022-08-08 ディジレンズ インコーポレイテッド 透過格子および反射格子を組み込んだ導波路、ならびに関連する製造方法
AU2020294144A1 (en) 2019-06-14 2022-01-27 Quantum-Si Incorporated Sliced grating coupler with increased beam alignment sensitivity
EP3980755A1 (en) 2019-06-19 2022-04-13 Quantum-Si Incorporated Optical nanostructure rejecter for an integrated device and related methods
JP2022539561A (ja) 2019-06-28 2022-09-12 クアンタム－エスアイ インコーポレイテッド 光学的および電気的な二次経路の除去
WO2021007039A1 (en) * 2019-07-08 2021-01-14 Illumina, Inc. Waveguide integration with optical coupling structures on light detection device
KR20220038452A (ko) 2019-07-29 2022-03-28 디지렌즈 인코포레이티드. 픽셀화된 디스플레이의 이미지 해상도와 시야를 증배하는 방법 및 장치
US12055481B2 (en) * 2019-08-01 2024-08-06 Viavi Solutions Inc. Sensor device
JP7593994B2 (ja) 2019-08-08 2024-12-03 クアンタム－エスアイ インコーポレイテッド 集積光学デバイスにおける放射収集効率の向上
US11442222B2 (en) 2019-08-29 2022-09-13 Digilens Inc. Evacuated gratings and methods of manufacturing
CA3153572A1 (en) 2019-10-08 2021-04-15 Nicholas Francis Borrelli Optical systems comprising binary photonics lattices
US11105745B2 (en) 2019-10-10 2021-08-31 Visera Technologies Company Limited Biosensor
KR20220091534A (ko) 2019-10-31 2022-06-30 퀀텀-에스아이 인코포레이티드 강화된 드레인을 갖는 픽셀
KR102292599B1 (ko) 2019-11-06 2021-08-23 주식회사 뷰웍스 광학 분석 장치 및 광학 분석 방법
US20210187503A1 (en) * 2019-12-19 2021-06-24 Personal Genomics Taiwan, Inc. Apparatus and system for single-molecule nucleic acids detection
WO2021146475A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Sensor for lifetime plus spectral characterization
WO2021146473A1 (en) 2020-01-14 2021-07-22 Quantum-Si Incorporated Integrated sensor for lifetime characterization
WO2021146477A1 (en) * 2020-01-14 2021-07-22 Quantum-Si Incorporated Waveguide excitation uniformity
KR20220137027A (ko) 2020-01-14 2022-10-11 퀀텀-에스아이 인코포레이티드 진폭 변조 레이저
CN111229342B (zh) * 2020-01-17 2022-02-11 上海新微技术研发中心有限公司 基于cmos图像传感的光栅波导多微流道芯片的制造方法
CN111229341B (zh) * 2020-01-17 2022-02-11 上海新微技术研发中心有限公司 光栅波导多微流道芯片的制造方法
TW202147591A (zh) 2020-03-02 2021-12-16 美商寬騰矽公司 用於多維信號分析之整合感應器
US12188870B2 (en) 2020-04-08 2025-01-07 Quantum-Si Incorporated Integrated sensor with reduced skew
CN115804093A (zh) * 2020-06-03 2023-03-14 诺基亚技术有限公司 用于视频编码和视频解码的方法、装置和计算机程序产品
US12013521B2 (en) * 2020-06-29 2024-06-18 Mgi Tech Co., Ltd. Systems and methods for optical scanning and imaging through a fluid medium for nucleic acid sequencing
CN116670494A (zh) 2020-10-22 2023-08-29 宽腾矽公司 具有按序耦合电荷存储的集成电路及相关技术
CN112779152A (zh) * 2020-12-30 2021-05-11 中国科学院长春光学精密机械与物理研究所 一种基因测序芯片及系统
EP4288831A4 (en) 2021-03-05 2025-01-15 Digilens Inc EVACUATED PERIODIC STRUCTURES AND THEIR MANUFACTURING PROCESSES
CN113109900B (zh) * 2021-03-15 2022-06-07 中国科学院苏州生物医学工程技术研究所 一种集成零模波导芯片及其制备方法
TWI798974B (zh) * 2021-05-18 2023-04-11 友達光電股份有限公司 感光裝置
US11703445B2 (en) * 2021-05-28 2023-07-18 Visera Technologies Company Limited Biosensor with grating array
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
WO2024010518A1 (en) * 2022-07-08 2024-01-11 Compoundtek Pte. Ltd. Waveguide terminator
WO2024039853A1 (en) 2022-08-19 2024-02-22 Quantum-Si Incorporated Backside illuminated structures with parallel charge transfer
FR3140451A1 (fr) * 2022-10-04 2024-04-05 Universite Grenoble Alpes Substrat optique à antennes intégrées et spectromètre le comprenant
TW202440035A (zh) 2022-12-15 2024-10-16 美商阿達普提克斯生物科學公司 分析物偵測之系統及方法
US20250066841A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
GB8509491D0 (en) * 1985-04-12 1985-05-15 Plessey Co Plc Optic waveguide biosensors
ATE77483T1 (de) 1986-04-23 1992-07-15 Avl Medical Instr Ag Sensorelement zur bestimmung von stoffkonzentrationen.
US5135876A (en) 1987-09-24 1992-08-04 University Of Utah Method and apparatus for the regulation of complex binding
GB8911462D0 (en) 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
DE3926604A1 (de) 1989-08-11 1991-02-14 Hoechst Ag Polyimidwellenleiter als optische sensoren
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
US5082629A (en) 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5173747A (en) 1990-09-20 1992-12-22 Battelle Memorial Institute Integrated optical directional-coupling refractometer apparatus
US5239178A (en) 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5233673A (en) 1991-10-09 1993-08-03 Hughes Aircraft Company Output steerable optical phased array
US5446534A (en) 1993-03-05 1995-08-29 Optical Solutions, Inc. Broad band waveguide spectrometer
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5439647A (en) 1994-02-25 1995-08-08 Fiberchem, Inc. Chip level waveguide sensor
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6017434A (en) 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5774305A (en) * 1995-06-07 1998-06-30 Seagate Technology, Inc. Head gimbal assembly to reduce slider distortion due to thermal stress
JP3039347B2 (ja) 1995-12-27 2000-05-08 日立電線株式会社 スイッチング機能を備えた光部品及びそれに使用する導波路型フィルタ
AU2335297A (en) 1996-03-19 1997-10-10 University Of Utah Research Foundation Lens and associatable flow cell
US5867266A (en) 1996-04-17 1999-02-02 Cornell Research Foundation, Inc. Multiple optical channels for chemical analysis
WO1997040181A1 (en) 1996-04-25 1997-10-30 Spectrametrix Inc. Analyte assay using particulate labels
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
JP3748571B2 (ja) * 1996-11-18 2006-02-22 ノバルティス アクチエンゲゼルシャフト 測定装置及びその使用方法
WO1998049587A1 (en) * 1997-05-01 1998-11-05 Trustees Of The Stevens Institute Of Technology Method and apparatus for modulation of guided plasmons
DE69838067T2 (de) 1997-05-23 2008-03-13 Bioarray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
ATE225858T1 (de) 1997-07-28 2002-10-15 Medical Biosystems Ltd Sequenzanalyse von nukleinsäuren
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
DE19815109A1 (de) 1998-04-03 1999-10-07 Bodenseewerk Perkin Elmer Co Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
GB9810350D0 (en) 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
ATE309390T1 (de) 1998-07-30 2005-11-15 Solexa Ltd Matrizen von biomolekülen und ihre verwendung in sequenzierung
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US6210896B1 (en) 1998-08-13 2001-04-03 Us Genomics Molecular motors
US6263286B1 (en) 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6603537B1 (en) 1998-08-21 2003-08-05 Surromed, Inc. Optical architectures for microvolume laser-scanning cytometers
CN1289448A (zh) 1998-11-18 2001-03-28 皇家菲利浦电子有限公司 荧光材料
JP4638043B2 (ja) 1998-12-14 2011-02-23 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法
US6438279B1 (en) 1999-01-07 2002-08-20 Cornell Research Foundation, Inc. Unitary microcapiliary and waveguide structure and method of fabrication
US6330388B1 (en) 1999-01-27 2001-12-11 Northstar Photonics, Inc. Method and apparatus for waveguide optics and devices
WO2000050172A1 (en) 1999-02-23 2000-08-31 Caliper Technologies Corp. Manipulation of microparticles in microfluidic systems
US6192168B1 (en) 1999-04-09 2001-02-20 The United States Of America As Represented By The Secretary Of The Navy Reflectively coated optical waveguide and fluidics cell integration
US6721053B1 (en) * 1999-05-19 2004-04-13 Corning Intellisense Corporation System for high resolution chemical and biological sensing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6287774B1 (en) 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
EP1190236A1 (de) 1999-06-05 2002-03-27 Zeptosens AG Sensorplatform und verfahren zur multianalytbestimmung
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7209836B1 (en) 1999-07-16 2007-04-24 Perkinelmer Las, Inc. Method and system for automatically creating crosstalk-corrected data of a microarray
US6982146B1 (en) 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
WO2001016375A2 (en) 1999-08-30 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
WO2001084197A1 (en) 2000-04-28 2001-11-08 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US6690467B1 (en) 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
GB0016472D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method and apparatus
GB0016473D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method
JP2002050778A (ja) 2000-08-02 2002-02-15 Nippon Sheet Glass Co Ltd 受光素子アレイおよびそれを用いた光通信モニタモジュール
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
WO2002059592A2 (en) 2001-01-26 2002-08-01 Biocal Technology, Inc. Optical detection in a multi-channel bio-separation system
JP2005507489A (ja) 2001-02-23 2005-03-17 ジェニコン サイエンスィズ コーポレーション 検体分析において拡張ダイナミックレンジを提供する方法
DE10133844B4 (de) 2001-07-18 2006-08-17 Micronas Gmbh Verfahren und Vorrichtung zur Detektion von Analyten
US7560254B2 (en) 2001-08-29 2009-07-14 Ge Healthcare Bio-Sciences Corp. Allele specific primer extension
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
US7052839B2 (en) 2001-08-29 2006-05-30 Amersham Biosciences Corp Terminal-phosphate-labeled nucleotides and methods of use
US6904186B2 (en) 2001-11-16 2005-06-07 Ngk Insulators, Ltd. Optical modulators and a method for modulating light
US7189361B2 (en) 2001-12-19 2007-03-13 3M Innovative Properties Company Analytical device with lightguide Illumination of capillary and microgrooves arrays
US6991726B2 (en) 2002-07-01 2006-01-31 Usfilter Corporation Filter having a media retaining plate
JP2004069395A (ja) 2002-08-02 2004-03-04 Nec Corp マイクロチップ、マイクロチップの製造方法および成分検出方法
US20040071466A1 (en) * 2002-10-10 2004-04-15 Buckman Lisa A. Controlled optical splitter using a diffractive optical element and optical demultiplexer incorporating same
US20040081384A1 (en) 2002-10-25 2004-04-29 Datesman Aaron M. Multiple-mode planar-waveguide sensor, fabrication materials and techniques
FR2846745B1 (fr) * 2002-10-30 2004-12-24 Genewave Dispositif de support d'elements chromophores.
US6970240B2 (en) 2003-03-10 2005-11-29 Applera Corporation Combination reader
AU2004237243B2 (en) 2003-05-05 2010-11-11 D4D Technologies, Llc Optical coherence tomography imaging
TWI329208B (en) 2003-06-03 2010-08-21 Oerlikon Trading Ag Optical substrate for enhanced detectability of fluorescence
FI20030867A (fi) 2003-06-10 2004-12-11 Wallac Oy Optinen mittausmenetelmä ja laboratoriomittauslaite
KR100503767B1 (ko) 2003-06-27 2005-07-26 학교법인연세대학교 2차원 광변조 미세 개구 어레이 장치 및 이를 이용한 고속미세패턴 기록시스템
US7075059B2 (en) 2003-09-11 2006-07-11 Applera Corporation Image enhancement by sub-pixel imaging
US7323681B1 (en) 2003-09-11 2008-01-29 Applera Corporation Image enhancement by sub-pixel imaging
US7233393B2 (en) 2004-08-05 2007-06-19 Applera Corporation Signal noise reduction for imaging in biological analysis
US20050135974A1 (en) 2003-12-18 2005-06-23 Harvey Michael A. Device for preparing multiple assay samples using multiple array surfaces
US7075695B2 (en) 2004-03-01 2006-07-11 Lucent Technologies Inc. Method and apparatus for controlling a bias voltage of a Mach-Zehnder modulator
KR100590548B1 (ko) * 2004-03-03 2006-06-19 삼성전자주식회사 광검출 장치
US7302348B2 (en) 2004-06-02 2007-11-27 Agilent Technologies, Inc. Method and system for quantifying and removing spatial-intensity trends in microarray data
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
EP1790202A4 (en) 2004-09-17 2013-02-20 Pacific Biosciences California APPARATUS AND METHOD FOR ANALYZING MOLECULES
US20070048748A1 (en) 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US7417740B2 (en) 2004-11-12 2008-08-26 Medeikon Corporation Single trace multi-channel low coherence interferometric sensor
US7130041B2 (en) 2005-03-02 2006-10-31 Li-Cor, Inc. On-chip spectral filtering using CCD array for imaging and spectroscopy
GB0507835D0 (en) 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
WO2006116726A2 (en) 2005-04-28 2006-11-02 Applera Corporation Multi-color light detection with imaging detectors
FR2886762B1 (fr) 2005-06-07 2007-08-10 Commissariat Energie Atomique Detecteur optique ultrasensible, a grande resolution temporelle, utilisant un guide d'onde, et procedes de fabrication de ce detecteur
WO2006135782A2 (en) 2005-06-10 2006-12-21 Applera Corporation Method and system for multiplex genetic analysis
US20060291706A1 (en) 2005-06-23 2006-12-28 Applera Corporation Method of extracting intensity data from digitized image
CN101203743B (zh) * 2005-06-23 2011-04-06 皇家飞利浦电子股份有限公司 使用亚波长孔径或狭缝的发光传感器
WO2007011549A1 (en) 2005-06-30 2007-01-25 Applera Corporation Two-dimensional spectral imaging system
US7227128B2 (en) 2005-06-30 2007-06-05 Applera Corporation System and methods for improving signal/noise ratio for signal detectors
CA2616433A1 (en) 2005-07-28 2007-02-01 Helicos Biosciences Corporation Consecutive base single molecule sequencing
US7805081B2 (en) 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US7763423B2 (en) 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
AU2006320739B2 (en) 2005-11-28 2012-03-29 Pacific Biosciences Of California, Inc. Uniform surfaces for hybrid material substrates and methods for making and using same
US7248361B2 (en) 2005-12-22 2007-07-24 Palo Alto Research Center Incorporated Fluorescence reader based on anti-resonant waveguide excitation
US7715001B2 (en) 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7995202B2 (en) 2006-02-13 2011-08-09 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US7692783B2 (en) 2006-02-13 2010-04-06 Pacific Biosciences Of California Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
US20080050747A1 (en) 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
US8975216B2 (en) 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
WO2007137060A2 (en) 2006-05-16 2007-11-29 Applied Biosystems Systems, methods, and apparatus for single molecule sequencing
US7463353B2 (en) * 2006-05-31 2008-12-09 Uchicago Argonne, Llc Modular, micro-scale, optical array and biodetection system
WO2008002765A2 (en) 2006-06-27 2008-01-03 Applera Corporation Method and system for compensating for spatial cross-talk
US7803609B2 (en) 2006-07-21 2010-09-28 Affymetrix, Inc. System, method, and product for generating patterned illumination
CA2662521C (en) * 2006-09-01 2016-08-09 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US7901763B2 (en) 2006-12-22 2011-03-08 E.I. Du Pont De Nemours And Company Porous infusible polymer parts
JP4982793B2 (ja) * 2007-02-02 2012-07-25 独立行政法人産業技術総合研究所 生細胞表層分子解析方法及び部材
US20080220537A1 (en) 2007-03-07 2008-09-11 Pacific Biosciences Of California, Inc. Substrates and methods for selective immobilization of active molecules
WO2008121375A2 (en) 2007-03-29 2008-10-09 Pacific Biosciences Of California, Inc. Modified surfaces for immobilization of active molecules
US8802424B2 (en) 2008-01-10 2014-08-12 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
KR20120086911A (ko) * 2011-01-27 2012-08-06 삼성전자주식회사 나노 입자 추적 장치, 나노 입자 추적 장치의 채널 구조, 및 나노 입자 추적 장치의 채널 구조의 제조 방법
EP3524964B1 (en) * 2012-12-18 2020-07-15 Pacific Biosciences Of California, Inc. An optical analytical device
WO2017066399A1 (en) * 2015-10-15 2017-04-20 The Usa, As Represented By The Secretary Of The Navy Trace-gas raman spectroscopy in functionalized waveguides

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