BRPI0922411A2 - classificação de templates de ácido nucléico - Google Patents
classificação de templates de ácido nucléicoInfo
- Publication number
- BRPI0922411A2 BRPI0922411A2 BRPI0922411A BRPI0922411A BRPI0922411A2 BR PI0922411 A2 BRPI0922411 A2 BR PI0922411A2 BR PI0922411 A BRPI0922411 A BR PI0922411A BR PI0922411 A BRPI0922411 A BR PI0922411A BR PI0922411 A2 BRPI0922411 A2 BR PI0922411A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- acid template
- template classification
- classification
- nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/113—Real time assay
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20155108P | 2008-12-11 | 2008-12-11 | |
| US18035009P | 2009-05-21 | 2009-05-21 | |
| US18666109P | 2009-06-12 | 2009-06-12 | |
| PCT/US2009/006517 WO2010068289A2 (en) | 2008-12-11 | 2009-12-10 | Classification of nucleic acid templates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0922411A2 true BRPI0922411A2 (pt) | 2018-06-05 |
Family
ID=42243263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0922411A BRPI0922411A2 (pt) | 2008-12-11 | 2009-12-10 | classificação de templates de ácido nucléico |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9175341B2 (pt) |
| EP (1) | EP2370598B1 (pt) |
| CN (1) | CN102317473A (pt) |
| AU (1) | AU2009325069B2 (pt) |
| BR (1) | BRPI0922411A2 (pt) |
| CA (1) | CA2746632C (pt) |
| WO (1) | WO2010068289A2 (pt) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8431367B2 (en) | 2007-09-14 | 2013-04-30 | Predictive Biosciences Corporation | Detection of nucleic acids and proteins |
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
| US9175338B2 (en) | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
| US20230148447A9 (en) | 2008-12-11 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
| BRPI0922411A2 (pt) | 2008-12-11 | 2018-06-05 | Pacific Biosciences California Inc | classificação de templates de ácido nucléico |
| EP2391732B1 (en) | 2009-01-30 | 2015-05-27 | Oxford Nanopore Technologies Limited | Methods using adaptors for nucleic acid constructs in transmembrane sequencing |
| WO2010117420A2 (en) | 2009-03-30 | 2010-10-14 | Pacific Biosciences Of California, Inc. | Fret-labeled compounds and uses therefor |
| US8518643B2 (en) * | 2010-02-04 | 2013-08-27 | Pacific Biosciences Of California, Inc. | Method to improve single molecule analyses |
| US9115353B2 (en) | 2011-01-31 | 2015-08-25 | Illumina, Inc. | Method for nucleotide detection |
| US9611510B2 (en) | 2011-04-06 | 2017-04-04 | The University Of Chicago | Composition and methods related to modification of 5-methylcytosine (5-mC) |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| KR20140050067A (ko) | 2011-07-25 | 2014-04-28 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 막횡단 포어를 사용한 이중 가닥 폴리뉴클레오티드 서열분석을 위한 헤어핀 루프 방법 |
| WO2013056241A2 (en) | 2011-10-14 | 2013-04-18 | Pacific Biosciences Of California, Inc. | Real-time redox sequencing |
| WO2013090588A1 (en) * | 2011-12-13 | 2013-06-20 | Oslo Universitetssykehus Hf | Methods and kits for detection of methylation status |
| US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
| EP3590948A1 (en) | 2012-02-15 | 2020-01-08 | Pacific Biosciences of California, Inc. | Polymerase enzyme substrates with protein shield |
| WO2013138644A2 (en) * | 2012-03-15 | 2013-09-19 | New England Biolabs, Inc. | Methods and compositions for discrimination between cytosine and modifications thereof, and for methylome analysis |
| AU2013240166A1 (en) * | 2012-03-30 | 2014-10-30 | Pacific Biosciences Of California, Inc. | Methods and composition for sequencing modified nucleic acids |
| WO2013163207A1 (en) | 2012-04-24 | 2013-10-31 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-c in nucleic acid templates |
| PL2851431T3 (pl) * | 2012-05-14 | 2018-04-30 | Bgi Genomics Co., Ltd. | Sposób, system i odczytywalny komputerowo nośnik do określania informacji o zasadach we wcześniej określonym obszarze genomu płodu |
| WO2013185137A1 (en) * | 2012-06-08 | 2013-12-12 | Pacific Biosciences Of California, Inc. | Modified base detection with nanopore sequencing |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| US10563248B2 (en) | 2012-11-30 | 2020-02-18 | Cambridge Epigenetix Limited | Oxidizing agent for modified nucleotides |
| ES2979018T3 (es) * | 2013-01-31 | 2024-09-23 | Codexis Inc | Métodos, sistemas y software para identificar biomoléculas usando modelos de forma multiplicativa |
| EP2964779B1 (en) | 2013-03-08 | 2018-08-29 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| WO2014153757A1 (zh) * | 2013-03-28 | 2014-10-02 | 深圳华大基因研究院 | 确定胚胎基因组中预定区域碱基信息的方法、系统和计算机可读介质 |
| US9957291B2 (en) | 2013-08-05 | 2018-05-01 | Pacific Biosciences Of California, Inc. | Protected fluorescent reagent compounds |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| EP3038738B1 (en) * | 2013-08-30 | 2019-02-27 | University of Washington through its Center for Commercialization | Selective modification of polymer subunits to improve nanopore-based analysis |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| DK3066201T3 (en) | 2013-11-07 | 2018-06-06 | Editas Medicine Inc | CRISPR-RELATED PROCEDURES AND COMPOSITIONS WITH LEADING GRADES |
| US20150166985A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting von willebrand factor point mutations |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| CA2956224A1 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3633047B1 (en) | 2014-08-19 | 2022-12-28 | Pacific Biosciences of California, Inc. | Method of sequencing nucleic acids based on an enrichment of nucleic acids |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| KR101719285B1 (ko) * | 2014-11-04 | 2017-03-23 | 한국과학기술원 | 표적 물질에 의해 조절되는 핵산 중합효소 활성을 이용한 생체물질의 검출 및 정량 방법 |
| US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
| US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
| US10429342B2 (en) | 2014-12-18 | 2019-10-01 | Edico Genome Corporation | Chemically-sensitive field effect transistor |
| US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| US10302972B2 (en) | 2015-01-23 | 2019-05-28 | Pacific Biosciences Of California, Inc. | Waveguide transmission |
| US10150872B2 (en) | 2015-02-04 | 2018-12-11 | Pacific Biosciences Of California, Inc. | Multimeric protected fluorescent reagents |
| CN107849607B (zh) | 2015-08-12 | 2022-10-11 | 香港中文大学 | 血浆dna的单分子测序 |
| US11459573B2 (en) | 2015-09-30 | 2022-10-04 | Trustees Of Boston University | Deadman and passcode microbial kill switches |
| JP7067793B2 (ja) | 2015-10-23 | 2022-05-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸塩基編集因子およびその使用 |
| US10280411B2 (en) | 2015-10-27 | 2019-05-07 | Pacific Biosciences of California, In.c | Methods, systems, and reagents for direct RNA sequencing |
| WO2017087696A1 (en) | 2015-11-18 | 2017-05-26 | Pacific Biosciences Of California, Inc. | Methods and compositions for loading of polymerase complexes |
| WO2017087894A1 (en) | 2015-11-19 | 2017-05-26 | Pacific Bioscienes Of California, Inc. | Compounds and systems for improving signal detection |
| US10676788B2 (en) | 2015-11-20 | 2020-06-09 | Pacific Biosciences Of California, Inc. | Modified nucleotide reagents |
| CN113321943A (zh) | 2015-11-20 | 2021-08-31 | 加利福尼亚太平洋生物科学股份有限公司 | 标记的核苷酸类似物、反应混合物以及测序方法和系统 |
| CN117024498A (zh) | 2015-11-20 | 2023-11-10 | 加利福尼亚太平洋生物科学股份有限公司 | 受保护的染料标记的试剂 |
| US10811539B2 (en) | 2016-05-16 | 2020-10-20 | Nanomedical Diagnostics, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
| US10648027B2 (en) | 2016-08-08 | 2020-05-12 | Roche Sequencing Solutions, Inc. | Basecalling for stochastic sequencing processes |
| EP3497214B1 (en) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| US11999998B2 (en) | 2016-08-24 | 2024-06-04 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| WO2018165459A1 (en) | 2017-03-08 | 2018-09-13 | The University Of Chicago | Method for highly sensitive dna methylation analysis |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| EP3589748B1 (en) * | 2017-04-13 | 2020-07-22 | IMBA-Institut für Molekulare Biotechnologie GmbH | Nucleic acid modification and identification method |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2019012481A2 (en) * | 2017-07-12 | 2019-01-17 | John Katz | G-QUADRUPLEXES DIVIDED FOR CAPTURE AND DETECTION OF NUCLEIC ACIDS |
| US20230193359A1 (en) * | 2017-07-27 | 2023-06-22 | John Fred KATZ | Split G-Quadruplexes for Capture and Detection of Nucleic Acids |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| JP7084470B2 (ja) * | 2017-08-23 | 2022-06-14 | エフ．ホフマン－ラ ロシュ アーゲー | 酵素のスクリーニング法 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| EP3697906A1 (en) | 2017-10-16 | 2020-08-26 | The Broad Institute, Inc. | Uses of adenosine base editors |
| CN108530539B (zh) * | 2018-03-20 | 2021-08-13 | 北京博雅捷康生物科技有限公司 | 一组识别dna受紫外线照射造成的嘧啶二聚体的抗体 |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US11332787B2 (en) | 2018-06-29 | 2022-05-17 | Pacific Biosciences Of California, Inc. | Methods and compositions for delivery of molecules and complexes to reaction sites |
| CN111434778A (zh) * | 2019-01-11 | 2020-07-21 | 中国人民解放军军事科学院军事医学研究院 | 一种RNA分子m6A修饰水平检测方法及用途 |
| WO2020191248A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Method and compositions for editing nucleotide sequences |
| ES2985191T3 (es) | 2019-08-16 | 2024-11-04 | Univ Hong Kong Chinese | Detección de metilación de nucleótidos en ácidos nucleicos |
| AU2021246531A1 (en) * | 2020-04-02 | 2022-11-24 | Altius Institute For Biomedical Sciences | Methods, compositions, and kits for identifying regions of genomic DNA bound to a protein |
| EP4127152A4 (en) * | 2020-04-02 | 2024-05-01 | Altius Institute For Biomedical Sciences | Methods, compositions, and kits for identifying regions of genomic dna bound to a protein |
| EP4146804A1 (en) | 2020-05-08 | 2023-03-15 | The Broad Institute Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| AU2021319150A1 (en) | 2020-07-30 | 2023-03-02 | Cambridge Epigenetix Limited | Compositions and methods for nucleic acid analysis |
| US20250043336A1 (en) * | 2023-08-04 | 2025-02-06 | Pacific Biosciences Of California, Inc. | Detection of 5-methylcytosine |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US740528A (en) | 1900-01-12 | 1903-10-06 | Frederick W Braun | Furnace. |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| EP0450060A1 (en) | 1989-10-26 | 1991-10-09 | Sri International | Dna sequencing |
| AU7516694A (en) | 1993-07-30 | 1995-02-28 | Affymax Technologies N.V. | Biotinylation of proteins |
| WO1996027025A1 (en) | 1995-02-27 | 1996-09-06 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
| DE69527444T3 (de) | 1995-07-11 | 2007-08-16 | Forfas (Trading As Bioresearch Ireland) | Glycosylase verwendende detektion von bestimmten nukleinsäuresequenzen |
| AUPO351996A0 (en) * | 1996-11-08 | 1996-12-05 | Western Health Care Network | Viral variants and methods for detecting same |
| ATE225858T1 (de) | 1997-07-28 | 2002-10-15 | Medical Biosystems Ltd | Sequenzanalyse von nukleinsäuren |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| JP4638043B2 (ja) | 1998-12-14 | 2011-02-23 | パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド | ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法 |
| WO2000050172A1 (en) | 1999-02-23 | 2000-08-31 | Caliper Technologies Corp. | Manipulation of microparticles in microfluidic systems |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| US7611869B2 (en) | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
| US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| GB0016473D0 (en) | 2000-07-05 | 2000-08-23 | Amersham Pharm Biotech Uk Ltd | Sequencing method |
| EP1373889A2 (en) * | 2000-07-31 | 2004-01-02 | Maxygen, Inc. | Biosensors, reagents and diagnostic applications of directed evolution |
| US7256019B2 (en) | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
| US7033762B2 (en) | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
| US7244566B2 (en) | 2001-08-29 | 2007-07-17 | Ge Healthcare Bio-Sciences Corp. | Analyte detection |
| DE10151055B4 (de) | 2001-10-05 | 2005-05-25 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierung in CpG Inseln |
| US20030166170A1 (en) | 2002-01-17 | 2003-09-04 | Invitrogen Corporation | Methods of random mutagenesis and methods of modifying nucleic acids using translesion DNA polymerases |
| EP1567669B1 (en) * | 2002-12-02 | 2010-03-24 | Illumina Cambridge Limited | Determination of methylation of nucleic acid sequences |
| EP1597602A4 (en) | 2003-02-05 | 2009-07-22 | Ge Healthcare Bio Sciences | SOLID PHASE SEQUENCING |
| US20060024676A1 (en) * | 2003-04-14 | 2006-02-02 | Karen Uhlmann | Method of detecting epigenetic biomarkers by quantitative methyISNP analysis |
| WO2005014506A2 (en) | 2003-08-06 | 2005-02-17 | Department Of Science & Technology (Dst) | A process for the manufacture of a bio-release fertiliser of an anionic micro nutrient viz molibdenum |
| JP2005204652A (ja) * | 2003-12-16 | 2005-08-04 | Bayer Healthcare Llc | メチル化特異的プライマー伸長（ｍｓｐｅ）によるメチル化状況を検出するアッセイ |
| AU2004311882A1 (en) * | 2003-12-29 | 2005-07-21 | Nugen Technologies, Inc. | Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids |
| US7459274B2 (en) | 2004-03-02 | 2008-12-02 | Orion Genomics Llc | Differential enzymatic fragmentation by whole genome amplification |
| US20050239085A1 (en) | 2004-04-23 | 2005-10-27 | Buzby Philip R | Methods for nucleic acid sequence determination |
| US7399614B2 (en) | 2004-06-30 | 2008-07-15 | Applera Corporation | 5-methylcytosine detection, compositions and methods therefor |
| US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
| EP1790202A4 (en) * | 2004-09-17 | 2013-02-20 | Pacific Biosciences California | APPARATUS AND METHOD FOR ANALYZING MOLECULES |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| US7805081B2 (en) | 2005-08-11 | 2010-09-28 | Pacific Biosciences Of California, Inc. | Methods and systems for monitoring multiple optical signals from a single source |
| JP5374679B2 (ja) | 2005-12-14 | 2013-12-25 | エピゲノミクス アーゲー | 重亜硫酸処理のための新規方法 |
| EP1963536B1 (en) | 2005-12-22 | 2016-05-04 | Pacific Biosciences of California, Inc. | Polymerases for nucleotide analogue incorporation |
| CA2662521C (en) | 2006-09-01 | 2016-08-09 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| US20080277595A1 (en) | 2007-05-10 | 2008-11-13 | Pacific Biosciences Of California, Inc. | Highly multiplexed confocal detection systems and methods of using same |
| EP2155855B1 (en) | 2007-06-06 | 2016-10-12 | Pacific Biosciences of California, Inc. | Methods and processes for calling bases in sequence by incorporation methods |
| US8486634B2 (en) | 2007-11-06 | 2013-07-16 | Ambergen, Inc. | Amplifying bisulfite-treated template |
| EP2263087B1 (en) | 2008-03-13 | 2017-08-09 | Pacific Biosciences of California, Inc. | Labeled reactants and their uses |
| US7973146B2 (en) | 2008-03-26 | 2011-07-05 | Pacific Biosciences Of California, Inc. | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing |
| US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
| CA2719747C (en) | 2008-03-28 | 2018-02-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2009132315A1 (en) | 2008-04-24 | 2009-10-29 | Life Technologies Corporation | Method of sequencing and mapping target nucleic acids |
| US20100120034A1 (en) | 2008-07-03 | 2010-05-13 | Life Technologies Corporation | Methylation analysis of mate pairs |
| WO2010022098A2 (en) | 2008-08-18 | 2010-02-25 | Life Technologies Corporation | Dna methylation detection methods |
| CA3063032A1 (en) | 2008-09-16 | 2010-03-25 | Pacific Biosciences Of California, Inc. | Substrates and optical systems and methods of use thereof |
| US8383369B2 (en) | 2008-09-24 | 2013-02-26 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| WO2010037001A2 (en) | 2008-09-26 | 2010-04-01 | Immune Disease Institute, Inc. | Selective oxidation of 5-methylcytosine by tet-family proteins |
| US8541207B2 (en) | 2008-10-22 | 2013-09-24 | Illumina, Inc. | Preservation of information related to genomic DNA methylation |
| US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
| WO2010059235A2 (en) | 2008-11-20 | 2010-05-27 | Pacific Biosciences Of California, Inc. | Algorithms for sequence determination |
| BRPI0922411A2 (pt) | 2008-12-11 | 2018-06-05 | Pacific Biosciences California Inc | classificação de templates de ácido nucléico |
| WO2010111690A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Polymerase compositions and methods |
| WO2010144150A2 (en) | 2009-06-12 | 2010-12-16 | Pacific Biosciences Of California, Inc. | Real-time analytical methods and systems |
| US20110104787A1 (en) | 2009-11-05 | 2011-05-05 | President And Fellows Of Harvard College | Fusion Peptides That Bind to and Modify Target Nucleic Acid Sequences |
| US20110237444A1 (en) | 2009-11-20 | 2011-09-29 | Life Technologies Corporation | Methods of mapping genomic methylation patterns |
-
2009
- 2009-12-10 BR BRPI0922411A patent/BRPI0922411A2/pt not_active Application Discontinuation
- 2009-12-10 CN CN2009801567967A patent/CN102317473A/zh active Pending
- 2009-12-10 AU AU2009325069A patent/AU2009325069B2/en active Active
- 2009-12-10 WO PCT/US2009/006517 patent/WO2010068289A2/en active Application Filing
- 2009-12-10 EP EP09832251.4A patent/EP2370598B1/en active Active
- 2009-12-10 CA CA2746632A patent/CA2746632C/en active Active
- 2009-12-10 US US12/635,618 patent/US9175341B2/en active Active
-
2012
- 2012-10-02 US US13/633,673 patent/US20130029853A1/en not_active Abandoned
-
2013
- 2013-06-28 US US13/930,178 patent/US20130316916A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100221716A1 (en) | 2010-09-02 |
| EP2370598A2 (en) | 2011-10-05 |
| US20130029853A1 (en) | 2013-01-31 |
| WO2010068289A3 (en) | 2010-10-14 |
| CA2746632C (en) | 2020-06-30 |
| AU2009325069A1 (en) | 2011-07-21 |
| CN102317473A (zh) | 2012-01-11 |
| CA2746632A1 (en) | 2010-06-17 |
| WO2010068289A2 (en) | 2010-06-17 |
| EP2370598B1 (en) | 2017-02-15 |
| US9175341B2 (en) | 2015-11-03 |
| AU2009325069B2 (en) | 2015-03-19 |
| EP2370598A4 (en) | 2012-06-13 |
| US20130316916A1 (en) | 2013-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0922411A2 (pt) | classificação de templates de ácido nucléico | |
| BRPI0914955A2 (pt) | modelos de mapas analíticos | |
| DK2129797T3 (da) | Nukleinsyrepåvisning | |
| EP2300910A4 (en) | INQUIRY INTO PROCESS | |
| EP2298608A4 (en) | ELECTRICAL BEAM | |
| DE602007005937D1 (de) | Objekterkennung | |
| BRPI0919868A2 (pt) | processo | |
| BRPI0911841A2 (pt) | processos de modelagem | |
| EP2314481A4 (en) | CABLE BEAM | |
| EP2256349A4 (en) | MICROFLUIDIC DEVICE | |
| BRPI0910689A2 (pt) | processo de síntese de rna por via química | |
| BRPI0914939A2 (pt) | tintas ácidas | |
| BRPI0921374A2 (pt) | processo | |
| PT2165971T (pt) | Processo de hidrotratamento | |
| BRPI0909083A2 (pt) | marcando de forma eficiente objetos com grandes conjuntos de referências | |
| BRPI0817667A2 (pt) | Método de marcação | |
| EP2208072A4 (en) | FORECAST PROCEDURES | |
| DK2265527T3 (da) | Sorteringsindretning | |
| BRPI0922957A2 (pt) | modificação de vetores de ácido nucleico | |
| DK2252471T3 (da) | Blyant | |
| FR2934953B1 (fr) | Nanoemulsions de nanocristaux | |
| BRPI0816237A2 (pt) | Processo de ciclopropanação | |
| BRPI0917940A2 (pt) | cartão de identificação | |
| DK2367562T3 (da) | Glycanspecifikke analyseværktøjer | |
| EP2343136A4 (en) | TRIAL PROCESS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |