DK3372584T3 - Fremgangsmåde til fremstillingen af en diarylthiohydantoin-forbindelse - Google Patents

Fremgangsmåde til fremstillingen af en diarylthiohydantoin-forbindelse Download PDF

Info

Publication number: DK3372584T3
Authority: DK; Denmark
Prior art keywords: procedure; preparation; diarylthiohydantoin compound; diarylthiohydantoin; compound
Prior art date: 2014-12-19

Application number

DK18169756.6T

Other languages

English (en)

Other versions

DK3372584T5 (da

Inventor

Andras Horvath

Johan Erwin Edmond Weerts

Haim Cyril Ben

Original Assignee

Aragon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-19

Filing date

2015-12-17

Publication date

2021-01-04

2015-12-17 Application filed by Aragon Pharmaceuticals Inc filed Critical Aragon Pharmaceuticals Inc

2021-01-04 Application granted granted Critical

2021-01-04 Publication of DK3372584T3 publication Critical patent/DK3372584T3/da

2021-05-17 Publication of DK3372584T5 publication Critical patent/DK3372584T5/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/14—Phosphorus; Compounds thereof
- B01J27/186—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- B01J27/195—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium with vanadium, niobium or tantalum
- B01J27/198—Vanadium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/04—Mixing
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

DK18169756.6T 2014-12-19 2015-12-17 Fremgangsmåde til fremstillingen af en diarylthiohydantoin-forbindelse DK3372584T5 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201462094436P	2014-12-19	2014-12-19
EP15823875.8A EP3233803B1 (en)	2014-12-19	2015-12-17	Process for the preparation of a diarylthiohydantoin compound

Publications (2)

Publication Number	Publication Date
DK3372584T3 true DK3372584T3 (da)	2021-01-04
DK3372584T5 DK3372584T5 (da)	2021-05-17

Family

ID=55168400

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK18169895.2T DK3372585T3 (da)	2014-12-19	2015-12-17	Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse
DK18169756.6T DK3372584T5 (da)	2014-12-19	2015-12-17	Fremgangsmåde til fremstillingen af en diarylthiohydantoin-forbindelse
DK15823875.8T DK3233803T3 (da)	2014-12-19	2015-12-17	Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK18169895.2T DK3372585T3 (da)	2014-12-19	2015-12-17	Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK15823875.8T DK3233803T3 (da)	2014-12-19	2015-12-17	Fremgangsmåde til fremstillingen af en diarylthiohydantoinforbindelse

Country Status (34)

Country	Link
US (1)	US9688655B2 (da)
EP (4)	EP3372584B9 (da)
JP (2)	JP6681902B2 (da)
KR (1)	KR102586059B1 (da)
CN (2)	CN118638097A (da)
AR (1)	AR103228A1 (da)
AU (1)	AU2015364537B2 (da)
BR (1)	BR112017013113B1 (da)
CA (1)	CA2970937A1 (da)
CY (2)	CY1121684T1 (da)
DK (3)	DK3372585T3 (da)
EA (4)	EA201791390A1 (da)
ES (3)	ES2919951T3 (da)
HR (3)	HRP20220750T1 (da)
HU (2)	HUE052475T2 (da)
IL (1)	IL252843B2 (da)
LT (3)	LT3372584T (da)
MA (1)	MA41200B1 (da)
MD (1)	MD3233803T2 (da)
ME (1)	ME03420B (da)
MX (1)	MX375467B (da)
NZ (1)	NZ732766A (da)
PH (1)	PH12017501152B1 (da)
PL (3)	PL3372585T3 (da)
PT (3)	PT3233803T (da)
RS (3)	RS63455B1 (da)
SG (4)	SG10201912805SA (da)
SI (3)	SI3372585T1 (da)
SM (3)	SMT202000618T1 (da)
TR (1)	TR201904739T4 (da)
TW (4)	TWI683810B (da)
UA (1)	UA123201C2 (da)
WO (1)	WO2016100652A2 (da)
ZA (1)	ZA201704877B (da)

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ES2919951T3 (es) *	2014-12-19	2022-07-29	Aragon Pharmaceuticals Inc	Proceso para la preparación de un compuesto de diariltiohidantoina
KR102586087B1 (ko) *	2014-12-19	2023-10-05	아라곤 파마슈티컬스, 인코포레이티드	다이아릴티오하이단토인 화합물의 제조 방법
CN108069869B (zh) *	2016-11-09	2022-03-01	上海医药工业研究院	一种Apalutamide的制备方法及其中间体
TW201831461A (zh) *	2017-01-18	2018-09-01	台灣神隆股份有限公司	製備阿帕魯醯胺的方法
US10364245B2 (en)	2017-06-07	2019-07-30	Chiesi Farmaceutici S.P.A.	Kinase inhibitors
CN107501237B (zh) *	2017-08-17	2022-03-22	上海西浦医药科技有限公司	一种Apalutamide的合成方法
CN108383749B (zh) *	2018-01-30	2021-03-09	杭州科巢生物科技有限公司	阿帕鲁胺的合成方法及其中间体
US10513504B2 (en)	2018-03-08	2019-12-24	Apotex Inc.	Processes for the preparation of apalutamide and intermediates thereof
CN108314646B (zh) *	2018-04-11	2021-03-19	武汉慧敏科技中心	一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法
CN109651256A (zh) *	2018-11-20	2019-04-19	上海健康医学院	一种式（viii）的恩杂鲁胺的制备方法
CN110511206A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN110511207A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN113968815A (zh) *	2020-07-24	2022-01-25	苏州科伦药物研究有限公司	一种硫代二氮杂螺类化合物的合成方法、其中间体及其合成方法
US20230312507A1 (en)	2020-09-04	2023-10-05	Synthon B.V.	Improved process for preparation of apalutamide
CN113402466B (zh) *	2021-06-18	2022-08-16	南京方生和医药科技有限公司	一种阿帕鲁胺中间体及制备阿帕鲁胺的方法
CN113292535B (zh) *	2021-06-18	2022-07-01	南京方生和医药科技有限公司	一种制备阿帕鲁胺中间体及阿帕鲁胺的方法
CN115850233B (zh) *	2021-09-24	2024-12-10	南京方生和医药科技有限公司	一种阿帕鲁胺的合成方法
CN115536634B (zh) *	2022-10-17	2024-06-11	上海博悦生物科技有限公司	一种阿帕他胺的合成方法
CN116332907A (zh) *	2023-03-16	2023-06-27	奥锐特药业股份有限公司	一种无定形阿帕他胺的制备方法
CN117645572A (zh) *	2023-11-23	2024-03-05	奥锐特药业股份有限公司	恩扎卢胺及其中间体的制备方法

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TWI445707B (zh)	2008-05-16	2014-07-21	Takeda California Inc	葡萄糖激酶活化劑
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2015
- 2015-12-17 ES ES18169895T patent/ES2919951T3/es active Active
- 2015-12-17 PL PL18169895.2T patent/PL3372585T3/pl unknown
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- 2015-12-17 UA UAA201707588A patent/UA123201C2/uk unknown
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- 2015-12-17 MA MA41200A patent/MA41200B1/fr unknown
- 2015-12-17 EA EA201791390A patent/EA201791390A1/ru unknown
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- 2015-12-17 EA EA201892486A patent/EA201892486A1/ru unknown
- 2015-12-17 SI SI201531848T patent/SI3372585T1/sl unknown
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2017
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2019
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2020
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Also Published As

Publication number	Publication date
ZA201704877B (en)	2019-02-27
KR20170095976A (ko)	2017-08-23
EP3372584B1 (en)	2020-09-23
SG11201704969QA (en)	2017-07-28
DK3372585T3 (da)	2022-05-30
AU2015364537A1 (en)	2017-07-06
JP6903785B2 (ja)	2021-07-14
TWI753336B (zh)	2022-01-21
EA201892485A1 (ru)	2019-07-31
CN118638097A (zh)	2024-09-13
CN107108507B (zh)	2024-05-28
PT3372584T (pt)	2020-11-13
EA201892487A1 (ru)	2019-07-31
HRP20220750T1 (hr)	2022-09-02
AU2015364537B2 (en)	2020-10-08
ES2718539T3 (es)	2019-07-02
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