SI3233803T1 - Postopek priprave spojine diariltiohidantoina - Google Patents

Postopek priprave spojine diariltiohidantoina

Info

Publication number: SI3233803T1
Authority: SI; Slovenia
Prior art keywords: preparation; diarylthiohydantoin compound; diarylthiohydantoin; compound
Prior art date: 2014-12-19

Application number

SI201530599T

Other languages

English (en)

Inventor

Cyril Ben Haim

Andras Horvath

Johan Erwin Edmond Weerts

Original Assignee

Aragon Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-19

Filing date

2015-12-17

Publication date

2019-05-31

2015-12-17 Application filed by Aragon Pharmaceuticals, Inc. filed Critical Aragon Pharmaceuticals, Inc.

2019-05-31 Publication of SI3233803T1 publication Critical patent/SI3233803T1/sl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/14—Phosphorus; Compounds thereof
- B01J27/186—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium
- B01J27/195—Phosphorus; Compounds thereof with arsenic, antimony, bismuth, vanadium, niobium, tantalum, polonium, chromium, molybdenum, tungsten, manganese, technetium or rhenium with vanadium, niobium or tantalum
- B01J27/198—Vanadium
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J37/00—Processes, in general, for preparing catalysts; Processes, in general, for activation of catalysts
- B01J37/04—Mixing
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Materials Engineering (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

SI201530599T 2014-12-19 2015-12-17 Postopek priprave spojine diariltiohidantoina SI3233803T1 (sl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462094436P	2014-12-19	2014-12-19
EP15823875.8A EP3233803B1 (en)	2014-12-19	2015-12-17	Process for the preparation of a diarylthiohydantoin compound
PCT/US2015/066356 WO2016100652A2 (en)	2014-12-19	2015-12-17	Process for the preparation of a diarylthiohydantoin compound

Publications (1)

Publication Number	Publication Date
SI3233803T1 true SI3233803T1 (sl)	2019-05-31

Family

ID=55168400

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
SI201531433T SI3372584T1 (sl)	2014-12-19	2015-12-17	Postopek za pripravo spojine diariltiohidantoin
SI201531848T SI3372585T1 (sl)	2014-12-19	2015-12-17	Postopek za pripravo diariltiohidantoinske spojine
SI201530599T SI3233803T1 (sl)	2014-12-19	2015-12-17	Postopek priprave spojine diariltiohidantoina

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
SI201531433T SI3372584T1 (sl)	2014-12-19	2015-12-17	Postopek za pripravo spojine diariltiohidantoin
SI201531848T SI3372585T1 (sl)	2014-12-19	2015-12-17	Postopek za pripravo diariltiohidantoinske spojine

Country Status (34)

Country	Link
US (1)	US9688655B2 (sl)
EP (4)	EP3372586A1 (sl)
JP (2)	JP6681902B2 (sl)
KR (1)	KR102586059B1 (sl)
CN (2)	CN107108507B (sl)
AR (1)	AR103228A1 (sl)
AU (1)	AU2015364537B2 (sl)
BR (1)	BR112017013113B1 (sl)
CA (1)	CA2970937A1 (sl)
CY (3)	CY1121684T1 (sl)
DK (3)	DK3372584T5 (sl)
EA (4)	EA201791390A1 (sl)
ES (3)	ES2718539T3 (sl)
HR (3)	HRP20190540T1 (sl)
HU (2)	HUE042409T2 (sl)
IL (1)	IL252843B2 (sl)
LT (3)	LT3233803T (sl)
MA (1)	MA41200B1 (sl)
MD (1)	MD3233803T2 (sl)
ME (1)	ME03420B (sl)
MX (1)	MX375467B (sl)
NZ (1)	NZ732766A (sl)
PH (1)	PH12017501152B1 (sl)
PL (3)	PL3372585T3 (sl)
PT (3)	PT3372584T (sl)
RS (3)	RS58454B1 (sl)
SG (4)	SG10201912805SA (sl)
SI (3)	SI3372584T1 (sl)
SM (3)	SMT202000618T1 (sl)
TR (1)	TR201904739T4 (sl)
TW (4)	TWI683810B (sl)
UA (1)	UA123201C2 (sl)
WO (1)	WO2016100652A2 (sl)
ZA (1)	ZA201704877B (sl)

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SI3233823T1 (sl) *	2014-12-19	2019-04-30	Aragon Pharmaceuticals, Inc.	Postopki priprave spojine diariltiohidantoina
MX375467B (es) *	2014-12-19	2025-03-06	Aragon Pharmaceuticals Inc	Proceso para la preparacion de un compuesto de diariltiohidantoina.
CN108069869B (zh) *	2016-11-09	2022-03-01	上海医药工业研究院	一种Apalutamide的制备方法及其中间体
TW201831461A (zh) *	2017-01-18	2018-09-01	台灣神隆股份有限公司	製備阿帕魯醯胺的方法
US10364245B2 (en)	2017-06-07	2019-07-30	Chiesi Farmaceutici S.P.A.	Kinase inhibitors
CN107501237B (zh) *	2017-08-17	2022-03-22	上海西浦医药科技有限公司	一种Apalutamide的合成方法
CN108383749B (zh) *	2018-01-30	2021-03-09	杭州科巢生物科技有限公司	阿帕鲁胺的合成方法及其中间体
US10513504B2 (en)	2018-03-08	2019-12-24	Apotex Inc.	Processes for the preparation of apalutamide and intermediates thereof
CN108314646B (zh) *	2018-04-11	2021-03-19	武汉慧敏科技中心	一种高分散双金属纳米材料制备泌尿生殖系统用药物中间体的方法
CN109651256A (zh) *	2018-11-20	2019-04-19	上海健康医学院	一种式（viii）的恩杂鲁胺的制备方法
CN110511207A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN110511206A (zh) *	2019-06-17	2019-11-29	扬子江药业集团江苏海慈生物药业有限公司	芳基-2-硫代海因类化合物中间体、其制备方法及应用
CN113968815A (zh) *	2020-07-24	2022-01-25	苏州科伦药物研究有限公司	一种硫代二氮杂螺类化合物的合成方法、其中间体及其合成方法
WO2022049265A1 (en)	2020-09-04	2022-03-10	Synthon B.V.	Improved process for preparation of apalutamide
CN113402466B (zh) *	2021-06-18	2022-08-16	南京方生和医药科技有限公司	一种阿帕鲁胺中间体及制备阿帕鲁胺的方法
CN113292535B (zh) *	2021-06-18	2022-07-01	南京方生和医药科技有限公司	一种制备阿帕鲁胺中间体及阿帕鲁胺的方法
CN115850233B (zh) *	2021-09-24	2024-12-10	南京方生和医药科技有限公司	一种阿帕鲁胺的合成方法
CN115536634B (zh) *	2022-10-17	2024-06-11	上海博悦生物科技有限公司	一种阿帕他胺的合成方法
CN116332907A (zh) *	2023-03-16	2023-06-27	奥锐特药业股份有限公司	一种无定形阿帕他胺的制备方法
CN117645572A (zh) *	2023-11-23	2024-03-05	奥锐特药业股份有限公司	恩扎卢胺及其中间体的制备方法

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MX375467B (es) *	2014-12-19	2025-03-06	Aragon Pharmaceuticals Inc	Proceso para la preparacion de un compuesto de diariltiohidantoina.

2015
- 2015-12-17 MX MX2017008179A patent/MX375467B/es active IP Right Grant
- 2015-12-17 PH PH1/2017/501152A patent/PH12017501152B1/en unknown
- 2015-12-17 TR TR2019/04739T patent/TR201904739T4/tr unknown
- 2015-12-17 PT PT181697566T patent/PT3372584T/pt unknown
- 2015-12-17 IL IL252843A patent/IL252843B2/en unknown
- 2015-12-17 EP EP18170050.1A patent/EP3372586A1/en not_active Withdrawn
- 2015-12-17 KR KR1020177019551A patent/KR102586059B1/ko active Active
- 2015-12-17 LT LTEP15823875.8T patent/LT3233803T/lt unknown
- 2015-12-17 EA EA201791390A patent/EA201791390A1/ru unknown
- 2015-12-17 SI SI201531433T patent/SI3372584T1/sl unknown
- 2015-12-17 SM SM20200618T patent/SMT202000618T1/it unknown
- 2015-12-17 SG SG10201912805SA patent/SG10201912805SA/en unknown
- 2015-12-17 SI SI201531848T patent/SI3372585T1/sl unknown
- 2015-12-17 HR HRP20190540TT patent/HRP20190540T1/hr unknown
- 2015-12-17 US US14/973,089 patent/US9688655B2/en active Active
- 2015-12-17 PL PL18169895.2T patent/PL3372585T3/pl unknown
- 2015-12-17 PT PT15823875T patent/PT3233803T/pt unknown
- 2015-12-17 LT LTEP18169895.2T patent/LT3372585T/lt unknown
- 2015-12-17 WO PCT/US2015/066356 patent/WO2016100652A2/en active Application Filing
- 2015-12-17 HU HUE15823875A patent/HUE042409T2/hu unknown
- 2015-12-17 ME MEP-2019-86A patent/ME03420B/me unknown
- 2015-12-17 ES ES15823875T patent/ES2718539T3/es active Active
- 2015-12-17 ES ES18169895T patent/ES2919951T3/es active Active
- 2015-12-17 DK DK18169756.6T patent/DK3372584T5/da active
- 2015-12-17 LT LTEP18169756.6T patent/LT3372584T/lt unknown
- 2015-12-17 EA EA201892486A patent/EA201892486A1/ru unknown
- 2015-12-17 RS RS20190350A patent/RS58454B1/sr unknown
- 2015-12-17 HU HUE18169756A patent/HUE052475T2/hu unknown
- 2015-12-17 SG SG11201704969QA patent/SG11201704969QA/en unknown
- 2015-12-17 CN CN201580069602.5A patent/CN107108507B/zh active Active
- 2015-12-17 MD MDE20170208T patent/MD3233803T2/ro unknown
- 2015-12-17 EP EP15823875.8A patent/EP3233803B1/en active Active
- 2015-12-17 RS RS20220542A patent/RS63455B1/sr unknown
- 2015-12-17 RS RS20201378A patent/RS61060B9/sr unknown
- 2015-12-17 AU AU2015364537A patent/AU2015364537B2/en active Active
- 2015-12-17 CN CN202410667649.2A patent/CN118638097A/zh active Pending
- 2015-12-17 MA MA41200A patent/MA41200B1/fr unknown
- 2015-12-17 EA EA201892487A patent/EA201892487A1/ru unknown
- 2015-12-17 EA EA201892485A patent/EA201892485A1/ru unknown
- 2015-12-17 NZ NZ732766A patent/NZ732766A/en unknown
- 2015-12-17 HR HRP20220750TT patent/HRP20220750T1/hr unknown
- 2015-12-17 SM SM20190208T patent/SMT201900208T1/it unknown
- 2015-12-17 PL PL18169756T patent/PL3372584T3/pl unknown
- 2015-12-17 SM SM20220242T patent/SMT202200242T1/it unknown
- 2015-12-17 CA CA2970937A patent/CA2970937A1/en active Pending
- 2015-12-17 BR BR112017013113-7A patent/BR112017013113B1/pt active IP Right Grant
- 2015-12-17 EP EP18169895.2A patent/EP3372585B1/en active Active
- 2015-12-17 PT PT181698952T patent/PT3372585T/pt unknown
- 2015-12-17 PL PL15823875T patent/PL3233803T3/pl unknown
- 2015-12-17 SG SG10201912802XA patent/SG10201912802XA/en unknown
- 2015-12-17 DK DK18169895.2T patent/DK3372585T3/da active
- 2015-12-17 EP EP18169756.6A patent/EP3372584B9/en active Active
- 2015-12-17 SG SG10201912811QA patent/SG10201912811QA/en unknown
- 2015-12-17 JP JP2017532725A patent/JP6681902B2/ja active Active
- 2015-12-17 DK DK15823875.8T patent/DK3233803T3/en active
- 2015-12-17 SI SI201530599T patent/SI3233803T1/sl unknown
- 2015-12-17 UA UAA201707588A patent/UA123201C2/uk unknown
- 2015-12-17 ES ES18169756T patent/ES2827549T3/es active Active
- 2015-12-18 TW TW104142692A patent/TWI683810B/zh active
- 2015-12-18 TW TW108146841A patent/TWI753336B/zh active
- 2015-12-18 TW TW108131623A patent/TWI689494B/zh active
- 2015-12-18 TW TW108131622A patent/TWI703132B/zh active
- 2015-12-21 AR ARP150104237A patent/AR103228A1/es unknown
2017
- 2017-07-18 ZA ZA2017/04877A patent/ZA201704877B/en unknown
2019
- 2019-04-10 CY CY20191100400T patent/CY1121684T1/el unknown
2020
- 2020-03-24 JP JP2020052658A patent/JP6903785B2/ja active Active
- 2020-11-02 CY CY20201101031T patent/CY1123611T1/el unknown
- 2020-11-20 HR HRP20201847TT patent/HRP20201847T2/hr unknown
2022
- 2022-06-10 CY CY20221100408T patent/CY1125243T1/el unknown

Also Published As

Publication number	Publication date
NZ732766A (en)	2023-07-28
DK3372585T3 (da)	2022-05-30
WO2016100652A3 (en)	2016-08-25
US9688655B2 (en)	2017-06-27
DK3372584T5 (da)	2021-05-17
EA201892487A1 (ru)	2019-07-31
JP2020114842A (ja)	2020-07-30
LT3372585T (lt)	2022-07-11
ES2827549T3 (es)	2021-05-21
MD3233803T2 (ro)	2019-07-31
PL3372585T3 (pl)	2022-10-10
TW202031639A (zh)	2020-09-01
BR112017013113A2 (pt)	2017-12-26
DK3372584T3 (da)	2021-01-04
TWI683810B (zh)	2020-02-01
KR102586059B1 (ko)	2023-10-05
ES2919951T3 (es)	2022-07-29
DK3233803T3 (en)	2019-04-08
EA201791390A1 (ru)	2017-10-31
BR112017013113B1 (pt)	2023-11-21
LT3372584T (lt)	2020-12-10
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