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DK3368683T3 - Fremgangsmåde til kvantifikationen af pd-l1 - Google Patents

Fremgangsmåde til kvantifikationen af pd-l1 Download PDF

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Publication number
DK3368683T3
DK3368683T3 DK15795217.7T DK15795217T DK3368683T3 DK 3368683 T3 DK3368683 T3 DK 3368683T3 DK 15795217 T DK15795217 T DK 15795217T DK 3368683 T3 DK3368683 T3 DK 3368683T3
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Denmark
Prior art keywords
quantification
procedure
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DK15795217.7T
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English (en)
Inventor
Evrykleia Lianidou
Areti Strati
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Pharmassist Ltd
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Publication of DK3368683T3 publication Critical patent/DK3368683T3/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/166Oligonucleotides used as internal standards, controls or normalisation probes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Liquid Crystal Substances (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
DK15795217.7T 2015-10-27 2015-10-27 Fremgangsmåde til kvantifikationen af pd-l1 DK3368683T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GR2015/000054 WO2017072539A1 (en) 2015-10-27 2015-10-27 Method for the quantification of pd-l1 expression

Publications (1)

Publication Number Publication Date
DK3368683T3 true DK3368683T3 (da) 2020-03-30

Family

ID=54548209

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15795217.7T DK3368683T3 (da) 2015-10-27 2015-10-27 Fremgangsmåde til kvantifikationen af pd-l1

Country Status (14)

Country Link
US (2) US20190085401A1 (da)
EP (1) EP3368683B1 (da)
CY (1) CY1122871T1 (da)
DK (1) DK3368683T3 (da)
ES (1) ES2779309T3 (da)
HR (1) HRP20200487T1 (da)
HU (1) HUE048265T2 (da)
LT (1) LT3368683T (da)
PL (1) PL3368683T3 (da)
PT (1) PT3368683T (da)
RS (1) RS60075B1 (da)
SI (1) SI3368683T1 (da)
SM (1) SMT202000159T1 (da)
WO (1) WO2017072539A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201901991QA (en) * 2016-09-06 2019-04-29 Incelldx Inc Methods of detecting per cell pd-l1 expression and uses thereof
US11726089B2 (en) 2016-09-06 2023-08-15 Incelldx, Inc. Methods of assaying neoplastic and neoplasia-related cells and uses thereof
CN107460239A (zh) * 2017-07-23 2017-12-12 嘉兴允英医学检验有限公司 一种用于pd‑l1表达水平检测的试剂盒
US11072820B2 (en) * 2017-10-19 2021-07-27 Bio-Rad Laboratories, Inc. Digital amplification assays with unconventional and/or inverse changes in photoluminescence
CN108507992A (zh) * 2018-04-09 2018-09-07 苏州大学附属第医院 循环肿瘤细胞表面标志分子pd-l1的检测方法
BR112021002639A2 (pt) * 2018-08-16 2021-05-11 Musc Foundation For Research Development vírus recombinantes do mixoma e usos dos mesmos
WO2020092589A1 (en) * 2018-10-31 2020-05-07 Nantomics, Llc Immune checkpoint therapeutic methods
CN109576350B (zh) * 2019-01-18 2021-01-29 深圳恒特基因有限公司 一种dna与rna同时定量的试剂盒、方法及质控方法
CN109628596A (zh) * 2019-01-18 2019-04-16 臻悦生物科技江苏有限公司 Rna水平检测pd-1和pd-l1表达量的试剂盒及方法
WO2020214606A1 (en) * 2019-04-15 2020-10-22 The Medical College Of Wisconsin, Inc. Recombinant pd-l1 peptides and methods of use
JP7593669B2 (ja) * 2020-02-18 2024-12-03 イノベイション バイオ カンパニー リミテッド コンパニオン診断用バイオマーカー組成物およびこれを含むコンパニオン診断用キット
CN111521796A (zh) * 2020-04-21 2020-08-11 山东第一医科大学(山东省医学科学院) 一种检测肾癌患者外周血循环肿瘤细胞pd-l1表达的免疫荧光试剂盒及检测方法
WO2022040350A1 (en) * 2020-08-19 2022-02-24 Ohio State Innovation Foundation Highly sensitive platform to characterize extracellular vesicular biomarkers for cancer immunotherapy
CN112462072B (zh) * 2020-09-24 2022-06-03 浙江大学 一种tmub1蛋白在制备肿瘤免疫抑制分子检测剂中的应用
CN112725418A (zh) * 2021-01-25 2021-04-30 深圳乐土生物科技有限公司 基于游离rna检测pd-l1表达量的方法及其试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6797813B2 (en) * 1996-09-23 2004-09-28 Schering Corporation AK155 antibodies and binding fragments thereof
SG11201507333XA (en) * 2013-03-15 2015-10-29 Genentech Inc Biomarkers and methods of treating pd-1 and pd-l1 related conditions
US20170275347A1 (en) * 2014-09-05 2017-09-28 Medimmune Limited Methods for identifying patients responsive to anti-pd-l1 antibody therapy

Also Published As

Publication number Publication date
SI3368683T1 (sl) 2020-07-31
HUE048265T2 (hu) 2020-08-28
PT3368683T (pt) 2020-04-06
PL3368683T3 (pl) 2020-07-27
ES2779309T3 (es) 2020-08-14
CY1122871T1 (el) 2021-05-05
HRP20200487T1 (hr) 2020-09-04
EP3368683A1 (en) 2018-09-05
EP3368683B1 (en) 2020-01-15
US20190085401A1 (en) 2019-03-21
WO2017072539A1 (en) 2017-05-04
RS60075B1 (sr) 2020-05-29
LT3368683T (lt) 2020-04-10
SMT202000159T1 (it) 2020-05-08
US20220073995A1 (en) 2022-03-10

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