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DK3353177T3 - Tricykliske heterocykler til behandling af cancer - Google Patents

Tricykliske heterocykler til behandling af cancer Download PDF

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Publication number
DK3353177T3
DK3353177T3 DK16770011.1T DK16770011T DK3353177T3 DK 3353177 T3 DK3353177 T3 DK 3353177T3 DK 16770011 T DK16770011 T DK 16770011T DK 3353177 T3 DK3353177 T3 DK 3353177T3
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DK
Denmark
Prior art keywords
cancer treatment
tricyclic heterocycles
tricyclic
heterocycles
cancer
Prior art date
Application number
DK16770011.1T
Other languages
English (en)
Inventor
Patrick René Angibaud
Diego Fernando Domenico Broggini
Hélène France Solange Colombel
Filip Albert C Cuyckens
Steven Anna Hostyn
Russell Mark Jones
Olivier Alexis Georges Querolle
Wim Vermeulen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK3353177T3 publication Critical patent/DK3353177T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK16770011.1T 2015-09-23 2016-09-22 Tricykliske heterocykler til behandling af cancer DK3353177T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186491 2015-09-23
PCT/EP2016/072499 WO2017050864A1 (en) 2015-09-23 2016-09-22 New compounds

Publications (1)

Publication Number Publication Date
DK3353177T3 true DK3353177T3 (da) 2020-08-24

Family

ID=54196892

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16770011.1T DK3353177T3 (da) 2015-09-23 2016-09-22 Tricykliske heterocykler til behandling af cancer

Country Status (18)

Country Link
US (1) US11155555B2 (da)
EP (1) EP3353177B1 (da)
JP (1) JP6898919B2 (da)
KR (1) KR102703498B1 (da)
CN (1) CN108026095B (da)
AU (1) AU2016328692B2 (da)
BR (1) BR112018005637B1 (da)
CA (1) CA2996857C (da)
DK (1) DK3353177T3 (da)
ES (1) ES2811845T3 (da)
HK (1) HK1254965A1 (da)
HR (1) HRP20201157T1 (da)
HU (1) HUE050567T2 (da)
LT (1) LT3353177T (da)
MX (1) MX2018003563A (da)
RU (1) RU2747645C2 (da)
SI (1) SI3353177T1 (da)
WO (1) WO2017050864A1 (da)

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JP7378488B2 (ja) * 2019-03-08 2023-11-13 ショウヤオ ホールディングス（ベイジン） カンパニー， リミテッド Ｆｇｆｒ４キナーゼ阻害剤、その製造方法及び用途
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CN113024517A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种制备厄达替尼的方法
CN113024518A (zh) * 2019-12-09 2021-06-25 武汉九州钰民医药科技有限公司 一种厄达替尼的制备方法
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EP4352059A1 (en) * 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
AR126101A1 (es) * 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr

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