DK3204381T3 - N-pyridinylacetamidderivater som wnt-signaleringsbanehæmmere - Google Patents

N-pyridinylacetamidderivater som wnt-signaleringsbanehæmmere Download PDF

Info

Publication number: DK3204381T3
Authority: DK; Denmark
Prior art keywords: pyridinylacetamid; derivatives; signaling pathway; wnt signaling; pathway inhibitors
Prior art date: 2014-10-08

Application number

DK15782044.0T

Other languages

English (en)

Inventor

Inder Bhamra

Michael Mathieson

Craig Donoghue

Richard Testar

Original Assignee

Redx Pharma Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-08

Filing date

2015-10-08

Publication date

2022-07-25

2014-10-08 Priority claimed from GBGB1417832.1A external-priority patent/GB201417832D0/en

2015-07-14 Priority claimed from GBGB1512279.9A external-priority patent/GB201512279D0/en

2015-10-08 Application filed by Redx Pharma Plc filed Critical Redx Pharma Plc

2022-07-25 Application granted granted Critical

2022-07-25 Publication of DK3204381T3 publication Critical patent/DK3204381T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK15782044.0T 2014-10-08 2015-10-08 N-pyridinylacetamidderivater som wnt-signaleringsbanehæmmere DK3204381T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB1417832.1A GB201417832D0 (en)	2014-10-08	2014-10-08	Compounds
GBGB1512279.9A GB201512279D0 (en)	2015-07-14	2015-07-14	Compounds
PCT/GB2015/052943 WO2016055790A1 (en)	2014-10-08	2015-10-08	N-pyridinyl acetamide derivatives as wnt signalling pathway inhibitors

Publications (1)

Publication Number	Publication Date
DK3204381T3 true DK3204381T3 (da)	2022-07-25

Family

ID=54337305

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK15782044.0T DK3204381T3 (da)	2014-10-08	2015-10-08	N-pyridinylacetamidderivater som wnt-signaleringsbanehæmmere

Country Status (22)

Country	Link
US (4)	US10202375B2 (da)
EP (2)	EP3204381B1 (da)
JP (1)	JP6588976B2 (da)
KR (1)	KR102476667B1 (da)
CN (1)	CN106795157B (da)
AU (1)	AU2015329788B2 (da)
BR (1)	BR112017007218B1 (da)
CA (1)	CA2961740C (da)
CY (1)	CY1125356T1 (da)
DK (1)	DK3204381T3 (da)
ES (1)	ES2922580T3 (da)
HR (1)	HRP20220864T8 (da)
HU (1)	HUE059537T2 (da)
LT (1)	LT3204381T (da)
MX (1)	MX380168B (da)
PL (1)	PL3204381T3 (da)
PT (1)	PT3204381T (da)
RS (1)	RS63397B1 (da)
SG (1)	SG11201702142UA (da)
SI (1)	SI3204381T1 (da)
SM (1)	SMT202200297T1 (da)
WO (1)	WO2016055790A1 (da)

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PL3204381T3 (pl) *	2014-10-08	2022-08-29	Redx Pharma Plc	Pochodne n-pirydynyloacetamidu jako inhibitory ścieżki sygnalizacji wnt
EA034822B9 (ru)	2014-10-08	2020-10-23	РЭДКС ФАРМА ПиЭлСи	Производные n-пиридинилацетамида в качестве ингибиторов сигнального пути wnt
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WO2017189647A1 (en) *	2016-04-26	2017-11-02	Memorial Sloan Kettering Cancer Center	Methods and compositions for the treatment of myelodysplastic syndrome
WO2019157085A2 (en) *	2018-02-06	2019-08-15	Vanderbilt University	INHIBITION OF WNT/β-CATENIN SIGNALING IN THE TREATMENT OF OSTEOARTHRITIS
SMT202200134T1 (it)	2018-03-08	2022-05-12	Incyte Corp	Composti di amminopirazindiolo come inibitori di pi3k-y
CN108752364B (zh) *	2018-06-14	2019-10-15	绍兴文理学院	一种对甲氧基取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108752365B (zh) *	2018-06-14	2019-10-18	绍兴文理学院	一种含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108752366B (zh) *	2018-06-14	2019-10-18	绍兴文理学院	一种对甲基取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108640930B (zh) *	2018-06-14	2019-09-10	绍兴文理学院	一种对氯取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108516983B (zh) *	2018-06-14	2019-10-18	绍兴文理学院	一种对甲巯基取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108484639B (zh) *	2018-06-14	2019-10-18	绍兴文理学院	一种对氟取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
CN108640929B9 (zh) *	2018-06-14	2019-09-06	绍兴文理学院	3,4,5-三甲氧基取代含吡唑结构的螺[吲哚嗪-异噁唑啉]衍生物及其制备方法与应用
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CN111349093B (zh) *	2018-12-21	2021-07-02	汇瀚医疗科技有限公司	5,6-双环化合物作为wnt信号通路抑制剂及其医学应用
CN111620874B (zh) *	2019-02-28	2022-11-15	汇瀚医疗科技有限公司	取代5,6-双杂环氨基化合物作为wnt信号通路抑制剂及其治疗应用
CN113024563B (zh) *	2019-12-24	2023-01-03	药康众拓(江苏)医药科技有限公司	嘧啶并五元杂环类化合物或其可药用的盐、异构体及其制备方法、药物组合物和用途
WO2021138450A1 (en) *	2019-12-30	2021-07-08	Buto Corporation	Novel small molecule shc blockers for treating liver disease and metabolic disease
WO2023072263A1 (zh) *	2021-10-29	2023-05-04	南京明德新药研发有限公司	5-取代的吡啶-2(1h)-酮类化合物及其应用
CN117396482A (zh) *	2022-07-28	2024-01-12	杭州阿诺生物医药科技有限公司	一种Wnt通路抑制剂化合物
TW202434248A (zh)	2022-11-04	2024-09-01	瑞典商阿斯特捷利康公司	n-吡啶基乙醯胺衍生物之口服配製物
WO2025171341A2 (en) *	2024-02-08	2025-08-14	Aconcagua Bio, Inc.	Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity
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CN118496159B (zh) *	2024-07-18	2024-09-24	广州医科大学附属市八医院	一种化合物在制备具有预防和/或治疗肝纤维化作用的药物中的应用
CN120943785B (zh) *	2025-10-17	2026-01-02	广州医科大学附属市八医院	一种化合物及其在制备具有抑制Wnt信号通路活性的药物中的应用

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EA034822B9 (ru)	2014-10-08	2020-10-23	РЭДКС ФАРМА ПиЭлСи	Производные n-пиридинилацетамида в качестве ингибиторов сигнального пути wnt

2015
- 2015-10-08 PL PL15782044.0T patent/PL3204381T3/pl unknown
- 2015-10-08 WO PCT/GB2015/052943 patent/WO2016055790A1/en not_active Ceased
- 2015-10-08 JP JP2017518912A patent/JP6588976B2/ja active Active
- 2015-10-08 ES ES15782044T patent/ES2922580T3/es active Active
- 2015-10-08 EP EP15782044.0A patent/EP3204381B1/en active Active
- 2015-10-08 EP EP22174506.0A patent/EP4071150A1/en active Pending
- 2015-10-08 SG SG11201702142UA patent/SG11201702142UA/en unknown
- 2015-10-08 RS RS20220662A patent/RS63397B1/sr unknown
- 2015-10-08 CA CA2961740A patent/CA2961740C/en active Active
- 2015-10-08 MX MX2017004639A patent/MX380168B/es unknown
- 2015-10-08 CN CN201580054505.9A patent/CN106795157B/zh active Active
- 2015-10-08 DK DK15782044.0T patent/DK3204381T3/da active
- 2015-10-08 US US15/514,061 patent/US10202375B2/en active Active
- 2015-10-08 SM SM20220297T patent/SMT202200297T1/it unknown
- 2015-10-08 KR KR1020177012230A patent/KR102476667B1/ko active Active
- 2015-10-08 HR HRP20220864TT patent/HRP20220864T8/hr unknown
- 2015-10-08 BR BR112017007218-1A patent/BR112017007218B1/pt active IP Right Grant
- 2015-10-08 HU HUE15782044A patent/HUE059537T2/hu unknown
- 2015-10-08 PT PT157820440T patent/PT3204381T/pt unknown
- 2015-10-08 SI SI201531858T patent/SI3204381T1/sl unknown
- 2015-10-08 LT LTEPPCT/GB2015/052943T patent/LT3204381T/lt unknown
- 2015-10-08 AU AU2015329788A patent/AU2015329788B2/en active Active
2019
- 2019-01-10 US US16/244,467 patent/US10793562B2/en active Active
2020
- 2020-09-10 US US17/017,023 patent/US11459326B2/en active Active
2022
- 2022-07-12 CY CY20221100473T patent/CY1125356T1/el unknown
- 2022-08-29 US US17/822,871 patent/US20230121489A1/en not_active Abandoned

Also Published As

Publication number	Publication date
LT3204381T (lt)	2022-08-25
CA2961740A1 (en)	2016-04-14
CN106795157B (zh)	2019-07-23
US20230121489A1 (en)	2023-04-20
US11459326B2 (en)	2022-10-04
EP3204381B1 (en)	2022-05-25
MX380168B (es)	2025-03-12
US20170298062A1 (en)	2017-10-19
US10202375B2 (en)	2019-02-12
US20200407356A1 (en)	2020-12-31
RS63397B1 (sr)	2022-08-31
AU2015329788A1 (en)	2017-04-06
KR20170063948A (ko)	2017-06-08
US10793562B2 (en)	2020-10-06
AU2015329788B2 (en)	2019-10-10
JP2017530985A (ja)	2017-10-19
CY1125356T1 (el)	2025-05-09
PL3204381T3 (pl)	2022-08-29
CA2961740C (en)	2023-03-07
WO2016055790A1 (en)	2016-04-14
KR102476667B1 (ko)	2022-12-09
BR112017007218B1 (pt)	2023-10-10
EP3204381A1 (en)	2017-08-16
SI3204381T1 (sl)	2022-10-28
HUE059537T2 (hu)	2022-11-28
MX2017004639A (es)	2017-07-17
PT3204381T (pt)	2022-07-18
HRP20220864T8 (en)	2023-02-03
CN106795157A (zh)	2017-05-31
SMT202200297T1 (it)	2022-09-14
EP4071150A1 (en)	2022-10-12
US20190144447A1 (en)	2019-05-16
HRP20220864T1 (hr)	2022-10-14
ES2922580T3 (es)	2022-09-16
JP6588976B2 (ja)	2019-10-09
SG11201702142UA (en)	2017-04-27
BR112017007218A2 (pt)	2017-12-19

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