[go: up one dir, main page]

DK3154561T3 - Modulering af komplementaktivitet - Google Patents

Modulering af komplementaktivitet Download PDF

Info

Publication number
DK3154561T3
DK3154561T3 DK15807069.8T DK15807069T DK3154561T3 DK 3154561 T3 DK3154561 T3 DK 3154561T3 DK 15807069 T DK15807069 T DK 15807069T DK 3154561 T3 DK3154561 T3 DK 3154561T3
Authority
DK
Denmark
Prior art keywords
modulation
complement activity
complement
activity
Prior art date
Application number
DK15807069.8T
Other languages
English (en)
Inventor
Ketki Ashok Dhamnaskar
Daniel Elbaum
Kelley Cronin Larson
Zhong Ma
Nathan Ezekiel Nims
Alonso Ricardo
Kathleen Seyb
Guo-Qing Tang
Douglas A Treco
Zhaolin Wang
Ping Ye
Hong Zheng
Sarah Jacqueline Perlmutter
Michelle Denise Hoarty
Robert Paul Hammer
Kristopher Josephson
Original Assignee
Ra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54834568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3154561(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ra Pharmaceuticals Inc filed Critical Ra Pharmaceuticals Inc
Application granted granted Critical
Publication of DK3154561T3 publication Critical patent/DK3154561T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15807069.8T 2014-06-12 2015-06-12 Modulering af komplementaktivitet DK3154561T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462011368P 2014-06-12 2014-06-12
US201462077460P 2014-11-10 2014-11-10
US201562108772P 2015-01-28 2015-01-28
PCT/US2015/035473 WO2015191951A2 (en) 2014-06-12 2015-06-12 Modulation of complement activity

Publications (1)

Publication Number Publication Date
DK3154561T3 true DK3154561T3 (da) 2019-10-07

Family

ID=54834568

Family Applications (2)

Application Number Title Priority Date Filing Date
DK15807069.8T DK3154561T3 (da) 2014-06-12 2015-06-12 Modulering af komplementaktivitet
DK19194070.9T DK3628680T3 (da) 2014-06-12 2015-06-12 Modulering af komplementaktivitet

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK19194070.9T DK3628680T3 (da) 2014-06-12 2015-06-12 Modulering af komplementaktivitet

Country Status (30)

Country Link
US (7) US10106579B2 (da)
EP (4) EP3154561B1 (da)
JP (4) JP6432954B2 (da)
KR (3) KR102346228B1 (da)
CN (3) CN111187338B (da)
AP (1) AP2016009612A0 (da)
AU (3) AU2015274482B2 (da)
BR (3) BR112016029076B1 (da)
CA (3) CA3241273A1 (da)
CY (3) CY1122227T1 (da)
DK (2) DK3154561T3 (da)
ES (2) ES2750556T3 (da)
FI (1) FIC20240015I1 (da)
FR (1) FR24C1022I2 (da)
HR (2) HRP20211561T8 (da)
HU (3) HUE055931T2 (da)
IL (3) IL249093B (da)
LT (2) LT3628680T (da)
MX (2) MX2016016449A (da)
NL (1) NL301275I2 (da)
NZ (1) NZ727420A (da)
PL (2) PL3154561T3 (da)
PT (2) PT3628680T (da)
RS (2) RS62428B1 (da)
RU (1) RU2670988C2 (da)
SG (1) SG11201610222UA (da)
SI (2) SI3154561T1 (da)
SM (2) SMT201900568T1 (da)
WO (1) WO2015191951A2 (da)
ZA (3) ZA201706379B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3154561T1 (sl) 2014-06-12 2019-11-29 Ra Pharmaceuticals Inc Modulacija aktivnosti komplementa
HUE056613T2 (hu) * 2015-01-28 2022-02-28 Ra Pharmaceuticals Inc Komplementaktivitás modulátorai
EP3389692B1 (en) 2015-12-16 2020-03-04 RA Pharmaceuticals, Inc. Modulators of complement activity
US11026945B2 (en) 2016-04-29 2021-06-08 The Trustees Of The University Of Pennsylvania Protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitors for prevention and/or treatment of lung injury and/or inflammation
AU2017370692A1 (en) * 2016-12-07 2019-06-06 Ra Pharmaceuticals, Inc. Modulators of complement activity
WO2019246387A1 (en) * 2018-06-21 2019-12-26 Ra Pharmaceuticals, Inc. Cyclic peptides for pcsk9 inhibition
EP3810196A4 (en) 2018-06-21 2022-05-04 Merck Sharp & Dohme Corp. CYCLIC POLYPEPTIDES FOR INHIBITION OF PCSK9
JOP20190150A1 (ar) 2018-06-21 2019-12-21 Merck Sharp & Dohme مركبات مناهضة لـ pcsk9
EP3810176B1 (en) 2018-06-21 2024-12-11 Ra Pharmaceuticals, Inc. Cyclic polypeptides for pcsk9 inhibition
CA3115828A1 (en) * 2018-10-22 2020-04-30 Ra Pharmaceuticals, Inc. Neurological disease treatment with zilucoplan
WO2020185541A2 (en) 2019-03-08 2020-09-17 Ra Pharmaceuticals, Inc. Modulators of complement activity
TW202106290A (zh) * 2019-04-24 2021-02-16 美商Ｒａ製藥公司 用於調節補體活性之組成物及方法
WO2020247607A1 (en) 2019-06-04 2020-12-10 Ra Pharmaceuticals, Inc. Inflammatory disease treatment with complement inhibitors
CA3150594A1 (en) 2019-09-12 2021-03-18 Ra Pharmaceuticals, Inc. Neurological disease treatment with complement inhibitors
US11932705B2 (en) 2020-12-18 2024-03-19 Merck Sharp & Dohme Llc Cyclic polypeptides for PCSK9 inhibition
IL304214B2 (en) 2021-01-20 2025-01-01 Viking Therapeutics Inc Compositions and methods for treating metabolic and liver disorders
WO2022177635A2 (en) * 2021-02-22 2022-08-25 Ra Pharmaceuticals, Inc. Compositions and methods for microbial disease treatment
WO2023215294A1 (en) * 2022-05-02 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Complement pathway inhibition for wound healing
WO2024039636A1 (en) * 2022-08-16 2024-02-22 Ps Therapy, Inc. Methods of use for disulfiram and metabolites thereof
TW202506645A (zh) * 2023-03-31 2025-02-16 美商弗列克斯美國公司 雜芳基抗降解劑

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271068A (en) 1968-05-10 1981-06-02 Ciba-Geigy Corporation Process for the manufacture of cystine-containing peptides
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4033940A (en) 1975-11-12 1977-07-05 Armour Pharmaceutical Company Cyclization of peptides
US4216141A (en) 1978-07-19 1980-08-05 The Salk Institute For Biological Studies Method for cyclization of peptides
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
DE3675588D1 (de) 1985-06-19 1990-12-20 Ajinomoto Kk Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5371109A (en) 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
FR2641081A1 (da) * 1988-12-23 1990-06-29 Medgenix Group
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
JP3127158B2 (ja) 1989-10-05 2001-01-22 オプテイン，インコーポレイティド 新規の遺伝子及びポリペチドの無細胞合成並びに単離
US5585353A (en) 1990-02-02 1996-12-17 The Rockefeller University Antibiotic peptides containing D-amino acids
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
CA2163620A1 (en) 1993-05-28 1994-12-08 Michael V. Doyle Method for selection of biologically active peptide sequences
PT710243E (pt) 1993-06-29 2000-11-30 Ferring Bv Sintese melhorada de peptidos ciclicos.
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6037453A (en) * 1995-03-15 2000-03-14 Genentech, Inc. Immunoglobulin variants
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
US6720472B2 (en) 1996-07-12 2004-04-13 University Of Medicine And Dentistry Of New Jersey HMGI proteins in cancer and obesity
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6348584B1 (en) 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
EP0962527B1 (en) 1996-10-17 2004-08-04 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US5922680A (en) 1996-10-23 1999-07-13 Ferring, B.V. Stabilized composition for oral administration of peptides
AU738328B2 (en) 1997-01-21 2001-09-13 General Hospital Corporation, The Selection of proteins using RNA-protein fusions
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
US6673901B2 (en) 1997-06-12 2004-01-06 Research Corporation Technologies, Inc. Artificial antibody polypeptides
EP0896001A1 (en) 1997-08-08 1999-02-10 Daicel Chemical Industries, Ltd. Method for preparing oxytocin antagoniste derivatives, intermediates for the preparation of oxytocin antagonist derivatives and method for preparing the intermediates
US6429301B1 (en) 1998-04-17 2002-08-06 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
TR200100366T2 (tr) 1998-08-07 2001-11-21 Emisphere Technologies, Inc. Aktif madde dağıtmaya mahsus bileşikler ve bileşimler.
AU6059099A (en) * 1998-09-25 2000-04-17 Children's Medical Center Corporation Short peptides which selectively modulate the activity of protein kinases
WO2000021559A2 (en) 1998-10-09 2000-04-20 Musc Foundation For Research Development Blocking factor b to treat complement-mediated immune disease
US6962781B1 (en) 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
US7244701B2 (en) 2000-06-16 2007-07-17 Zealand Phama A/S Diuretic peptide conjugate
WO2003074992A2 (en) * 2002-03-01 2003-09-12 Mds Proteomics Inc. Phosphorylated proteins and uses related thereto
WO2004035624A2 (en) * 2002-10-14 2004-04-29 Novo Nordisk A/S Glucagon - like peptide - 2 variants
DK1569685T3 (da) * 2002-11-15 2012-11-12 Univ Colorado Regents Komplementmodulatorer rettet mod komplementreceptor-2
EP2206496B1 (en) * 2003-05-05 2014-09-17 Probiodrug AG Screening of inhibitors of formation of pyroglutamic acid in amyloid beta peptide
ES2387275T3 (es) 2003-05-15 2012-09-19 Genentech, Inc. Métodos y composiciones para la prevención y el tratamiento de la sepsis
US7348401B2 (en) 2003-09-10 2008-03-25 Innate Biotech, Inc. Peptides that inhibit complement activation
US20050191343A1 (en) 2003-11-26 2005-09-01 Shire Laboratories, Inc. Micellar systems useful for delivery of lipophilic or hydrophobic compounds
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
US20060027059A1 (en) 2004-08-09 2006-02-09 Chih-Ching Hsien Extendable handle device
WO2006066258A2 (en) * 2004-12-17 2006-06-22 Neose Technologies, Inc. Lipoconjugation of peptides
CA2595902C (en) 2005-01-24 2017-08-22 Pepscan Systems B.V. Binding compounds, immunogenic compounds and peptidomimetics of the beta-3 hairpin loop of cystine-knot growth factors
US20060270590A1 (en) 2005-03-29 2006-11-30 Lockwood Samuel F Reduction in complement activation and inflammation during tissue injury by carotenoids, carotenoid analogs, or derivatives thereof
BRPI0618160A2 (pt) 2005-05-26 2011-08-16 Univ Colorado inibição da via alternativa complemento para tratamento de danos cerebrais traumáticos, danos na medula espinhal e condições relacionadas
US8546326B2 (en) 2005-06-06 2013-10-01 Camurus Ab Glp-1 analogue formulations
EP3299027A1 (en) 2005-11-04 2018-03-28 Genentech, Inc. Use of complement pathway inhibitors to treat ocular diseases
SI2359834T1 (sl) 2006-03-15 2017-02-28 Alexion Pharmaceuticals, Inc. Zdravljenje pacientov,ki imajo paroksizmalno nočno hemoglobinurijo, z zaviralcem komplementa
EP1876183A1 (en) * 2006-07-04 2008-01-09 Technische Universität München Minimized small peptides with high affinity for factor VIII and factor VIII-like proteins
CA2980614A1 (en) 2006-10-10 2008-04-17 Regenesance B.V. Anti-sense oligonucleotide for use in facilitating axonal regeneration
US7736860B2 (en) 2006-11-09 2010-06-15 Univeristy Of Massachusetts Methods of identifying compounds for the treatment of sterile inflammation
CN101668541A (zh) * 2007-03-06 2010-03-10 诺和诺德公司 调节补体系统的激活以用于治疗出血相关炎症
WO2008113834A2 (en) * 2007-03-22 2008-09-25 Novartis Ag C5 antigens and uses thereof
US20100015139A1 (en) 2008-07-10 2010-01-21 Rekha Bansal METHOD OF INHIBITING COMPLEMENT ACTIVATION WITH FACTOR Ba SPECIFIC ANTIBODIES AND USE THEREOF
BRPI0811007A2 (pt) 2007-04-30 2015-01-27 Alcon Res Ltd Tratamento de degeneração macular relacionada à idade usando inibidores de fator de complemento d
KR20150029002A (ko) 2007-06-07 2015-03-17 제넨테크, 인크. 보체-관련 장애의 예방 및 치료를 위한 Ｃ３ｂ 항체 및 방법
WO2009014633A1 (en) 2007-07-20 2009-01-29 Trustees Of The University Of Pennsylvania Method of treating acute respiratory distress syndrome
CN101854916A (zh) 2007-10-02 2010-10-06 博泰迪亚制药公司 由凝胶持续递送坎普他汀类似物
WO2009067191A2 (en) 2007-11-16 2009-05-28 The General Hospital Corporation Methods and compositions for the treatment of hepatitis c virus (hcv) infection
EP2278987A4 (en) 2008-03-28 2012-08-22 Apellis Ag MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM
WO2010014830A2 (en) 2008-07-30 2010-02-04 Cosmix Therapeutics Llc Peptide therapeutics that bind vegf and methods of use thereof
BRPI0916668B1 (pt) * 2008-08-05 2021-12-28 Novartis Ag Anticorpo monoclonal isolado, composição farmacêutica, ácido nucleico isolado e vetor
US20110172126A1 (en) 2008-09-03 2011-07-14 Xenome Ltd Libraries of peptide conjugates and methods for making them
SI2894165T1 (sl) 2008-11-10 2023-04-28 Alexion Pharmaceuticals, Inc. Postopki in sestavki za zdravljenje motenj povezanih s komplementom
AU2009230735B1 (en) 2009-01-08 2010-01-21 Shane Ramodien Electronic equipment housing
SI2488203T1 (sl) 2009-10-16 2017-07-31 Omeros Corporation Metode za zdravljenje diseminirane intravaskularne koagulacije z inhibiranjem aktivacije masp-2 odvisnega komplementa
US10239937B2 (en) 2009-11-05 2019-03-26 Alexion Pharmaceuticals, Inc. Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
EP2513141B1 (en) 2009-12-16 2017-03-01 Novo Nordisk A/S Glp-1 analogues and derivatives
US9172511B2 (en) 2009-12-24 2015-10-27 Samsung Electronics Co., Ltd. Apparatus and method of communicating automatic repeat request (ARQ) feedback in a wireless communication network
WO2011106635A1 (en) 2010-02-25 2011-09-01 The Trustees Of The University Of Pennsylvania Treatment of sepsis using complement inhibitors
WO2011112999A2 (en) 2010-03-12 2011-09-15 The Regents Of The University Of California Lipid-peptide-polymer conjugates and nanoparticles thereof
WO2011139343A2 (en) * 2010-04-28 2011-11-10 Wu Nian Amino acid linked peg-lipid conjugates
EP2563359A1 (en) 2010-04-30 2013-03-06 Allergan, Inc. Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase
TW201241008A (en) * 2010-10-01 2012-10-16 Alexion Pharma Inc Polypeptides that bind to human complement component C5
EA201391331A1 (ru) * 2011-03-16 2014-02-28 Эмджен Инк. Активные и селективные ингибиторы nav1.3 и nav1.7
CA3237802A1 (en) 2011-04-08 2012-10-11 Omeros Corporation Methods for treating conditions associated with masp-2 dependent complement activation
WO2012162215A1 (en) 2011-05-20 2012-11-29 The Trustees Of The University Of Pennsylvania Promotion of fracture healing using complement inhibitors
WO2012174055A1 (en) 2011-06-13 2012-12-20 The Trustees Of The University Of Pennsylvania Wound healing using complement inhibitors
CN102321170B (zh) * 2011-09-14 2013-11-13 深圳翰宇药业股份有限公司 利拉鲁肽变构体及其缀合物
WO2013052736A2 (en) * 2011-10-06 2013-04-11 The Medicines Company Methods of treating or preventing blood loss during surgery using the serine protease inhibitor mdco-2010
EP2817329B1 (en) * 2012-02-20 2019-01-02 Swedish Orphan Biovitrum AB (Publ) Polypeptides binding to human complement c5
US20130246083A1 (en) 2012-03-16 2013-09-19 Alexion Pharmaceuticals, Inc. Methods of distributing complement-inhibiting drugs to patients receiving a complement inhibitor
US9238676B2 (en) 2012-05-17 2016-01-19 Ra Pharmaceuticals, Inc. Peptide and peptidomimetic inhibitors
US9579360B2 (en) 2012-06-20 2017-02-28 The Trustees Of The University Of Pennsylvania Methods of treating or preventing periodontitis and diseases associated with periodontitis
WO2014004733A1 (en) 2012-06-26 2014-01-03 The Regents Of The University Of California Composition for lupus nephritis and methods of making and using the same
WO2014078622A1 (en) 2012-11-15 2014-05-22 The Brigham And Women's Hospital, Inc. Method and system for diagnosing and treating preeclampsia
US9700633B2 (en) * 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
GB201301632D0 (en) * 2013-01-30 2013-03-13 Imp Innovations Complement System
US20140234275A1 (en) 2013-02-15 2014-08-21 Jason Williams Method for treating als via the increased production of factor h
US20150057342A1 (en) 2013-08-21 2015-02-26 Cannabics Pharmaceuticals Inc Compositions for combined immediate and sustained release of cannabinoids, methods of manufacture and use thereof
SG11201607740TA (en) 2014-03-20 2016-10-28 Inflarx Gmbh Inhibitors of c5a for the treatment of viral pneumonia
SI3154561T1 (sl) 2014-06-12 2019-11-29 Ra Pharmaceuticals Inc Modulacija aktivnosti komplementa
WO2016094834A2 (en) 2014-12-12 2016-06-16 Alexion Pharmaceuticals, Inc. A method for treating a complement mediated disorder caused by an infectious agent in a patient
ES2704299T3 (es) 2015-01-21 2019-03-15 Pacira Pharmaceuticals Inc Formulaciones de liposomas multivesiculares de ácido tranexámico
HUE056613T2 (hu) 2015-01-28 2022-02-28 Ra Pharmaceuticals Inc Komplementaktivitás modulátorai
WO2017035362A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses
EP3389692B1 (en) 2015-12-16 2020-03-04 RA Pharmaceuticals, Inc. Modulators of complement activity
AU2017370692A1 (en) 2016-12-07 2019-06-06 Ra Pharmaceuticals, Inc. Modulators of complement activity
US10376595B2 (en) 2017-04-03 2019-08-13 Inflarx Gmbh Treatment of inflammatory diseases with inhibitors of C5a activity
WO2019051436A1 (en) 2017-09-11 2019-03-14 Ra Pharmaceuticals, Inc. FORMULATIONS FOR THE ADMINISTRATION OF COMPOUNDS
MX2020005547A (es) 2017-12-04 2020-08-20 Ra Pharmaceuticals Inc Moduladores de la actividad del complemento.
WO2020185541A2 (en) 2019-03-08 2020-09-17 Ra Pharmaceuticals, Inc. Modulators of complement activity
TW202106290A (zh) 2019-04-24 2021-02-16 美商Ｒａ製藥公司 用於調節補體活性之組成物及方法

Also Published As

Publication number Publication date
SMT202100588T1 (it) 2021-11-12
NZ761610A (en) 2024-03-22
AP2016009612A0 (en) 2016-12-31
HUE055931T2 (hu) 2022-01-28
CA3241273A1 (en) 2015-12-17
JP2017523232A (ja) 2017-08-17
EP4223317A2 (en) 2023-08-09
IL249093A0 (en) 2017-01-31
BR112016029076A8 (pt) 2022-02-08
MX2016016449A (es) 2017-08-24
AU2019200828B2 (en) 2021-04-08
CY1124595T1 (el) 2022-07-22
PT3154561T (pt) 2019-10-25
US10106579B2 (en) 2018-10-23
RU2016147080A (ru) 2018-06-01
AU2015274482B2 (en) 2018-11-08
HUE045646T2 (hu) 2020-01-28
US10435438B2 (en) 2019-10-08
RU2670988C2 (ru) 2018-10-29
EP3154561A2 (en) 2017-04-19
CA3174909A1 (en) 2015-12-17
HRP20211561T8 (hr) 2022-03-04
JP2022034057A (ja) 2022-03-02
BR122021025449B1 (pt) 2024-02-15
US20180371019A1 (en) 2018-12-27
US20190119328A1 (en) 2019-04-25
FR24C1022I1 (fr) 2024-07-19
US20200002380A1 (en) 2020-01-02
SG11201610222UA (en) 2017-01-27
CA2949985C (en) 2023-10-17
PL3628680T3 (pl) 2022-01-10
FR24C1022I2 (fr) 2025-05-23
US20210246167A1 (en) 2021-08-12
CY1122227T1 (el) 2020-11-25
RS59353B1 (sr) 2019-10-31
JP2019048834A (ja) 2019-03-28
RU2018136750A3 (da) 2021-10-19
EP3154561B1 (en) 2019-09-04
KR102346228B1 (ko) 2022-01-04
AU2021204313A1 (en) 2021-07-22
LT3154561T (lt) 2019-11-25
HRP20211561T1 (hr) 2021-12-24
CN106456701A (zh) 2017-02-22
ZA201706379B (en) 2018-12-19
NL301275I2 (nl) 2024-06-20
LT3628680T (lt) 2021-11-25
US11535650B1 (en) 2022-12-27
WO2015191951A3 (en) 2016-03-03
AU2019200828A1 (en) 2019-02-28
JP7002597B2 (ja) 2022-02-04
ZA201900497B (en) 2019-10-30
WO2015191951A2 (en) 2015-12-17
CN106456701B (zh) 2020-01-07
KR102503319B1 (ko) 2023-02-28
CN111187338B (zh) 2024-08-02
AU2021204313B2 (en) 2024-01-04
SMT201900568T1 (it) 2019-11-13
DK3628680T3 (da) 2021-10-11
BR112016029076A2 (pt) 2018-06-05
IL281264B (en) 2022-05-01
KR101981532B1 (ko) 2019-09-02
RU2016147080A3 (da) 2018-06-01
CN119236050A (zh) 2025-01-03
KR20170003993A (ko) 2017-01-10
BR122023024819A2 (pt) 2023-12-26
MX2021009309A (es) 2021-10-26
NZ727420A (en) 2018-06-29
ES2895029T3 (es) 2022-02-17
NZ736573A (en) 2024-03-22
PT3628680T (pt) 2021-10-07
ZA202001859B (en) 2021-04-28
IL273746A (en) 2020-05-31
CY2024015I1 (el) 2024-12-13
US20200123202A1 (en) 2020-04-23
US11014965B2 (en) 2021-05-25
AU2015274482A1 (en) 2017-01-12
ES2750556T3 (es) 2020-03-26
SI3628680T1 (sl) 2021-12-31
US11965040B2 (en) 2024-04-23
HRP20191763T1 (hr) 2019-12-27
FIC20240015I1 (fi) 2024-05-28
EP3973994A1 (en) 2022-03-30
EP3628680A1 (en) 2020-04-01
RS62428B1 (sr) 2021-11-30
US10208089B2 (en) 2019-02-19
EP3628680B1 (en) 2021-09-08
RU2018136750A (ru) 2018-11-06
PL3154561T3 (pl) 2019-12-31
JP6770043B2 (ja) 2020-10-14
IL281264A (en) 2021-04-29
BR112016029076B1 (pt) 2024-02-15
KR20220002727A (ko) 2022-01-06
CA2949985A1 (en) 2015-12-17
IL273746B (en) 2021-03-25
IL249093B (en) 2020-05-31
HUS2400015I1 (hu) 2024-06-28
JP2020128417A (ja) 2020-08-27
CN111187338A (zh) 2020-05-22
CY2024015I2 (el) 2024-12-13
US10562934B2 (en) 2020-02-18
JP6432954B2 (ja) 2018-12-05
EP4223317A3 (en) 2023-09-27
SI3154561T1 (sl) 2019-11-29
KR20190057420A (ko) 2019-05-28
JP7454545B2 (ja) 2024-03-22
US20170137468A1 (en) 2017-05-18
EP3154561A4 (en) 2018-04-18

Similar Documents

Publication Publication Date Title
HUS2400015I1 (hu) Komplement aktivitás modulálása
DK3137169T3 (da) Hæmmere af lysin-specifik demethylase-1
DK3851537T5 (da) Behandling af hyperbilirubinæmi
DK3102576T3 (da) Dihydropyrrolopyridininhibitorer af ror-gamma
DK3389692T3 (da) Modulatorer af komplement-aktivitet
HUE056613T2 (hu) Komplementaktivitás modulátorai
HUE056544T2 (hu) Gamma-C-citokin aktivitás modulálása
DK3143123T3 (da) Mikrorna-induktion af kardiologisk regenerering
DK3511000T3 (da) Krystallinsk form x2 af grapiprant
DK3175593T3 (da) Signalering af modulationskonfiguration
DK3418273T3 (da) Derivater af flavagliner
DK3141052T3 (da) Konfiguration af beskyttelsesperiode til LTE HD-FDD
DK2942098T3 (da) Forbedret fremgangsmåde til fjernelse af nitrit
DK3200783T3 (da) Behandling af erytromelalgi
DK3161136T3 (da) Fremgangsmåde til berigelse af mikrovesikler
DK3417873T3 (da) Ultrarene hypoallergene opløsninger af sacrosidase
TH1601001450A (th) มอดุเลเตอร์ของคอมพลีเมนต์แฟคเตอร์ b