DK3152296T3 - Human hepatisk 3d-samkulturmodel og anvendelser deraf - Google Patents
Human hepatisk 3d-samkulturmodel og anvendelser deraf Download PDFInfo
- Publication number
- DK3152296T3 DK3152296T3 DK15726971.3T DK15726971T DK3152296T3 DK 3152296 T3 DK3152296 T3 DK 3152296T3 DK 15726971 T DK15726971 T DK 15726971T DK 3152296 T3 DK3152296 T3 DK 3152296T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- human hepatic
- cultural model
- cultural
- model
- Prior art date
Links
- 230000002440 hepatic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/407—Liver; Hepatocytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5067—Liver cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1410048.1A GB201410048D0 (en) | 2014-06-06 | 2014-06-06 | Human hepatic 3d co-culture model and uses thereof |
GBGB1505012.3A GB201505012D0 (en) | 2015-03-25 | 2015-03-25 | Human hepatic 3D co-culture model and uses thereof |
PCT/EP2015/062551 WO2015185714A1 (en) | 2014-06-06 | 2015-06-05 | Human hepatic 3d co-culture model and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3152296T3 true DK3152296T3 (da) | 2021-11-08 |
Family
ID=53284272
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15726971.3T DK3152296T3 (da) | 2014-06-06 | 2015-06-05 | Human hepatisk 3d-samkulturmodel og anvendelser deraf |
Country Status (6)
Country | Link |
---|---|
US (1) | US20170166870A1 (da) |
EP (1) | EP3152296B1 (da) |
CA (1) | CA2950470A1 (da) |
DK (1) | DK3152296T3 (da) |
ES (1) | ES2897553T3 (da) |
WO (1) | WO2015185714A1 (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
ES2860423T3 (es) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida |
AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
RU2661105C2 (ru) * | 2016-01-21 | 2018-07-11 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | СПОСОБ ПОЛУЧЕНИЯ СФЕРОИДОВ КЛЕТОК HepaRG В СРЕДЕ БЕЗ ДИМЕТИЛСУЛЬФОКСИДА |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US20190298775A1 (en) | 2016-11-04 | 2019-10-03 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
WO2018106628A1 (en) | 2016-12-05 | 2018-06-14 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CN109423472A (zh) * | 2017-08-22 | 2019-03-05 | 中国食品药品检定研究院 | 体外3d肝脏模型和肠肝共培养模型及其建立方法和应用 |
US12247223B2 (en) | 2019-02-22 | 2025-03-11 | Cyfuse Biomedical K.K. | Human liver-like three-dimensional structure, method for evaluating hepatotoxicity and human liver-like complex |
CN111826338B (zh) * | 2019-12-27 | 2022-03-29 | 四川大学华西医院 | 一种快速培养肝芽类器官的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0030584D0 (en) * | 2000-12-15 | 2001-01-31 | Univ Nottingham | Hepatocyte Co-Culture |
TWI294461B (en) * | 2004-12-28 | 2008-03-11 | Ind Tech Res Inst | Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis |
-
2015
- 2015-06-05 ES ES15726971T patent/ES2897553T3/es active Active
- 2015-06-05 CA CA2950470A patent/CA2950470A1/en not_active Abandoned
- 2015-06-05 DK DK15726971.3T patent/DK3152296T3/da active
- 2015-06-05 EP EP15726971.3A patent/EP3152296B1/en active Active
- 2015-06-05 WO PCT/EP2015/062551 patent/WO2015185714A1/en active Application Filing
- 2015-06-05 US US15/316,199 patent/US20170166870A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2950470A1 (en) | 2015-12-10 |
WO2015185714A1 (en) | 2015-12-10 |
US20170166870A1 (en) | 2017-06-15 |
EP3152296B1 (en) | 2021-08-04 |
EP3152296A1 (en) | 2017-04-12 |
ES2897553T3 (es) | 2022-03-01 |
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