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DK3152296T3 - Human hepatisk 3d-samkulturmodel og anvendelser deraf - Google Patents

Human hepatisk 3d-samkulturmodel og anvendelser deraf Download PDF

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Publication number
DK3152296T3
DK3152296T3 DK15726971.3T DK15726971T DK3152296T3 DK 3152296 T3 DK3152296 T3 DK 3152296T3 DK 15726971 T DK15726971 T DK 15726971T DK 3152296 T3 DK3152296 T3 DK 3152296T3
Authority
DK
Denmark
Prior art keywords
applications
human hepatic
cultural model
cultural
model
Prior art date
Application number
DK15726971.3T
Other languages
English (en)
Inventor
Sofia Batista Leite
Grunsven Leo Van
Original Assignee
Univ Brussel Vrije
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1410048.1A external-priority patent/GB201410048D0/en
Priority claimed from GBGB1505012.3A external-priority patent/GB201505012D0/en
Application filed by Univ Brussel Vrije filed Critical Univ Brussel Vrije
Application granted granted Critical
Publication of DK3152296T3 publication Critical patent/DK3152296T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0671Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/407Liver; Hepatocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5067Liver cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/14Coculture with; Conditioned medium produced by hepatocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00Use of cells in diagnostics
    • C12N2503/04Screening or testing on artificial tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK15726971.3T 2014-06-06 2015-06-05 Human hepatisk 3d-samkulturmodel og anvendelser deraf DK3152296T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1410048.1A GB201410048D0 (en) 2014-06-06 2014-06-06 Human hepatic 3d co-culture model and uses thereof
GBGB1505012.3A GB201505012D0 (en) 2015-03-25 2015-03-25 Human hepatic 3D co-culture model and uses thereof
PCT/EP2015/062551 WO2015185714A1 (en) 2014-06-06 2015-06-05 Human hepatic 3d co-culture model and uses thereof

Publications (1)

Publication Number Publication Date
DK3152296T3 true DK3152296T3 (da) 2021-11-08

Family

ID=53284272

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15726971.3T DK3152296T3 (da) 2014-06-06 2015-06-05 Human hepatisk 3d-samkulturmodel og anvendelser deraf

Country Status (6)

Country Link
US (1) US20170166870A1 (da)
EP (1) EP3152296B1 (da)
CA (1) CA2950470A1 (da)
DK (1) DK3152296T3 (da)
ES (1) ES2897553T3 (da)
WO (1) WO2015185714A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
RU2661105C2 (ru) * 2016-01-21 2018-07-11 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" СПОСОБ ПОЛУЧЕНИЯ СФЕРОИДОВ КЛЕТОК HepaRG В СРЕДЕ БЕЗ ДИМЕТИЛСУЛЬФОКСИДА
US11066650B2 (en) 2016-05-05 2021-07-20 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
US20190298775A1 (en) 2016-11-04 2019-10-03 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
WO2018106628A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
CN109423472A (zh) * 2017-08-22 2019-03-05 中国食品药品检定研究院 体外3d肝脏模型和肠肝共培养模型及其建立方法和应用
US12247223B2 (en) 2019-02-22 2025-03-11 Cyfuse Biomedical K.K. Human liver-like three-dimensional structure, method for evaluating hepatotoxicity and human liver-like complex
CN111826338B (zh) * 2019-12-27 2022-03-29 四川大学华西医院 一种快速培养肝芽类器官的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0030584D0 (en) * 2000-12-15 2001-01-31 Univ Nottingham Hepatocyte Co-Culture
TWI294461B (en) * 2004-12-28 2008-03-11 Ind Tech Res Inst Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis

Also Published As

Publication number Publication date
CA2950470A1 (en) 2015-12-10
WO2015185714A1 (en) 2015-12-10
US20170166870A1 (en) 2017-06-15
EP3152296B1 (en) 2021-08-04
EP3152296A1 (en) 2017-04-12
ES2897553T3 (es) 2022-03-01

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