DK315085A - Isoinsolinyl-alkyl-piperaziner og fremgangsmaade til fremstilling deraf - Google Patents

Isoinsolinyl-alkyl-piperaziner og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number: DK315085A
Authority: DK; Denmark
Prior art keywords: isoinsolinyl; piperazines; procedures; alkyl; preparing
Prior art date: 1984-07-11

Application number

DK315085A

Other languages

English (en)

Other versions

DK163057B (da

DK315085D0 (da

DK163057C (da

Inventor

Terence M Dolak

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-11

Filing date

1985-07-10

Publication date

1986-01-12

1985-07-10 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1985-07-10 Publication of DK315085D0 publication Critical patent/DK315085D0/da

1986-01-12 Publication of DK315085A publication Critical patent/DK315085A/da

1992-01-13 Publication of DK163057B publication Critical patent/DK163057B/da

1992-06-09 Application granted granted Critical

1992-06-09 Publication of DK163057C publication Critical patent/DK163057C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK315085A 1984-07-11 1985-07-10 Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme DK163057C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62964984		1984-07-11
US06/629,649 US4585773A (en)	1984-07-11	1984-07-11	Isoindolinyl-alkyl-piperazines

Publications (4)

Publication Number	Publication Date
DK315085D0 DK315085D0 (da)	1985-07-10
DK315085A true DK315085A (da)	1986-01-12
DK163057B DK163057B (da)	1992-01-13
DK163057C DK163057C (da)	1992-06-09

Family

ID=24523882

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK315085A DK163057C (da)	1984-07-11	1985-07-10	Isoindsolinyl-alkyl-piperaziner, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
DK006691A DK6691D0 (da)	1984-07-11	1991-01-14	Isoindelinyl-alkyl-piperaziner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK006691A DK6691D0 (da)	1984-07-11	1991-01-14	Isoindelinyl-alkyl-piperaziner

Country Status (25)

Country	Link
US (1)	US4585773A (da)
JP (2)	JPS6136260A (da)
KR (1)	KR870000355B1 (da)
AT (1)	AT385270B (da)
AU (1)	AU584104B2 (da)
BE (1)	BE902847A (da)
CA (1)	CA1255311A (da)
CH (1)	CH664964A5 (da)
DE (1)	DE3524635A1 (da)
DK (2)	DK163057C (da)
ES (2)	ES8705425A1 (da)
FI (1)	FI79837C (da)
FR (1)	FR2567519B1 (da)
GB (1)	GB2161807B (da)
GR (1)	GR851678B (da)
HU (1)	HU195213B (da)
IE (1)	IE58787B1 (da)
IT (1)	IT1187756B (da)
LU (1)	LU85999A1 (da)
MY (1)	MY102973A (da)
NL (1)	NL8501998A (da)
NO (1)	NO163775C (da)
PT (1)	PT80794B (da)
SE (1)	SE457449B (da)
ZA (1)	ZA855092B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
FR2628425B1 (fr) *	1988-03-08	1992-04-03	Rhone Poulenc Sante	Derives d'isoindolinone, leurs procedes de preparation et les medicaments les contenant
WO1990002552A1 (en) *	1988-09-16	1990-03-22	Pfizer Inc.	Antipsychotic 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyl bridged bicyclic imides
US5332733A (en) *	1990-11-24	1994-07-26	Kali-Chemie Pharma Gmbh	Heterocyclically substituted piperazinoakylbenzoxazine and piperazinoalkylbenzothiazine compounds, processes for preparing them, and medicaments containing them
IT1254469B (it) *	1992-02-25	1995-09-25	Recordati Chem Pharm	Derivati benzopiranici e benzotiopiranici
US5605896A (en) *	1992-02-25	1997-02-25	Recordati S.A., Chemical And Pharmaceutical Company	Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) *	1992-05-26	1995-12-12	Recordati S.A., Chemical And Pharmaceutical Company	Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
IT1258315B (it) *	1992-04-10	1996-02-22	Recordati Chem Pharm	Derivati del flavone
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6387909B1 (en)	1999-07-30	2002-05-14	Recordati S.A. Chemical And Pharmaceutical Company	Thienopyranecarboxamide derivatives
US6306861B1 (en)	1999-07-30	2001-10-23	Recordati S.A. Chemical And Pharmaceutical Company	Thienopyrancecarboxamide derivatives
ITMI20012060A1 (it) *	2001-10-05	2003-04-05	Recordati Chem Pharm	Nuovi eterocilcli n-acilati
WO2012058133A1 (en) *	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	Isoindolinone pde10 inhibitors
CN115417772B (zh) *	2022-09-26	2024-07-19	无锡双启科技有限公司	一种3-硝基-4-氟苯甲醚的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1264070A (fr) *	1959-05-08	1961-06-19	Knoll Ag	Procédé de préparation de dérivés de la phtalimidine et produits conformes à ceux obtenus
DE1135461B (de) *	1959-05-08	1962-08-30	Knoll Ag	Verfahren zur Herstellung von basisch substituierten Phthalimidinen
US3198798A (en) *	1962-11-02	1965-08-03	Sterling Drug Inc	Phthalimido- and isoindolinyl-alkylpiperazines and their preparation
US3579524A (en) *	1968-06-05	1971-05-18	Miles Lab	2-aminoalkyl derivatives of phthalimidines
SE368009B (da) *	1971-09-16	1974-06-17	Kabi Ab
IL52413A (en) *	1977-06-29	1980-01-31	Teva Pharma	Process for the preparazione of 5-chloro-6-sulfamyl-isoindolinone derivatives
SE7907121L (sv) *	1979-08-27	1981-02-28	Astra Laekemedel Ab	Ftalimidinderivat
US4524206A (en) *	1983-09-12	1985-06-18	Mead Johnson & Company	1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
US4505911A (en) *	1983-10-13	1985-03-19	Mead Johnson & Company	Isoindole diuretic derivatives, compositions and use

1984
- 1984-07-11 US US06/629,649 patent/US4585773A/en not_active Expired - Fee Related
1985
- 1985-06-28 CA CA000485831A patent/CA1255311A/en not_active Expired
- 1985-07-05 ZA ZA855092A patent/ZA855092B/xx unknown
- 1985-07-05 GR GR851678A patent/GR851678B/el unknown
- 1985-07-08 FI FI852694A patent/FI79837C/fi not_active IP Right Cessation
- 1985-07-09 SE SE8503415A patent/SE457449B/sv not_active IP Right Cessation
- 1985-07-09 ES ES545003A patent/ES8705425A1/es not_active Expired
- 1985-07-10 DK DK315085A patent/DK163057C/da not_active IP Right Cessation
- 1985-07-10 LU LU85999A patent/LU85999A1/fr unknown
- 1985-07-10 FR FR858510587A patent/FR2567519B1/fr not_active Expired - Fee Related
- 1985-07-10 AU AU44764/85A patent/AU584104B2/en not_active Ceased
- 1985-07-10 KR KR1019850004919A patent/KR870000355B1/ko not_active IP Right Cessation
- 1985-07-10 NO NO852779A patent/NO163775C/no unknown
- 1985-07-10 HU HU852669A patent/HU195213B/hu not_active IP Right Cessation
- 1985-07-10 IT IT21498/85A patent/IT1187756B/it active
- 1985-07-10 PT PT80794A patent/PT80794B/pt not_active IP Right Cessation
- 1985-07-10 IE IE173485A patent/IE58787B1/en not_active IP Right Cessation
- 1985-07-10 DE DE19853524635 patent/DE3524635A1/de not_active Ceased
- 1985-07-10 GB GB08517418A patent/GB2161807B/en not_active Expired
- 1985-07-10 BE BE0/215319A patent/BE902847A/fr not_active IP Right Cessation
- 1985-07-11 NL NL8501998A patent/NL8501998A/nl not_active Application Discontinuation
- 1985-07-11 JP JP15333385A patent/JPS6136260A/ja active Granted
- 1985-07-11 CH CH3016/85A patent/CH664964A5/de not_active IP Right Cessation
- 1985-07-11 AT AT0206285A patent/AT385270B/de not_active IP Right Cessation
- 1985-12-02 JP JP60271277A patent/JPS61178964A/ja active Pending
1986
- 1986-02-17 ES ES552108A patent/ES8707525A1/es not_active Expired
1987
- 1987-10-09 MY MYPI87002888A patent/MY102973A/en unknown
1991
- 1991-01-14 DK DK006691A patent/DK6691D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATA206285A (de)	1987-08-15
IT1187756B (it)	1987-12-23
DK6691A (da)	1991-01-14
NL8501998A (nl)	1986-02-03
DK163057B (da)	1992-01-13
FI852694A0 (fi)	1985-07-08
GR851678B (da)	1985-11-26
GB2161807B (en)	1987-12-09
NO163775B (no)	1990-04-09
US4585773A (en)	1986-04-29
NO163775C (no)	1990-07-18
AU584104B2 (en)	1989-05-18
KR870000355B1 (ko)	1987-03-05
DE3524635A1 (de)	1986-01-23
FR2567519B1 (fr)	1990-04-13
MY102973A (en)	1993-03-31
ES8707525A1 (es)	1987-08-01
FI79837C (fi)	1990-03-12
BE902847A (fr)	1986-01-10
HU195213B (en)	1988-04-28
GB2161807A (en)	1986-01-22
LU85999A1 (fr)	1986-02-12
CH664964A5 (de)	1988-04-15
DK6691D0 (da)	1991-01-14
FI79837B (fi)	1989-11-30
SE457449B (sv)	1988-12-27
FR2567519A1 (fr)	1986-01-17
FI852694L (fi)	1986-01-12
GB8517418D0 (en)	1985-08-14
SE8503415L (sv)	1986-01-12
AT385270B (de)	1988-03-10
PT80794A (en)	1985-08-01
AU4476485A (en)	1986-01-16
HUT39177A (en)	1986-08-28
IE58787B1 (en)	1993-11-17
ES545003A0 (es)	1987-05-01
IT8521498A0 (it)	1985-07-10
JPS6136260A (ja)	1986-02-20
NO852779L (no)	1986-01-13
DK315085D0 (da)	1985-07-10
JPS61178964A (ja)	1986-08-11
SE8503415D0 (sv)	1985-07-09
JPH0466B2 (da)	1992-01-06
PT80794B (pt)	1987-10-20
DK163057C (da)	1992-06-09
CA1255311A (en)	1989-06-06
ES552108A0 (es)	1987-08-01
ES8705425A1 (es)	1987-05-01
IE851734L (en)	1986-01-11
KR860001098A (ko)	1986-02-22
ZA855092B (en)	1986-02-26

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DK554685A (da)	1986-05-31	Renininhiberende dipeptider og fremgangsmaade til fremstilling deraf
DK493882A (da)	1983-05-08	Faeldningskiselsyre og fremgangsmaade til fremstilling deraf
DK276683A (da)	1983-12-19	Carbapenemer og fremgangsmaade til fremstilling deraf
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NO855026L (no)	1986-06-16	Aminoacyllabdaner og fremgangsmaate til fremstilling derav.
DK335986D0 (da)	1986-07-15	Poly-4-aminopropyl-2-carboxamidoderivat og fremgangsmaade til fremstilling deraf
DK315085A (da)	1986-01-12	Isoinsolinyl-alkyl-piperaziner og fremgangsmaade til fremstilling deraf
DK375085A (da)	1986-04-12	Quinolon-carboxylsyre-derivater og fremgangsmaade til fremstilling deraf
DK621484A (da)	1985-06-24	Acylaminomitosaner og fremgangsmaade til fremstilling deraf
DK313785D0 (da)	1985-07-09	Dihydroorotsyrederivat og fremgangsmaade til fremstilling deraf
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DK362987A (da)	1988-01-15	Hexahydroarylquinolizin og fremgangsmaade til fremstilling deraf
DK343183D0 (da)	1983-07-27	Ketoquinoliner og fremgangsmade til fremstilling deraf
DK286285A (da)	1985-12-27	Laktaseholdigt praeparat og fremgangsmaade til fremstilling deraf
DK467984D0 (da)	1984-09-28	4-alkylmethylendioxy-2-1(h)-quinazolinoner og fremgangsmaade til fremstilling deraf
DK81192A (da)	1992-06-18	Substituerede ethandiimidamider og fremgangsmaade til fremstilling deraf
DK446685A (da)	1986-04-03	Carbapenemderivater og fremgangsmaade til fremstilling deraf
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DK112682A (da)	1982-09-17	Azaspiroalkandioner og fremgangsmaade til fremstilling deraf
DK552284D0 (da)	1984-11-21	2-chlor-3-trifluormethylbenzaldehyd og fremgangsmaade til fremstilling deraf
DK284184D0 (da)	1984-06-08	1-phenoxy-3-hydroxyindolylalkylamino-3-propanoler og fremgangsmaade til fremstilling deraf
DK301785D0 (da)	1985-07-02	Tert-butyl-gamma-dimethylamino-beta-hydroxybutyrat og fremgangsmaadetil fremstilling deraf
DK50686A (da)	1986-08-05	Difficolforbindelse og fremgangsmaade til fremstilling deraf
DK150007C (da)	1987-05-25	Doermaatte og fremgangsmaade til fremstilling heraf
DK319188A (da)	1989-02-03	Glycerolacetalaminoacylat og fremgangsmaade til fremstilling deraf

Legal Events

Date	Code	Title	Description
1995-04-03	PBP	Patent lapsed