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DK3126361T3 - Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer - Google Patents

Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer Download PDF

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Publication number
DK3126361T3
DK3126361T3 DK15714951.9T DK15714951T DK3126361T3 DK 3126361 T3 DK3126361 T3 DK 3126361T3 DK 15714951 T DK15714951 T DK 15714951T DK 3126361 T3 DK3126361 T3 DK 3126361T3
Authority
DK
Denmark
Prior art keywords
chromen
dions
tetrahydrocyclopropa
pyridopyrazine
gamma secretase
Prior art date
Application number
DK15714951.9T
Other languages
English (en)
Inventor
Ende Christopher William Am
John Michael Humphrey
Douglas Scott Johnson
Gregory Wayne Kauffman
Martin Youngjin Pettersson
Danica Antonia Rankic
Antonia Friederike Stepan
Patrick Robert Verhoest
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52815058&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3126361(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK3126361T3 publication Critical patent/DK3126361T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK15714951.9T 2014-04-01 2015-03-18 Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer DK3126361T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461973436P 2014-04-01 2014-04-01
PCT/IB2015/051988 WO2015150957A1 (en) 2014-04-01 2015-03-18 Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators

Publications (1)

Publication Number Publication Date
DK3126361T3 true DK3126361T3 (da) 2020-01-02

Family

ID=52815058

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15714951.9T DK3126361T3 (da) 2014-04-01 2015-03-18 Chromen og 1,1a,2,7b-tetrahydrocyclopropa[c]chromen- pyridopyrazindioner som gamma-sekretase-modulatorer

Country Status (30)

Country Link
US (2) US20150274721A1 (da)
EP (1) EP3126361B1 (da)
JP (1) JP6643247B2 (da)
KR (1) KR101886945B1 (da)
CN (1) CN106211770B (da)
AP (1) AP2016009465A0 (da)
AR (1) AR099874A1 (da)
AU (1) AU2015242330B2 (da)
BR (1) BR112016022519A8 (da)
CA (1) CA2944308A1 (da)
CL (1) CL2016002422A1 (da)
CR (1) CR20160454A (da)
CU (1) CU20160140A7 (da)
DK (1) DK3126361T3 (da)
DO (1) DOP2016000266A (da)
EA (1) EA031419B1 (da)
EC (1) ECSP16078289A (da)
ES (1) ES2759277T3 (da)
HK (1) HK1231481A1 (da)
IL (1) IL248154B (da)
MD (1) MD20160102A2 (da)
MX (1) MX369074B (da)
NI (1) NI201600149A (da)
PE (1) PE20161364A1 (da)
PH (1) PH12016501864A1 (da)
SG (1) SG11201607465UA (da)
TW (1) TWI568733B (da)
UY (1) UY36054A (da)
WO (1) WO2015150957A1 (da)
ZA (1) ZA201606252B (da)

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CN110907542A (zh) * 2018-09-17 2020-03-24 复旦大学 一种液质联用检测唾液中司来吉兰及其代谢物的方法
TW202100526A (zh) 2019-03-06 2021-01-01 日商第一三共股份有限公司 吡咯并吡唑衍生物
AU2020353055B2 (en) 2019-09-26 2024-03-07 Gilead Sciences, Inc. Antiviral pyrazolopyridinone compounds
WO2024084363A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Use of patatin-like phospholipase domain-containing protein 3 compounds
WO2024084360A1 (en) 2022-10-18 2024-04-25 Pfizer Inc. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers

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Also Published As

Publication number Publication date
CL2016002422A1 (es) 2017-02-03
US20170166566A1 (en) 2017-06-15
PH12016501864A1 (en) 2016-12-19
WO2015150957A1 (en) 2015-10-08
AU2015242330B2 (en) 2017-08-17
AU2015242330A1 (en) 2016-09-22
US20150274721A1 (en) 2015-10-01
PE20161364A1 (es) 2016-12-25
EP3126361B1 (en) 2019-11-06
IL248154A0 (en) 2016-11-30
BR112016022519A8 (pt) 2018-03-06
MX369074B (es) 2019-10-28
EA031419B1 (ru) 2018-12-28
TWI568733B (zh) 2017-02-01
JP2017512803A (ja) 2017-05-25
TW201540716A (zh) 2015-11-01
JP6643247B2 (ja) 2020-02-12
AR099874A1 (es) 2016-08-24
CU20160140A7 (es) 2017-02-02
ECSP16078289A (es) 2017-02-24
AP2016009465A0 (en) 2016-09-30
MD20160102A2 (ro) 2017-04-30
HK1231481A1 (zh) 2017-12-22
BR112016022519A2 (pt) 2017-08-15
CA2944308A1 (en) 2015-10-08
ZA201606252B (en) 2018-05-30
CN106211770A (zh) 2016-12-07
CN106211770B (zh) 2018-02-06
NI201600149A (es) 2016-11-18
DOP2016000266A (es) 2016-11-15
EP3126361A1 (en) 2017-02-08
KR20160137635A (ko) 2016-11-30
KR101886945B1 (ko) 2018-08-08
CR20160454A (es) 2016-12-06
IL248154B (en) 2020-09-30
EA201600619A1 (ru) 2017-03-31
ES2759277T3 (es) 2020-05-08
SG11201607465UA (en) 2016-10-28
UY36054A (es) 2015-10-30
MX2016012904A (es) 2016-12-07

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