DK3115372T3 - Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf - Google Patents

Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf Download PDF

Info

Publication number: DK3115372T3
Authority: DK; Denmark
Prior art keywords: enzymfusion; proteins; targeted therapeutic; therapeutic lysosomal; lysosomal
Prior art date: 2012-11-27

Application number

DK16182420.6T

Other languages

English (en)

Inventor

Mika Aoyagi-Scharber

Teresa Margaret Christianson

Melita Dvorak-Ewell

Daniel Wendt

Shinong Long

Jonathan Lebowitz

Daniel Solomon Gold

Original Assignee

Biomarin Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-11-27

Filing date

2013-11-27

Publication date

2019-06-11

2013-11-27 Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc

2019-06-11 Application granted granted Critical

2019-06-11 Publication of DK3115372T3 publication Critical patent/DK3115372T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/06—Fusion polypeptide containing a localisation/targetting motif containing a lysosomal/endosomal localisation signal

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Toxicology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)

DK16182420.6T 2012-11-27 2013-11-27 Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf DK3115372T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261730378P	2012-11-27	2012-11-27
US201361788968P	2013-03-15	2013-03-15
EP13802834.5A EP2925776B1 (en)	2012-11-27	2013-11-27	Targeted therapeutic lysosomal enzyme fusion proteins and uses thereof

Publications (1)

Publication Number	Publication Date
DK3115372T3 true DK3115372T3 (da)	2019-06-11

Family

ID=49753532

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK13802834.5T DK2925776T3 (da)	2012-11-27	2013-11-27	Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf
DK16182420.6T DK3115372T3 (da)	2012-11-27	2013-11-27	Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK13802834.5T DK2925776T3 (da)	2012-11-27	2013-11-27	Målrettede terapeutiske lysosomale enzymfusionsproteiner og anvendelser deraf

Country Status (27)

Country	Link
US (8)	US9376480B2 (da)
EP (2)	EP2925776B1 (da)
JP (2)	JP6831176B2 (da)
KR (4)	KR102262882B1 (da)
CN (1)	CN104822701B (da)
AR (1)	AR093626A1 (da)
AU (1)	AU2013352184B2 (da)
BR (1)	BR112015012152B1 (da)
CA (1)	CA2892146A1 (da)
CL (1)	CL2015001371A1 (da)
CY (1)	CY1122555T1 (da)
DK (2)	DK2925776T3 (da)
ES (2)	ES2679374T3 (da)
HK (1)	HK1216026A1 (da)
HR (2)	HRP20181351T1 (da)
HU (2)	HUE043679T2 (da)
IL (3)	IL238824B (da)
LT (1)	LT3115372T (da)
MX (2)	MX367024B (da)
PL (2)	PL2925776T3 (da)
PT (2)	PT2925776T (da)
RS (1)	RS58916B1 (da)
RU (1)	RU2680581C2 (da)
SI (1)	SI3115372T1 (da)
TW (2)	TWI626250B (da)
WO (1)	WO2014085621A1 (da)
ZA (1)	ZA201503509B (da)

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CL2016003282A1 (es)	2016-12-21	2017-08-18	Univ Chile	Virus aav/igf2, método de tratamiento genético y su uso en enfermedades relacionadas con mal plegamiento de proteínas tal como la enfermedad de huntington
KR102760654B1 (ko)	2017-06-07	2025-02-04	리제너론 파마슈티칼스 인코포레이티드	효소 내재화를 위한 조성물 및 방법
AU2018335752A1 (en)	2017-09-22	2020-03-12	Christian HINDERER	Gene therapy for treating Mucopolysaccharidosis type ii
MA50746A (fr)	2017-10-02	2020-08-12	Denali Therapeutics Inc	Protéines de fusion comprenant des enzymes d'enzymothérapie substitutive
MA51796A (fr)	2018-02-07	2020-12-16	Regeneron Pharma	Procédés et compositions pour l'administration de protéines thérapeutiques
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JP2021526026A (ja)	2018-06-08	2021-09-30	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	翻訳後修飾が低減したペプチドリンカー
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WO2021183895A1 (en)	2020-03-13	2021-09-16	Biomarin Pharmaceutical Inc.	Treatment of fabry disease with aav gene therapy vectors
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WO2024159071A1 (en) *	2023-01-27	2024-08-02	Regeneron Pharmaceuticals, Inc.	Modified rhabdovirus glycoproteins and uses thereof

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2013
- 2013-11-27 ES ES13802834.5T patent/ES2679374T3/es active Active
- 2013-11-27 PL PL13802834T patent/PL2925776T3/pl unknown
- 2013-11-27 KR KR1020157017224A patent/KR102262882B1/ko active Active
- 2013-11-27 TW TW102143329A patent/TWI626250B/zh active
- 2013-11-27 SI SI201331450T patent/SI3115372T1/sl unknown
- 2013-11-27 EP EP13802834.5A patent/EP2925776B1/en active Active
- 2013-11-27 KR KR1020237012007A patent/KR20230054482A/ko not_active Ceased
- 2013-11-27 DK DK13802834.5T patent/DK2925776T3/da active
- 2013-11-27 JP JP2015544209A patent/JP6831176B2/ja active Active
- 2013-11-27 AR ARP130104367A patent/AR093626A1/es active IP Right Grant
- 2013-11-27 HU HUE16182420A patent/HUE043679T2/hu unknown
- 2013-11-27 MX MX2015006644A patent/MX367024B/es active IP Right Grant
- 2013-11-27 HU HUE13802834A patent/HUE039334T2/hu unknown
- 2013-11-27 WO PCT/US2013/072287 patent/WO2014085621A1/en active Application Filing
- 2013-11-27 AU AU2013352184A patent/AU2013352184B2/en active Active
- 2013-11-27 CN CN201380061935.4A patent/CN104822701B/zh active Active
- 2013-11-27 ES ES16182420T patent/ES2729997T3/es active Active
- 2013-11-27 DK DK16182420.6T patent/DK3115372T3/da active
- 2013-11-27 LT LTEP16182420.6T patent/LT3115372T/lt unknown
- 2013-11-27 US US14/092,336 patent/US9376480B2/en active Active
- 2013-11-27 PT PT138028345T patent/PT2925776T/pt unknown
- 2013-11-27 PL PL16182420T patent/PL3115372T3/pl unknown
- 2013-11-27 RU RU2015125491A patent/RU2680581C2/ru active
- 2013-11-27 CA CA2892146A patent/CA2892146A1/en active Pending
- 2013-11-27 EP EP16182420.6A patent/EP3115372B1/en active Active
- 2013-11-27 BR BR112015012152-7A patent/BR112015012152B1/pt active IP Right Grant
- 2013-11-27 MX MX2019009191A patent/MX377150B/es active IP Right Grant
- 2013-11-27 KR KR1020217017007A patent/KR102385392B1/ko active Active
- 2013-11-27 PT PT16182420T patent/PT3115372T/pt unknown
- 2013-11-27 KR KR1020227011416A patent/KR102521039B1/ko active Active
- 2013-11-27 TW TW107114660A patent/TWI711632B/zh active
- 2013-11-27 RS RS20190585A patent/RS58916B1/sr unknown
2015
- 2015-05-14 IL IL238824A patent/IL238824B/en active IP Right Grant
- 2015-05-19 ZA ZA2015/03509A patent/ZA201503509B/en unknown
- 2015-05-20 CL CL2015001371A patent/CL2015001371A1/es unknown
- 2015-10-14 US US14/883,203 patent/US9834588B2/en active Active
- 2015-10-14 US US14/883,211 patent/US9771408B2/en active Active
- 2015-10-14 US US14/883,193 patent/US9834587B2/en active Active
- 2015-10-14 US US14/883,169 patent/US9845346B2/en active Active
2016
- 2016-04-06 HK HK16103915.8A patent/HK1216026A1/zh unknown
2017
- 2017-08-28 US US15/688,438 patent/US10301369B2/en active Active
2018
- 2018-08-23 HR HRP20181351TT patent/HRP20181351T1/hr unknown
- 2018-11-13 IL IL262976A patent/IL262976B/en active IP Right Grant
2019
- 2019-04-08 US US16/378,163 patent/US11254725B2/en active Active
- 2019-05-17 HR HRP20190918TT patent/HRP20190918T1/hr unknown
- 2019-06-06 CY CY20191100600T patent/CY1122555T1/el unknown
- 2019-07-24 JP JP2019136013A patent/JP6913719B2/ja active Active
2020
- 2020-02-23 IL IL272854A patent/IL272854B/en unknown
2022
- 2022-01-10 US US17/572,018 patent/US20220127326A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2680581C2 (ru)	2019-02-22
KR20150088317A (ko)	2015-07-31
PL3115372T3 (pl)	2019-09-30
EP2925776B1 (en)	2018-05-30
US20140161788A1 (en)	2014-06-12
CN104822701A (zh)	2015-08-05
AR093626A1 (es)	2015-06-17
US20160031965A1 (en)	2016-02-04
JP2019206556A (ja)	2019-12-05
CL2015001371A1 (es)	2015-10-09
US9376480B2 (en)	2016-06-28
JP6831176B2 (ja)	2021-02-17
TWI711632B (zh)	2020-12-01
US20160039900A1 (en)	2016-02-11
ES2679374T3 (es)	2018-08-24
MX367024B (es)	2019-08-02
HUE039334T2 (hu)	2018-12-28
TWI626250B (zh)	2018-06-11
HUE043679T2 (hu)	2019-09-30
HRP20190918T1 (hr)	2019-09-20
IL262976B (en)	2020-02-27
TW201431884A (zh)	2014-08-16
AU2013352184A1 (en)	2015-06-04
IL238824A0 (en)	2015-06-30
KR102521039B1 (ko)	2023-04-12
MX377150B (es)	2025-03-07
RU2015125491A (ru)	2017-01-10
US10301369B2 (en)	2019-05-28
KR20210070389A (ko)	2021-06-14
KR20220047892A (ko)	2022-04-19
US9834588B2 (en)	2017-12-05
EP3115372A1 (en)	2017-01-11
HRP20181351T1 (hr)	2018-11-02
PT2925776T (pt)	2018-07-30
PT3115372T (pt)	2019-06-12
DK2925776T3 (da)	2018-09-03
SI3115372T1 (sl)	2019-08-30
IL272854B (en)	2021-07-29
US11254725B2 (en)	2022-02-22
US20220127326A1 (en)	2022-04-28
US20160031964A1 (en)	2016-02-04
LT3115372T (lt)	2019-06-25
AU2013352184B2 (en)	2018-05-31
ES2729997T3 (es)	2019-11-07
IL262976A (en)	2018-12-31
WO2014085621A1 (en)	2014-06-05
JP6913719B2 (ja)	2021-08-04
BR112015012152A2 (pt)	2017-08-15
BR112015012152B1 (pt)	2023-04-25
US20170355744A1 (en)	2017-12-14
EP3115372B1 (en)	2019-03-06
US9834587B2 (en)	2017-12-05
CY1122555T1 (el)	2021-01-27
ZA201503509B (en)	2016-11-30
IL238824B (en)	2018-11-29
RS58916B1 (sr)	2019-08-30
CN104822701B (zh)	2018-09-21
US9845346B2 (en)	2017-12-19
KR102385392B1 (ko)	2022-04-11
US9771408B2 (en)	2017-09-26
HK1216026A1 (zh)	2016-10-07
EP2925776A1 (en)	2015-10-07
CA2892146A1 (en)	2014-06-05
JP2016505539A (ja)	2016-02-25
KR102262882B1 (ko)	2021-06-10
US20190225666A1 (en)	2019-07-25
KR20230054482A (ko)	2023-04-24
US20160031963A1 (en)	2016-02-04
PL2925776T3 (pl)	2018-11-30
TW201827468A (zh)	2018-08-01
IL272854A (en)	2020-04-30
MX2015006644A (es)	2015-08-10
MX2019009191A (es)	2019-10-09

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