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DK2545939T3 - Tetrahydrobiopterin til behandling af tilstande associeret med forhøjede phenylalaninniveauer - Google Patents

Tetrahydrobiopterin til behandling af tilstande associeret med forhøjede phenylalaninniveauer Download PDF

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Publication number
DK2545939T3
DK2545939T3 DK12005352.5T DK12005352T DK2545939T3 DK 2545939 T3 DK2545939 T3 DK 2545939T3 DK 12005352 T DK12005352 T DK 12005352T DK 2545939 T3 DK2545939 T3 DK 2545939T3
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DK
Denmark
Prior art keywords
tetrahydrobiopterin
treatment
conditions associated
phenylalanine levels
elevated phenylalanine
Prior art date
Application number
DK12005352.5T
Other languages
English (en)
Inventor
Daniel I Oppenheimer
Alejandro Dorenbaum
Augustus Okhamafe
Erik Foehr
Paul John Kostel
Sianna Castillo
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39620159&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2545939(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Application granted granted Critical
Publication of DK2545939T3 publication Critical patent/DK2545939T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
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    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
DK12005352.5T 2007-04-11 2008-04-11 Tetrahydrobiopterin til behandling af tilstande associeret med forhøjede phenylalaninniveauer DK2545939T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92282107P 2007-04-11 2007-04-11
US1975308P 2008-01-08 2008-01-08
EP08745614A EP2139485B1 (en) 2007-04-11 2008-04-11 Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring

Publications (1)

Publication Number Publication Date
DK2545939T3 true DK2545939T3 (da) 2021-02-15

Family

ID=39620159

Family Applications (3)

Application Number Title Priority Date Filing Date
DK08745614.1T DK2139485T3 (da) 2007-04-11 2008-04-11 Fremgangsmåder til admistration af tetrahydrobiopterin, associerede sammensætninger, og fremgangsmåder til måling
DK12005352.5T DK2545939T3 (da) 2007-04-11 2008-04-11 Tetrahydrobiopterin til behandling af tilstande associeret med forhøjede phenylalaninniveauer
DK18205446.0T DK3461503T3 (da) 2007-04-11 2008-04-11 Fremgangsmåder til indgivelse af tetrahydrobiopterin, associerede sammensætninger og målingsfremgangsmåder

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08745614.1T DK2139485T3 (da) 2007-04-11 2008-04-11 Fremgangsmåder til admistration af tetrahydrobiopterin, associerede sammensætninger, og fremgangsmåder til måling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK18205446.0T DK3461503T3 (da) 2007-04-11 2008-04-11 Fremgangsmåder til indgivelse af tetrahydrobiopterin, associerede sammensætninger og målingsfremgangsmåder

Country Status (23)

Country Link
US (6) US7612073B2 (da)
EP (4) EP2139485B1 (da)
JP (2) JP2010523708A (da)
KR (5) KR20100016445A (da)
CN (1) CN101678025A (da)
AU (1) AU2008240259C1 (da)
BR (1) BRPI0809470A2 (da)
CA (1) CA2682598C (da)
CY (3) CY1113543T1 (da)
DE (1) DE22154751T1 (da)
DK (3) DK2139485T3 (da)
ES (3) ES2906582T3 (da)
HK (1) HK1139864A1 (da)
HR (3) HRP20220188T3 (da)
HU (2) HUE053107T2 (da)
IL (1) IL201101A (da)
LT (2) LT2545939T (da)
MX (1) MX2009010977A (da)
PL (3) PL2545939T3 (da)
PT (3) PT2545939T (da)
RU (1) RU2486899C2 (da)
SI (2) SI3461503T1 (da)
WO (1) WO2008128049A2 (da)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06005451A (es) 2003-11-17 2007-01-26 Biomarin Pharm Inc Metodos y composiciones para el tratamiento de trastornos metabolicos.
CN101678025A (zh) 2007-04-11 2010-03-24 生物马林药物股份有限公司 四氢生物蝶呤组合物及其测量方法
JP2011530540A (ja) * 2008-08-12 2011-12-22 オルファ スイス ゲーエムベーハー テトラヒドロビオプテリンを含有する医薬剤形
WO2011011092A1 (en) 2009-07-22 2011-01-27 University Of Massachusetts Methods and compositions to reduce oxidative stress
EP2562176B1 (en) 2010-04-22 2018-08-15 Nihon University Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same
TWI618536B (zh) * 2010-12-03 2018-03-21 歐瑞根治療有限公司 於納曲酮療法中增加藥物生物可利用性
CN103458900A (zh) * 2011-03-01 2013-12-18 鲁必康研究私人有限公司 四氢生物蝶呤的稳定组合物
CA2852114A1 (en) * 2011-10-24 2013-05-02 Kickass Candy, Llc Sweet tart energy tablet
US9216178B2 (en) * 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CA2862076C (en) 2012-01-23 2020-04-21 Sage Therapeutics, Inc. Neuroactive steroid formulations and methods of treating cns disorders
US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
WO2013112949A2 (en) 2012-01-26 2013-08-01 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CN102650621B (zh) * 2012-05-02 2014-06-25 安徽农业大学 一种从蚕体提取的墨蝶呤的鉴定方法
IL275725B (en) 2012-08-21 2022-08-01 Sage Therapeutics Inc Methods of treating epilepsy or status epilepticus
WO2014124396A1 (en) * 2013-02-08 2014-08-14 University Of Iowa Research Foundation Therapeutic strategies for the treatment of preeclampsia
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US20150204834A1 (en) * 2014-01-22 2015-07-23 Sarfaraz K. Niazi Thermodynamic equivalence surrogate test (test) for bioequivalence
EP2926805B1 (en) * 2014-03-31 2016-05-18 Vasopharm GmbH Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
MA41124A (fr) * 2014-12-05 2017-10-10 Sun Pharmaceutical Ind Ltd Compositions en suspension à libération prolongée à rétention gastrique
JP6996713B2 (ja) 2015-10-06 2022-02-04 エイチエルビー・セラピューティクス・カンパニー・リミテッド チモシンベータ４を含む眼科用製剤の製造方法
TWI798173B (zh) 2016-03-08 2023-04-11 美商賽吉醫療公司 神經活性類固醇，其組合物及用途
MA46972A (fr) * 2016-11-29 2019-10-09 Censa Pharmaceuticals Inc Forme polymorphe de sépiaptérine
MA46973A (fr) * 2016-11-29 2019-10-09 Censa Pharmaceuticals Inc Polymorphes de sépiaptérine et leurs sels
CN108627576A (zh) * 2017-03-17 2018-10-09 武汉宏韧生物医药科技有限公司 一种人血浆中他达拉非的定量分析方法
EP3634528B1 (en) 2017-06-07 2023-06-07 Shifamed Holdings, LLC Intravascular fluid movement devices, systems, and methods of use
WO2019008144A1 (en) * 2017-07-06 2019-01-10 Treeway Tw001 B.V. USE OF EDARAVONE IN THE ORAL TREATMENT OF NEURODEGENERATIVE DISORDERS INDUCED BY OXIDATIVE STRESS
CA3079245A1 (en) * 2017-07-13 2019-03-21 Tab Protein, Llc Supplement tablet and packaging
WO2019046849A1 (en) * 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
CN111556763B (zh) 2017-11-13 2023-09-01 施菲姆德控股有限责任公司 血管内流体运动装置、系统
CN110461332A (zh) * 2017-11-20 2019-11-15 麦迪贝肯有限公司 制备和分析血浆中的荧光化合物的方法
CN109946412B (zh) * 2017-12-21 2021-10-15 上海产业技术研究院 一种体液蝶呤谱检测试剂盒及其使用
JP7410034B2 (ja) 2018-02-01 2024-01-09 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに使用および製造の方法
CN110269099B (zh) * 2018-03-16 2023-01-31 共生地球生物科技有限公司 多重pH缓冲配方与蛋白质消化助剂的组合物及其用途
WO2019024509A1 (zh) * 2018-03-16 2019-02-07 共生地球生物科技有限公司 多重pH缓冲配方与蛋白质消化助剂的组合物及其用途
MX2020012980A (es) 2018-05-30 2021-04-29 Ptc Therapeutics Mp Inc Composiciones y métodos para incrementar la exposición plasmática de tetrahidrobiopterina.
MX2020012978A (es) * 2018-05-30 2021-04-28 Ptc Therapeutics Mp Inc Sales de sepiapterina farmacéuticamente aceptables.
AU2019277382B2 (en) * 2018-05-30 2025-01-09 Ptc Therapeutics Mp, Inc. Methods for increasing sepiapterin plasma exposure
CN108813410B (zh) * 2018-07-06 2021-12-14 浙江工商大学 一种降低发酵香肠中生物胺的方法及其应用
WO2020028537A1 (en) 2018-07-31 2020-02-06 Shifamed Holdings, Llc Intravascaular blood pumps and methods of use
WO2020073047A1 (en) 2018-10-05 2020-04-09 Shifamed Holdings, Llc Intravascular blood pumps and methods of use
JP7553906B2 (ja) * 2018-11-01 2024-09-19 宏 一瀬 Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
CN110174363A (zh) * 2019-01-09 2019-08-27 北京九强生物技术股份有限公司 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途
US20200276200A1 (en) * 2019-02-28 2020-09-03 Clark Gerald Sullivan Treatment of cns and developmental disorders using high-dose 5-formyl-(6s)-tetrahydrofolate
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US20220249455A1 (en) * 2019-07-15 2022-08-11 R.P. Scherer Technologies, Llc Enteric proton pump inhibitor softgel capsule
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
TR201914416A1 (tr) * 2019-09-23 2021-04-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Sapropteri̇n di̇hi̇droklorürün efervesan formülasyonlari
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
WO2021062270A1 (en) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
US12121713B2 (en) 2019-09-25 2024-10-22 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
CN111505179B (zh) * 2020-04-07 2021-07-13 厦门大学 海洋水体中生物蝶呤的检测方法
CN112057423A (zh) * 2020-10-21 2020-12-11 兆科药业（广州）有限公司 一种含有盐酸沙丙蝶呤的颗粒剂药物及其制备方法
CN112697919B (zh) * 2020-12-22 2023-02-28 北京和合医学诊断技术股份有限公司 度洛西汀的检测方法
WO2022204517A1 (en) * 2021-03-26 2022-09-29 Emory University Managing the acute and long-term effects of coronaviral infections and compositions related thereto
US11944586B2 (en) * 2021-05-25 2024-04-02 Baxter International Inc. Containers with selective dissolved gas content
CN113607870B (zh) * 2021-07-22 2024-06-21 中国食品药品检定研究院 一种头孢羟氨苄原料药及其制剂中聚合物杂质的检测方法
CN114814036B (zh) * 2022-05-09 2024-02-20 上海谱锐赛思生物技术有限公司 血浆中阿齐沙坦和氨氯地平浓度的测定方法
WO2024084421A1 (en) * 2022-10-18 2024-04-25 Qrgenetics Ltd. Treatment of vascular diseases associated with genetic variations in acta2
WO2025038846A1 (en) * 2023-08-15 2025-02-20 Emory University L-arginine formulations and methods of managing pain

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6021A (en) * 1849-01-09 Cast-iron cab-wheel
US6019A (en) * 1849-01-09 Cast-iron car-wheel
US2601215A (en) 1948-03-17 1952-06-17 American Cyanamid Co Process of preparing dihydropterins
US3505329A (en) 1968-02-06 1970-04-07 Smithkline Corp Process for the synthesis of biopterin
JPS5883691A (ja) 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS5925323A (ja) 1982-03-03 1984-02-09 鐘淵化学工業株式会社 プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤
JPS5921685A (ja) 1982-07-28 1984-02-03 Suntory Ltd Ｌ―エリスロ―バイオプテリンの製造法
JPS5976086A (ja) 1982-09-20 1984-04-28 ザ　ウエルカム　フアウンデ−シヨン　リミテツド プテリジン化合物
GB8318833D0 (en) 1983-07-12 1983-08-10 Wellcome Found Chemical compounds
US5196533A (en) 1983-04-11 1993-03-23 South Alabama Medical Science Foundation, Usa Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines
US4587340A (en) 1983-09-19 1986-05-06 Burroughs Wellcome Co. Biopterin analogs
JPS60178887A (ja) 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
US4550109A (en) 1984-05-31 1985-10-29 The Board Of Regents, The University Of Texas System Lipoidal biopterin compounds
DE3437944A1 (de) 1984-10-17 1986-07-31 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verwendung von pterinen zur steigerung der aktivitaet von lymphokinen und anderen blutfaktoren, sowie ein diagnostisches oder therapeutisches praeparat, das pterine in kombination mit lymphokinen enthaelt
US4713454A (en) 1985-01-28 1987-12-15 Shiratori Pharmaceutical Co., Ltd. Preparation process of (6R)-tetrahydro-L-biopterin
JPS61277618A (ja) 1985-06-04 1986-12-08 Suntory Ltd 自閉症治療剤
JPS621688A (ja) * 1985-06-28 1987-01-07 Nippon Kokan Kk <Nkk> ばら積船
AU598205B2 (en) * 1985-08-22 1990-06-21 Gropep Pty Ltd Peptide analogues of mammalian insulin-like growth factor-1
US4937342A (en) 1987-11-30 1990-06-26 Kabushiki Kaisha Vitamin Kenkyusyo Intermediates for synthesizing BH4 and its derivatives
JP3137333B2 (ja) 1990-07-21 2001-02-19 サントリー株式会社 テトラヒドロビオプテリンの製法およびそれに用いる酵素
JP2534423B2 (ja) 1991-12-26 1996-09-18 コーネル・リサーチ・ファンデーション・インコーポレイテッド 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤
US5198547A (en) 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
DE4308739C1 (de) 1993-03-19 1994-06-23 Henning Berlin Gmbh Pterinderivate, ihre Herstellung und ihre Verwendung
US5945452A (en) 1993-06-11 1999-08-31 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity
US5502050A (en) 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
DE69526918T2 (de) 1994-08-05 2002-12-19 Suntory Ltd., Osaka Arzneimittel gegen spinocerebellare degeneration
JP2711828B2 (ja) 1996-06-25 1998-02-10 白鳥製薬株式会社 （６ｒ）−テトラヒドローｌ−バイオプテリン塩酸塩の製造法
US20020076782A1 (en) 1996-07-05 2002-06-20 John P.N. Rosazza Purified nitric oxide synthase
GB9617990D0 (en) 1996-08-29 1996-10-09 Scotia Holdings Plc Treatment of pain
CH693255A5 (de) 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
US5922713A (en) 1997-06-26 1999-07-13 Werner; Ernst Inhibition of nitric oxide synthase
US6723560B2 (en) * 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
JP4306825B2 (ja) 1998-02-27 2009-08-05 アスビオファーマ株式会社 インスリン抵抗性が関与する血管機能異常を伴う疾患の予防または治療剤
ATE295172T1 (de) 1998-02-27 2005-05-15 Daiichi Suntory Pharma Co Ltd Propylaxe und behandlung der arzneimittel induzierten nierenstörungen
US6200758B1 (en) 1999-02-19 2001-03-13 New York State Office Of Mental Health Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders
JP2002539257A (ja) 1999-03-19 2002-11-19 イーノス・ファーマシューティカルス・インコーポレーテッド 薬剤の脳内生物学的利用率の増加
GB2355191A (en) 1999-10-12 2001-04-18 Laxdale Ltd Combination formulations for fatigue, head injury and strokes
US6544994B2 (en) 2000-06-07 2003-04-08 Eprov Ag Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase
US20040014167A1 (en) * 2000-08-31 2004-01-22 Masayuki Yabuta Process for producing biopterin
RU2180233C1 (ru) * 2001-06-26 2002-03-10 Общество с ограниченной ответственностью "Протеиновый контур" Способ получения жидких лекарственных форм рекомбинантных белков
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
DE10260263A1 (de) * 2002-12-20 2004-07-15 Biocrates Life Sciences Gmbh Verwendung von Tetrahydrobiopterinderivaten zur Behandlung und Ernährung von Patienten mit Aminosäurestoffwechselstörungen
CA2546482A1 (en) * 2003-09-01 2005-03-10 F H Faulding & Co Limited Compositions and methods for delivery of biologically active agents
ES2755334T3 (es) 2003-11-17 2020-04-22 Merck & Cie Proceso para la preparación de formas cristalinas B de clorhidrato de (6R)-L-eritro-tetrahidrobiopterina a partir de otras formas cristalinas
AU2004290692A1 (en) 2003-11-17 2005-06-02 Biomarin Pharmaceutical Inc. Processes for preparing tetrahydrobiopterin, and analogs of tetrahydrobiopterin
MXPA06005451A (es) 2003-11-17 2007-01-26 Biomarin Pharm Inc Metodos y composiciones para el tratamiento de trastornos metabolicos.
AU2005239939C1 (en) 2004-05-11 2011-06-30 Daiichi Sankyo Company Limited BH4-responsive hyperphenylalaninemia remedies
EP1768653A4 (en) 2004-06-25 2012-08-01 Univ Texas METHOD AND COMPOSITIONS FOR TREATING ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY AND HYPERPHENYL ALANINEMIA
JP2008513027A (ja) 2004-09-17 2008-05-01 バイオマリン ファーマシューティカル インコーポレイテッド フェニルアラニンアンモニアーリアーゼの改変体および化学的に修飾された改変体
MX2007005039A (es) 2004-11-17 2007-06-19 Biomarin Pharm Inc Formulacion de tableta estable.
US20060194808A1 (en) * 2005-01-14 2006-08-31 Chronorx Llc, An Alaska Limited Liability Company Clinical applications of tetrahydrobiopterin, lipoic acid and their salts and methods of preparing tetrahydrobiopterin bis-lipoate
JPWO2007072911A1 (ja) 2005-12-22 2009-06-04 アスビオファーマ株式会社 塩酸サプロプテリンの生体内吸収性を向上させた製剤
US20080075666A1 (en) 2006-08-25 2008-03-27 Dudley Samuel C Jr Methods and compositions for treating diastolic dysfunction
ES2732293T3 (es) 2007-02-22 2019-11-21 Childrens Hospital & Res Center At Oakland Formulaciones de ácidos grasos y métodos para el uso de las mismas
CN101678025A (zh) 2007-04-11 2010-03-24 生物马林药物股份有限公司 四氢生物蝶呤组合物及其测量方法

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