DK2426106T3 - Piperidin- og piperazinderivat til behandling af tumorer - Google Patents

Piperidin- og piperazinderivat til behandling af tumorer

Info

Publication number: DK2426106T3
Authority: DK; Denmark
Prior art keywords: piperidine; tumors; treatment; piperazine derivatives; piperazine
Prior art date: 2007-10-05

Application number

DK11007349.1T

Other languages

English (en)

Inventor

Kai Schiemann

Melanie Schultz

Andree Blaukat

Ingo Kober

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-05

Filing date

2008-09-19

Publication date

2013-11-04

2008-09-19 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2013-11-04 Application granted granted Critical

2013-11-04 Publication of DK2426106T3 publication Critical patent/DK2426106T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Indole Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK11007349.1T 2007-10-05 2008-09-19 Piperidin- og piperazinderivat til behandling af tumorer DK2426106T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007047737A DE102007047737A1 (de)	2007-10-05	2007-10-05	Piperidin- und Piperazinderivate
EP08802402A EP2193118B1 (de)	2007-10-05	2008-09-19	Piperidin- und piperazinderivate zur behandlung von tumoren

Publications (1)

Publication Number	Publication Date
DK2426106T3 true DK2426106T3 (da)	2013-11-04

Family

ID=40089983

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK08802402.1T DK2193118T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivater til behandling af tumorer
DK11007349.1T DK2426106T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivat til behandling af tumorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK08802402.1T DK2193118T3 (da)	2007-10-05	2008-09-19	Piperidin- og piperazinderivater til behandling af tumorer

Country Status (22)

Country	Link
US (2)	US8791111B2 (da)
EP (2)	EP2193118B1 (da)
JP (2)	JP5597538B2 (da)
KR (1)	KR20100075601A (da)
CN (1)	CN101808988A (da)
AR (1)	AR068657A1 (da)
AU (1)	AU2008310067B2 (da)
BR (1)	BRPI0817644A2 (da)
CA (1)	CA2701519C (da)
CY (2)	CY1113757T1 (da)
DE (1)	DE102007047737A1 (da)
DK (2)	DK2193118T3 (da)
EA (1)	EA017787B1 (da)
ES (2)	ES2429843T3 (da)
HR (2)	HRP20120802T1 (da)
IL (1)	IL204562A0 (da)
MX (1)	MX2010003366A (da)
PL (2)	PL2193118T3 (da)
PT (2)	PT2426106E (da)
SI (2)	SI2193118T1 (da)
WO (1)	WO2009046841A2 (da)
ZA (1)	ZA201003124B (da)

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CN104758286B (zh) *	2015-03-05	2016-09-14	南京工业大学	1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用
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KR20180054635A (ko)	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	오토탁신(atx) 억제제로서 이환형 화합물
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CN110392679B (zh)	2017-03-16	2023-04-07	豪夫迈·罗氏有限公司	可用作双重atx/ca抑制剂的杂环化合物
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2007
- 2007-10-05 DE DE102007047737A patent/DE102007047737A1/de not_active Withdrawn
2008
- 2008-09-19 MX MX2010003366A patent/MX2010003366A/es not_active Application Discontinuation
- 2008-09-19 EA EA201000549A patent/EA017787B1/ru not_active IP Right Cessation
- 2008-09-19 US US12/681,440 patent/US8791111B2/en not_active Expired - Fee Related
- 2008-09-19 DK DK08802402.1T patent/DK2193118T3/da active
- 2008-09-19 AU AU2008310067A patent/AU2008310067B2/en not_active Ceased
- 2008-09-19 EP EP08802402A patent/EP2193118B1/de not_active Not-in-force
- 2008-09-19 PT PT110073491T patent/PT2426106E/pt unknown
- 2008-09-19 CN CN200880109583A patent/CN101808988A/zh active Pending
- 2008-09-19 ES ES11007349T patent/ES2429843T3/es active Active
- 2008-09-19 EP EP11007349.1A patent/EP2426106B1/de not_active Not-in-force
- 2008-09-19 SI SI200830792T patent/SI2193118T1/sl unknown
- 2008-09-19 PT PT08802402T patent/PT2193118E/pt unknown
- 2008-09-19 BR BRPI0817644 patent/BRPI0817644A2/pt not_active IP Right Cessation
- 2008-09-19 PL PL08802402T patent/PL2193118T3/pl unknown
- 2008-09-19 JP JP2010527349A patent/JP5597538B2/ja not_active Expired - Fee Related
- 2008-09-19 SI SI200831052T patent/SI2426106T1/sl unknown
- 2008-09-19 WO PCT/EP2008/007893 patent/WO2009046841A2/de not_active Ceased
- 2008-09-19 KR KR1020107009776A patent/KR20100075601A/ko not_active Ceased
- 2008-09-19 PL PL11007349T patent/PL2426106T3/pl unknown
- 2008-09-19 ES ES08802402T patent/ES2392475T3/es active Active
- 2008-09-19 CA CA2701519A patent/CA2701519C/en not_active Expired - Fee Related
- 2008-09-19 HR HRP20120802AT patent/HRP20120802T1/hr unknown
- 2008-09-19 DK DK11007349.1T patent/DK2426106T3/da active
- 2008-10-03 AR ARP080104328A patent/AR068657A1/es unknown
2010
- 2010-03-16 IL IL204562A patent/IL204562A0/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03124A patent/ZA201003124B/en unknown
2012
- 2012-08-22 US US13/591,765 patent/US8754097B2/en not_active Expired - Fee Related
- 2012-10-17 CY CY20121100967T patent/CY1113757T1/el unknown
2013
- 2013-10-03 HR HRP20130929AT patent/HRP20130929T1/hr unknown
- 2013-10-25 CY CY20131100944T patent/CY1114574T1/el unknown
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Also Published As

Publication number	Publication date
KR20100075601A (ko)	2010-07-02
JP2014129427A (ja)	2014-07-10
WO2009046841A3 (de)	2009-06-18
SI2426106T1 (sl)	2013-10-30
AR068657A1 (es)	2009-11-25
MX2010003366A (es)	2010-04-30
PL2193118T3 (pl)	2013-01-31
ES2429843T3 (es)	2013-11-18
EP2193118B1 (de)	2012-08-22
EP2426106A1 (de)	2012-03-07
SI2193118T1 (sl)	2012-12-31
EP2193118A2 (de)	2010-06-09
PT2426106E (pt)	2013-11-07
US8791111B2 (en)	2014-07-29
US20120316162A1 (en)	2012-12-13
PT2193118E (pt)	2012-11-02
WO2009046841A8 (de)	2010-01-21
CN101808988A (zh)	2010-08-18
EA017787B1 (ru)	2013-03-29
ES2392475T3 (es)	2012-12-11
HRP20120802T1 (hr)	2012-11-30
JP5847226B2 (ja)	2016-01-20
CY1114574T1 (el)	2016-10-05
AU2008310067A1 (en)	2009-04-16
IL204562A0 (en)	2010-11-30
DE102007047737A1 (de)	2009-04-30
JP5597538B2 (ja)	2014-10-01
CA2701519A1 (en)	2009-04-16
JP2010540579A (ja)	2010-12-24
US20100222341A1 (en)	2010-09-02
EA201000549A1 (ru)	2010-10-29
WO2009046841A2 (de)	2009-04-16
ZA201003124B (en)	2011-04-28
DK2193118T3 (da)	2012-10-22
BRPI0817644A2 (pt)	2015-03-31
EP2426106B1 (de)	2013-07-31
US8754097B2 (en)	2014-06-17
HRP20130929T1 (hr)	2013-11-08
PL2426106T3 (pl)	2013-11-29
AU2008310067B2 (en)	2013-09-26
CA2701519C (en)	2017-07-11
CY1113757T1 (el)	2016-07-27

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