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DK2313087T4 - Farmaceutisk doseringsform til øjeblikkelig frigivelse af et indolinderivat - Google Patents

Farmaceutisk doseringsform til øjeblikkelig frigivelse af et indolinderivat Download PDF

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Publication number
DK2313087T4
DK2313087T4 DK09757601.1T DK09757601T DK2313087T4 DK 2313087 T4 DK2313087 T4 DK 2313087T4 DK 09757601 T DK09757601 T DK 09757601T DK 2313087 T4 DK2313087 T4 DK 2313087T4
Authority
DK
Denmark
Prior art keywords
dosage form
pharmaceutical dosage
immediate release
release pharmaceutical
indoline derivative
Prior art date
Application number
DK09757601.1T
Other languages
English (en)
Other versions
DK2313087T3 (da
Inventor
Roman Messerschmid
Peter Lach
Torsten Sokoliess
Peter Stopfer
Dirk Trommeshauser
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41017080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2313087(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of DK2313087T3 publication Critical patent/DK2313087T3/da
Application granted granted Critical
Publication of DK2313087T4 publication Critical patent/DK2313087T4/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
    • G09B19/00—Teaching not covered by other main groups of this subclass

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Business, Economics & Management (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Entrepreneurship & Innovation (AREA)
  • Educational Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Educational Administration (AREA)
  • Theoretical Computer Science (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK09757601.1T 2008-06-06 2009-06-04 Farmaceutisk doseringsform til øjeblikkelig frigivelse af et indolinderivat DK2313087T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08157750 2008-06-06
PCT/EP2009/056895 WO2009147220A1 (en) 2008-06-06 2009-06-04 Pharmaceutical dosage form for immediate release of an indolinone derivative

Publications (2)

Publication Number Publication Date
DK2313087T3 DK2313087T3 (da) 2019-02-18
DK2313087T4 true DK2313087T4 (da) 2024-01-15

Family

ID=41017080

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09757601.1T DK2313087T4 (da) 2008-06-06 2009-06-04 Farmaceutisk doseringsform til øjeblikkelig frigivelse af et indolinderivat

Country Status (35)

Country Link
US (3) US20110190318A1 (da)
EP (1) EP2313087B2 (da)
JP (2) JP5583119B2 (da)
KR (1) KR20110022586A (da)
CN (1) CN102056599A (da)
AR (1) AR072060A1 (da)
AU (1) AU2009254556B2 (da)
BR (1) BRPI0913235A2 (da)
CA (1) CA2726648A1 (da)
CL (1) CL2010001362A1 (da)
CO (1) CO6280468A2 (da)
CY (1) CY1121272T1 (da)
DK (1) DK2313087T4 (da)
EA (1) EA201001857A1 (da)
EC (1) ECSP10010717A (da)
ES (1) ES2711913T5 (da)
FI (1) FI2313087T4 (da)
HR (1) HRP20190181T4 (da)
HU (1) HUE042524T2 (da)
IL (1) IL209055A0 (da)
LT (1) LT2313087T (da)
MA (1) MA32386B1 (da)
MX (1) MX338001B (da)
PE (1) PE20100050A1 (da)
PL (1) PL2313087T5 (da)
PT (1) PT2313087T (da)
RS (1) RS58280B2 (da)
SG (1) SG191607A1 (da)
SI (1) SI2313087T2 (da)
TR (1) TR201901579T4 (da)
TW (1) TW201002692A (da)
UA (1) UA107560C2 (da)
UY (1) UY31876A (da)
WO (1) WO2009147220A1 (da)
ZA (1) ZA201007972B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040077604A1 (en) * 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
ES2669469T3 (es) * 2008-06-06 2018-05-25 Boehringer Ingelheim International Gmbh Forma de dosificación farmacéutica en cápsula que comprende una formulación en suspensión de un derivado de indolinona
BR112015006363A2 (pt) 2012-09-28 2017-08-08 Boehringer Ingelheim Int combinações farmacêuticas compreendendo ligantes angiopoietina-2/dll4 duplos e agentes anti-vegf-r
US20140350022A1 (en) 2013-05-10 2014-11-27 Boehringer Ingelheim International Gmbh Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment
WO2014197415A1 (en) 2013-06-04 2014-12-11 Monosol Llc Water-soluble film sealing solutions, related methods, and related articles
US20150044288A1 (en) 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
AU2016276170B2 (en) 2015-06-06 2021-08-05 Cloudbreak Therapeutics, Llc Compositions and methods for treating pterygium
WO2017210130A1 (en) 2016-06-02 2017-12-07 Cloudbreak Therapeutics, Llc Compositions and methods of using nintedanib for improving glaucoma surgery success
WO2018108669A1 (en) 2016-12-12 2018-06-21 Boehringer Ingelheim International Gmbh Nintedanib for use in methods for the treatment of interstitial lung diseases by coadministration with olodaterol
EP3600322A1 (en) * 2017-03-28 2020-02-05 Boehringer Ingelheim International GmbH Nintedanib for use in methods for the treatment of muscular dystrophy
CN111278442B (zh) 2017-10-23 2023-06-06 勃林格殷格翰国际有限公司 用于治疗进行性纤维化间质性肺病(pf-ild)的活性剂的新组合
CN112135612B (zh) 2018-03-07 2025-06-17 普利安特治疗公司 氨基酸化合物和使用方法
WO2021198253A1 (en) 2020-04-01 2021-10-07 Boehringer Ingelheim International Gmbh Use of biomarkers in the treatment of fibrotic conditions
EP4098246A1 (en) 2021-05-31 2022-12-07 Lotus Pharmaceutical Co., Ltd. Formulation of nintedanib
JP2025525881A (ja) 2022-08-16 2025-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 眼内使用するためのニンテダニブの医薬製剤

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3579384D1 (de) 1984-07-24 1990-10-04 Scherer Gmbh R P Oxytetracyclin-hc1-weichgelatinekapseln und verfahren zu ihrer herstellung.
DE19603402A1 (de) 1995-02-24 1996-08-29 Basf Ag Weichgelatinekapseln
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US20060058311A1 (en) * 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
PE20060777A1 (es) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US20090306101A1 (en) 2005-11-11 2009-12-10 Flavio Solca Combination treatment of cancer comprising egfr/her2 inhibitors
LT2985025T (lt) * 2008-06-06 2018-04-10 Boehringer Ingelheim International Gmbh Farmacinis derinys
ES2669469T3 (es) * 2008-06-06 2018-05-25 Boehringer Ingelheim International Gmbh Forma de dosificación farmacéutica en cápsula que comprende una formulación en suspensión de un derivado de indolinona
EP2387401A1 (en) * 2009-01-14 2011-11-23 Boehringer Ingelheim International GmbH Method for treating colorectal cancer
US8802384B2 (en) * 2009-03-12 2014-08-12 Boehringer Ingelheim International Gmbh Method or system using biomarkers for the monitoring of a treatment
EP2647375A1 (en) * 2009-05-14 2013-10-09 Boehringer Ingelheim International Gmbh Combination of vargatef and dabigatran for the treatment of oncological and fibrotic diseases

Also Published As

Publication number Publication date
AU2009254556A1 (en) 2009-12-10
DK2313087T3 (da) 2019-02-18
EA201001857A1 (ru) 2011-06-30
JP2014098045A (ja) 2014-05-29
MX338001B (es) 2016-03-30
RS58280B2 (sr) 2024-02-29
ES2711913T3 (es) 2019-05-08
WO2009147220A1 (en) 2009-12-10
CL2010001362A1 (es) 2011-05-13
ZA201007972B (en) 2011-07-27
PL2313087T5 (pl) 2024-03-04
ECSP10010717A (es) 2011-02-28
JP5992937B2 (ja) 2016-09-14
PT2313087T (pt) 2019-02-15
MA32386B1 (fr) 2011-06-01
UY31876A (es) 2010-01-29
RS58280B1 (sr) 2019-03-29
PL2313087T3 (pl) 2019-05-31
IL209055A0 (en) 2011-01-31
KR20110022586A (ko) 2011-03-07
AR072060A1 (es) 2010-08-04
TW201002692A (en) 2010-01-16
SI2313087T1 (sl) 2019-03-29
SG191607A1 (en) 2013-07-31
BRPI0913235A2 (pt) 2016-01-19
TR201901579T4 (tr) 2019-02-21
JP2011522010A (ja) 2011-07-28
HRP20190181T4 (hr) 2024-07-05
PE20100050A1 (es) 2010-01-29
AU2009254556B2 (en) 2015-08-20
LT2313087T (lt) 2019-02-25
UA107560C2 (uk) 2015-01-26
US20140163040A1 (en) 2014-06-12
EP2313087B1 (en) 2018-11-21
CN102056599A (zh) 2011-05-11
EP2313087B2 (en) 2023-11-22
HRP20190181T1 (hr) 2019-03-22
JP5583119B2 (ja) 2014-09-03
HUE042524T2 (hu) 2019-07-29
CA2726648A1 (en) 2009-12-10
CY1121272T1 (el) 2020-05-29
US20130203773A1 (en) 2013-08-08
MX2010013092A (es) 2011-02-25
FI2313087T4 (fi) 2023-12-28
CO6280468A2 (es) 2011-05-20
ES2711913T5 (es) 2024-06-24
EP2313087A1 (en) 2011-04-27
US20110190318A1 (en) 2011-08-04
SI2313087T2 (sl) 2024-03-29

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