DK2283117T3 - Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller - Google Patents
Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamcellerInfo
- Publication number
- DK2283117T3 DK2283117T3 DK08816858.8T DK08816858T DK2283117T3 DK 2283117 T3 DK2283117 T3 DK 2283117T3 DK 08816858 T DK08816858 T DK 08816858T DK 2283117 T3 DK2283117 T3 DK 2283117T3
- Authority
- DK
- Denmark
- Prior art keywords
- cleaning
- procedure
- embryonic stem
- human embryonic
- pancreatic endoderm
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2008/061053 WO2009131568A1 (en) | 2008-04-21 | 2008-04-21 | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2283117T3 true DK2283117T3 (da) | 2014-01-20 |
Family
ID=41217089
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13188913.1T DK2727998T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåder til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
| DK08816858.8T DK2283117T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåde til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK13188913.1T DK2727998T3 (da) | 2008-04-21 | 2008-04-21 | Fremgangsmåder til oprensning af pancreatiske endodermceller afledt fra humane embryoniske stamceller |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP2727998B1 (da) |
| AU (1) | AU2008355123B2 (da) |
| DK (2) | DK2727998T3 (da) |
| HK (1) | HK1154404A1 (da) |
| WO (1) | WO2009131568A1 (da) |
Families Citing this family (51)
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| US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
| PL1888123T3 (pl) | 2005-06-08 | 2013-06-28 | Janssen Biotech Inc | Terapia komórkowa chorób degeneracyjnych oka |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| CN101952415B (zh) | 2007-07-31 | 2017-06-27 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
| JP5710264B2 (ja) | 2007-11-27 | 2015-04-30 | ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． | ヒト胚性幹細胞の分化 |
| EP2254990B1 (en) | 2008-02-21 | 2020-04-15 | Janssen Biotech, Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| CN102159703B (zh) | 2008-06-30 | 2015-11-25 | 森托科尔奥索生物科技公司 | 多能干细胞的分化 |
| JP2012507289A (ja) | 2008-10-31 | 2012-03-29 | ヤンセン バイオテツク，インコーポレーテツド | ヒト胚性幹細胞の膵内分泌系への分化 |
| CN102272291B (zh) | 2008-10-31 | 2018-01-16 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌谱系的分化 |
| MX2011005288A (es) | 2008-11-20 | 2011-06-01 | Centocor Ortho Biotech Inc | Celulas madre pluripotentes en microportadores. |
| CA2744227C (en) | 2008-11-20 | 2018-10-02 | Centocor Ortho Biotech Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
| JP6219568B2 (ja) | 2009-07-20 | 2017-10-25 | ヤンセン バイオテツク，インコーポレーテツド | ヒト胚性幹細胞の分化 |
| ES2693088T3 (es) | 2009-07-20 | 2018-12-07 | Janssen Biotech, Inc. | Diferenciación de células madre embriónicas humanas |
| SG177416A1 (en) | 2009-07-20 | 2012-02-28 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| ES2365343B1 (es) * | 2009-11-19 | 2012-07-10 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de cd98 como marcador de receptividad endometrial. |
| KR101773538B1 (ko) | 2009-12-23 | 2017-08-31 | 얀센 바이오테크 인코포레이티드 | 인간 배아 줄기 세포의 분화 |
| US9133439B2 (en) | 2009-12-23 | 2015-09-15 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| BR112012022145A2 (pt) | 2010-03-01 | 2020-10-06 | Janssen Biotech, Inc. | métodos para purificar células derivadas de células-tronco pluripotentes |
| DK2569419T3 (da) | 2010-05-12 | 2019-05-13 | Janssen Biotech Inc | Differentiering af humane embryoniske stamceller |
| BR112013004614A2 (pt) | 2010-08-31 | 2024-01-16 | Janssen Biotech Inc | Diferenciação de células-tronco pluripotentes |
| SG187944A1 (en) | 2010-08-31 | 2013-04-30 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| EP3372672A1 (en) | 2010-08-31 | 2018-09-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CA2812194C (en) * | 2010-09-17 | 2022-12-13 | President And Fellows Of Harvard College | Functional genomics assay for characterizing pluripotent stem cell utility and safety |
| US9388386B2 (en) | 2011-12-22 | 2016-07-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
| MX354775B (es) | 2012-03-07 | 2018-03-20 | Janssen Biotech Inc | Medios definidos para la expansion y el mantenimiento de celulas madre pluripotentes. |
| CN108103006A (zh) | 2012-06-08 | 2018-06-01 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌细胞的分化 |
| US20150247123A1 (en) | 2012-09-03 | 2015-09-03 | Novo Nordisk A/S | Generation of pancreatic endoderm from Pluripotent Stem cells using small molecules |
| US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
| KR102084561B1 (ko) | 2012-12-31 | 2020-03-04 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 세포로의 분화를 위한 공기-액체 계면에서의 인간 배아 줄기세포의 배양 |
| WO2014106141A1 (en) | 2012-12-31 | 2014-07-03 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells |
| RU2684215C2 (ru) | 2012-12-31 | 2019-04-04 | Янссен Байотек, Инк. | Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток |
| US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| WO2014200905A2 (en) | 2013-06-10 | 2014-12-18 | President And Fellows Of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| BR112015030946A8 (pt) | 2013-06-11 | 2020-01-28 | Harvard College | composição compreendendo uma célula ß pancreática não-nativa, método de diferenciação de células progenitoras em células ß pancreáticas in vitro e uso de uma célula ß pancreática não-nativa |
| JP6588969B2 (ja) | 2014-05-16 | 2019-10-09 | ヤンセン バイオテツク，インコーポレーテツド | 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用 |
| WO2016100930A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Methods for generating stem cell-derived b cells and methods of use thereof |
| US10443042B2 (en) | 2014-12-18 | 2019-10-15 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof |
| WO2016100909A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF |
| EP3819372A3 (en) | 2015-04-24 | 2021-10-06 | University of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| WO2017094001A1 (en) * | 2015-11-30 | 2017-06-08 | Kadimastem Ltd | Methods for differentiating and purifying pancreatic endocrine cells |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| CN111094547B (zh) * | 2017-06-14 | 2024-02-09 | 德国亥姆霍兹慕尼黑中心健康与环境研究中心（有限公司） | 用于纯化源自人胚胎干细胞的内胚层和胰腺内胚层细胞的方法 |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| JP7428653B2 (ja) | 2017-11-15 | 2024-02-06 | バーテックス ファーマシューティカルズ インコーポレイテッド | 島細胞製造組成物および使用方法 |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| CA3139591C (en) | 2019-05-31 | 2024-01-16 | Timothy M. BRUHN | A biocompatible membrane composite |
| CA3139590C (en) | 2019-05-31 | 2024-01-23 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4542104A (en) | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| CA1335181C (en) | 1988-10-11 | 1995-04-11 | R. Alan Hardwick | System for selective cell separation from cell concentrate |
| EP0452342B1 (en) | 1988-12-28 | 1994-11-30 | MILTENYI, Stefan | Methods and materials for high gradient magnetic separation of biological materials |
| US5272257A (en) | 1990-05-21 | 1993-12-21 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use |
| US5171846A (en) | 1990-05-21 | 1992-12-15 | Coulter Corporation | Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use |
| US5240640A (en) | 1990-06-04 | 1993-08-31 | Coulter Corporation | In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles |
| US5639620A (en) | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| US5466609A (en) | 1990-10-31 | 1995-11-14 | Coulter Corporation | Biodegradable gelatin-aminodextran particle coatings of and processes for making same |
| US5248772A (en) | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| US5453357A (en) | 1992-10-08 | 1995-09-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| US5690926A (en) | 1992-10-08 | 1997-11-25 | Vanderbilt University | Pluripotential embryonic cells and methods of making same |
| WO1994029724A1 (en) | 1993-06-11 | 1994-12-22 | Coulter Corporation | Anti-cd3 antibody-aminodextran conjugates for induction of t-cell activation and proliferation |
| US5989833A (en) | 1994-09-20 | 1999-11-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for detection of molecules with affinity for MPL polypeptides |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| AU2192997A (en) | 1996-02-28 | 1997-09-16 | Vanderbilt University | Compositions and methods of making embryonic stem cells |
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| US6074884A (en) | 1997-10-09 | 2000-06-13 | Coulter International Corp. | Stable protein-nickel particles and methods of production and use thereof |
| CA2307807C (en) | 1997-10-23 | 2008-09-02 | Andrea G. Bodnar | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
| US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
| CA2536067A1 (en) * | 2003-08-27 | 2005-03-10 | Stemcells California, Inc. | Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations |
| NZ547920A (en) | 2003-12-23 | 2009-06-26 | Cythera Inc | Definitive endoderm |
| PL2471903T3 (pl) * | 2005-12-29 | 2018-09-28 | Anthrogenesis Corporation | Populacje komórek macierzystych łożyska |
| US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB2506936A (en) | 2012-10-15 | 2014-04-16 | Innovia Films Ltd | Birefringence authentication apparatus and method |
-
2008
- 2008-04-21 AU AU2008355123A patent/AU2008355123B2/en active Active
- 2008-04-21 WO PCT/US2008/061053 patent/WO2009131568A1/en active Application Filing
- 2008-04-21 EP EP13188913.1A patent/EP2727998B1/en active Active
- 2008-04-21 EP EP08816858.8A patent/EP2283117B1/en active Active
- 2008-04-21 DK DK13188913.1T patent/DK2727998T3/da active
- 2008-04-21 DK DK08816858.8T patent/DK2283117T3/da active
-
2011
- 2011-08-15 HK HK11108564.6A patent/HK1154404A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008355123B2 (en) | 2014-12-04 |
| HK1154404A1 (en) | 2012-04-20 |
| AU2008355123A2 (en) | 2010-12-16 |
| EP2727998A2 (en) | 2014-05-07 |
| EP2727998A3 (en) | 2014-08-13 |
| DK2727998T3 (da) | 2019-08-26 |
| EP2283117A4 (en) | 2011-09-07 |
| WO2009131568A1 (en) | 2009-10-29 |
| EP2283117A1 (en) | 2011-02-16 |
| EP2727998B1 (en) | 2019-06-12 |
| AU2008355123A1 (en) | 2009-10-29 |
| EP2283117B1 (en) | 2013-10-23 |
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