|
US2386796A
(en)
|
1942-08-05 |
1945-10-16 |
Bond Crown & Cork Co |
Extruding device
|
|
DE2855719A1
(de)
|
1978-12-22 |
1980-07-10 |
Siemens Ag |
Zahnaerztliche handstueckanordnung
|
|
US4336336A
(en)
|
1979-01-12 |
1982-06-22 |
President And Fellows Of Harvard College |
Fused gene and method of making and using same
|
|
AU545912B2
(en)
|
1980-03-10 |
1985-08-08 |
Cetus Corporation |
Cloned heterologous jive products in bacillies
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
NZ199722A
(en)
|
1981-02-25 |
1985-12-13 |
Genentech Inc |
Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
|
|
JPS57181099A
(en)
|
1981-04-29 |
1982-11-08 |
Biogen Nv |
Bacillus cloning vector, recombinant dna molecule, bacillus host transformed thereby and manufacture of polypeptide expressing dna order and being coded thereby
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
US4603112A
(en)
|
1981-12-24 |
1986-07-29 |
Health Research, Incorporated |
Modified vaccinia virus
|
|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
|
US4876197A
(en)
|
1983-02-22 |
1989-10-24 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
CA1341302C
(en)
|
1983-02-22 |
2001-10-09 |
Rae Lyn Burke |
Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4546083A
(en)
|
1983-04-22 |
1985-10-08 |
Stolle Research & Development Corporation |
Method and device for cell culture growth
|
|
US4588684A
(en)
|
1983-04-26 |
1986-05-13 |
Chiron Corporation |
a-Factor and its processing signals
|
|
JPS59205983A
(ja)
|
1983-04-28 |
1984-11-21 |
ジエネツクス・コ−ポレイシヨン |
異種遺伝子を原核微生物で発現させる方法
|
|
US4663280A
(en)
|
1983-05-19 |
1987-05-05 |
Public Health Research Institute Of The City Of New York |
Expression and secretion vectors and method of constructing vectors
|
|
EP0127839B1
(en)
|
1983-05-27 |
1992-07-15 |
THE TEXAS A&M UNIVERSITY SYSTEM |
Method for producing a recombinant baculovirus expression vector
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
JPS6054685A
(ja)
|
1983-09-02 |
1985-03-29 |
Suntory Ltd |
改良発現ベクタ−およびその利用
|
|
EP0136907A3
(en)
|
1983-10-03 |
1986-12-30 |
Genentech, Inc. |
A xenogeneic expression control system, a method of using it, expression vectors containing it, cells transformed thereby and heterologous proteins produced therefrom
|
|
DK518384A
(da)
|
1984-01-31 |
1985-07-01 |
Idaho Res Found |
Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
|
|
US4880734A
(en)
|
1984-05-11 |
1989-11-14 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
ATE102250T1
(de)
|
1984-05-11 |
1994-03-15 |
Chiron Corp |
Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion.
|
|
US5288641A
(en)
|
1984-06-04 |
1994-02-22 |
Arch Development Corporation |
Herpes Simplex virus as a vector
|
|
CA1282721C
(en)
|
1984-06-04 |
1991-04-09 |
Bernard Roizman |
Herpes simplex virus as a vector
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4745056A
(en)
|
1984-10-23 |
1988-05-17 |
Biotechnica International, Inc. |
Streptomyces secretion vector
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
US4762915A
(en)
|
1985-01-18 |
1988-08-09 |
Liposome Technology, Inc. |
Protein-liposome conjugates
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
CA1260858A
(en)
|
1985-03-28 |
1989-09-26 |
Lawrence S. Cousens |
Expression using fused genes providing for protein product
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4865974A
(en)
|
1985-09-20 |
1989-09-12 |
Cetus Corporation |
Bacterial methionine N-terminal peptidase
|
|
JPS6296086A
(ja)
|
1985-10-21 |
1987-05-02 |
Agency Of Ind Science & Technol |
複合プラスミド
|
|
US5091309A
(en)
|
1986-01-16 |
1992-02-25 |
Washington University |
Sindbis virus vectors
|
|
ES2061482T3
(es)
|
1986-05-02 |
1994-12-16 |
Gist Brocades Nv |
Metodo para la identificacion de secuencias de señal secretora para sintesis de proteina extracelular en bacillus.
|
|
JP2612874B2
(ja)
|
1986-10-02 |
1997-05-21 |
マサチユセツツ・インスチチユート・オブ・テクノロジー |
タンパク質の代謝的安定性を調節する方法
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節dna配列および発現ベクタ−
|
|
EP0284044B1
(en)
|
1987-03-23 |
1994-03-23 |
Zymogenetics, Inc. |
High level expression in yeast
|
|
RU2023448C1
(ru)
|
1987-07-30 |
1994-11-30 |
Сентро Насьональ Де Биопрепарадос |
Способ получения вакцины против различных патогенных серотипов менингита нейссера группы в
|
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
|
DK463887D0
(da)
|
1987-09-07 |
1987-09-07 |
Novo Industri As |
Gaerleader
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
CA1340772C
(en)
|
1987-12-30 |
1999-09-28 |
Patricia Tekamp-Olson |
Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
|
|
WO1989006699A1
(en)
|
1988-01-13 |
1989-07-27 |
Institut Pasteur |
Dna probe specific for hemolytic listeria
|
|
US4973551A
(en)
|
1988-01-15 |
1990-11-27 |
Merck & Co., Inc. |
Vector for the expression of fusion proteins and protein immunogens
|
|
US5591624A
(en)
|
1988-03-21 |
1997-01-07 |
Chiron Viagene, Inc. |
Retroviral packaging cell lines
|
|
US5662896A
(en)
|
1988-03-21 |
1997-09-02 |
Chiron Viagene, Inc. |
Compositions and methods for cancer immunotherapy
|
|
US5206152A
(en)
|
1988-04-08 |
1993-04-27 |
Arch Development Corporation |
Cloning and expression of early growth regulatory protein genes
|
|
US5422120A
(en)
|
1988-05-30 |
1995-06-06 |
Depotech Corporation |
Heterovesicular liposomes
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
ES2070312T5
(es)
|
1988-12-19 |
2003-05-16 |
American Cyanamid Co |
Vacuna de proteina de membrana exterior meningococica de clase 1.
|
|
US5217879A
(en)
|
1989-01-12 |
1993-06-08 |
Washington University |
Infectious Sindbis virus vectors
|
|
CA2006700A1
(en)
|
1989-01-17 |
1990-07-17 |
Antonello Pessi |
Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
|
|
WO1990009441A1
(en)
|
1989-02-01 |
1990-08-23 |
The General Hospital Corporation |
Herpes simplex virus type i expression vector
|
|
JP3140757B2
(ja)
|
1989-02-06 |
2001-03-05 |
デイナ・フアーバー・キヤンサー・インステイテユート |
パッケージング欠陥hivプロウイルス、細胞系及びその使用
|
|
EP0463056A1
(en)
|
1989-03-17 |
1992-01-02 |
E.I. Du Pont De Nemours And Company |
External regulation of gene expression
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
DE69034078T2
(de)
|
1989-03-21 |
2004-04-01 |
Vical, Inc., San Diego |
Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
|
|
WO1990014837A1
(en)
|
1989-05-25 |
1990-12-13 |
Chiron Corporation |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
KR920703114A
(ko)
|
1989-07-14 |
1992-12-17 |
원본미기재 |
접합체 백신을 위한 시토킨 및 호르몬 운반체
|
|
US5166057A
(en)
|
1989-08-28 |
1992-11-24 |
The Mount Sinai School Of Medicine Of The City University Of New York |
Recombinant negative strand rna virus expression-systems
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
AU7007491A
(en)
|
1990-02-02 |
1991-08-08 |
Schweiz. Serum- & Impfinstitut Bern |
Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
|
|
NZ237464A
(en)
|
1990-03-21 |
1995-02-24 |
Depotech Corp |
Liposomes with at least two separate chambers encapsulating two separate biologically active substances
|
|
CA2039921A1
(en)
|
1990-04-16 |
1991-10-17 |
Xandra O. Breakefield |
Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
|
|
US5149655A
(en)
|
1990-06-21 |
1992-09-22 |
Agracetus, Inc. |
Apparatus for genetic transformation
|
|
IL98715A0
(en)
|
1990-08-13 |
1992-07-15 |
American Cyanamid Co |
Filamentous hemaglutinin of bodetella pertussis as a carrier molecule for conjugate vaccines
|
|
AU665176B2
(en)
|
1990-09-21 |
1995-12-21 |
Novartis Vaccines And Diagnostics, Inc. |
Packaging cells
|
|
WO1992007945A1
(en)
|
1990-10-30 |
1992-05-14 |
Dana Farber Cancer Institute |
Cell type specific alteration of levels of gene products in neural cells
|
|
SE9003978D0
(sv)
|
1990-12-13 |
1990-12-13 |
Henrik Garoff |
Dna expressionssystem baserade paa ett virus replikon
|
|
JP3337214B2
(ja)
|
1990-12-20 |
2002-10-21 |
アーチ・ディベロップメント・コーポレーション |
電離線による遺伝子発現の調節
|
|
CA2128616A1
(en)
|
1992-01-23 |
1993-08-05 |
Gary H. Rhodes |
Ex vivo gene transfer
|
|
DE69334197T2
(de)
|
1992-03-02 |
2008-12-11 |
Novartis Vaccines And Diagnostics S.R.L. |
Helicobacter pylori Cytotoxin verwendbar in Impfstoffe und Diagnostik
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
DE69327599T2
(de)
|
1992-06-25 |
2000-08-10 |
Smithkline Beecham Biolog |
Adjuvantien enthaltende Impfstoffzusammensetzung
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
NL9201716A
(nl)
|
1992-10-02 |
1994-05-02 |
Nederlanden Staat |
Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
|
|
DE69431750T2
(de)
|
1993-04-22 |
2003-04-03 |
Skyepharma Inc., San Diego |
Multivesikuläre liposomen mit verkapseltem cyclodextrin und pharmakologisch wirksamen verbindungen sowie verfahren zu deren verwendung
|
|
JPH09501564A
(ja)
|
1993-07-27 |
1997-02-18 |
ザ・ウイスター・インステイテユート・オブ・アナトミー・アンド・バイオロジー |
改質dnaウイルスベクターおよびその使用
|
|
US5362865A
(en)
|
1993-09-02 |
1994-11-08 |
Monsanto Company |
Enhanced expression in plants using non-translated leader sequences
|
|
EP0711829A3
(en)
|
1993-09-15 |
1997-07-09 |
Viagene Inc |
Recombinant alphavirus vector
|
|
BR9408072A
(pt)
|
1993-11-16 |
1997-08-12 |
Depotech Corp |
Vesículas com liberação controlada de ativos
|
|
US5693506A
(en)
|
1993-11-16 |
1997-12-02 |
The Regents Of The University Of California |
Process for protein production in plants
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
ES2297831T3
(es)
|
1994-05-09 |
2008-05-01 |
Oxford Biomedica (Uk) Limited |
Vectores retroviricos que presentan una tasa de recombinacion reducida.
|
|
JPH10502365A
(ja)
|
1994-07-01 |
1998-03-03 |
リカン・リミテッド |
ヘリコバクタータンパク質およびワクチン
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
ATE420171T1
(de)
|
1994-07-15 |
2009-01-15 |
Univ Iowa Res Found |
Immunomodulatorische oligonukleotide
|
|
WO1996037626A1
(en)
|
1995-05-22 |
1996-11-28 |
Chiron Corporation |
Position-specific integration of vector constructs into eukaryotic genomes mediated by a chimeric integrase protein
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
DE69737413T2
(de)
|
1996-01-04 |
2007-10-31 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
Bakterioferritin aus helicobacter pylori
|
|
US5753235A
(en)
|
1996-02-15 |
1998-05-19 |
Heska Corporation |
Recombinant canine herpesviruses
|
|
DE19630390A1
(de)
|
1996-07-26 |
1998-01-29 |
Chiron Behring Gmbh & Co |
Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung
|
|
CA2264012C
(en)
|
1996-08-13 |
2011-04-26 |
Chiron Corporation |
Compositions and methods for polynucleotide delivery
|
|
EP0930893B1
(en)
|
1996-10-11 |
2005-04-13 |
The Regents of The University of California |
Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
|
|
US5980898A
(en)
|
1996-11-14 |
1999-11-09 |
The United States Of America As Represented By The U.S. Army Medical Research & Material Command |
Adjuvant for transcutaneous immunization
|
|
EP0991403B1
(en)
|
1997-01-30 |
2003-04-02 |
Chiron Corporation |
Use of microparticles with adsorbed antigen to stimulate immune responses
|
|
EP1039935A4
(en)
|
1997-02-28 |
2005-04-27 |
Univ Iowa Res Found |
USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
|
|
ATE441432T1
(de)
|
1997-03-10 |
2009-09-15 |
Ottawa Hospital Res Inst |
Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien
|
|
ATE370740T1
(de)
|
1997-05-20 |
2007-09-15 |
Ottawa Health Research Inst |
Verfahren zur herstellung von nukleinsäurekonstrukten
|
|
AU753172B2
(en)
|
1997-06-06 |
2002-10-10 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
EP1279401B1
(en)
|
1997-09-05 |
2008-01-09 |
GlaxoSmithKline Biologicals S.A. |
Oil in water emulsions containing saponins
|
|
ATE476508T1
(de)
|
1997-11-06 |
2010-08-15 |
Novartis Vaccines & Diagnostic |
Neisseriale antigene
|
|
KR20010032336A
(ko)
|
1997-11-21 |
2001-04-16 |
브랑디 빠스깔 |
클라미디아 뉴모니아 게놈 서열과 폴리펩티드, 이의 단편및 이의 용도, 특히, 감염의 진단, 예방 및 치료 용도
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
CN1280619A
(zh)
|
1997-11-28 |
2001-01-17 |
根瑟特公司 |
沙眼衣原体的基因组序列和多肽,其片段以及其用途,特别是用于诊断、预防和治疗感染
|
|
ES2333071T5
(es)
|
1998-01-14 |
2015-08-17 |
Novartis Vaccines And Diagnostics S.R.L. |
Antígenos de Neisseria meningitidis
|
|
EP1069910A1
(en)
|
1998-04-09 |
2001-01-24 |
GlaxoSmithKline Biologicals S.A. |
Adjuvant compositions
|
|
BR9910089A
(pt)
|
1998-05-01 |
2004-06-08 |
Chiron Corp |
Composições e antìgenos de neisseria meningitidis
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
CZ301212B6
(cs)
|
1998-10-16 |
2009-12-09 |
Smithkline Beecham Biologicals S. A. |
Vakcinacní prostredek
|
|
GB9823978D0
(en)
*
|
1998-11-02 |
1998-12-30 |
Microbiological Res Authority |
Multicomponent meningococcal vaccine
|
|
AU1722300A
(en)
|
1998-11-12 |
2000-05-29 |
Regents Of The University Of California, The |
Chlamydia pneumoniae genome sequence
|
|
GB9828000D0
(en)
|
1998-12-18 |
1999-02-10 |
Chiron Spa |
Antigens
|
|
DE122009000054I1
(de)
|
1999-03-19 |
2009-12-31 |
Glaxosmithkline Biolog Sa |
Impfstoff gegen bakterielle antigene
|
|
WO2000061761A2
(en)
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
HK1044484B
(en)
|
1999-04-19 |
2005-07-29 |
Smithkline Beecham Biologicals S.A. |
Adjuvant composition containing saponin and immunostimulatory oligonucleotide
|
|
ES2563650T3
(es)
*
|
1999-05-19 |
2016-03-15 |
Glaxosmithkline Biologicals Sa |
Composiciones de combinaciones de Neisseria
|
|
GB9918319D0
(en)
|
1999-08-03 |
1999-10-06 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
CO5200837A1
(es)
|
1999-09-24 |
2002-09-27 |
Smithkline Beecham Corp |
Vacunas
|
|
HK1046861A1
(zh)
|
1999-09-24 |
2003-01-30 |
Smithkline Beecham Biologicals S.A. |
包括聚氧乙烯烷基酯或者醚以及至少一種非離子表面活性劑的佐劑
|
|
BR0015961A
(pt)
|
1999-11-29 |
2003-06-10 |
Chiron Spa |
Antìgeno de neisseria de 85kda
|
|
PT1248647E
(pt)
*
|
2000-01-17 |
2010-11-18 |
Novartis Vaccines & Diagnostics Srl |
Vacina de vesícula da membrana externa (omv) compreendendo proteínas de membrana externa de n. meningitidis do serogrupo b
|
|
ES2299476T3
(es)
|
2000-02-28 |
2008-06-01 |
Novartis Vaccines And Diagnostics S.R.L. |
Expresion hibrida de proteinas de neisseria.
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
NO20002828D0
(no)
|
2000-06-02 |
2000-06-02 |
Statens Inst For Folkehelse |
Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
|
|
WO2002002606A2
(en)
|
2000-07-03 |
2002-01-10 |
Chiron S.P.A. |
Immunisation against chlamydia pneumoniae
|
|
GB0103170D0
(en)
|
2001-02-08 |
2001-03-28 |
Smithkline Beecham Biolog |
Vaccine composition
|
|
AU9489801A
(en)
|
2000-09-28 |
2002-04-08 |
Chiron Corp |
Microparticle compositions and methods for the manufacture thereof
|
|
NZ560966A
(en)
|
2000-10-27 |
2010-06-25 |
Novartis Vaccines & Diagnostic |
Nucleic acids and proteins from streptococcus groups A & B
|
|
GB0103424D0
(en)
|
2001-02-12 |
2001-03-28 |
Chiron Spa |
Gonococcus proteins
|
|
GB0115176D0
(en)
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
GB0121591D0
(en)
|
2001-09-06 |
2001-10-24 |
Chiron Spa |
Hybrid and tandem expression of neisserial proteins
|