DK2083863T3 - Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi - Google Patents
Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasiInfo
- Publication number
- DK2083863T3 DK2083863T3 DK07867199.7T DK07867199T DK2083863T3 DK 2083863 T3 DK2083863 T3 DK 2083863T3 DK 07867199 T DK07867199 T DK 07867199T DK 2083863 T3 DK2083863 T3 DK 2083863T3
- Authority
- DK
- Denmark
- Prior art keywords
- sourcopulmonal
- dysplasy
- babies
- beta
- risk
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82793306P | 2006-10-03 | 2006-10-03 | |
PCT/US2007/021234 WO2008060371A1 (en) | 2006-10-03 | 2007-10-03 | USE OF TGF-β ANTAGONISTS TO TREAT INFANTS AT RISK OF DEVELOPING BRONCHOPULMONARY DYSPLASIA |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2083863T3 true DK2083863T3 (da) | 2015-06-22 |
Family
ID=39217964
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15154393.1T DK2918288T3 (da) | 2006-10-03 | 2007-10-03 | Anvendelse af TGF-beta-antagonister til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
DK07867199.7T DK2083863T3 (da) | 2006-10-03 | 2007-10-03 | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK15154393.1T DK2918288T3 (da) | 2006-10-03 | 2007-10-03 | Anvendelse af TGF-beta-antagonister til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
Country Status (10)
Country | Link |
---|---|
US (3) | US8642034B2 (da) |
EP (3) | EP2918288B1 (da) |
CN (2) | CN101553254A (da) |
DK (2) | DK2918288T3 (da) |
ES (2) | ES2538265T3 (da) |
HU (1) | HUE035575T2 (da) |
IL (2) | IL197797A (da) |
MX (1) | MX2009003518A (da) |
PL (2) | PL2918288T3 (da) |
WO (1) | WO2008060371A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012061811A2 (en) * | 2010-11-05 | 2012-05-10 | Fibrogen, Inc. | Treatment method for lung remodeling diseases |
US9797903B2 (en) | 2012-10-24 | 2017-10-24 | Winthrop-University Hospital | Non-invasive biomarker to identify subject at risk of preterm delivery |
AR095240A1 (es) | 2013-03-11 | 2015-09-30 | Genzyme Corp | ANTICUERPOS ANTI-TGF-b MODIFICADOS POR INGENIERÍA GENÉTICA Y FRAGMENTOS DE UNIÓN A ANTÍGENOS |
CA2911514A1 (en) | 2013-05-06 | 2014-11-13 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
CN116655801A (zh) | 2013-08-22 | 2023-08-29 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
TWI733661B (zh) | 2015-03-04 | 2021-07-21 | 美商健臻公司 | 以高親合性、結合性及特異性結合轉化生長因子-β1的經修飾IgG抗體 |
TWI726870B (zh) | 2015-03-04 | 2021-05-11 | 美商健臻公司 | 具有高親和性、結合性及專一性之結合轉形生長因子-β1的scFv-Fc二聚體 |
JP7320350B2 (ja) | 2015-08-04 | 2023-08-03 | アクセルロン ファーマ インコーポレイテッド | 骨髄増殖性障害を処置するための方法 |
WO2017044302A1 (en) * | 2015-09-09 | 2017-03-16 | Rush University Medical Center | Compositions and methods for treating bone diseases |
GB201610044D0 (en) * | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
CN110785431B (zh) | 2017-05-04 | 2024-05-07 | 阿塞勒隆制药公司 | TGF-β受体II型融合蛋白及其用途 |
SG11202002065VA (en) | 2017-09-13 | 2020-04-29 | Progenity Inc | Preeclampsia biomarkers and related systems and methods |
EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
Family Cites Families (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS606629A (ja) | 1983-06-23 | 1985-01-14 | Sumitomo Chem Co Ltd | ホルムアルデヒドの製造法 |
US5262319A (en) | 1985-04-19 | 1993-11-16 | Oncogene Science, Inc. | Method for obtaining bone marrow free of tumor cells using transforming growth factor β3 |
US5654270A (en) | 1988-06-28 | 1997-08-05 | La Jolla Cancer Research Foundation | Use of fibromodulin to prevent or reduce dermal scarring |
AU633011B2 (en) | 1988-06-28 | 1993-01-21 | La Jolla Cancer Research Foundation | Suppression of cell proliferation by decorin |
US5705609A (en) | 1988-06-28 | 1998-01-06 | La Jolla Cancer Research Foundation | Decorin fragments inhibiting cell regulatory factors |
US5583103A (en) | 1988-06-28 | 1996-12-10 | La Jolla Cancer Research Foundation | Inhibition of transforming growth factor beta activity |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
JPH0780780B2 (ja) | 1989-09-29 | 1995-08-30 | ラ ホヤ キャンサー リサーチ ファウンデーション | 細胞外マトリックスの蓄積防止のためのトランスフォーミング増殖因子βの阻害 |
JPH05503003A (ja) | 1989-11-22 | 1993-05-27 | ジェネンテク,インコーポレイテッド | 潜在性関与ペプチドおよびその使用 |
WO1991010727A1 (en) | 1990-01-22 | 1991-07-25 | La Jolla Cancer Research Foundation | Inhibitors of cell regulatory factors |
FR2677038B1 (fr) * | 1991-06-03 | 1994-08-12 | Bel Fromageries | Additif alimentaire pour l'alimentation humaine et animale et aliments le contenant. |
US6008011A (en) | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
CA2122491A1 (en) | 1991-10-31 | 1993-05-13 | Herbert Y. Lin | Tgf-.beta. type receptor cdnas and uses therefor |
WO1993009800A1 (en) | 1991-11-14 | 1993-05-27 | La Jolla Cancer Research Foundation | Inhibitors of cell regulatory factors and methods for preventing or reducing scarring |
GB9205800D0 (en) | 1992-03-17 | 1992-04-29 | British Tech Group | Treatment of fibrotic disorders |
US5869462A (en) | 1992-09-10 | 1999-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
US5821234A (en) | 1992-09-10 | 1998-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of proliferation of vascular smooth muscle cell |
WO1994009812A1 (en) | 1992-10-26 | 1994-05-11 | Kirin Brewery Company, Limited | METHOD FOR PRODUCING LARGE LATENT TRANSFORMING GROWTH FACTOR-β COMPLEXES AND LARGE LATENCY ASSOCIATED PEPTIDE |
JPH08504763A (ja) | 1992-10-29 | 1996-05-21 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 治療薬としてのTGF−βレセプターフラグメントの使用 |
AU5541094A (en) | 1992-10-30 | 1994-05-24 | Consejo Superior De Investigaciones Cientificas | Compositions and methods for modifying the regulatory activity of tgf-beta |
US5830847A (en) | 1992-10-30 | 1998-11-03 | Hsc Research & Development Limited Partnership | Soluble TGF-β-binding endoglin polypeptides and homodimers |
ATE211762T1 (de) | 1993-04-30 | 2002-01-15 | Biognostik Ges | Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1) |
EP0737071A1 (en) | 1993-06-15 | 1996-10-16 | Il- Yang Pharm. Co., Ltd. | Anti-sense oligodeoxynucleotide to fibrogenic cytokines and use thereof |
WO1995010610A1 (en) | 1993-10-15 | 1995-04-20 | La Jolla Cancer Research Foundation | BETAGLYCAN POLYPEPTIDES HAVING TGF-β BINDING ACTIVITY |
AU2404695A (en) | 1994-05-04 | 1995-11-29 | Mount Sinai Hospital Corporation | Modulators of cytokines of the tgf-beta superfamily and methods for assaying for same |
US5772995A (en) | 1994-07-18 | 1998-06-30 | Sidney Kimmel Cancer Center | Compositions and methods for enhanced tumor cell immunity in vivo |
CA2156767A1 (en) | 1994-08-25 | 1996-02-26 | Kenichi Matsunaga | Binding agent for growth factor |
JPH08119984A (ja) | 1994-08-31 | 1996-05-14 | Nkk Corp | ストレプトミセス属放線菌及びこの菌由来のTGF−β 阻害剤 |
US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
AU2749697A (en) | 1996-04-30 | 1997-11-19 | Genzyme Corporation | Use of prolactin as a tgf-beta antagonist |
JPH1067674A (ja) | 1996-06-19 | 1998-03-10 | Advanced Sukin Res Kenkyusho:Kk | 細胞外マトリツクスの異常蓄積抑制剤 |
ES2253788T3 (es) | 1996-10-25 | 2006-06-01 | Ethicon, Inc. | Ensayo de agente anti-fibrotico. |
DE69838061T2 (de) | 1997-04-18 | 2008-03-13 | Biogen Idec Ma Inc., Cambridge | Typ ii tgf-beta receptor/immunoglobulin konstante domäne fusionsproteine |
US7779020B2 (en) | 2002-03-01 | 2010-08-17 | International Business Machines Corporation | Small-footprint applicative query interpreter method, system and program product |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
WO2000047102A2 (en) * | 1999-02-11 | 2000-08-17 | The General Hospital Corporation | COMPOSITIONS AND METHODS FOR MODULATING TGF-β SIGNALING |
US6492497B1 (en) | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
KR100425525B1 (ko) | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
AU3956002A (en) | 2000-11-28 | 2002-06-11 | Childrens Medical Center | Determination of risk and treatment of complications of prematurity |
EP1363904A1 (en) | 2001-02-02 | 2003-11-26 | Glaxo Group Limited | Pyrazoles as tgf inhibitors |
GB0102673D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
GB0102668D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
DE60203263T2 (de) | 2001-02-02 | 2006-02-09 | Smithkline Beecham Corp. | Pyrazolderivate gegen tgf überexprimierung |
GB0102672D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
GB0102665D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
EP1397364B1 (en) | 2001-05-24 | 2007-07-25 | Eli Lilly And Company | Novel pyrrole derivatives as pharmaceutical agents |
WO2003061587A2 (en) | 2002-01-22 | 2003-07-31 | Genzyme Corporation | USE OF TGF-β ANTAGONISTS TO TREAT OR TO PREVENT CHRONIC TRANSPLANT REJECTION |
AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
EP1506191A1 (en) | 2002-05-15 | 2005-02-16 | Smithkline Beecham Corporation | Benzoxazine and benzoxazinone substituted triazoles |
WO2003097615A1 (en) | 2002-05-17 | 2003-11-27 | Scios, Inc. | TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-β INHIBITORS |
AU2003256783A1 (en) | 2002-07-25 | 2004-02-16 | Scios, Inc. | METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-Beta INHIBITORS |
GB0217786D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
EP1549316A4 (en) | 2002-09-10 | 2008-04-09 | Scios Inc | HAMMER OF TFGbeta |
ES2291664T3 (es) | 2002-09-17 | 2008-03-01 | Eli Lilly And Company | Derivados de pirazolopiridina como inhibidores de la transduccion de señales de tgf beta para el tratamiento del cancer. |
AU2003268155A1 (en) | 2002-09-19 | 2004-04-08 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
AU2003291642A1 (en) | 2002-11-22 | 2004-06-18 | Eli Lilly And Company | Pyrazoloazepine compounds as pharmaceutical agents |
UA80571C2 (en) | 2002-11-22 | 2007-10-10 | Lilly Co Eli | Quinolinyl-pyrrolopyrazoles |
AU2003291149A1 (en) | 2002-11-22 | 2004-06-18 | Scios, Inc. | USE OF TFG-Beta INHIBITORSTO COUNTERACT PATHOLOGIC CHANGES IN THE LEVEL OR FUNCTION OF STEROID/THYROID RECEPTORS |
EP1572208A4 (en) | 2002-11-22 | 2007-08-29 | Scios Inc | METHOD FOR CONTROLLING PATHOLOGICAL CHANGE IN THE BETA-ADRENERGIC PATHWAY |
EP1567527A1 (en) | 2002-11-27 | 2005-08-31 | Eli Lilly And Company | Condensed pyrazolo derivatives |
AU2003297460A1 (en) | 2002-12-19 | 2004-07-14 | Scios, Inc. | TREATMENT OF OBESITY AND ASSOCIATED CONDITIONS WITH TGF-Beta INHIBITORS |
ATE553378T1 (de) | 2003-02-06 | 2012-04-15 | Hologic Inc | Screening und behandlungsverfahren zur vorbeugung von frühgeburten |
CL2004000234A1 (es) | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
US7223766B2 (en) | 2003-03-28 | 2007-05-29 | Scios, Inc. | Bi-cyclic pyrimidine inhibitors of TGFβ |
WO2005010049A2 (en) * | 2003-07-09 | 2005-02-03 | Eli Lilly And Company | Tgf-beta1 ligands |
WO2005032481A2 (en) | 2003-09-30 | 2005-04-14 | Scios Inc. | Quinazoline derivatives as medicaments |
EP1708712A1 (en) | 2003-12-24 | 2006-10-11 | Scios, Inc. | Treatment of malignant gliomas with tgf-beta inhibitors |
US7368445B2 (en) | 2004-03-01 | 2008-05-06 | Eli Lilly And Company | Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms |
BRPI0508761A (pt) * | 2004-03-31 | 2007-08-14 | Genentech Inc | anticorpo humanizado, composição que compreende um anticorpo humanizado, ácido nucléico isolado, vetor, célula hospedeira, processo de produção de anticorpo humanizado, método de tratamento de disfunção tgf-beta, método de detecção de tgf-beta, artigo industrializado e método de tratamento de cáncer |
DE102004019253A1 (de) | 2004-04-16 | 2005-11-10 | Codewrights Gmbh | Verfahren zum Fernbedienen eines Feldgerätes der Prozessautomatisierungstechnik |
MX2007001589A (es) * | 2004-08-09 | 2007-08-02 | Alios Biopharma Inc | Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas. |
AU2005280168A1 (en) | 2004-08-31 | 2006-03-09 | Biogen Idec Ma Inc. | Pyrimidinylimidazoles as TGF-beta inhibitors |
EP1786803A1 (en) | 2004-08-31 | 2007-05-23 | Biogen Idec MA, Inc. | Pyrimidinylpyrazoles as tgf-beta inhibitors |
US7511056B2 (en) | 2004-11-10 | 2009-03-31 | Eli Lilly And Company | TGF-β inhibitors |
US7723486B2 (en) | 2005-02-08 | 2010-05-25 | Optein, Inc. | Antibodies to TGF-β |
-
2007
- 2007-10-03 DK DK15154393.1T patent/DK2918288T3/da active
- 2007-10-03 EP EP15154393.1A patent/EP2918288B1/en active Active
- 2007-10-03 PL PL15154393T patent/PL2918288T3/pl unknown
- 2007-10-03 MX MX2009003518A patent/MX2009003518A/es active IP Right Grant
- 2007-10-03 ES ES07867199.7T patent/ES2538265T3/es active Active
- 2007-10-03 DK DK07867199.7T patent/DK2083863T3/da active
- 2007-10-03 PL PL07867199T patent/PL2083863T3/pl unknown
- 2007-10-03 EP EP17181294.4A patent/EP3254696A1/en not_active Withdrawn
- 2007-10-03 CN CNA2007800447494A patent/CN101553254A/zh active Pending
- 2007-10-03 HU HUE15154393A patent/HUE035575T2/en unknown
- 2007-10-03 US US12/444,059 patent/US8642034B2/en active Active
- 2007-10-03 CN CN201510002215.1A patent/CN104645328A/zh active Pending
- 2007-10-03 EP EP07867199.7A patent/EP2083863B1/en not_active Not-in-force
- 2007-10-03 ES ES15154393.1T patent/ES2647472T3/es active Active
- 2007-10-03 WO PCT/US2007/021234 patent/WO2008060371A1/en active Application Filing
-
2009
- 2009-03-25 IL IL197797A patent/IL197797A/en active IP Right Grant
-
2013
- 2013-12-23 US US14/139,332 patent/US20140199399A1/en not_active Abandoned
-
2016
- 2016-11-28 US US15/362,392 patent/US20170233464A1/en not_active Abandoned
-
2017
- 2017-04-27 IL IL251994A patent/IL251994B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP2083863A1 (en) | 2009-08-05 |
IL251994B (en) | 2021-01-31 |
CN104645328A (zh) | 2015-05-27 |
US20100008911A1 (en) | 2010-01-14 |
WO2008060371A1 (en) | 2008-05-22 |
EP2918288B1 (en) | 2017-08-16 |
PL2918288T3 (pl) | 2018-02-28 |
US8642034B2 (en) | 2014-02-04 |
HUE035575T2 (en) | 2018-05-28 |
CN101553254A (zh) | 2009-10-07 |
US20140199399A1 (en) | 2014-07-17 |
ES2538265T3 (es) | 2015-06-18 |
EP2083863B1 (en) | 2015-03-18 |
EP2918288A1 (en) | 2015-09-16 |
PL2083863T3 (pl) | 2015-08-31 |
US20170233464A1 (en) | 2017-08-17 |
IL251994A0 (en) | 2017-06-29 |
DK2918288T3 (da) | 2017-11-27 |
MX2009003518A (es) | 2009-08-25 |
ES2647472T3 (es) | 2017-12-21 |
EP3254696A1 (en) | 2017-12-13 |
IL197797A (en) | 2017-05-29 |
WO2008060371A8 (en) | 2008-07-10 |
IL197797A0 (en) | 2011-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2083863T3 (da) | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi | |
DK2068889T3 (da) | Anakinra til anvendelse i behandling af bronchiolitis obliterans syndrom | |
DK2100614T3 (da) | Antistof mod PDGFR-alfa til anvendelse ved behandlingen af tumorer | |
EP2248496A4 (en) | VOIDABLE ARTICLE | |
LTC2152290I2 (lt) | Anti-il-5 antikūnų skyrimo būdai | |
DK2068874T3 (da) | Fremgangsmåder til behandling af multiple myelom med anvendelse af kombinationsterapier baseret på anti-cs1 antistoffer | |
EP2034073A4 (en) | VOIDABLE ARTICLE | |
EP2079489A4 (en) | ABSORBENT ARTICLE WITH ABSORPTION STRUCTURE | |
BRPI0819073A2 (pt) | fralda descartável | |
EP2500003A4 (en) | VOIDABLE ARTICLE | |
DK2300560T3 (da) | Termisk behandling af biomasse | |
DK2139987T3 (da) | Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelser | |
DK3017829T3 (da) | Behandling af PRDC hos svin | |
EP2299957A4 (en) | POCKET BAGS IN POURABLE ARTICLES | |
DK3399667T3 (da) | Forhindring af selvinduceret interferens i anordning med dobbelt radio | |
EP2111835A4 (en) | VOIDABLE ARTICLE | |
DK2231091T3 (da) | Absorber og absorberende engangsartikel | |
DK2034830T3 (da) | Anti-vla-1-antistof til behandling af slagtilfælde | |
EP2415437A4 (en) | VOIDABLE ARTICLE | |
DK2470202T3 (da) | Clostridium-neurotoksiner til anvendelse i behandling af præmatur ejakulation | |
DK1849445T3 (da) | Absorberende engangsartikel og fremgangsmåde til fremstilling af samme | |
EP2478881A4 (en) | VOIDABLE ARTICLE | |
BRPI0819071A2 (pt) | fralda descartável | |
DK2342346T3 (da) | Thermotoga til behandling af biomasse | |
EP2365947A4 (en) | TREATMENT OF FLYBAG FOR USE IN CONCRETE |