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DK200100223A - - Google Patents

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Publication number
DK200100223A
DK200100223A DKPA200100223A DK200100223A DK 200100223 A DK200100223 A DK 200100223A DK PA200100223 A DKPA200100223 A DK PA200100223A DK 200100223 A DK200100223 A DK 200100223A
Authority
DK
Denmark
Prior art keywords
paroxetine hydrochloride
organic solvent
solvent
substantially free
bound
Prior art date
Application number
Other languages
English (en)
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK200100223(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9502297.6A external-priority patent/GB9502297D0/en
Priority claimed from GBGB9503112.6A external-priority patent/GB9503112D0/en
Priority claimed from GBGB9509807.5A external-priority patent/GB9509807D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of DK200100223A publication Critical patent/DK200100223A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Patentkrav: 1. Paroxetin-hydrochloridanhydrat, som i det væsentlige er frit for bundet propan-2-ol og acetone 2. Paroxetin-hydrochloridanhydrat, som i det væsentlige er frit for bundet organisk opløsningsmiddel. 3. Paroxetin-hydrochloridanhydrat ifølge krav 1 eller 2, på i det væsentlige ren form. 4. Fremgangsmåde til fremstilling af paroxetin-hydrochloridanhydrat, som i det væsentlige er frit for bundet organisk opløsningsmiddel, som omfatter krystallisation af paroxetin-hydrochlorid i enten; i) et organisk opløsningsmiddel eller en blanding af organiske opløsningsmidler, som danner et solvat med paroxetin-hydrochloridet, og som ikke kan fjernes ved traditionelle tørreteknikker; eller ii) et organisk opløsningsmiddel eller en blanding af organiske opløsningsmidler, som danner eller ikke danner et solvat med paroxetin-hydrochloridet, men som kan fjernes ved traditionel tørring i vakuumovn; og derefter, hvor der er tale om i), fortrængning af det eller de solvatiserede opløsningsmidler ved at anvende et fortrængningsmiddel og, hvor der er tale om ii) , ved fjernelse af opløsningsmidlet. 5. Fremgangsmåde til fremstilling af paroxetin-hydrochloridanhydrat, som i det væsentlige er frit for bundet organisk opløsningsmiddel, hvilken fremgangsmåde omfatter fortrængning af det eller de solvatiserede opløsningsmidler fra et paroxetin-hydrochloridsolvat ved at anvende et fortrængningsmiddel.
DKPA200100223 1995-02-06 2001-02-12 DK200100223A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9502297.6A GB9502297D0 (en) 1995-02-06 1995-02-06 Novel compound
GBGB9503112.6A GB9503112D0 (en) 1995-02-17 1995-02-17 Novel compound
GBGB9509807.5A GB9509807D0 (en) 1995-05-15 1995-05-15 Novel compounds

Publications (1)

Publication Number Publication Date
DK200100223A true DK200100223A (da) 2001-02-12

Family

ID=27267578

Family Applications (2)

Application Number Title Priority Date Filing Date
DK011996A DK11996A (da) 1995-02-06 1996-02-05 Ny forbindelse, fremgangsmåde til fremstilling deraf samt anvendelse deraf til fremstilling af et medikament
DKPA200100223 DK200100223A (da) 1995-02-06 2001-02-12

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK011996A DK11996A (da) 1995-02-06 1996-02-05 Ny forbindelse, fremgangsmåde til fremstilling deraf samt anvendelse deraf til fremstilling af et medikament

Country Status (47)

Country Link
EP (3) EP0808314B1 (da)
JP (2) JP2915338B2 (da)
KR (1) KR100289885B1 (da)
CN (3) CN1289496C (da)
AR (2) AR001982A1 (da)
AT (1) AT407528B (da)
AU (2) AU4786496A (da)
BE (1) BE1009112A3 (da)
BG (1) BG62967B1 (da)
BR (1) BR9600534A (da)
CA (4) CA2210022C (da)
CH (3) CH689804A5 (da)
CZ (1) CZ297171B6 (da)
DE (3) DE19603797C2 (da)
DK (2) DK11996A (da)
DZ (1) DZ1989A1 (da)
ES (1) ES2114471B1 (da)
FI (3) FI111544B (da)
FR (1) FR2730232B1 (da)
GR (1) GR1002466B (da)
HK (1) HK59397A (da)
HU (1) HUP9600255A1 (da)
IE (1) IE80500B1 (da)
IL (1) IL117035A (da)
IT (1) IT1289532B1 (da)
LU (1) LU88711A1 (da)
LV (1) LV11618B (da)
MA (1) MA23802A1 (da)
MC (1) MC2411A1 (da)
MX (1) MX9600484A (da)
MY (1) MY132529A (da)
NL (1) NL1002248C2 (da)
NO (3) NO301009B1 (da)
NZ (1) NZ280943A (da)
OA (1) OA10261A (da)
PL (1) PL189247B1 (da)
PT (1) PT101827B (da)
RO (1) RO112426B1 (da)
RU (1) RU2125052C1 (da)
SE (1) SE521084C2 (da)
SG (1) SG43787A1 (da)
SI (2) SI21923B (da)
SK (1) SK283608B6 (da)
TR (1) TR199600096A2 (da)
TW (1) TW503238B (da)
UA (1) UA49796C2 (da)
WO (1) WO1996024595A1 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1384720A1 (en) 1996-06-13 2004-01-28 SUMIKA FINE CHEMICALS Co., Ltd. Process for drying paroxetine hydrochloride
WO1998002556A2 (en) * 1996-07-15 1998-01-22 Smithkline Beecham Plc Screening for and use of an esterase for a stereospecific resolution
US5672612A (en) * 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
CA2193939C (en) * 1996-12-24 2002-02-12 K.S. Keshava Murthy Useful form of anhydrous paroxetine hydrochloride
EE03970B1 (et) * 1997-06-10 2003-02-17 Synthon B.V. 4-fenüülpiperidiinühend, selle valmistamine ja kasutamine ning seda sisaldav ravim
DK0987256T3 (da) * 1997-08-08 2002-02-11 Aventis Pharma Gmbh Krystalform af N-(4-trifluormethylphenyl)-5-methylisoxazol-4-carboxylsyreamid
GB9726907D0 (en) * 1997-12-19 1998-02-18 Smithkline Beecham Plc Novel compounds
BR9908825A (pt) * 1998-03-16 2000-11-21 Smithkline Beecham Plc Forma cristalina de paroxetina
GB9806312D0 (en) * 1998-03-24 1998-05-20 Smithkline Beecham Plc Novel formulations
US6699882B2 (en) 1998-03-24 2004-03-02 Smithkline Beecham P.L.C. Paroxetine compositions
AU2003200534B2 (en) * 1998-03-24 2004-12-02 Smithkline Beecham Plc Paroxetine compositions
JP3796351B2 (ja) 1998-04-13 2006-07-12 住友化学株式会社 パロキセチン塩酸塩無水和物の乾燥方法
GB9812941D0 (en) * 1998-06-16 1998-08-12 Smithkline Beecham Plc Method of treatment
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
ES2138937B1 (es) 1998-07-07 2000-10-01 Medichem Sa Polimorfo de maleato de paroxetina y formulaciones farmaceuticas que lo contienen.
AP2001002072A0 (en) * 1998-08-07 2001-03-31 Smithkline Becham P L C Process for the preparation of a non-crystalline anhydrate form of paroxetine hydrochloride
GB9824298D0 (en) * 1998-11-05 1998-12-30 Smithkline Beecham Plc Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826176D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
GB9826180D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826171D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel compounds
PT1135383E (pt) * 1998-11-30 2004-04-30 Smithkline Beecham Plc Solvatos mistos de propan-2-ol de paroxetina
GB9826242D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9826178D0 (en) * 1998-11-30 1999-01-20 Smithkline Beecham Plc Novel process
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
EP1161241B1 (de) * 1999-03-12 2005-12-07 Aesica Pharmaceuticals Ltd. Stabile pharmazeutische anwendungsform für paroxetin-anhydrat
GB9914585D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9919001D0 (en) * 1999-08-12 1999-10-13 Smithkline Beecham Plc Novel process
GB9923439D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923446D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
GB9923445D0 (en) * 1999-10-04 1999-12-08 Smithkline Beecham Plc Novel process
HU226912B1 (en) * 2000-04-07 2010-03-01 Richter Gedeon Nyrt New paroxetin salt and medicament containing it
WO2002022609A1 (fr) * 2000-09-14 2002-03-21 Asahi Glass Company, Limited Procede de production de sel de paroxetine sensiblement exempt de solvant organique
WO2003072104A1 (en) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
CA2625299A1 (en) * 2005-11-22 2007-05-31 Teva Pharmaceutical Industries Ltd. Crystal forms of cinacalcet hci and processes for their preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
ES2058061T3 (es) * 1985-10-25 1994-11-01 Beecham Group Plc Derivado de piperidina, su preparacion y su uso como medicamento.
GB8626936D0 (en) * 1986-11-11 1986-12-10 Ferrosan As Treatment
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
DK716088D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Reduktion af piperidin-dion-derivater samt intermediat
JPH06502854A (ja) * 1990-11-24 1994-03-31 ビーチャム・グループ・パブリック・リミテッド・カンパニー 老年痴呆、過食症、片頭痛または食欲不振の治療用のパロキセチンの使用
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation

Also Published As

Publication number Publication date
SI9600036A (en) 1996-10-31
TR199600096A2 (tr) 1996-08-21
CN1090187C (zh) 2002-09-04
CA2211522A1 (en) 1996-08-07
FI111544B (fi) 2003-08-15
CA2210023A1 (en) 1996-08-07
AR001982A1 (es) 1998-01-07
CA2210022A1 (en) 1996-08-07
BG100333A (bg) 1996-08-30
CH689804A5 (de) 1999-11-30
EP0808314A1 (en) 1997-11-26
LV11618A (lv) 1996-12-20
HU9600255D0 (en) 1996-03-28
NL1002248C2 (nl) 1996-09-11
NO301009B1 (no) 1997-09-01
NO960472L (no) 1996-08-07
HUP9600255A1 (en) 1997-03-28
NO960472D0 (no) 1996-02-05
ES2114471A1 (es) 1998-05-16
IL117035A0 (en) 1996-09-12
CA2210022C (en) 2005-09-13
DE69621777T2 (de) 2003-01-02
CA2210023C (en) 1999-02-09
JPH08245620A (ja) 1996-09-24
KR960031409A (ko) 1996-09-17
TW503238B (en) 2002-09-21
AU701518B2 (en) 1999-01-28
CN1310180A (zh) 2001-08-29
DK11996A (da) 1996-08-07
DZ1989A1 (fr) 2002-10-15
NL1002248A1 (nl) 1996-08-06
NO20015070D0 (no) 2001-10-18
NO970939L (no) 1996-08-07
DE69631298T2 (de) 2004-11-18
SK283608B6 (sk) 2003-10-07
CA2211522C (en) 1999-12-07
LU88711A1 (fr) 1996-08-23
SE521084C2 (sv) 2003-09-30
UA49796C2 (uk) 2002-10-15
WO1996024595A1 (en) 1996-08-15
SG43787A1 (en) 1997-11-14
CH689229A5 (de) 1998-12-31
ATA21096A (de) 2000-08-15
CZ297171B6 (cs) 2006-09-13
AR036856A2 (es) 2004-10-06
AU4786496A (en) 1996-08-27
FI960519L (fi) 1996-08-07
HK59397A (en) 1997-05-16
LV11618B (en) 1997-04-20
CZ32096A3 (en) 1996-08-14
NO970939D0 (no) 1997-02-28
CA2168829A1 (en) 1996-08-07
PT101827A (pt) 1996-09-30
MX9600484A (es) 1997-01-31
BG62967B1 (bg) 2000-12-29
CA2168829C (en) 1997-12-16
SK14396A3 (en) 1996-11-06
MX198371B (da) 2000-08-29
JP2915338B2 (ja) 1999-07-05
IT1289532B1 (it) 1998-10-15
CN1289496C (zh) 2006-12-13
CN1143643A (zh) 1997-02-26
NO311519B1 (no) 2001-12-03
EP1378508A1 (en) 2004-01-07
DE19603797A1 (de) 1996-08-14
MC2411A1 (fr) 1996-12-02
AT407528B (de) 2001-04-25
SI9600036B (sl) 2006-12-31
DE19603797C2 (de) 1998-11-12
FI20030162L (fi) 2003-02-03
FR2730232B1 (fr) 1997-08-01
AU4332896A (en) 1996-08-15
OA10261A (en) 1997-09-19
NO20015070L (no) 1996-08-07
JPH11228571A (ja) 1999-08-24
SE9600406L (sv) 1996-08-07
NO301009B3 (da) 2003-01-06
EP1136490A1 (en) 2001-09-26
PL189247B1 (pl) 2005-07-29
DE69631298D1 (de) 2004-02-12
RU2125052C1 (ru) 1999-01-20
ITMI960203A1 (it) 1997-08-05
IL117035A (en) 2000-02-29
AU701518C (en) 2006-12-07
KR100289885B1 (ko) 2001-05-15
EP0808314B1 (en) 2002-06-12
PT101827B (pt) 1997-08-29
ES2114471B1 (es) 1999-08-16
GR1002466B (el) 1996-11-06
FI960519A0 (fi) 1996-02-05
PL312646A1 (en) 1996-08-19
ITMI960203A0 (da) 1996-02-05
FR2730232A1 (fr) 1996-08-09
EP1136490B1 (en) 2004-01-07
BR9600534A (pt) 1997-05-13
IE960104A1 (en) 1996-08-07
MY132529A (en) 2007-10-31
SI21923B (sl) 2006-12-31
CN1216055C (zh) 2005-08-24
MA23802A1 (fr) 1996-10-01
BE1009112A3 (fr) 1996-11-05
RO112426B1 (ro) 1997-09-30
NZ280943A (en) 1997-01-29
CN1636993A (zh) 2005-07-13
FI20030370L (fi) 2003-03-12
DE69621777D1 (de) 2002-07-18
IE80500B1 (en) 1998-08-12
SE9600406D0 (sv) 1996-02-05
CH688353A5 (de) 1997-08-15
SI21923A (sl) 2006-06-30

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