DK1982708T3 - Terapeutisk middel til inflammatorisk tarmsygdom omfattende 2-amino-1,3-propandiolderivativ som aktiv bestanddel, og fremgangsmåde til behandling af inflammatorisk tarmsygdom - Google Patents
Terapeutisk middel til inflammatorisk tarmsygdom omfattende 2-amino-1,3-propandiolderivativ som aktiv bestanddel, og fremgangsmåde til behandling af inflammatorisk tarmsygdom Download PDFInfo
- Publication number
- DK1982708T3 DK1982708T3 DK07713815.4T DK07713815T DK1982708T3 DK 1982708 T3 DK1982708 T3 DK 1982708T3 DK 07713815 T DK07713815 T DK 07713815T DK 1982708 T3 DK1982708 T3 DK 1982708T3
- Authority
- DK
- Denmark
- Prior art keywords
- inflammatory bowel
- disease
- bowel disease
- amino
- compound
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title claims description 27
- 239000003814 drug Substances 0.000 title claims description 14
- 239000004480 active ingredient Substances 0.000 title claims description 5
- 229940124597 therapeutic agent Drugs 0.000 title description 4
- 238000000034 method Methods 0.000 title description 3
- KJJPLEZQSCZCKE-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical class OCC(N)CO KJJPLEZQSCZCKE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 25
- 208000011231 Crohn disease Diseases 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 14
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 13
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 13
- 208000025865 Ulcer Diseases 0.000 claims description 10
- 230000002265 prevention Effects 0.000 claims description 10
- 231100000397 ulcer Toxicity 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 208000009137 Behcet syndrome Diseases 0.000 claims description 8
- 208000002389 Pouchitis Diseases 0.000 claims description 8
- 206010038063 Rectal haemorrhage Diseases 0.000 claims description 8
- 230000000968 intestinal effect Effects 0.000 claims description 8
- 210000001072 colon Anatomy 0.000 claims description 4
- XXHKHLYABSAFDW-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol Chemical compound C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 XXHKHLYABSAFDW-UHFFFAOYSA-N 0.000 claims description 3
- JGCZBUBEWYTICT-UHFFFAOYSA-N 5-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]pentane-1,3-diol;hydrochloride Chemical compound Cl.C1=C(Cl)C(C(CC(O)CCO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 JGCZBUBEWYTICT-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 20
- 201000010099 disease Diseases 0.000 description 19
- MYIFLDFUXIHOCJ-UHFFFAOYSA-N 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol;hydrochloride Chemical compound Cl.C1=C(Cl)C(CCC(CO)(CO)N)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 MYIFLDFUXIHOCJ-UHFFFAOYSA-N 0.000 description 15
- 210000002429 large intestine Anatomy 0.000 description 12
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002483 medication Methods 0.000 description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 2
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- 210000004877 mucosa Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- RVYNIIJBIAINNT-UHFFFAOYSA-N propane-1,3-diol;hydrochloride Chemical compound Cl.OCCCO RVYNIIJBIAINNT-UHFFFAOYSA-N 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
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- 238000002054 transplantation Methods 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000011960 Brassica ruvo Nutrition 0.000 description 1
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- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
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- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 241001163743 Perlodes Species 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 1
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 229960004168 balsalazide Drugs 0.000 description 1
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- VQODGRNSFPNSQE-DVTGEIKXSA-N betamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-DVTGEIKXSA-N 0.000 description 1
- 229950006991 betamethasone phosphate Drugs 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
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- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
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- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (8)
1. Forbindelsen 2-am¡no-2-[4-(3-benzyloxyphenylth¡o)-2-chlorphenyl]ethyl-l,3-propandiol, eller et farmaceutisk acceptabelt salt eller hydrat deraf, til anvendelse ¡ behandlingen eller forebyggelse af en ¡nflammatorisk tarmsygdom.
2. Forbindelsen til anvendelse i behandlingen eller forebyggelse af en ¡nflammatorisk tarmsygdom ifolge krav 1, hvor forbindelsen er 2-amino-2-[4-(3-benzyloxyphenylth¡o)-2-chlorphenyl]ethyl-l,3-propandiol-hydrochlorid.
3. Forbindelsen til anvendelse i behandlingen eller forebyggelse af en ¡nflammatorisk tarmsygdom ¡folge krav 1 eller 2, hvor den inflammatoriske tarmsygdom er Crohn's sygdom, Crohn's sygdom i tyktarmen, intestinal -Behcet's sygdom, ulcerativ colitis, blodende rektalsár, eller pouchitis.
4. Forbindelsen til anvendelse i behandlingen eller forebyggelse af en ¡nflammatorisk tarmsygdom ¡folge krav 1 eller 2, hvor den inflammatoriske tarmsygdom er Crohn's sygdom eller ulcerativ colitis.
5. Anvendelse af 2-am¡no-2-[4-(3-benzyloxyphenylthio)-2-chlorphenyl]ethyl-l,3-propandiol, eller et farmaceutisk acceptabelt salt eller hydrat deraf, som en aktiv bestanddel, til fremstillingen af et medikament til behandling eller forebyggelse af en ¡nflammatorisk tarmsygdom.
6. Anvendelsen ifolge krav 5, hvor den inflammatoriske tarmsygdom er Crohn's sygdom, Crohn's sygdom i tyktarmen, intestinal -Behcet's sygdom, ulcerativ colitis, blodende rektalsár, eller pouchitis.
7. Anvendelsen ifolge krav 5 eller 6, hvor forbindelsen er 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorphenyl]ethyl-l,3-propandiol-hydrochlorid.
8. Anvendelsen ifolge krav 5 eller 7, hvor den inflammatoriske tarmsygdom er Crohn's sygdom eller ulcerativ colitis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006027883 | 2006-02-06 | ||
| PCT/JP2007/051887 WO2007091501A1 (ja) | 2006-02-06 | 2007-02-05 | ２－アミノ－１，３－プロパンジオール誘導体を有効成分とする炎症性腸疾患治療剤又は炎症性腸疾患の治療方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1982708T3 true DK1982708T3 (da) | 2014-12-01 |
Family
ID=38345101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07713815.4T DK1982708T3 (da) | 2006-02-06 | 2007-02-05 | Terapeutisk middel til inflammatorisk tarmsygdom omfattende 2-amino-1,3-propandiolderivativ som aktiv bestanddel, og fremgangsmåde til behandling af inflammatorisk tarmsygdom |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US8318811B2 (da) |
| EP (2) | EP1982708B1 (da) |
| JP (1) | JP5042042B2 (da) |
| KR (1) | KR101334153B1 (da) |
| CN (1) | CN101378743B (da) |
| AU (1) | AU2007213194B9 (da) |
| BR (1) | BRPI0706971A2 (da) |
| CA (1) | CA2641546C (da) |
| CY (1) | CY1116112T1 (da) |
| DK (1) | DK1982708T3 (da) |
| EC (1) | ECSP088662A (da) |
| ES (1) | ES2524056T3 (da) |
| GT (1) | GT200800148A (da) |
| HK (1) | HK1126119A1 (da) |
| HR (1) | HRP20080421B1 (da) |
| IL (1) | IL192150A (da) |
| MA (1) | MA31338B1 (da) |
| MX (1) | MX2008008872A (da) |
| MY (1) | MY151193A (da) |
| NO (1) | NO20082708L (da) |
| NZ (1) | NZ568907A (da) |
| PL (1) | PL1982708T3 (da) |
| PT (1) | PT1982708E (da) |
| RU (1) | RU2428976C2 (da) |
| SG (1) | SG169370A1 (da) |
| SI (1) | SI1982708T1 (da) |
| TN (1) | TNSN08246A1 (da) |
| TW (1) | TWI389683B (da) |
| WO (1) | WO2007091501A1 (da) |
| ZA (1) | ZA200806199B (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0513110A (pt) | 2004-07-16 | 2008-04-29 | Kyorin Seiyaku Kk | medicamento compreendendo composto sulfeto diaril ou composto éter diaril tendo uma estrutura 2-amina-1, 3-propanediol tendo uma atividade de redução de linfócitos perifericamente circulante, em combinação com um agente imunosupressivo e/ou um agente antiinflamatório e método de expressão de prevenção do efeito secundário |
| US7795472B2 (en) | 2004-10-12 | 2010-09-14 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride and hydrates thereof, and intermediates in the production thereof |
| CA2624909C (en) | 2005-10-07 | 2013-10-01 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease |
| TWI389683B (zh) | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| MY146775A (en) | 2006-08-08 | 2012-09-28 | Kyorin Seiyaku Kk | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| MY152176A (en) | 2006-08-08 | 2014-08-15 | Kyorin Seiyaku Kk | Amino phosphate derivative and s1p receptor modulator having same as an active ingredient |
| WO2009099174A1 (ja) * | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| SG191598A1 (en) * | 2008-05-20 | 2013-07-31 | Kyorin Seiyaku Kk | Agent for induction/maintenance of remission |
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