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TW200702326A - 2-aminobutanol compound and its pharmaceutical use - Google Patents

2-aminobutanol compound and its pharmaceutical use

Info

Publication number
TW200702326A
TW200702326A TW095119107A TW95119107A TW200702326A TW 200702326 A TW200702326 A TW 200702326A TW 095119107 A TW095119107 A TW 095119107A TW 95119107 A TW95119107 A TW 95119107A TW 200702326 A TW200702326 A TW 200702326A
Authority
TW
Taiwan
Prior art keywords
atom
halogen atom
optionally substituted
alkyl group
compound
Prior art date
Application number
TW095119107A
Other languages
Chinese (zh)
Inventor
Masatoshi Kiuchi
Nobutaka Kobayashi
Kunio Sugahara
Mitsuharu Nakamura
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Publication of TW200702326A publication Critical patent/TW200702326A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention provides a novel 2-aminobutanol compound of the following formula (1), excellent in immune suppression and repulsion suppression, and reducing the side effect of bradycardia; its acid addition salts permitted on the medicine manufacture or those hydrates, and solvate; and a pharmaceutical composition containing those compound and the carrier permitted on the medicine manufacture. (wherein, R represents a hydrogen atom or P(=O)(OH)2, R1 represents an alkyl group having 1 to 4 carbon atom(s), which optionally substituted by hydroxyl group or halogen atom; R2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atom(s), which optionally substituted by halogen atom; R3 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atom(s), which optionally substituted by halogen atom.)
TW095119107A 2005-05-31 2006-05-30 2-aminobutanol compound and its pharmaceutical use TW200702326A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005159672 2005-05-31
PCT/JP2006/310841 WO2006129688A1 (en) 2005-05-31 2006-05-31 2-aminobutanol compound and pharmaceutical use thereof

Publications (1)

Publication Number Publication Date
TW200702326A true TW200702326A (en) 2007-01-16

Family

ID=37481617

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095119107A TW200702326A (en) 2005-05-31 2006-05-30 2-aminobutanol compound and its pharmaceutical use

Country Status (2)

Country Link
TW (1) TW200702326A (en)
WO (1) WO2006129688A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006009092A1 (en) 2004-07-16 2006-01-26 Kyorin Pharmaceutical Co., Ltd. Method of effectively using medicine and method concerning prevention of side effect
PL1806338T3 (en) 2004-10-12 2016-07-29 Kyorin Seiyaku Kk Process for producing 2-amino-2-[2-[4-(3-benzyloxy­phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof
JP5116476B2 (en) 2005-10-07 2013-01-09 杏林製薬株式会社 Liver disease therapeutic agent and liver disease treatment method comprising 2-amino-1,3-propanediol derivative as an active ingredient
TWI389683B (en) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
PL2058317T3 (en) 2006-08-08 2014-03-31 Kyorin Seiyaku Kk Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
EP2053038B1 (en) 2006-08-08 2016-10-05 Kyorin Pharmaceutical Co., Ltd. Amino alcohol derivative and immunosuppressive agent having same as an active ingredient
JP5198293B2 (en) * 2007-02-13 2013-05-15 杏林製薬株式会社 Therapeutic or preventive agent for demyelinating disease comprising amino alcohol derivative as active ingredient
WO2009025767A1 (en) 2007-08-17 2009-02-26 Research Foundation Of The City University Of New York Boron dipyrromethene difluoro (bodipy) conjugates
JP5452237B2 (en) 2008-02-07 2014-03-26 杏林製薬株式会社 Therapeutic or prophylactic agent for inflammatory bowel disease comprising an amino alcohol derivative as an active ingredient
AU2009226975B2 (en) * 2008-03-19 2012-09-06 Novartis Ag Process for the preparation of 2-amino-2- [2- (4-C3-C21-alkyl-phenyl)ethyl] propane-1, 3-diols
WO2011070066A1 (en) * 2009-12-10 2011-06-16 Novartis Ag Fty720 halogenated derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2286315C (en) * 1997-04-04 2007-03-06 Yoshitomi Pharmaceutical Industries Ltd. 2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor

Also Published As

Publication number Publication date
WO2006129688A1 (en) 2006-12-07

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