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IL204621A - Bicyclic - gamma - amino acid derivatives, compositions comprising the same and uses thereof - Google Patents

Bicyclic - gamma - amino acid derivatives, compositions comprising the same and uses thereof

Info

Publication number
IL204621A
IL204621A IL204621A IL20462110A IL204621A IL 204621 A IL204621 A IL 204621A IL 204621 A IL204621 A IL 204621A IL 20462110 A IL20462110 A IL 20462110A IL 204621 A IL204621 A IL 204621A
Authority
IL
Israel
Prior art keywords
bicyclic
amino acid
gamma
compositions
same
Prior art date
Application number
IL204621A
Other languages
Hebrew (he)
Other versions
IL204621A0 (en
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of IL204621A0 publication Critical patent/IL204621A0/en
Publication of IL204621A publication Critical patent/IL204621A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/613—Unsaturated compounds containing a keto groups being part of a ring polycyclic
    • C07C49/617—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/623—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
    • C07C49/627—Unsaturated compounds containing a keto groups being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing seven carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/94—Spiro compounds containing "free" spiro atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

It is intended to provide a bicyclic ³-amino acid derivative having excellent activity as an ± 2 ´ ligand. The present invention provides a compound represented by the general formula (I): wherein R 1 , R 2 , R 2' , R 4 , R 5 , R 6 , R 7 , R 8 , and R 8' are a hydrogen atom or the like; and R 3 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like.
IL204621A 2007-09-28 2010-03-21 Bicyclic - gamma - amino acid derivatives, compositions comprising the same and uses thereof IL204621A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007255430 2007-09-28
PCT/JP2008/067223 WO2009041453A1 (en) 2007-09-28 2008-09-25 Bicyclic γ-amino acid derivative

Publications (2)

Publication Number Publication Date
IL204621A0 IL204621A0 (en) 2010-11-30
IL204621A true IL204621A (en) 2013-04-30

Family

ID=40511336

Family Applications (1)

Application Number Title Priority Date Filing Date
IL204621A IL204621A (en) 2007-09-28 2010-03-21 Bicyclic - gamma - amino acid derivatives, compositions comprising the same and uses thereof

Country Status (26)

Country Link
US (1) US7947738B2 (en)
EP (2) EP2192109B1 (en)
JP (1) JP4479974B2 (en)
KR (2) KR101335784B1 (en)
CN (2) CN101878193B (en)
AU (1) AU2008304933B2 (en)
BR (2) BR122013020635A2 (en)
CA (1) CA2701110C (en)
CO (1) CO6270314A2 (en)
CY (1) CY1114836T1 (en)
DK (1) DK2192109T3 (en)
ES (2) ES2433890T3 (en)
HK (2) HK1139381A1 (en)
HR (1) HRP20130935T1 (en)
IL (1) IL204621A (en)
MX (1) MX2010003394A (en)
MY (2) MY153910A (en)
NZ (1) NZ584699A (en)
PH (1) PH12013501663B1 (en)
PL (1) PL2192109T3 (en)
PT (1) PT2192109E (en)
RU (1) RU2446148C2 (en)
SI (1) SI2192109T1 (en)
TW (2) TWI436762B (en)
WO (1) WO2009041453A1 (en)
ZA (1) ZA201002013B (en)

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AU2008304933B2 (en) 2007-09-28 2011-02-24 Daiichi Sankyo Company, Limited Bicyclic y-amino acid derivative
WO2010079668A1 (en) * 2009-01-08 2010-07-15 第一三共株式会社 Olefin compound
CA2756750C (en) * 2009-03-26 2014-05-13 Daiichi Sankyo Company, Limited A method for producing bicyclic .gamma.-amino acid derivative
EP2719676B1 (en) 2011-06-08 2017-12-13 Daiichi Sankyo Company, Limited Method for producing bicyclic compound via iminium salt
CA2838651C (en) 2011-06-08 2016-05-17 Daiichi Sankyo Company, Limited Method for producing bicyclic compound via claisen rearrangement
EP2792664B1 (en) 2011-12-15 2018-07-04 Daiichi Sankyo Company, Limited Optical resolution method for bicyclic compound using asymmetric catalyst
WO2013089189A1 (en) * 2011-12-16 2013-06-20 第一三共株式会社 Optical resolution method for bicyclic compound using hydroxysulfonic acid
EP2813513B1 (en) * 2012-02-08 2019-07-03 Stella Pharma Corporation Method for producing cereulide and derivative thereof, intermediate for production of cereulide, and cereulide derivative
CA2869994C (en) * 2012-04-10 2017-05-30 Daiichi Sankyo Company, Limited Optical resolution method for bicyclic compound using enzyme
EP2826477B1 (en) * 2013-04-04 2017-05-31 Daiichi Sankyo Company, Limited Solid composition of amino carboxylate salt
TWI635071B (en) * 2013-07-08 2018-09-11 第一三共股份有限公司 OPTICALLY ACTIVE BICYCLIC γ-AMINO ACID AND PREPARATION METHOD FOR THE SAME
RU2679407C1 (en) * 2013-12-18 2019-02-08 Новассе Са Gamma-aminobutyric acid (gaba) analogues for treatment of pain and other disorders
WO2016148263A1 (en) 2015-03-19 2016-09-22 第一三共株式会社 Solid preparation containing antioxidant agent
EP3513788B1 (en) 2015-03-19 2020-07-29 Daiichi Sankyo Company, Limited Solid preparation containing colorant
CN107848953B (en) * 2015-12-25 2021-05-18 四川海思科制药有限公司 Fused ring gamma-amino acid derivative, preparation method and application thereof in medicine
CN106928080B (en) * 2015-12-31 2020-12-25 四川海思科制药有限公司 Fused ring gamma-amino acid derivative, preparation method and application thereof in medicine
CN107848952B (en) * 2015-12-31 2021-04-09 四川海思科制药有限公司 Fused tricyclic gamma-amino acid derivative, preparation method and application thereof in medicine
WO2017183539A1 (en) * 2016-04-18 2017-10-26 第一三共株式会社 Method for producing bicyclic compound using meldrum's acid
TW201806928A (en) * 2016-07-01 2018-03-01 第一三共股份有限公司 Crystals of aminocarboxylic acid acid addition salts and the synthetic method thereof
RU2756270C2 (en) * 2016-07-21 2021-09-29 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Indole derivative used as crth2 inhibitor
CA3035121C (en) * 2016-09-14 2021-02-16 Sichuan Haisco Pharmaceutical Co., Ltd. Fused tricyclic .gamma.-amino acid derivative, preparation method therefor, and medical use thereof
JP7051332B2 (en) * 2017-08-23 2022-04-11 キヤノン株式会社 Organic compounds and photoelectric conversion elements
WO2020011258A1 (en) * 2018-07-12 2020-01-16 四川海思科制药有限公司 Crystal form of salt of fused tricyclic γ-amino acid derivative and preparation and use thereof
AU2019302611B2 (en) * 2018-07-12 2022-02-17 Sichuan Haisco Pharmaceutical Co., Ltd. Composition of Fused Tricyclic gamma-Amino Acid Derivatives and the Preparation Thereof
CN118286172A (en) * 2018-07-30 2024-07-05 第一三共株式会社 Solid pharmaceutical preparation containing a stabilizer
WO2020029762A1 (en) * 2018-08-09 2020-02-13 四川海思科制药有限公司 PREPARATION METHOD FOR FUSED TRICYCLIC γ-AMINO ACID DERIVATIVE AND INTERMEDIATE THEREOF
CN114402198A (en) * 2019-09-03 2022-04-26 四川海思科制药有限公司 Impurity detection method for 2- ((1S,2S,3R,6S,8S) -2- (aminomethyl) tricyclo [4.2.1.03,8] nonane-2-yl) acetic acid benzene sulfonate or composition thereof
CN110511141B (en) * 2019-09-09 2022-04-29 上海凌凯医药科技有限公司 Synthesis method of valproyl urea
EP4049679A4 (en) * 2019-10-25 2023-11-01 Kyoto University THERAPEUTIC OR TAUOPATHY PREVENTION AGENT
CN110818582B (en) * 2019-11-20 2023-06-09 合肥拓锐生物科技有限公司 GABA analogue and salt thereof, and synthetic method, application and medicine thereof
CN111116345A (en) * 2019-12-30 2020-05-08 上海华理生物医药股份有限公司 Novel method for preparing Mirogabalin
AU2022273980A1 (en) 2021-05-12 2023-10-12 Boehringer Ingelheim International Gmbh Pyridine derivatives with c-linked cyclic substituents as cgas inhibitors
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CN117986143A (en) * 2022-11-03 2024-05-07 中科中山药物创新研究院 Gamma-aminobutyric acid derivatives containing polycyclic structures and preparation methods and uses thereof
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CN117800858B (en) * 2023-12-28 2024-06-21 南京津泓科技有限公司 Preparation method for catalytic cyanation of milbelin
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Also Published As

Publication number Publication date
BRPI0818193B8 (en) 2021-05-25
HRP20130935T1 (en) 2013-11-22
BRPI0818193B1 (en) 2020-11-10
WO2009041453A1 (en) 2009-04-02
ES2433890T3 (en) 2013-12-12
CN101878193A (en) 2010-11-03
KR101409079B1 (en) 2014-06-18
MX2010003394A (en) 2010-04-09
CN101878193B (en) 2014-07-09
MY172034A (en) 2019-11-12
KR101335784B1 (en) 2013-12-05
CA2701110C (en) 2013-01-08
PL2192109T3 (en) 2014-01-31
HK1139381A1 (en) 2010-09-17
EP2192109B1 (en) 2013-09-04
JP4479974B2 (en) 2010-06-09
SI2192109T1 (en) 2014-03-31
BRPI0818193A2 (en) 2017-12-12
TWI526425B (en) 2016-03-21
MY153910A (en) 2015-04-15
KR20100065342A (en) 2010-06-16
ES2531324T3 (en) 2015-03-13
CY1114836T1 (en) 2016-12-14
KR20130093181A (en) 2013-08-21
EP2657219B1 (en) 2014-12-10
NZ584699A (en) 2011-04-29
BR122013020635A2 (en) 2019-08-06
PH12013501663B1 (en) 2018-09-07
US7947738B2 (en) 2011-05-24
RU2446148C2 (en) 2012-03-27
TW200924743A (en) 2009-06-16
CA2701110A1 (en) 2009-04-02
AU2008304933B2 (en) 2011-02-24
AU2008304933A1 (en) 2009-04-02
DK2192109T3 (en) 2013-12-16
CN103483169A (en) 2014-01-01
RU2010116708A (en) 2011-11-10
IL204621A0 (en) 2010-11-30
TW201439053A (en) 2014-10-16
EP2192109A4 (en) 2012-04-18
EP2657219A1 (en) 2013-10-30
PH12013501663A1 (en) 2015-02-09
ZA201002013B (en) 2010-11-24
TWI436762B (en) 2014-05-11
PT2192109E (en) 2013-12-09
US20100249229A1 (en) 2010-09-30
EP2192109A1 (en) 2010-06-02
HK1190698A1 (en) 2014-07-11
JPWO2009041453A1 (en) 2011-01-27
CO6270314A2 (en) 2011-04-20

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