DK1869056T3 - Nye 5-substituerede 7-amino-[1,3]thiazolo[4,5-D]pyrimidin-derivater - Google Patents

Nye 5-substituerede 7-amino-[1,3]thiazolo[4,5-D]pyrimidin-derivater

Info

Publication number: DK1869056T3
Authority: DK; Denmark
Prior art keywords: thiazolo; amino; substituted; new; pyrimidine derivatives
Prior art date: 2005-04-06

Application number

DK06717078.7T

Other languages

English (en)

Inventor

Gunnar Nordvall

Colin Ray

Tobias Rein

Daniel Sohn

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-04-06

Filing date

2006-04-03

Publication date

2011-02-07

2006-04-03 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2011-02-07 Application granted granted Critical

2011-02-07 Publication of DK1869056T3 publication Critical patent/DK1869056T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK06717078.7T 2005-04-06 2006-04-03 Nye 5-substituerede 7-amino-[1,3]thiazolo[4,5-D]pyrimidin-derivater DK1869056T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0500767		2005-04-06
PCT/SE2006/000399 WO2006107258A1 (en)	2005-04-06	2006-04-03	Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
DK1869056T3 true DK1869056T3 (da)	2011-02-07

Family

ID=37073739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06717078.7T DK1869056T3 (da)	2005-04-06	2006-04-03	Nye 5-substituerede 7-amino-[1,3]thiazolo[4,5-D]pyrimidin-derivater

Country Status (31)

Country	Link
US (2)	US7947693B2 (da)
EP (1)	EP1869056B1 (da)
JP (1)	JP5165553B2 (da)
KR (1)	KR101335055B1 (da)
CN (1)	CN101193897B (da)
AR (1)	AR055890A1 (da)
AT (1)	ATE487727T1 (da)
AU (1)	AU2006231836B2 (da)
BR (1)	BRPI0609738A2 (da)
CA (1)	CA2604017C (da)
CY (1)	CY1111316T1 (da)
DE (1)	DE602006018124D1 (da)
DK (1)	DK1869056T3 (da)
ES (1)	ES2354450T3 (da)
HK (1)	HK1118556A1 (da)
HR (1)	HRP20110047T1 (da)
IL (1)	IL185912A0 (da)
MX (1)	MX2007012060A (da)
NO (1)	NO20075603L (da)
NZ (1)	NZ561460A (da)
PL (1)	PL1869056T3 (da)
PT (1)	PT1869056E (da)
RS (1)	RS51581B (da)
RU (1)	RU2419623C2 (da)
SA (1)	SA06270072B1 (da)
SI (1)	SI1869056T1 (da)
TW (1)	TW200714605A (da)
UA (1)	UA90707C2 (da)
UY (1)	UY29454A1 (da)
WO (1)	WO2006107258A1 (da)
ZA (1)	ZA200708187B (da)

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EP1806145B1 (en)	2004-10-29	2017-08-16	Eisai R&D Management Co., Ltd.	Remedy for inflammatory diseases
AR053347A1 (es)	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos
TW200820973A (en)	2006-09-29	2008-05-16	Astrazeneca Ab	Novel compounds 480
JP2010504963A (ja) *	2006-09-29	2010-02-18	アストラゼネカ・アクチエボラーグ	新規な５，７−二置換された［１，３］チアゾロ［４，５−ｄ］ピリミジン−２（３ｈ）−アミン誘導体及び治療におけるその使用
MX2010009625A (es)	2008-03-07	2010-09-28	Acraf	Derivados de 1-bencil-3-hidroximetilindazol y uso de los mismos en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1 y p40.
AU2009221063B2 (en)	2008-03-07	2013-03-21	Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.	1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, and CX3CR1
PT2254869T (pt)	2008-03-07	2017-07-18	Acraf	Novos derivados de 1-benzil-3-hidroximetilindazole e suas utilizações no tratamento de doenças com base na expressão de cx3cr1 e p40
WO2010132999A1 (en)	2009-05-21	2010-11-25	Chlorion Pharma, Inc.	Methyl sulfanyl pyrmidmes useful as antiinflammatories, analgesics, and antiepileptics
JO3437B1 (ar)	2009-10-30	2019-10-20	Esai R & D Man Co Ltd	أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
EP2648754A4 (en)	2010-12-07	2016-02-24	Philadelphia Health & Educatio	METHOD OF INHIBITING CANCER METASTASES
US8476301B2 (en)	2011-09-13	2013-07-02	Eisai R&D Management Co., Ltd.	Pyrrolidin-3-ylacetic acid derivative
JO3082B1 (ar)	2011-09-13	2017-03-15	Eisai R&D Man Co Ltd	مشتق بيروليدين-3- يل حمض خليك
US9550732B2 (en)	2013-03-12	2017-01-24	Eisai R&D Management Co., Ltd.	Salt of pyrrolidin-3-yl acetic acid derivative and crystals thereof
MX2016003843A (es) *	2013-09-27	2017-02-15	Nimbus Iris Inc	Inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos.
US20180222922A1 (en) *	2015-06-08	2018-08-09	The Johns Hopkins University	Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
US11267817B2 (en)	2017-05-02	2022-03-08	Drexel University	Substituted pyrrolo[1,2-a]quinoxalin-4(5H)-ones as CX3CR1 antagonists
GB201807898D0 (en) *	2018-05-15	2018-06-27	Kancera Ab	New processes and products with increased chiral purity
GB201811169D0 (en)	2018-07-06	2018-08-29	Kancera Ab	New compounds
GB202006849D0 (en)	2020-05-08	2020-06-24	Kancera Ab	New use
US20240199558A1 (en)	2022-10-19	2024-06-20	Astrazeneca Ab	2,4,6-trisubstituted 1,3,5-triazines as modulators of cx3cr1

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BE543978A (da) *	1955-01-03
US4698327A (en) *	1985-04-25	1987-10-06	Eli Lilly And Company	Novel glycopeptide derivatives
US4639433A (en) *	1985-08-14	1987-01-27	Eli Lilly And Company	Glycopeptide derivatives
US4643987A (en) *	1985-08-14	1987-02-17	Eli Lilly And Company	Modified glycopeptides
CA2031803C (en) *	1989-12-13	2001-05-29	Ramakrishnan Nagarajan	Improvements in or relating to glycopeptide deriveratives
US5202328A (en) *	1991-03-06	1993-04-13	Merck & Co., Inc.	Substituted fused pyrimidinones
US5840684A (en) *	1994-01-28	1998-11-24	Eli Lilly And Company	Glycopeptide antibiotic derivatives
WO1999051608A1 (en) *	1998-04-03	1999-10-14	Du Pont Pharmaceuticals Company	THIAZOLO[4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS
JP4307723B2 (ja)	1998-05-01	2009-08-05	イーライリリーアンドカンパニー	Ｎ１−修飾グリコペプチド
SE9802729D0 (sv)	1998-08-13	1998-08-13	Astra Pharma Prod	Novel Compounds
SE9903544D0 (sv) *	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
EP1257555B1 (en) *	2000-02-11	2003-12-03	AstraZeneca AB	Pyrimidine compounds and their use as modulators of chemokine receptor activity
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
SE0004110L (sv) *	2000-11-10	2002-05-11	Forsheda Ab	Tätningsring
SE0101082D0 (sv) *	2001-03-27	2001-03-27	Astrazeneca Ab	Novel use
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221829D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
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WO2006064228A2 (en) *	2004-12-17	2006-06-22	Astrazeneca Ab	Thiazolopyramidine compounds for the modulation of chemokine receptor activity
AR053347A1 (es) *	2005-04-06	2007-05-02	Astrazeneca Ab	Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos

2006
- 2006-03-04 UA UAA200710491A patent/UA90707C2/ru unknown
- 2006-03-27 AR ARP060101169A patent/AR055890A1/es not_active Application Discontinuation
- 2006-03-28 TW TW095110726A patent/TW200714605A/zh unknown
- 2006-03-29 SA SA06270072A patent/SA06270072B1/ar unknown
- 2006-04-03 US US11/910,780 patent/US7947693B2/en active Active
- 2006-04-03 EP EP06717078A patent/EP1869056B1/en active Active
- 2006-04-03 CN CN2006800200726A patent/CN101193897B/zh active Active
- 2006-04-03 DE DE602006018124T patent/DE602006018124D1/de active Active
- 2006-04-03 NZ NZ561460A patent/NZ561460A/en not_active IP Right Cessation
- 2006-04-03 MX MX2007012060A patent/MX2007012060A/es active IP Right Grant
- 2006-04-03 PT PT06717078T patent/PT1869056E/pt unknown
- 2006-04-03 KR KR1020077022813A patent/KR101335055B1/ko not_active IP Right Cessation
- 2006-04-03 AU AU2006231836A patent/AU2006231836B2/en not_active Ceased
- 2006-04-03 BR BRPI0609738-3A patent/BRPI0609738A2/pt not_active IP Right Cessation
- 2006-04-03 AT AT06717078T patent/ATE487727T1/de active
- 2006-04-03 JP JP2008505262A patent/JP5165553B2/ja active Active
- 2006-04-03 SI SI200630886T patent/SI1869056T1/sl unknown
- 2006-04-03 RU RU2007140551/04A patent/RU2419623C2/ru not_active IP Right Cessation
- 2006-04-03 PL PL06717078T patent/PL1869056T3/pl unknown
- 2006-04-03 CA CA2604017A patent/CA2604017C/en not_active Expired - Fee Related
- 2006-04-03 DK DK06717078.7T patent/DK1869056T3/da active
- 2006-04-03 RS RS20110006A patent/RS51581B/en unknown
- 2006-04-03 WO PCT/SE2006/000399 patent/WO2006107258A1/en active Application Filing
- 2006-04-03 ES ES06717078T patent/ES2354450T3/es active Active
- 2006-04-04 UY UY29454A patent/UY29454A1/es not_active Application Discontinuation
2007
- 2007-09-11 IL IL185912A patent/IL185912A0/en unknown
- 2007-09-25 ZA ZA200708187A patent/ZA200708187B/xx unknown
- 2007-11-05 NO NO20075603A patent/NO20075603L/no not_active Application Discontinuation
2008
- 2008-11-14 HK HK08112536.8A patent/HK1118556A1/xx not_active IP Right Cessation
2010
- 2010-12-28 US US12/979,720 patent/US9440992B2/en active Active
2011
- 2011-01-13 CY CY20111100040T patent/CY1111316T1/el unknown
- 2011-01-21 HR HR20110047T patent/HRP20110047T1/hr unknown

Also Published As

Publication number	Publication date
CN101193897A (zh)	2008-06-04
US9440992B2 (en)	2016-09-13
JP5165553B2 (ja)	2013-03-21
KR20080004483A (ko)	2008-01-09
RU2007140551A (ru)	2009-05-20
US20110092519A1 (en)	2011-04-21
EP1869056A4 (en)	2010-02-17
EP1869056B1 (en)	2010-11-10
TW200714605A (en)	2007-04-16
EP1869056A1 (en)	2007-12-26
US20080214578A1 (en)	2008-09-04
NZ561460A (en)	2010-12-24
CA2604017A1 (en)	2006-10-12
CA2604017C (en)	2012-03-06
DE602006018124D1 (de)	2010-12-23
NO20075603L (no)	2008-01-04
AU2006231836A1 (en)	2006-10-12
MX2007012060A (es)	2007-12-13
HK1118556A1 (en)	2009-02-13
RS51581B (en)	2011-08-31
AU2006231836B2 (en)	2010-07-15
PL1869056T3 (pl)	2011-04-29
IL185912A0 (en)	2008-01-06
SI1869056T1 (sl)	2011-02-28
ES2354450T3 (es)	2011-03-15
AR055890A1 (es)	2007-09-12
US7947693B2 (en)	2011-05-24
ZA200708187B (en)	2008-11-26
WO2006107258A1 (en)	2006-10-12
CN101193897B (zh)	2010-12-01
JP2008535835A (ja)	2008-09-04
CY1111316T1 (el)	2015-08-05
SA06270072B1 (ar)	2009-02-07
HRP20110047T1 (hr)	2011-03-31
RU2419623C2 (ru)	2011-05-27
KR101335055B1 (ko)	2013-12-02
PT1869056E (pt)	2011-01-13
BRPI0609738A2 (pt)	2011-10-18
UY29454A1 (es)	2006-11-30
UA90707C2 (en)	2010-05-25
ATE487727T1 (de)	2010-11-15

Publication	Publication Date	Title
DK1869056T3 (da)	2011-02-07	Nye 5-substituerede 7-amino-[1,3]thiazolo[4,5-D]pyrimidin-derivater
NL2000323A1 (nl)	2007-06-21	Pyrimidine-derivaten.
MA28824B1 (fr)	2007-08-01	Derives de pyrimidine
MA28813B1 (fr)	2007-08-01	Derives de pyrimidine
DK1957492T3 (da)	2011-02-28	Substituerede bicykliske pyrimidonderivater
EP1724267A4 (en)	2009-04-22	pyrimidine derivative
SMP200800029B (it)	2008-05-07	2-ammino-7,8-diidro-6h-pirido[4,3-d]pirimidin-5-oni
EP1890703A4 (en)	2010-11-03	pyrimidine
DE122012000043I1 (de)	2012-09-13	Pyrrolo[2,3-B]pyridinderivate als proteinkinaseinhibitoren.
ATE512966T1 (de)	2011-07-15	Pyrazolo-pyrimidin-derivate als mglur2- antagonisten
DK1797099T3 (da)	2010-11-29	Piperidinylamino-thieno[2,3-D]pyrimidinforbindelser
ATE520672T1 (de)	2011-09-15	Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine
DK1913000T3 (da)	2012-03-12	Pyrrolo[2,3-D]pyrimidinderivater; deres mellemprodukter og syntese
DK1919907T3 (da)	2011-04-18	Heterocyklisk forbindelse
DK1937650T3 (da)	2011-10-03	Heterocykliske forbindelser
NL2000284A1 (nl)	2007-05-07	Pyrazine-derivaten.
ATE449080T1 (de)	2009-12-15	4-phenyl-6-substituierte pyrimidin-2- carbonitrilderivate
GB0525080D0 (en)	2006-01-18	Pyrimidine derivatives
EP1717225A4 (en)	2009-10-21	BICYCLIC AMIDE DERIVATIVES
DK1854789T3 (da)	2013-10-21	Quinazolinderivat med tyrosin-kinase inhibitorisk aktivitet
GB0525083D0 (en)	2006-01-18	Pyrimidine derivatives
EP1907393A4 (en)	2011-10-05	INTROVERTIS CUCURBITURILIC COMPOUNDS
ATE442539T1 (de)	2009-09-15	Rollspindel
BRPI0822239A2 (pt)	2015-06-30	Composto de pirazolo[1,5-a] pirimidina
NO20070299L (no)	2007-03-26	Novel heterocyclic compounds