DK175666B1 - Behandling af autoimmune sygdomme ved oral administration af autoantigener - Google Patents

Behandling af autoimmune sygdomme ved oral administration af autoantigener Download PDF

Info

Publication number: DK175666B1
Authority: DK; Denmark
Prior art keywords: mbp; rats; cell; eae; suppression
Prior art date: 1987-06-24

Application number

DK198906516A

Other languages

Danish (da)

English (en)

Other versions

DK651689A (da

DK651689D0 (da

Inventor

Howard L Weiner

David A Hafler

Original Assignee

Autoimmune Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-24

Filing date

1989-12-20

Publication date

2005-01-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22064733&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175666(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-12-20 Application filed by Autoimmune Inc filed Critical Autoimmune Inc

1989-12-20 Publication of DK651689D0 publication Critical patent/DK651689D0/da

1990-02-26 Publication of DK651689A publication Critical patent/DK651689A/da

2005-01-10 Application granted granted Critical

2005-01-10 Publication of DK175666B1 publication Critical patent/DK175666B1/da

Links

208000023275 Autoimmune disease Diseases 0.000 title claims abstract description 35
238000011282 treatment Methods 0.000 title claims description 14
239000012634 fragment Substances 0.000 claims abstract description 52
210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 33
230000001404 mediated effect Effects 0.000 claims abstract description 14
210000004027 cell Anatomy 0.000 claims description 52
230000001419 dependent effect Effects 0.000 claims description 13
201000006417 multiple sclerosis Diseases 0.000 claims description 11
239000003814 drug Substances 0.000 claims description 9
229940079593 drug Drugs 0.000 claims description 7
208000024891 symptom Diseases 0.000 claims description 7
208000030836 Hashimoto thyroiditis Diseases 0.000 claims description 3
206010012601 diabetes mellitus Diseases 0.000 claims description 2
230000001712 encephalitogenic effect Effects 0.000 claims description 2
238000009472 formulation Methods 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
206010039073 rheumatoid arthritis Diseases 0.000 claims 1
241001465754 Metazoa Species 0.000 abstract description 59
238000000034 method Methods 0.000 abstract description 17
230000001225 therapeutic effect Effects 0.000 abstract description 2
230000000069 prophylactic effect Effects 0.000 abstract 1
241000700159 Rattus Species 0.000 description 103
201000002491 encephalomyelitis Diseases 0.000 description 62
230000001629 suppression Effects 0.000 description 52
201000010099 disease Diseases 0.000 description 37
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 37
108091007433 antigens Proteins 0.000 description 33
102000036639 antigens Human genes 0.000 description 33
230000003053 immunization Effects 0.000 description 33
238000002649 immunization Methods 0.000 description 33
239000000427 antigen Substances 0.000 description 32
239000002953 phosphate buffered saline Substances 0.000 description 26
108091003079 Bovine Serum Albumin Proteins 0.000 description 24
229940098773 bovine serum albumin Drugs 0.000 description 22
230000004044 response Effects 0.000 description 21
210000001165 lymph node Anatomy 0.000 description 20
230000035755 proliferation Effects 0.000 description 18
238000011694 lewis rat Methods 0.000 description 17
241000700199 Cavia porcellus Species 0.000 description 15
102000006386 Myelin Proteins Human genes 0.000 description 14
108010083674 Myelin Proteins Proteins 0.000 description 14
239000002671 adjuvant Substances 0.000 description 13
230000000694 effects Effects 0.000 description 12
230000006698 induction Effects 0.000 description 12
210000004989 spleen cell Anatomy 0.000 description 12
238000002474 experimental method Methods 0.000 description 11
238000000338 in vitro Methods 0.000 description 11
230000009696 proliferative response Effects 0.000 description 11
230000028993 immune response Effects 0.000 description 10
238000001802 infusion Methods 0.000 description 10
238000002347 injection Methods 0.000 description 10
239000007924 injection Substances 0.000 description 10
210000002966 serum Anatomy 0.000 description 10
101001018322 Sus scrofa Myelin basic protein Proteins 0.000 description 9
238000004519 manufacturing process Methods 0.000 description 9
210000000952 spleen Anatomy 0.000 description 9
238000012546 transfer Methods 0.000 description 9
208000009386 Experimental Arthritis Diseases 0.000 description 8
108090000765 processed proteins & peptides Proteins 0.000 description 8
108090000623 proteins and genes Proteins 0.000 description 8
239000000126 substance Substances 0.000 description 8
201000008827 tuberculosis Diseases 0.000 description 8
238000006243 chemical reaction Methods 0.000 description 7
239000006228 supernatant Substances 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
241000283707 Capra Species 0.000 description 6
238000011161 development Methods 0.000 description 6
210000004698 lymphocyte Anatomy 0.000 description 6
102000004169 proteins and genes Human genes 0.000 description 6
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
241000699666 Mus <mouse, genus> Species 0.000 description 5
241000699670 Mus sp. Species 0.000 description 5
241000187479 Mycobacterium tuberculosis Species 0.000 description 5
125000003275 alpha amino acid group Chemical group 0.000 description 5
230000005764 inhibitory process Effects 0.000 description 5
210000002751 lymph Anatomy 0.000 description 5
102000013415 peroxidase activity proteins Human genes 0.000 description 5
108040007629 peroxidase activity proteins Proteins 0.000 description 5
239000000243 solution Substances 0.000 description 5
230000000638 stimulation Effects 0.000 description 5
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
229920001213 Polysorbate 20 Polymers 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
238000010171 animal model Methods 0.000 description 4
206010003246 arthritis Diseases 0.000 description 4
210000004556 brain Anatomy 0.000 description 4
230000001939 inductive effect Effects 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 4
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000007790 solid phase Substances 0.000 description 4
238000005406 washing Methods 0.000 description 4
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 4
102100028626 4-hydroxyphenylpyruvate dioxygenase Human genes 0.000 description 3
208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
206010023232 Joint swelling Diseases 0.000 description 3
241000272168 Laridae Species 0.000 description 3
206010033799 Paralysis Diseases 0.000 description 3
229930182555 Penicillin Natural products 0.000 description 3
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 3
150000001413 amino acids Chemical class 0.000 description 3
230000001363 autoimmune Effects 0.000 description 3
230000006472 autoimmune response Effects 0.000 description 3
230000004071 biological effect Effects 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
239000006285 cell suspension Substances 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
239000004927 clay Substances 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
231100000673 dose–response relationship Toxicity 0.000 description 3
238000003306 harvesting Methods 0.000 description 3
230000003832 immune regulation Effects 0.000 description 3
210000000987 immune system Anatomy 0.000 description 3
230000016784 immunoglobulin production Effects 0.000 description 3
230000002757 inflammatory effect Effects 0.000 description 3
210000003141 lower extremity Anatomy 0.000 description 3
210000000713 mesentery Anatomy 0.000 description 3
229940049954 penicillin Drugs 0.000 description 3
238000007639 printing Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
230000009257 reactivity Effects 0.000 description 3
230000035945 sensitivity Effects 0.000 description 3
229960005322 streptomycin Drugs 0.000 description 3
239000000758 substrate Substances 0.000 description 3
210000001519 tissue Anatomy 0.000 description 3
230000020192 tolerance induction in gut-associated lymphoid tissue Effects 0.000 description 3
IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
241000700198 Cavia Species 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
241000208202 Linaceae Species 0.000 description 2
235000004431 Linum usitatissimum Nutrition 0.000 description 2
102000007079 Peptide Fragments Human genes 0.000 description 2
108010033276 Peptide Fragments Proteins 0.000 description 2
239000012980 RPMI-1640 medium Substances 0.000 description 2
206010070834 Sensitisation Diseases 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
230000002159 abnormal effect Effects 0.000 description 2
238000010521 absorption reaction Methods 0.000 description 2
230000004913 activation Effects 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
239000012888 bovine serum Substances 0.000 description 2
230000036755 cellular response Effects 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
230000008878 coupling Effects 0.000 description 2
238000010168 coupling process Methods 0.000 description 2
238000005859 coupling reaction Methods 0.000 description 2
231100000433 cytotoxic Toxicity 0.000 description 2
230000001472 cytotoxic effect Effects 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
238000001514 detection method Methods 0.000 description 2
238000010586 diagram Methods 0.000 description 2
239000003937 drug carrier Substances 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
210000003414 extremity Anatomy 0.000 description 2
230000001605 fetal effect Effects 0.000 description 2
239000011152 fibreglass Substances 0.000 description 2
230000006870 function Effects 0.000 description 2
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
210000002443 helper t lymphocyte Anatomy 0.000 description 2
230000002962 histologic effect Effects 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
230000000366 juvenile effect Effects 0.000 description 2
210000000265 leukocyte Anatomy 0.000 description 2
239000002609 medium Substances 0.000 description 2
210000004379 membrane Anatomy 0.000 description 2
239000012528 membrane Substances 0.000 description 2
210000005012 myelin Anatomy 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
230000037361 pathway Effects 0.000 description 2
230000002688 persistence Effects 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
230000000306 recurrent effect Effects 0.000 description 2
230000009467 reduction Effects 0.000 description 2
230000028327 secretion Effects 0.000 description 2
230000008313 sensitization Effects 0.000 description 2
DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
239000008279 sol Substances 0.000 description 2
241000894007 species Species 0.000 description 2
229910001220 stainless steel Inorganic materials 0.000 description 2
239000010935 stainless steel Substances 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
235000011149 sulphuric acid Nutrition 0.000 description 2
239000000725 suspension Substances 0.000 description 2
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 1
GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
101100515517 Arabidopsis thaliana XI-I gene Proteins 0.000 description 1
101001018362 Bos taurus Myelin basic protein Proteins 0.000 description 1
241000269420 Bufonidae Species 0.000 description 1
101100459439 Caenorhabditis elegans nac-2 gene Proteins 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
102000000503 Collagen Type II Human genes 0.000 description 1
108010041390 Collagen Type II Proteins 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
206010061818 Disease progression Diseases 0.000 description 1
206010013142 Disinhibition Diseases 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
239000004097 EU approved flavor enhancer Substances 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
241000160765 Erebia ligea Species 0.000 description 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 1
241000282412 Homo Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
206010021639 Incontinence Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
125000000773 L-serino group Chemical group [H]OC(=O)[C@@]([H])(N([H])*)C([H])([H])O[H] 0.000 description 1
201000005505 Measles Diseases 0.000 description 1
241001529936 Murinae Species 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
108010058846 Ovalbumin Proteins 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
206010037714 Quadriplegia Diseases 0.000 description 1
239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 1
241001275117 Seres Species 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
101000793689 Sus scrofa Azurocidin Proteins 0.000 description 1
230000005867 T cell response Effects 0.000 description 1
102000009843 Thyroglobulin Human genes 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
241000700605 Viruses Species 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
229960000583 acetic acid Drugs 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000001147 anti-toxic effect Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
238000003556 assay Methods 0.000 description 1
108010052315 basic protein I Proteins 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000008512 biological response Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
238000012754 cardiac puncture Methods 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
230000008859 change Effects 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
238000012790 confirmation Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
230000009260 cross reactivity Effects 0.000 description 1
229960004397 cyclophosphamide Drugs 0.000 description 1
230000009089 cytolysis Effects 0.000 description 1
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
230000029087 digestion Effects 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
230000005750 disease progression Effects 0.000 description 1
239000012154 double-distilled water Substances 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
239000003797 essential amino acid Substances 0.000 description 1
235000020776 essential amino acid Nutrition 0.000 description 1
210000003746 feather Anatomy 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000012091 fetal bovine serum Substances 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
235000019264 food flavour enhancer Nutrition 0.000 description 1
230000005021 gait Effects 0.000 description 1
239000012362 glacial acetic acid Substances 0.000 description 1
101150118163 h gene Proteins 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000008105 immune reaction Effects 0.000 description 1
238000010166 immunofluorescence Methods 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000002386 leaching Methods 0.000 description 1
230000003902 lesion Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000002502 liposome Substances 0.000 description 1
238000005567 liquid scintillation counting Methods 0.000 description 1
230000007257 malfunction Effects 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000010172 mouse model Methods 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
229940092253 ovalbumin Drugs 0.000 description 1
210000004417 patella Anatomy 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
230000001175 peptic effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000007981 phosphate-citrate buffer Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
230000002516 postimmunization Effects 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
229940054269 sodium pyruvate Drugs 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
230000001005 suppressogenic effect Effects 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
230000024664 tolerance induction Effects 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000008979 vitamin B4 Nutrition 0.000 description 1
239000011579 vitamin B4 Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Rheumatology (AREA)
Mycology (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Rehabilitation Therapy (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Marine Sciences & Fisheries (AREA)
Pain & Pain Management (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DK198906516A 1987-06-24 1989-12-20 Behandling af autoimmune sygdomme ved oral administration af autoantigener DK175666B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US6573487A	1987-06-24	1987-06-24
US6573487		1987-06-24
PCT/US1988/002139 WO1988010120A1 (en)	1987-06-24	1988-06-24	Treatment of autoimmune diseases by oral administration of autoantigens
US8802139		1988-06-24

Publications (3)

Publication Number	Publication Date
DK651689D0 DK651689D0 (da)	1989-12-20
DK651689A DK651689A (da)	1990-02-26
DK175666B1 true DK175666B1 (da)	2005-01-10

Family

ID=22064733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198906516A DK175666B1 (da)	1987-06-24	1989-12-20	Behandling af autoimmune sygdomme ved oral administration af autoantigener

Country Status (8)

Country	Link
EP (2)	EP0666080B1 (de)
JP (1)	JP2512796B2 (de)
AT (2)	ATE130762T1 (de)
AU (1)	AU632991B2 (de)
CA (1)	CA1336954C (de)
DE (2)	DE3856566T2 (de)
DK (1)	DK175666B1 (de)
WO (1)	WO1988010120A1 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5571499A (en) *	1987-06-24	1996-11-05	Autoimmune, Inc.	Treatment of autoimmune diseases by aerosol administration of autoantigens
US5849298A (en) *	1987-06-24	1998-12-15	Autoimmune Inc.	Treatment of multiple sclerosis by oral administration of bovine myelin
US6645504B1 (en)	1987-06-24	2003-11-11	Autoimmune Inc.	Bystander suppression of type I diabetes by oral administration of glucagon
US5869054A (en) *	1987-06-24	1999-02-09	Autoimmune Inc.	Treatment of multiple sclerosis by oral administration of autoantigens
US5843445A (en) *	1987-06-24	1998-12-01	Autoimmune, Inc.	Method of treating rheumatoid arthritis with type II collagen
US5571500A (en) *	1987-06-24	1996-11-05	Autoimmune, Inc.	Treatment of autoimmune diseases through administration by inhalation of autoantigens
US5641474A (en) *	1987-06-24	1997-06-24	Autoimmune, Inc.	Prevention of autoimmune diseases by aerosol administration of autoantigens
US5645820A (en) *	1987-06-24	1997-07-08	Autoimmune, Inc.	Treatment of autoimmune diseases by aerosol administration of autoantigens
CA1340012C (en) *	1987-08-17	1998-08-25	Trustees Of Leland Stanford Jr. University	Peptide determinant associated with immunity
WO1990004979A2 (en) *	1988-11-03	1990-05-17	Schering Corporation	Method of preventing or reducing eosinophilia
NO306996B1 (no) *	1989-02-17	2000-01-24	Bayer Ag	Isolert bukspyttkjerteloey-celle-(ICA)-antigen for in vitro- bruk
IL89431A0 (en) *	1989-02-27	1989-09-10	Yeda Res & Dev	Pharmaceutical compositions for the treatment of autoimmune diseases
BR9007527A (pt) *	1989-07-14	1992-06-23	Autoimmune Inc	Metodo para tratar ou prevenir a manifestacao clinica de uma doenca tendo os sintomas de uveoretinite e formulacao farmaceutica para tratar mamiferos sofrendo de uveoretinite
JP2625253B2 (ja) *	1989-12-20	1997-07-02	オートイミューンインク	吸入投与形態をとる自己免疫疾患および／または予防用薬剤
JPH06501464A (ja) *	1990-09-28	1994-02-17	ブリティッシュ・テクノロジー・グループ・リミテッド	抗原−抗体結合体
US5620686A (en) *	1990-09-28	1997-04-15	British Technology Group Limited	Antigen-antibody conjugates
IL99699A (en) *	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
JP2635444B2 (ja) *	1990-10-15	1997-07-30	オートイミューンインク	自己抗体の経口投与による自己免疫性疾患の治療
GB2251186A (en) *	1990-12-04	1992-07-01	Randall Neal Gatz	Polypeptide for use in treatment of autoimmune disease
US5817629A (en)	1991-10-22	1998-10-06	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US6252040B1 (en)	1991-10-22	2001-06-26	The Governors Of The University Of Alberta	Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
NZ266739A (en) *	1993-06-02	1997-07-27	Tvw Telethon Inst Child Health	Inducing immunologic tolerance by administering a cryptic peptide derived from the antigen der pi
GB9319429D0 (en)	1993-09-21	1993-11-03	London Health Ass	Methods and products for controlling immune responses in mammals
JPH10504039A (ja) *	1994-10-25	1998-04-14	イミユロジク・フアーマシユーチカル・コーポレーシヨン	多発性硬化症のための組成物および治療法
US6251396B1 (en)	1994-11-18	2001-06-26	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6379670B1 (en)	1994-11-18	2002-04-30	Neurocrine Biosciences, Inc.	Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6488933B2 (en)	1995-07-05	2002-12-03	Yeda Research And Development Co. Ltd.	Preparations for the treatment of T cell mediated diseases
US5856446A (en) *	1995-07-07	1999-01-05	Autoimmune Inc.	Method of treating rheumatoid arthritis with low dose type II collagen
US5843462A (en)	1995-11-30	1998-12-01	Regents Of The University Of Minnesota	Diphtheria toxin epitopes
KR19990071782A (ko) *	1996-01-05	1999-09-27	왈리스 조 앤	유형ⅱ 콜라겐의 제조방법
JP2001511134A (ja) *	1997-01-24	2001-08-07	オートイミューンインク	メトトレキサートと組合せる耐性化を用いる自己免疫疾患の治療
US7097845B2 (en)	1997-04-23	2006-08-29	Jacob Sten Petersen	Combinations of antigen and mucosal binding component for inducing specific immunological tolerance
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en)	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6905686B1 (en)	1997-12-02	2005-06-14	Neuralab Limited	Active immunization for treatment of alzheimer's disease
US7790856B2 (en)	1998-04-07	2010-09-07	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
US6710226B1 (en)	1997-12-02	2004-03-23	Neuralab Limited	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics
US6923964B1 (en)	1997-12-02	2005-08-02	Neuralab Limited	Active immunization of AScr for prion disorders
US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US7179892B2 (en)	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
US7588766B1 (en)	2000-05-26	2009-09-15	Elan Pharma International Limited	Treatment of amyloidogenic disease
US6761888B1 (en)	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US6750324B1 (en)	1997-12-02	2004-06-15	Neuralab Limited	Humanized and chimeric N-terminal amyloid beta-antibodies
WO1999030736A2 (en)	1997-12-16	1999-06-24	Regents Of The University Of Minnesota	Methods to treat undesirable immune responses
US20030147882A1 (en)	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
ES2527760T3 (es)	1998-07-23	2015-01-29	Yeda Research And Development Co., Ltd.	Tratamiento de enfermedad de Crohn con copolímero 1 y polipéptidos
IL141021A0 (en)	1998-07-23	2002-02-10	Yeda Res & Dev	Treatment of autoimmune conditions with copolymer 1 and related copolymers
US6800287B2 (en)	1998-09-25	2004-10-05	Yeda Research And Development Co., Ltd.	Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
UA81216C2 (en)	1999-06-01	2007-12-25		Prevention and treatment of amyloid disease
ZA200206457B (en)	2000-02-18	2003-08-13	Yeda Res & Dev	Oral, nasal and pulmonary dosage formulations of copolymer 1.
AU2001249214A1 (en)	2000-03-15	2001-09-24	The Brigham And Women's Hospital, Inc.	Suppression of vascular disorders by mucosal administration of heat shock protein peptides
US20020077278A1 (en)	2000-06-05	2002-06-20	Yong V. Wee	Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
WO2002076503A1 (en)	2000-06-20	2002-10-03	Mayo Foundation For Medical Education And Research	Treatment of central nervous system diseases by antibodies against glatiramer acetate
CA2420949C (en)	2000-08-21	2012-01-03	Apitope Technology (Bristol) Limited	Peptide selection method
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
TWI255272B (en)	2000-12-06	2006-05-21	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
KR100657048B1 (ko)	2001-12-04	2006-12-12	테바 파마슈티컬 인더스트리즈 리미티드	글라티라머 아세테이트의 효능 측정 방법
MY139983A (en)	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
PE20050627A1 (es)	2003-05-30	2005-08-10	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido beta amiloideo
JP2008529960A (ja)	2003-06-23	2008-08-07	バイオテックトゥールスソシエテアノニム	エピトープ組成物
ES2396555T3 (es)	2004-12-15	2013-02-22	Janssen Alzheimer Immunotherapy	Anticuerpos que reconocen péptido beta amiloide
ES2434732T3 (es)	2004-12-15	2013-12-17	Janssen Alzheimer Immunotherapy	Anticuerpos para beta-amiloide humanizados para su uso en mejorar la cognición
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
PT2182983E (pt)	2007-07-27	2014-09-01	Janssen Alzheimer Immunotherap	Tratamento de doenças amiloidogénicas com anticorpos anti-abeta humanizados
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3989819A (en) *	1969-03-05	1976-11-02	American Cyanamid Company	Process for separating proteins from central nervous system tissue and treating experimentally induced demyelinating diseases
US4350682A (en) †	1979-05-11	1982-09-21	Lescarden Ltd.	Cartilage extraction processes and products
DE3751553T2 (de) †	1986-06-30	1996-04-25	Massachusetts Inst Technology	Immunomodulare mittel und deren verwendung.
CA1340012C (en) †	1987-08-17	1998-08-25	Trustees Of Leland Stanford Jr. University	Peptide determinant associated with immunity
GB8803881D0 (en) *	1988-02-19	1988-03-23	Traqson Ltd	Novel photoactive compounds processes for their production & intermediates thereof
AU3320089A (en) *	1988-04-20	1989-10-26	Hartech (Australia) Pty. Ltd.	Portable traffic lights

1988
- 1988-06-24 AT AT88906457T patent/ATE130762T1/de not_active IP Right Cessation
- 1988-06-24 CA CA000570406A patent/CA1336954C/en not_active Expired - Fee Related
- 1988-06-24 AU AU20797/88A patent/AU632991B2/en not_active Expired
- 1988-06-24 AT AT95102528T patent/ATE258065T1/de not_active IP Right Cessation
- 1988-06-24 DE DE3856566T patent/DE3856566T2/de not_active Expired - Lifetime
- 1988-06-24 EP EP95102528A patent/EP0666080B1/de not_active Expired - Lifetime
- 1988-06-24 DE DE3854741T patent/DE3854741T3/de not_active Expired - Lifetime
- 1988-06-24 EP EP88906457A patent/EP0359783B2/de not_active Expired - Lifetime
- 1988-06-24 JP JP63506040A patent/JP2512796B2/ja not_active Expired - Lifetime
- 1988-06-24 WO PCT/US1988/002139 patent/WO1988010120A1/en active IP Right Grant
1989
- 1989-12-20 DK DK198906516A patent/DK175666B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0359783B1 (de)	1995-11-29
DE3854741D1 (de)	1996-01-11
EP0359783A4 (de)	1990-06-27
ATE130762T1 (de)	1995-12-15
DE3856566D1 (de)	2004-02-26
DE3854741T3 (de)	2002-08-14
EP0666080B1 (de)	2004-01-21
AU632991B2 (en)	1993-01-21
JPH02503919A (ja)	1990-11-15
EP0359783B2 (de)	2002-04-17
EP0666080A1 (de)	1995-08-09
ATE258065T1 (de)	2004-02-15
DK651689A (da)	1990-02-26
EP0359783A1 (de)	1990-03-28
DK651689D0 (da)	1989-12-20
DE3856566T2 (de)	2004-06-24
DE3854741T2 (de)	1996-04-18
WO1988010120A1 (en)	1988-12-29
JP2512796B2 (ja)	1996-07-03
CA1336954C (en)	1995-09-12
AU2079788A (en)	1989-01-19

Publication	Publication Date	Title
DK175666B1 (da)	2005-01-10	Behandling af autoimmune sygdomme ved oral administration af autoantigener
CA2092905C (en)	2002-01-08	Treatment of autoimmune diseases by oral administration of autoantigens
US5869054A (en)	1999-02-09	Treatment of multiple sclerosis by oral administration of autoantigens
US5849298A (en)	1998-12-15	Treatment of multiple sclerosis by oral administration of bovine myelin
US20050208061A1 (en)	2005-09-22	Treatment of autoimmune diseases by oral administration of autoantigens
Kim et al.	1999	Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255–274) in patients with rheumatoid arthritis
TW496872B (en)	2002-08-01	Peptide p277 analogs, and pharmaceutical compositions comprising them for treatment or diagnosis of diabetes
EP0482089B1 (de)	1997-10-08	Behandlung der autoimmunen uveoretinitis in menschen
Birnbaum et al.	1996	Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2′, 3′ cyclic nucleotide 3′ phosphodiesterase that is cross‐reactive with a heat shock protein alters the course of EAE
Akuffo et al.	1988	Differential recognition of Leishmania aethiopica antigens by lymphocytes from patients with local and diffuse cutaneous leishmaniasis. Evidence for antigen-induced immune suppression.
Gentner et al.	1976	The relation between the cell-mediated immunological response and the induction of circulating antibodies to collagen in guinea-pigs
JP2001029067A (ja)	2001-02-06	抗原特異的細胞傷害抑制性細胞の誘導方法
Zabriskie et al.	2009	12. Immunological Aspects of Cardiac Disease
JPH11509196A (ja)	1999-08-17	糖尿病の治療のためのヒト熱ショックタンパク質６０由来の新規ペプチド、組成物、方法およびキット

Legal Events

Date	Code	Title	Description
2008-07-14	PUP	Patent expired