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DK173674B1 - Anti-allergiske præparater indeholdende N-heterocyclyl-4-piperidinaminer, N-heterocyclyl-4-piperidinaminer til brug som antiallergikum og hidtil ukendte N-heterocyclyl-4-piperidinaminer samt fremgangsmåde til fremstilling deraf - Google Patents

Anti-allergiske præparater indeholdende N-heterocyclyl-4-piperidinaminer, N-heterocyclyl-4-piperidinaminer til brug som antiallergikum og hidtil ukendte N-heterocyclyl-4-piperidinaminer samt fremgangsmåde til fremstilling deraf Download PDF

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Publication number
DK173674B1
DK173674B1 DK198700541A DK54187A DK173674B1 DK 173674 B1 DK173674 B1 DK 173674B1 DK 198700541 A DK198700541 A DK 198700541A DK 54187 A DK54187 A DK 54187A DK 173674 B1 DK173674 B1 DK 173674B1
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DK
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Prior art keywords
alkyl
furanyl
formula
methyl
substituted
Prior art date
Application number
DK198700541A
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Danish (da)
English (en)
Other versions
DK54187D0 (da
DK54187A (da
Inventor
Frans Eduard Janssens
Joseph Leo Ghislanus Torremans
Jozef Francis Hens
Jozef Jan Pieter Heykants
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK54187D0 publication Critical patent/DK54187D0/da
Publication of DK54187A publication Critical patent/DK54187A/da
Application granted granted Critical
Publication of DK173674B1 publication Critical patent/DK173674B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198700541A 1986-02-03 1987-02-02 Anti-allergiske præparater indeholdende N-heterocyclyl-4-piperidinaminer, N-heterocyclyl-4-piperidinaminer til brug som antiallergikum og hidtil ukendte N-heterocyclyl-4-piperidinaminer samt fremgangsmåde til fremstilling deraf DK173674B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82549186A 1986-02-03 1986-02-03
US82549186 1986-02-03

Publications (3)

Publication Number Publication Date
DK54187D0 DK54187D0 (da) 1987-02-02
DK54187A DK54187A (da) 1987-08-04
DK173674B1 true DK173674B1 (da) 2001-06-05

Family

ID=25244134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700541A DK173674B1 (da) 1986-02-03 1987-02-02 Anti-allergiske præparater indeholdende N-heterocyclyl-4-piperidinaminer, N-heterocyclyl-4-piperidinaminer til brug som antiallergikum og hidtil ukendte N-heterocyclyl-4-piperidinaminer samt fremgangsmåde til fremstilling deraf

Country Status (26)

Country Link
EP (1) EP0232937B1 (no)
JP (2) JPH0794393B2 (no)
CN (1) CN1018614B (no)
AT (1) ATE79620T1 (no)
AU (1) AU583706B2 (no)
CA (1) CA1327579C (no)
CY (1) CY1865A (no)
DE (1) DE3781173T2 (no)
DK (1) DK173674B1 (no)
EG (1) EG17993A (no)
ES (1) ES2052544T3 (no)
FI (1) FI870448A (no)
GR (1) GR3006158T3 (no)
HK (1) HK114695A (no)
HU (1) HU201067B (no)
IE (1) IE60885B1 (no)
IL (1) IL81448A (no)
MA (1) MA20868A1 (no)
NO (1) NO870407L (no)
NZ (1) NZ219165A (no)
PH (1) PH24738A (no)
PT (1) PT84234B (no)
TN (1) TNSN87015A1 (no)
ZA (1) ZA87744B (no)
ZM (1) ZM1287A1 (no)
ZW (1) ZW2087A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
IT1229231B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Aminoimidazopiridine farmacologicamente attive
CA2043564A1 (en) * 1990-07-06 1992-01-07 Alfons G. M. De Knaep 3-[(5-methyl-2-furanyl)methyl]-n-(4-piperidinyl)-3h-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate
NZ239540A (en) * 1990-09-24 1993-11-25 Neurosearch As 1-phenyl benzimidazole derivatives and medicaments
DK0658110T3 (da) * 1992-09-03 2000-04-17 Sepracor Inc Anvendelse af norastemizol til behandling af allergisk rhinitis
AU730229B2 (en) * 1992-09-03 2001-03-01 Sepracor, Inc. Use of norastemizole for the treatment of allergic disorders
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
CA2284705A1 (en) * 1997-03-26 1998-10-01 Sepracor Inc. Chemically and thermally stable norastemizole formulations
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
SK18952001A3 (sk) * 1999-06-28 2002-11-06 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncyciálneho vírusu
PT1196409E (pt) 1999-06-28 2004-06-30 Janssen Pharmaceutica Nv Inibidores da replicacao do virus sincicial respiratorio
MXPA02000112A (es) * 1999-06-28 2002-07-02 Janssen Pharmaceutica Nv Inhibidores de la replicacion del virus sincitial respiratorio.
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
WO2004113297A2 (en) * 2003-06-24 2004-12-29 Neurosearch A/S Aza-ring derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20050222198A1 (en) 2003-12-22 2005-10-06 K.U. Leuven Research & Development, Gerhard Puerstinger And Gilead Sciences, Inc. Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
DE602005013580D1 (de) 2004-12-21 2009-05-07 Leuven K U Res & Dev Imidazoä4,5-cüpyridinverbindung und verfahren zur antiviralen behandlung
WO2006067532A1 (en) 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor agonists
AU2006221984C1 (en) 2005-03-08 2012-02-09 Janssen Pharmaceutica N.V. Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists
AU2007269614B2 (en) 2006-07-07 2011-09-08 Gilead Sciences, Inc. Novel pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
JP5764064B2 (ja) * 2008-09-26 2015-08-12 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病薬として有用な新規な環状ベンゾイミダゾール誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (no) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (en) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−ヘテロシクリル−４−ピペリジンアミン
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines

Also Published As

Publication number Publication date
AU583706B2 (en) 1989-05-04
IL81448A0 (en) 1987-09-16
HUT44544A (en) 1988-03-28
CN1018614B (zh) 1992-10-14
JPH07179458A (ja) 1995-07-18
JPH0794393B2 (ja) 1995-10-11
GR3006158T3 (no) 1993-06-21
CY1865A (en) 1996-04-05
ZM1287A1 (en) 1988-08-29
ZW2087A1 (en) 1988-08-31
DE3781173T2 (de) 1992-12-17
CA1327579C (en) 1994-03-08
EG17993A (en) 1991-08-30
IE870258L (en) 1987-08-03
ZA87744B (en) 1988-10-26
ATE79620T1 (de) 1992-09-15
DK54187D0 (da) 1987-02-02
DK54187A (da) 1987-08-04
EP0232937B1 (en) 1992-08-19
FI870448A0 (fi) 1987-02-02
PT84234B (pt) 1989-09-14
AU6821887A (en) 1987-08-06
NO870407D0 (no) 1987-02-02
HU201067B (en) 1990-09-28
EP0232937A3 (en) 1988-04-06
JPS62215575A (ja) 1987-09-22
DE3781173D1 (de) 1992-09-24
MA20868A1 (fr) 1987-10-01
FI870448A (fi) 1987-08-04
JPH0819126B2 (ja) 1996-02-28
NZ219165A (en) 1990-04-26
IL81448A (en) 1990-09-17
NO870407L (no) 1987-08-04
PH24738A (en) 1990-10-01
EP0232937A2 (en) 1987-08-19
HK114695A (en) 1995-07-21
TNSN87015A1 (fr) 1990-01-01
IE60885B1 (en) 1994-08-24
ES2052544T3 (es) 1994-07-16
CN87100563A (zh) 1987-08-19
PT84234A (en) 1987-03-01

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired