DK173033B1 - Farmaceutisk præparat med forlænget frigørelse og fremstilling deraf - Google Patents

Farmaceutisk præparat med forlænget frigørelse og fremstilling deraf Download PDF

Info

Publication number: DK173033B1
Authority: DK; Denmark
Prior art keywords: composition according; active substance; weight; composition; castor oil
Prior art date: 1986-04-11

Application number

DK198701549A

Other languages

Danish (da)

English (en)

Other versions

DK154987D0 (da

DK154987A (da

Inventor

Karl-Erik Lennart Falk

John Albert Sjoegren

Sven Morgan Hugosson

Adam Rosinski

Original Assignee

Haessle Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-11

Filing date

1987-03-26

Publication date

1999-11-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20364135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK173033(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-03-26 Application filed by Haessle Ab filed Critical Haessle Ab

1987-03-26 Publication of DK154987D0 publication Critical patent/DK154987D0/da

1987-10-12 Publication of DK154987A publication Critical patent/DK154987A/da

1999-11-29 Application granted granted Critical

1999-11-29 Publication of DK173033B1 publication Critical patent/DK173033B1/da

Links

238000002360 preparation method Methods 0.000 title claims abstract description 17
238000013265 extended release Methods 0.000 title claims abstract description 7
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000002904 solvent Substances 0.000 claims abstract description 35
238000000034 method Methods 0.000 claims abstract description 8
239000007788 liquid Substances 0.000 claims abstract description 4
239000007787 solid Substances 0.000 claims abstract description 4
230000008569 process Effects 0.000 claims abstract description 3
239000000203 mixture Substances 0.000 claims description 47
RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical group CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 claims description 32
229960003580 felodipine Drugs 0.000 claims description 32
HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical group COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 22
229960001597 nifedipine Drugs 0.000 claims description 18
239000013543 active substance Substances 0.000 claims description 14
239000008389 polyethoxylated castor oil Substances 0.000 claims description 13
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 11
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 10
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 10
235000014113 dietary fatty acids Nutrition 0.000 claims description 9
239000000194 fatty acid Substances 0.000 claims description 9
229930195729 fatty acid Natural products 0.000 claims description 9
150000004665 fatty acids Chemical class 0.000 claims description 9
125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims description 8
239000004359 castor oil Substances 0.000 claims description 7
235000019438 castor oil Nutrition 0.000 claims description 7
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
150000002148 esters Chemical class 0.000 claims description 4
229920001223 polyethylene glycol Polymers 0.000 claims description 4
150000002170 ethers Chemical class 0.000 claims description 3
-1 hydroxypropyl Chemical group 0.000 claims description 3
239000008247 solid mixture Substances 0.000 claims description 3
238000013268 sustained release Methods 0.000 claims description 3
239000012730 sustained-release form Substances 0.000 claims description 3
YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims description 2
150000002191 fatty alcohols Chemical class 0.000 claims description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
229940096529 carboxypolymethylene Drugs 0.000 claims 1
150000002314 glycerols Chemical class 0.000 claims 1
150000001875 compounds Chemical class 0.000 abstract description 15
239000003814 drug Substances 0.000 description 42
229940079593 drug Drugs 0.000 description 41
238000013270 controlled release Methods 0.000 description 14
230000036470 plasma concentration Effects 0.000 description 13
238000010521 absorption reaction Methods 0.000 description 9
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
239000000499 gel Substances 0.000 description 8
239000008187 granular material Substances 0.000 description 8
239000008101 lactose Substances 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
239000000126 substance Substances 0.000 description 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
239000002775 capsule Substances 0.000 description 6
239000003405 delayed action preparation Substances 0.000 description 6
238000004090 dissolution Methods 0.000 description 6
239000000463 material Substances 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
239000001267 polyvinylpyrrolidone Substances 0.000 description 6
229920000036 polyvinylpyrrolidone Polymers 0.000 description 6
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 6
230000002035 prolonged effect Effects 0.000 description 6
239000000243 solution Substances 0.000 description 6
MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 5
229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 description 5
229940045902 sodium stearyl fumarate Drugs 0.000 description 5
PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 4
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
235000010980 cellulose Nutrition 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000007903 gelatin capsule Substances 0.000 description 4
239000001863 hydroxypropyl cellulose Substances 0.000 description 4
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
229920000609 methyl cellulose Polymers 0.000 description 4
239000001923 methylcellulose Substances 0.000 description 4
235000010981 methylcellulose Nutrition 0.000 description 4
229920000642 polymer Polymers 0.000 description 4
238000005063 solubilization Methods 0.000 description 4
230000007928 solubilization Effects 0.000 description 4
IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 description 3
239000001856 Ethyl cellulose Substances 0.000 description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 description 3
229920002907 Guar gum Polymers 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 3
229940092980 adalat Drugs 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
229920001249 ethyl cellulose Polymers 0.000 description 3
DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 description 3
229960002867 griseofulvin Drugs 0.000 description 3
239000000665 guar gum Substances 0.000 description 3
235000010417 guar gum Nutrition 0.000 description 3
229960002154 guar gum Drugs 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
230000009467 reduction Effects 0.000 description 3
239000000230 xanthan gum Substances 0.000 description 3
229920001285 xanthan gum Polymers 0.000 description 3
235000010493 xanthan gum Nutrition 0.000 description 3
229940082509 xanthan gum Drugs 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 2
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 2
108010036949 Cyclosporine Proteins 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
239000000969 carrier Substances 0.000 description 2
229960001265 ciclosporin Drugs 0.000 description 2
239000007931 coated granule Substances 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
239000008120 corn starch Substances 0.000 description 2
229930182912 cyclosporin Natural products 0.000 description 2
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 2
229960005156 digoxin Drugs 0.000 description 2
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
239000000693 micelle Substances 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
ADIMAYPTOBDMTL-UHFFFAOYSA-N oxazepam Chemical compound C12=CC(Cl)=CC=C2NC(=O)C(O)N=C1C1=CC=CC=C1 ADIMAYPTOBDMTL-UHFFFAOYSA-N 0.000 description 2
229960004535 oxazepam Drugs 0.000 description 2
239000012188 paraffin wax Substances 0.000 description 2
229960002036 phenytoin Drugs 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
101100248253 Arabidopsis thaliana RH40 gene Proteins 0.000 description 1
206010003497 Asphyxia Diseases 0.000 description 1
229940127291 Calcium channel antagonist Drugs 0.000 description 1
208000024172 Cardiovascular disease Diseases 0.000 description 1
229930105110 Cyclosporin A Natural products 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
ZBBHBTPTTSWHBA-UHFFFAOYSA-N Nicardipine Chemical class COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN(C)CC=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZBBHBTPTTSWHBA-UHFFFAOYSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920002675 Polyoxyl Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000009471 action Effects 0.000 description 1
229910000323 aluminium silicate Inorganic materials 0.000 description 1
208000037849 arterial hypertension Diseases 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
229960001714 calcium phosphate Drugs 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
230000003292 diminished effect Effects 0.000 description 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical group CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
239000002085 irritant Substances 0.000 description 1
231100000021 irritant Toxicity 0.000 description 1
238000002483 medication Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
229960001783 nicardipine Drugs 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
230000035699 permeability Effects 0.000 description 1
XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
125000001189 phytyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 description 1
229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
230000003381 solubilizing effect Effects 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229920003051 synthetic elastomer Polymers 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
239000005061 synthetic rubber Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK198701549A 1986-04-11 1987-03-26 Farmaceutisk præparat med forlænget frigørelse og fremstilling deraf DK173033B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8601624		1986-04-11
SE8601624A SE8601624D0 (sv)	1986-04-11	1986-04-11	New pharmaceutical preparations

Publications (3)

Publication Number	Publication Date
DK154987D0 DK154987D0 (da)	1987-03-26
DK154987A DK154987A (da)	1987-10-12
DK173033B1 true DK173033B1 (da)	1999-11-29

Family

ID=20364135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198701549A DK173033B1 (da)	1986-04-11	1987-03-26	Farmaceutisk præparat med forlænget frigørelse og fremstilling deraf

Country Status (34)

Country	Link
US (1)	US4803081A (de)
EP (1)	EP0249587B1 (de)
JP (1)	JPH0778016B2 (de)
KR (2)	KR870009720A (de)
CN (1)	CN1025150C (de)
AT (1)	ATE76288T1 (de)
AU (1)	AU602677B2 (de)
CA (1)	CA1304294C (de)
CS (1)	CS270560B2 (de)
CY (1)	CY1826A (de)
DD (1)	DD263231A5 (de)
DE (1)	DE3779183D1 (de)
DK (1)	DK173033B1 (de)
DZ (1)	DZ1067A1 (de)
EG (1)	EG18265A (de)
ES (1)	ES2031929T3 (de)
FI (1)	FI91826C (de)
GR (1)	GR3005286T3 (de)
HK (1)	HK26795A (de)
HU (1)	HU204699B (de)
IE (1)	IE59419B1 (de)
IS (1)	IS1553B (de)
MY (1)	MY101553A (de)
NO (1)	NO174795B (de)
NZ (1)	NZ219633A (de)
PH (1)	PH22494A (de)
PL (1)	PL265078A1 (de)
PT (1)	PT84663B (de)
SE (1)	SE8601624D0 (de)
SG (1)	SG4295G (de)
SU (1)	SU1743332A3 (de)
UA (1)	UA12336A (de)
YU (1)	YU47258B (de)
ZA (1)	ZA871911B (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3720757A1 (de) *	1987-06-24	1989-01-05	Bayer Ag	Dhp-manteltablette
NO883326L (no) *	1987-08-11	1989-02-13	Bayer Ag	Dhp-retard-tilberedning.
DE3738236A1 (de) *	1987-11-11	1989-05-24	Euro Celtique Sa	Beisskapsel
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
US6007840A (en) *	1988-09-16	1999-12-28	Novartis Ag	Pharmaceutical compositions comprising cyclosporins
US4946684A (en) *	1989-06-20	1990-08-07	American Home Products Corporation	Fast dissolving dosage forms
US5006344A (en) *	1989-07-10	1991-04-09	E. R. Squibb & Sons, Inc.	Fosinopril tablet formulations
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
US6262022B1 (en)	1992-06-25	2001-07-17	Novartis Ag	Pharmaceutical compositions containing cyclosporin as the active agent
US5834496A (en) *	1991-12-02	1998-11-10	Sepracor, Inc.	Methods for treating hypertension using optically pure S(-) felodipine
JPH07502274A (ja) *	1991-12-10	1995-03-09	ラシユ−プレスビタリアン−セントルークス・メデイカル・センター	多薬剤耐性を低下させる方法および組成物
US5681812A (en) *	1991-12-10	1997-10-28	Rush Presbyterian-St. Luke's Medical Center	Methods and compositions for reducing multidrug resistance
GB9200607D0 (en) *	1992-01-13	1992-03-11	Ethical Pharma Ltd	Pharmaceutical compositions containing nifedipine and process for the preparation thereof
ES2098739T3 (es)	1992-05-13	1997-05-01	Sandoz Ltd	Composiciones oftalmicas conteniendo una cyclosporin.
US5472711A (en) *	1992-07-30	1995-12-05	Edward Mendell Co., Inc.	Agglomerated hydrophilic complexes with multi-phasic release characteristics
SK281042B6 (sk)	1992-09-18	2000-11-07	Yamanouchi Pharmaceutical Co., Ltd	Prípravok hydrogélového typu s ustáleným uvoľňovaním
JP3598049B2 (ja) *	1992-09-18	2004-12-08	山之内製薬株式会社	ハイドロゲル徐放性製剤
EP0589843B1 (de)	1992-09-25	2001-11-28	Novartis AG	Cyclosporin enthaltende pharmazeutische Zusammensetzungen
BE1006990A5 (nl) *	1993-04-22	1995-02-07	Univ Gent	Werkwijze en samenstelling om een aktief bestanddeel in een vaste toedieningsvorm te brengen.
US5455046A (en) *	1993-09-09	1995-10-03	Edward Mendell Co., Inc.	Sustained release heterodisperse hydrogel systems for insoluble drugs
US6726930B1 (en) *	1993-09-09	2004-04-27	Penwest Pharmaceuticals Co.	Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) *	1993-09-09	1998-06-30	Edward Mendell Co., Inc.	Sustained release heterodisperse hydrogel systems--amorphous drugs
US20060263428A1 (en) *	1993-09-20	2006-11-23	Eugenio Cefali	Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6676967B1 (en)	1993-09-20	2004-01-13	Kos Pharmaceuticals, Inc.	Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6746691B2 (en)	1993-09-20	2004-06-08	Kos Pharmaceuticals, Inc.	Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6129930A (en)	1993-09-20	2000-10-10	Bova; David J.	Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en)	1993-09-20	2000-06-27	Bova; David J.	Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en)	1993-09-20	2004-11-16	Kos Pharmaceuticals, Inc.	Intermediate release nicotinic acid compositions for treating hyperlipidemia
DE4340781C3 (de) *	1993-11-30	2000-01-27	Novartis Ag	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
US5945125A (en) *	1995-02-28	1999-08-31	Temple University	Controlled release tablet
US5783212A (en) *	1996-02-02	1998-07-21	Temple University--of the Commonwealth System of Higher Education	Controlled release drug delivery system
JP3148256B2 (ja)	1996-07-08	2001-03-19	エドワードメンデルカンパニー．，インコーポレーテッド	高用量難溶性薬物用持続放出マトリックス
RU2211047C2 (ru)	1997-01-30	2003-08-27	Новартис Аг	Желатиновые капсулы с твердым покрытием, включающие фармацевтические композиции, практически не содержащие масел
US5895663A (en) *	1997-07-31	1999-04-20	L. Perrigo Company	Pseudoephedrine hydrochloride extended-release tablets
AR017512A1 (es)	1997-08-22	2001-09-12	Smithkline Beecham Corp	Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
AR016827A1 (es)	1997-08-22	2001-08-01	Smithkline Beecham Corp	PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
US6056977A (en)	1997-10-15	2000-05-02	Edward Mendell Co., Inc.	Once-a-day controlled release sulfonylurea formulation
US6555139B2 (en)	1999-06-28	2003-04-29	Wockhardt Europe Limited	Preparation of micron-size pharmaceutical particles by microfluidization
SE9902742D0 (sv) *	1999-07-20	1999-07-20	Astra Ab	New pharmaceutical formultion
CA2352211C (en) *	1999-09-30	2009-03-24	Edward Mendell Co., Inc.	Sustained release matrix systems for highly soluble drugs
FR2802424B1 (fr) *	1999-12-17	2002-02-15	Adir	Comprime matriciel permettant la liberation prolongee de trimetazidine apres administration par voie orale
GB0001449D0 (en) *	2000-01-21	2000-03-08	Cortendo Ab	Compositions
DE60128683T2 (de) *	2000-04-11	2008-01-24	Sankyo Co., Ltd.	Stabilisierte pharmazeutische zusammenstellungen die den calziumkanalblocker azelnidipine enthalten
CA2311734C (en)	2000-04-12	2011-03-08	Bristol-Myers Squibb Company	Flash-melt oral dosage formulation
SE0004671D0 (sv) *	2000-12-15	2000-12-15	Amarin Dev Ab	Pharmaceutical formulation
WO2002056883A1 (en) *	2001-01-18	2002-07-25	Wockhardt Limited	Preparation of micron-size felodipine particles by microfluidization
DE60219478T2 (de) *	2001-07-06	2008-01-03	Endo Pharmaceuticals Inc.	Orale gabe von 6-hydroxy-oxymorphon als analgetikum
MXPA04002891A (es) *	2001-09-28	2005-06-20	Johnson & Johnson	Composicion farmaceutica a base de pasta de azucar.
US8101209B2 (en)	2001-10-09	2012-01-24	Flamel Technologies	Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
TWI324074B (en) *	2001-10-09	2010-05-01	Bristol Myers Squibb Co	Flashmelt oral dosage formulation
JP4625637B2 (ja)	2002-02-22	2011-02-02	シャイアエルエルシー	活性物質送達系及び活性物質を保護し投与する方法
US6726931B2 (en) *	2002-04-08	2004-04-27	Standard Chem. & Pharm. Co., Ltd.	Process for preparing oral sustained-release formulation of felodipine
DE60325709D1 (de)	2002-04-09	2009-02-26	Flamel Tech Sa	Orale wässrige suspension, mikrokapseln enthaltend, zur kontrollierten freisetzung von wirkstoffen
PT1492531E (pt)	2002-04-09	2008-12-10	Flamel Tech Sa	Formulação farmacêutica oral sob a forma de suspensão aquosa de microcápsulas que permite a libertação modificada de amoxicilina
US20030211149A1 (en) *	2002-05-07	2003-11-13	Sherman Bernard Charles	Extended release tablets comprising felodipine
JP4563642B2 (ja) *	2002-05-31	2010-10-13	ワトソンラボラトリーズ、インコーポレイテッド	医薬製剤
FR2842735B1 (fr)	2002-07-26	2006-01-06	Flamel Tech Sa	Microcapsules a liberation modifiee de principes actifs peu solubles pour l'administration per os
FR2842736B1 (fr)	2002-07-26	2005-07-22	Flamel Tech Sa	Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)
US20080051411A1 (en) *	2002-12-17	2008-02-28	Cink Russell D	Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof
US7259186B2 (en) *	2002-12-17	2007-08-21	Abbott Laboratories	Salts of fenofibric acid and pharmaceutical formulations thereof
JP2006511541A (ja) *	2002-12-17	2006-04-06	アボットゲーエムベーハーウントカンパニーカーゲー	フェノフィブル酸、その生理学的に許容し得る塩または誘導体を含有してなる製剤
US20050032879A1 (en) *	2003-08-07	2005-02-10	Temple Okarter	Formulations and use of a beta-blocker and an ACE-inhibitor for the treatment of cardiovascular diseases
TWI372066B (en)	2003-10-01	2012-09-11	Wyeth Corp	Pantoprazole multiparticulate formulations
US8987322B2 (en) *	2003-11-04	2015-03-24	Circ Pharma Research And Development Limited	Pharmaceutical formulations for carrier-mediated transport statins and uses thereof
US20070196396A1 (en) *	2004-02-11	2007-08-23	Rubicon Research Private Limited	Controlled release pharmaceutical compositions with improved bioavailability
KR100598326B1 (ko) *	2004-04-10	2006-07-10	한미약품 주식회사	ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법
US20080152714A1 (en) *	2005-04-08	2008-06-26	Yi Gao	Pharmaceutical Formulations
PL1915137T3 (pl) *	2005-08-10	2014-03-31	Add Advanced Drug Delivery Tech Ltd	Preparat doustny o kontrolowanym uwalnianiu
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
CN101103964B (zh) *	2006-07-14	2010-09-29	海南盛科生命科学研究院	一种含有非洛地平的缓释制剂及其制备方法
US20080081067A1 (en) *	2006-10-03	2008-04-03	Gupta Manishkumar	Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
EP2700158B1 (de)	2011-04-20	2018-10-10	NXP USA, Inc.	Verstärker und zugehörige integrierte schaltungen
CN104997750B (zh) *	2015-07-30	2018-03-20	杭州康恩贝制药有限公司	一种非洛地平缓释片及其制备方法
US9675585B1 (en)	2016-03-24	2017-06-13	Ezra Pharma	Extended release pharmaceutical formulations
US9687475B1 (en)	2016-03-24	2017-06-27	Ezra Pharma Llc	Extended release pharmaceutical formulations with controlled impurity levels
CN109200026B (zh) *	2017-07-03	2021-01-05	北京四环科宝制药有限公司	一种非洛地平缓释片及其制备方法
CN112955965B (zh)	2018-06-14	2024-04-09	阿斯利康(英国)有限公司	使用二氢吡啶类钙通道阻断剂医药组合物降低血压的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2714065A1 (de) *	1977-03-30	1978-10-12	Boehringer Mannheim Gmbh	Instillationszubereitung
JPS5495721A (en) *	1978-01-11	1979-07-28	Nippon Kayaku Co Ltd	Nifedipine preparation
CA1146866A (en) *	1979-07-05	1983-05-24	Yamanouchi Pharmaceutical Co. Ltd.	Process for the production of sustained release pharmaceutical composition of solid medical material
JPS58109412A (ja) *	1981-12-23	1983-06-29	Toa Eiyou Kagaku Kogyo Kk	ニフエジピン固形製剤
DE3318649A1 (de) *	1983-05-21	1984-11-22	Bayer Ag, 5090 Leverkusen	Zweiphasenformulierung
DE3400106A1 (de) *	1984-01-04	1985-07-11	Klaus-Dieter Dr. 3550 Marburg Bremecker	Pharmazeutische zubereitungen mit gesteuerter arzneistoff-freisetzung
JPS61501511A (ja) *	1984-03-21	1986-07-24	アメリカン・ホ−ム・プロダクツ・コ−ポレイション	徐放性医薬カプセル
JPS618A (ja) *	1984-06-09	1986-01-06	Sawai Seiyaku Kk	ニフエジピン含有製剤
IT1178511B (it) *	1984-09-14	1987-09-09	Pharmatec Spa	Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio
IT1187751B (it) *	1985-10-15	1987-12-23	Eurand Spa	Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute

1986
- 1986-04-11 SE SE8601624A patent/SE8601624D0/xx unknown
1987
- 1987-03-10 PH PH35003A patent/PH22494A/en unknown
- 1987-03-12 YU YU40787A patent/YU47258B/sh unknown
- 1987-03-16 NZ NZ219633A patent/NZ219633A/xx unknown
- 1987-03-16 ZA ZA871911A patent/ZA871911B/xx unknown
- 1987-03-16 AU AU70043/87A patent/AU602677B2/en not_active Expired
- 1987-03-22 EG EG171/87A patent/EG18265A/xx active
- 1987-03-23 NO NO871199A patent/NO174795B/no unknown
- 1987-03-25 DE DE8787850098T patent/DE3779183D1/de not_active Expired - Lifetime
- 1987-03-25 AT AT87850098T patent/ATE76288T1/de not_active IP Right Cessation
- 1987-03-25 ES ES198787850098T patent/ES2031929T3/es not_active Expired - Lifetime
- 1987-03-25 EP EP87850098A patent/EP0249587B1/de not_active Expired - Lifetime
- 1987-03-26 DK DK198701549A patent/DK173033B1/da not_active IP Right Cessation
- 1987-04-03 US US07/034,500 patent/US4803081A/en not_active Expired - Lifetime
- 1987-04-07 MY MYPI87000450A patent/MY101553A/en unknown
- 1987-04-07 DZ DZ870056A patent/DZ1067A1/fr active
- 1987-04-07 CA CA000533985A patent/CA1304294C/en not_active Expired - Lifetime
- 1987-04-09 DD DD87301670A patent/DD263231A5/de unknown
- 1987-04-09 IE IE92587A patent/IE59419B1/en not_active IP Right Cessation
- 1987-04-09 PL PL1987265078A patent/PL265078A1/xx unknown
- 1987-04-10 CS CS872587A patent/CS270560B2/cs not_active IP Right Cessation
- 1987-04-10 IS IS3214A patent/IS1553B/is unknown
- 1987-04-10 KR KR870003416A patent/KR870009720A/ko not_active Application Discontinuation
- 1987-04-10 FI FI871585A patent/FI91826C/fi not_active IP Right Cessation
- 1987-04-10 HU HU871622A patent/HU204699B/hu unknown
- 1987-04-10 PT PT84663A patent/PT84663B/pt unknown
- 1987-04-10 SU SU874202349A patent/SU1743332A3/ru active
- 1987-04-10 JP JP62087250A patent/JPH0778016B2/ja not_active Expired - Lifetime
- 1987-04-10 UA UA4202349A patent/UA12336A/uk unknown
- 1987-04-10 CN CN87102758A patent/CN1025150C/zh not_active Expired - Lifetime
- 1987-07-06 KR KR1019870007169A patent/KR950002147B1/ko not_active IP Right Cessation
1992
- 1992-07-29 GR GR920401616T patent/GR3005286T3/el unknown
1995
- 1995-01-11 SG SG4295A patent/SG4295G/en unknown
- 1995-03-02 HK HK26795A patent/HK26795A/xx not_active IP Right Cessation
- 1995-12-01 CY CY182695A patent/CY1826A/xx unknown

Also Published As

Publication number	Publication date
SG4295G (en)	1995-06-16
FI91826B (fi)	1994-05-13
IE870925L (en)	1987-10-11
US4803081A (en)	1989-02-07
ZA871911B (en)	1987-12-30
JPS62242613A (ja)	1987-10-23
DK154987D0 (da)	1987-03-26
FI871585A0 (fi)	1987-04-10
ES2031929T3 (es)	1993-01-01
HU204699B (en)	1992-02-28
FI91826C (fi)	1994-08-25
EP0249587B1 (de)	1992-05-20
DD263231A5 (de)	1988-12-28
EP0249587A1 (de)	1987-12-16
DK154987A (da)	1987-10-12
JPH0778016B2 (ja)	1995-08-23
CS258787A2 (en)	1989-11-14
HK26795A (en)	1995-03-10
KR950002147B1 (ko)	1995-03-14
CA1304294C (en)	1992-06-30
CY1826A (en)	1995-12-01
CS270560B2 (en)	1990-07-12
PT84663A (en)	1987-05-01
NO174795B (no)	1994-04-05
YU40787A (sh)	1992-09-07
NO174795C (de)	1994-07-13
IS1553B (is)	1994-08-10
UA12336A (uk)	1996-12-25
AU7004387A (en)	1987-10-15
FI871585A (fi)	1987-10-12
IS3214A7 (is)	1987-10-12
KR870009720A (ko)	1987-11-30
AU602677B2 (en)	1990-10-25
SU1743332A3 (ru)	1992-06-23
PT84663B (pt)	1989-11-30
KR890001521A (ko)	1989-03-27
GR3005286T3 (de)	1993-05-24
NZ219633A (en)	1989-11-28
HUT43786A (en)	1987-12-28
NO871199L (no)	1987-10-12
DE3779183D1 (de)	1992-06-25
SE8601624D0 (sv)	1986-04-11
NO871199D0 (no)	1987-03-23
ATE76288T1 (de)	1992-06-15
PH22494A (en)	1988-09-12
IE59419B1 (en)	1994-02-23
EG18265A (en)	1992-12-30
PL265078A1 (en)	1988-07-21
CN1025150C (zh)	1994-06-29
MY101553A (en)	1991-12-17
CN87102758A (zh)	1987-10-21
DZ1067A1 (fr)	2004-09-13
YU47258B (sh)	1995-01-31

Publication	Publication Date	Title
DK173033B1 (da)	1999-11-29	Farmaceutisk præparat med forlænget frigørelse og fremstilling deraf
JP2619936B2 (ja)	1997-06-11	新規な薬学的製剤およびその製法
RU2161956C2 (ru)	2001-01-20	Трехфазная фармацевтическая форма с постоянным и регулируемым высвобождением аморфного активного ингредиента для одноразового применения в сутки
RU2163803C2 (ru)	2001-03-10	Фармацевтические композиции, содержащие дарифенацин
JP2010519200A (ja)	2010-06-03	シロスタゾールを含む制御放出製剤及びその製造方法
CA2920758A1 (en)	2015-02-05	Pharmaceutical compositions of fingolimod
EP0284849A1 (de)	1988-10-05	Tabletten mit verzögerter Freisetzung auf der Basis von hochmolekularer Hydroxypropylmethylcellulose und Verfahren zu ihrer Herstellung
KR20240102908A (ko)	2024-07-03	아픽사반을 포함하는 서방성 정제
JP2003504392A (ja)	2003-02-04	新規医薬製剤
HRP920630A2 (en)	1995-10-31	New pharmaceutical preparations having extended delivery
KR20050029376A (ko)	2005-03-28	펠로디핀의 방출 제어형 제제
MXPA01007814A (es)	2002-05-09	Formulacion farmaceutica de libekracion prolongada independiente al ph

Legal Events

Date	Code	Title
1989-10-09	PHB	Application deemed withdrawn due to non-payment or other reasons
1999-11-29	B1	Patent granted (law 1993)
2007-04-10	PUP	Patent expired