[go: up one dir, main page]

DK172664B1 - Benzodiazepiner, mellemprodukter til deres fremstilling, medicinsk produkt indeholdende benzodiazepinerne samt deres anvend - Google Patents

Benzodiazepiner, mellemprodukter til deres fremstilling, medicinsk produkt indeholdende benzodiazepinerne samt deres anvend Download PDF

Info

Publication number
DK172664B1
DK172664B1 DK198901972A DK197289A DK172664B1 DK 172664 B1 DK172664 B1 DK 172664B1 DK 198901972 A DK198901972 A DK 198901972A DK 197289 A DK197289 A DK 197289A DK 172664 B1 DK172664 B1 DK 172664B1
Authority
DK
Denmark
Prior art keywords
ppm
formula
proton
protons
phenyl
Prior art date
Application number
DK198901972A
Other languages
Danish (da)
English (en)
Other versions
DK197289A (da
DK197289D0 (da
Inventor
Jean-Louis Junien
Xavier Bernard Pascaud
Alain Pierre Calvet
Francois Joseph Roman
Yves Robert Pascal
Original Assignee
Jouveinal Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jouveinal Sa filed Critical Jouveinal Sa
Publication of DK197289D0 publication Critical patent/DK197289D0/da
Publication of DK197289A publication Critical patent/DK197289A/da
Application granted granted Critical
Publication of DK172664B1 publication Critical patent/DK172664B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
DK198901972A 1988-04-25 1989-04-24 Benzodiazepiner, mellemprodukter til deres fremstilling, medicinsk produkt indeholdende benzodiazepinerne samt deres anvend DK172664B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8805443 1988-04-25
FR8805443A FR2630440B1 (fr) 1988-04-25 1988-04-25 Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique

Publications (3)

Publication Number Publication Date
DK197289D0 DK197289D0 (da) 1989-04-24
DK197289A DK197289A (da) 1989-10-26
DK172664B1 true DK172664B1 (da) 1999-05-10

Family

ID=9365634

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198901972A DK172664B1 (da) 1988-04-25 1989-04-24 Benzodiazepiner, mellemprodukter til deres fremstilling, medicinsk produkt indeholdende benzodiazepinerne samt deres anvend

Country Status (19)

Country Link
US (1) US4929614A (ja)
EP (1) EP0340064B1 (ja)
JP (1) JP2805634B2 (ja)
KR (1) KR0142328B1 (ja)
AT (1) ATE86995T1 (ja)
AU (1) AU618086B2 (ja)
CA (1) CA1340074C (ja)
DE (1) DE68905365T2 (ja)
DK (1) DK172664B1 (ja)
ES (1) ES2054045T3 (ja)
FI (1) FI91409C (ja)
FR (1) FR2630440B1 (ja)
HK (1) HK95496A (ja)
IE (1) IE62663B1 (ja)
IS (1) IS3454A7 (ja)
NO (1) NO169653C (ja)
NZ (1) NZ228650A (ja)
PT (1) PT90339B (ja)
ZA (1) ZA892682B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
US5248679A (en) * 1988-09-09 1993-09-28 Fujisawa Pharmaceutical Co., Ltd. Tricyclic compounds
PH26955A (en) * 1989-03-08 1992-12-03 Kali Chemie Pharma Gmbh Novel 1,7-fused 1H-indole-2-carboxylic acid N-(1,4-benzodiazepin-3-YL) amides
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.
IE904560A1 (en) * 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
US5206238A (en) * 1990-11-13 1993-04-27 Merck & Co., Inc. Cholecystokinin antagonists
CA2056809A1 (en) * 1990-12-07 1992-06-08 Mark G. Bock Benzodiazepine analogs
HUT70950A (en) * 1993-03-03 1995-11-28 Fujisawa Pharmaceutical Co Pharmaceutical composition of optical isomerization inhibitor activity containing benzodiazepine derivatives
JPH10505818A (ja) * 1994-08-30 1998-06-09 藤沢薬品工業株式会社 リポソーム製剤
FR2725719B1 (fr) * 1994-10-14 1996-12-06 Jouveinal Inst Rech Diazepino-indoles inhibiteurs de phosphodiesterases iv
FR2776660B1 (fr) * 1998-03-27 2000-05-12 Parke Davis Diazepino-indoles de phosphodiesterases iv
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
US6890492B1 (en) * 1998-08-13 2005-05-10 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
AU778005B2 (en) 1998-12-24 2004-11-11 Bristol-Myers Squibb Pharma Company Succinoylamino benzodiazepines as inhibitors of Abeta protein production
WO2001027091A1 (en) * 1999-10-08 2001-04-19 Du Pont Pharmaceuticals Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
CA2395862A1 (en) * 2000-02-17 2001-08-23 Hong Liu Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
MXPA02009755A (es) * 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co Lactamas ciclicas como inhibidores de la produccion de proteina a-beta.
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Disubstituted 1,9-annelated [1,4] benzodiazepinone compounds, processes for the preparation thereof and pharmaceutical compositions containing the same
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

Also Published As

Publication number Publication date
FI91409B (fi) 1994-03-15
IE62663B1 (en) 1995-02-22
KR900016158A (ko) 1990-11-12
PT90339B (pt) 1994-08-31
FR2630440B1 (fr) 1991-09-20
EP0340064A1 (fr) 1989-11-02
DE68905365T2 (de) 1993-10-14
HK95496A (en) 1996-06-07
IS3454A7 (is) 1989-10-26
PT90339A (pt) 1989-11-10
ES2054045T3 (es) 1994-08-01
JP2805634B2 (ja) 1998-09-30
IE891067L (en) 1989-10-25
NZ228650A (en) 1990-12-21
CA1340074C (en) 1998-10-06
KR0142328B1 (ko) 1998-06-01
ZA892682B (en) 1990-12-28
JPH0215083A (ja) 1990-01-18
NO891692L (no) 1989-10-26
FI891952A0 (fi) 1989-04-25
US4929614A (en) 1990-05-29
NO169653B (no) 1992-04-13
AU618086B2 (en) 1991-12-12
DK197289A (da) 1989-10-26
ATE86995T1 (de) 1993-04-15
FR2630440A1 (fr) 1989-10-27
DE68905365D1 (de) 1993-04-22
DK197289D0 (da) 1989-04-24
AU3302589A (en) 1989-10-26
EP0340064B1 (fr) 1993-03-17
NO169653C (no) 1992-07-22
FI891952A (fi) 1989-10-26
FI91409C (fi) 1994-06-27
NO891692D0 (no) 1989-04-24

Similar Documents

Publication Publication Date Title
DK172664B1 (da) Benzodiazepiner, mellemprodukter til deres fremstilling, medicinsk produkt indeholdende benzodiazepinerne samt deres anvend
US5536832A (en) N-acyl-2,3-benzodiazepine derivatives pharmaceutical compositions containing them and process for preparing same
AU700544B2 (en) Novel phenylalkylaminoalcohol carbamates and process for preparing the same
IE921579A1 (en) New perhydroisoindole derivatives and their preparation
DK157995B (da) Analogifremgangsmaade til fremstilling af indolderivater
FI102174B (fi) Menetelmä 1,2,3,4-tetrahydro- ja 1,2,3,3a,4,8b-heksahydrosyklopent£b|i ndolijohdannaisten valmistamiseksi
FI92205B (fi) Menetelmä terapeuttisesti käyttökelpoisten N-pyrrolo- ja pyrido /3,2,1,-j k/ /1,4/ bentsodiatsepinyyli-N'-aryyliurea ja tioureajohdannaisten valmistamiseksi
NZ232774A (en) 1,7-fused 1h-indole-2-carboxylic acid n-(1,4-benzodiazepin-3-yl)amide derivatives; preparatory processes and pharmaceutical compositions
AU649153B2 (en) Pharmaceutically active 6-oxoazepinoindole compounds
BG63632B1 (bg) N-заместени азабициклохептанови производни, приложими като невролептици
KR910003711B1 (ko) 2-(n-피롤리디노)-3-이소부톡시-n-치환된 페닐-n-벤질-프로필아민의 제조방법
AU771745B2 (en) New aminopyrroline compounds, a process for their preparation and pharmaceutical compositions containing them
KR100382998B1 (ko) 6-메톡시-1h-벤조트리아졸-5-카르복사미드유도체,그제조방법및그것을함유하는의약조성물
Kohl et al. Synthesis and CNS activity of 3-substituted 7-chloro-5-phenyl-1, 3, 4-benzotriazepin-2-ones
EP0167922B1 (en) Pyrrolo [1,2-b] [1,2,5] triazepines, a process and intermediates for their preparation and their use as medicaments
KR100305156B1 (ko) N-치환아자비시클로헵탄유도체,그의제조방법및용도
JPS59184184A (ja) ７，８，９，１０−テトラヒドロチエノ〔３，２−ｅ〕ピリド〔４，３−ｂ〕−インド−ル、その製造法及びそれらを含む医薬
JP5727139B2 (ja) ３−（３−アミノ−２−（ｒ）−ヒドロキシ−プロピル）−１−（４−フルオロ−フェニル）−８−（８−メチル−ナフタレン−１−イルメチル）−１，３，８−トリアザ−スピロ［４．５］デカン−４−オンの塩
JPH08208643A (ja) ６−メトキシ−１ｈ−ベンゾトリアゾール−５−カルボキサミド誘導体及びそれを含有する医薬組成物
JPH08225571A (ja) ６−アルコキシ−１ｈ−ベンゾトリアゾール−５−カルボキサミド誘導体及びその中間体並びに該化合物を含有する医薬組成物
JPH01102077A (ja) ２，６‐メタノピロロ‐３‐ベンズアゾジン類
HU215391B (hu) N-Szubsztituált aza-bicikloheptán-származékok, eljárás előállításukra és eljárás ezeket tartalmazó gyógyszerkészítmények előállítására
JPS6183171A (ja) ジベンゾ〔ｂ，ｆ〕〔１，５〕オキサゾシン誘導体及びその製造法並びにそれを有効成分とする医薬

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK